The macular assessment profile test - A new VDU-based technique for measuring the spatial distribution of the macular pigment, lens density and rapid flicker sensitivity

Ophthalmic and Physiological Optics

Volumn 30, Issue 5, 2010, Pages 470-483

  Barbur, J L ^a   Konstantakopoulou, E ^a   Rodriguez Carmona, M ^a   Harlow, J A ^a   Robson, A G ^b   Moreland, J D ^c  

^a CITY UNIVERSITY   (United Kingdom)

^b MOORFIELDS EYE HOSPITAL   (United Kingdom)

^c KEELE UNIVERSITY   (United Kingdom)

Author keywords

Colour vision; Flicker sensitivity; Heterochromatic flicker photometry; Lens optical density; Macular pigment optical density; MAP test

Indexed keywords

VISUAL PIGMENT;

ADOLESCENT; ADULT; AGING; ARTICLE; CHEMISTRY; COLOR VISION; COLOR VISION TEST; COMPUTER TERMINAL; CRITICAL FLICKER FUSION; FEMALE; HUMAN; LENS; MALE; METHODOLOGY; MIDDLE AGED; PERCEPTIVE THRESHOLD; PHOTOMETRY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; RETINA MACULA LUTEA; VISUAL SYSTEM EXAMINATION;

ADOLESCENT; ADULT; AGING; COLOR PERCEPTION; COLOR PERCEPTION TESTS; COLOR VISION; COMPUTER TERMINALS; DIAGNOSTIC TECHNIQUES, OPHTHALMOLOGICAL; FEMALE; FLICKER FUSION; HUMANS; LENS, CRYSTALLINE; MACULA LUTEA; MALE; MIDDLE AGED; PHOTOMETRY; RETINAL PIGMENTS; SENSORY THRESHOLDS; YOUNG ADULT;

EID: 77956155309     PISSN: 02755408     EISSN: 14751313     Source Type: Journal    
DOI: 10.1111/j.1475-1313.2010.00748.x     Document Type: Conference Paper

References (57)

