Influence of specific blocking of the delta-like ligand 4/notch signal transduction pathway on the biological behavior of human umbilical vein endothelial cells

Cancer Biotherapy and Radiopharmaceuticals

Volumn 25, Issue 4, 2010, Pages 449-454

  Lv, Wei ^a   Chen, Lin ^b   Zhou, Ding Hua ^a   Wei, Bo ^b  

^a Second Artillery General Hospital   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

adeno associated virus; angiogenesis; DLL; HUVECS; Notch; proliferation

Indexed keywords

COLLAGEN TYPE 1; DELTA LIKE LIGAND 4; MESSENGER RNA; NOTCH RECEPTOR; PARVOVIRUS VECTOR; PROTEIN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; CANCER GENE THERAPY; CELL ASSAY; CELL CULTURE; CELL CYCLE; CELL FUNCTION; CELL GROWTH; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; FLOW CYTOMETRY; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STABLE TRANSFECTION; UMBILICAL VEIN; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; DEPENDOVIRUS; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTORS, NOTCH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UMBILICAL VEINS;

EID: 77956163974     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/cbr.2010.0782     Document Type: Article

References (17)

1. Folkman J. Tumor angiogenesis: Therapeutic implications. N Engl J Med 1971;285:1182.
2. Hellström M, Phng LK, Hofmann JJ, et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 2007;445:776.
3. SiTu ZQ, Wu ZJ. Cell Culture. Xian: World Publishing Corporation, 1996;58-90,173-196.
4. Hu GF, Kang Y, Yu SX, et al. Transgene expressions in human peripheral blood monocyte-derived dendritic cells by infected with recombinant adeno-associated virus 2 carrying exogenous genes. Chin J Immunol 2005;21:728.
5. Ausubel F, Brent R, Kingston RE, et al. Short Protocols in Molecular Biology, 1st ed. Beijing: Beijing Science Press, 1998:673.
6. Kojika S, Griffin JD. Notch receptors and hemtopoiesis. Exp Hematol 2001;29:1041.
7. High FA, Epstein JA. The multifaceted role of Notch in cardiac development and disease. Nat Rev Genet 2008;9:49.
8. Patel NS, Li JL, Generali D, et al. Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res 2005;65:8690.
9. Bush G, diSibio G, Miyamoto A, et al. Ligand-induced signaling in the absence of furin processing of Notch1. Dev Biol 2001;229:494.
10. Yamaguchi E, Chiba S, Kuillano K, et al. Expression of Notch ligands, Jagged 1,2 and delta 1 in antigen presenting cells in mice. Immunol Lett 2002;81:59.
11. Roca C, Adams RH. Regulation of vascular morphogenesis by Notch signaling. Genes Dev 2007;21:2511.
12. Lotte TR. Gene therapy progress and prospects: recombinant adeno-associated virus (rAAV) vectors. Gene Ther 2004;11: 805.
13. Trindade A, Kumar SR, Scehnet JS, et al. Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos. Blood 2008; 112:1720.
14. Harrington LS, Sainson RC, Williams CK, et al. Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells. Microvase Res 2008; 75:144.
15. Folkman J, Haudenschild C. Angiogenesis in vitro. Nature 1980;288:551.
16. Auerbach R, Lewis R, Shinners B, et al. Angiogenesis assays: A critical overview. Clin Chem 2003;49:32.
17. Flotte TR. Gene therapy progress and prospects: Recombinant adeno-associated virus (rAAV) vectors. Gene Ther 2004;11:805.