1. Barbur, J. L., Harlow, A. J. Plant, G. T. (1994) Insights into the different exploits of colour in the visual cortex. Proc. Biol. Sci. 258, 327 334.
2. Beatty, S., Murray, I. J., Henson, D. B., Carden, D., Koh, H. Boulton, M. E. (2001) Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Invest. Ophthalmol. Vis. Sci. 42, 439 446.
3. Berendschot, T. T., Broekmans, W. M., Klopping-Ketelaars, I. A., Kardinaal, A. F., Van Poppel, G. Van Norren, D. (2002a) Lens aging in relation to nutritional determinants and possible risk factors for age-related cataract. Arch. Ophthalmol. 120, 1732 1737.
4. Berendschot, T. T. van Norren, D. (2006) Macular pigment shows ringlike structures. Invest. Ophthalmol. Vis. Sci. 47, 709 714.
5. Berendschot, T. T., Willemse-Assink, J. J., Bastiaanse, M. P., de Jong, T. van Norren, D. (2002b) Macular pigment and melanin in age-related maculopathy in a general population. Invest. Ophthalmol. Vis. Sci. 43, 1928 1932.
6. Bernstein, P. S., Yoshida, M. D., Katz, N. B., McClane, R. W. Gellermann, W. (1998) Raman detection of macular carotenoid pigments in intact human retina. Invest. Ophthalmol. Vis. Sci. 39, 2003 2011.
7. Bone, R. A., Landrum, J. T., Adams, M. Gibert, J. C. (2007) Validity of macular pigment optical density measurements by heterochromatic flicker photometry. Invest. Ophthalmol. Vis. Sci. 48, E-Abstract 2131.
8. Bone, R. A., Landrum, J. T. Cains, A. (1992) Optical density spectra of the macular pigment in vivo and in vitro. Vision Res. 32, 105 110.
9. Bone, R. A., Landrum, J. T. Tarsis, S. L. (1985) Preliminary identification of the human macular pigment. Vision Res. 25, 1531 1535.
10. Casson, E. J., Johnson, C. A. Nelson-Quigg, J. M. (1993) Temporal modulation perimetry: the effects of aging and eccentricity on sensitivity in normals. Invest. Ophthalmol. Vis. Sci. 34, 3096 3102.
11. Ciulla, T. A. Hammond, B. R. Jr. (2004) Macular pigment density and aging, assessed in the normal elderly and those with cataracts and age-related macular degeneration. Am. J. Ophthalmol. 138, 582 587.
12. Dain, S. J., Cassimaty, V. T. Psarakis, D. T. (2004) Differences in FM100-Hue test performance related to iris colour may be due to pupil size as well as presumed amounts of macular pigmentation. Clin. Exp. Optom. 87, 322 325.
13. Egan, C. A., Robson, A. G. Moreland, J. D. (2009) Comparison of motion photometry and 2-wavelength fundus autofluorescence assessments of macular pigment spatial profiles in healthy subjects. Invest. Ophthalmol. Vis. Sci. 50 (E-abstract 1714).
14. Hammond, B. R. Jr. Caruso-Avery, M. (2000) Macular pigment optical density in a Southwestern sample. Invest. Ophthalmol. Vis. Sci. 41, 1492 1497.
15. Hammond, B. R. Jr., Fuld, K. Snodderly, D. M. (1996a) Iris color and macular pigment optical density. Exp. Eye Res. 62, 293 297.
16. Hammond, B. R. Jr., Wooten, B. R. Snodderly, D. M. (1996b) Cigarette smoking and retinal carotenoids: implications for age-related macular degeneration. Vision Res. 36, 3003 3009.
17. Hammond, B. R. Jr., Wooten, B. R. Snodderly, D. M. (1997) Individual variations in the spatial profile of human macular pigment. J. Opt. Soc. Am. A Opt. Image Sci. Vis. 14, 1187 1196.
18. Hammond, B. R. Jr., Wooten, B. R. Snodderly, D. M. (1998) Preservation of visual sensitivity of older subjects: association with macular pigment density. Invest. Ophthalmol. Vis. Sci. 39, 397 406.
19. Handelman, G. J., Dratz, E. A., Reay, C. C. van Kuijk, J. G. (1988) Carotenoids in the human macula and whole retina. Invest. Ophthalmol. Vis. Sci. 29, 850 855.
20. Kim, C. B. Mayer, M. J. (1994) Foveal flicker sensitivity in healthy aging eyes. II. Cross-sectional aging trends from 18 through 77 years of age. J. Opt. Soc. Am. A Opt. Image Sci. Vis. 11, 1958 1969.
21. Kvansakul, J., Rodriguez-Carmona, M., Edgar, D. F., Barker, F. M., Kopcke, W., Schalch, W. Barbur, J. L. (2006) Supplementation with the carotenoids lutein or zeaxanthin improves human visual performance. Ophthalmic Physiol. Opt. 26, 362 371.
22. LaRowe, T. L., Mares, J. A., Snodderly, D. M., Klein, M. L., Wooten, B. R. Chappell, R. (2008) Macular pigment density and age-related maculopathy in the Carotenoids in Age-Related Eye Disease Study. An ancillary study of the women's health initiative. Ophthalmology 115, 876 883 e1.
23. Moreland, J. D. (2004) Macular pigment assessment by motion photometry. Arch. Biochem. Biophys. 430, 143 148.
24. Moreland, J. D. Dain, S. L. (1995) Macular pigment contributes to variance in 100-hue tests. Doc. Ophthalmol. Proc. Ser. 57, 517 522.
25. Moreland, J. D. Kerr, J. (1979) Optimization of a Rayleigh-type equation for the detection of tritanomaly. Vision Res. 19, 1369 1375.
26. Moreland, J. D., Robson, A. G. Kulikowski, J. J. (2001) Macular pigment assessment using a colour monitor. Color Res. Appl. 26, S261 S263.
27. Neitz, J. Jacobs, G. H. (1986) Polymorphism of the long-wavelength cone in normal human colour vision. Nature 323, 623 625.
28. Nolan, J. M., Stack, J., O'Donovan, O., Loane, E. Beatty, S. (2007) Risk factors for age-related maculopathy are associated with a relative lack of macular pigment. Exp. Eye Res. 84, 61 74.
29. Robson, A. G., Harding, G., van Kuijk, F. J., Pauleikhoff, D., Holder, G. E., Bird, A. C., Fitzke, F. W. Moreland, J. D. (2005) Comparison of fundus autofluorescence and minimum-motion measurements of macular pigment distribution profiles derived from identical retinal areas. Perception 34, 1029 1034.
30. Robson, A. G., Moreland, J. D., Pauleikhoff, D., Morrissey, T., Holder, G. E., Fitzke, F. W., Bird, A. C. van Kuijk, F. J. (2003) Macular pigment density and distribution: comparison of fundus autofluorescence with minimum motion photometry. Vision Res. 43, 1765 1775.
31. Robson, A. G. Parry, N. R. (2008) Measurement of macular pigment optical density and distribution using the steady-state visual evoked potential. Vis. Neurosci. 25, 575 583.
32. Rodriguez-Carmona, M., Harlow, A. J., Walker, G. Barbur, J. L. (2005) The variability of normal trichromatic vision and the establishment of the normal matching range. In : Proceedings of the 10th Congress of the Association Internationale de la Couleur (eds Juan L. Nieves Javier Hernãndez Andrés Granada, Spain, pp. 979 982.
33. Rodriguez-Carmona, M., Kvansakul, J., Harlow, J. A., Kopcke, W., Schalch, W. Barbur, J. L. (2006) The effects of supplementation with lutein and/or zeaxanthin on human macular pigment density and colour vision. Ophthalmic Physiol. Opt. 26, 137 147.
34. Ruddock, K. H. (1965) The effect of age upon colour vision. II. Changes with age in light transmission of the ocular media. Vision Res. 5, 47 58.
35. Ruddock, K. H. (1972) Observer variations in foveal colour vision responses. Vision Res. 12, 145 149.
36. Sample, P. A., Esterson, F. D., Weinreb, R. N. Boynton, R. M. (1988) The aging lens: in vivo assessment of light absorption in 84 human eyes. Invest. Ophthalmol. Vis. Sci. 29, 1306 1311.
37. Savage, G. L., Johnson, C. A. Howard, D. L. (2001) A comparison of noninvasive objective and subjective measurements of the optical density of human ocular media. Optom. Vis. Sci. 78, 386 395.
38. Schalch, W. (1992) Carotenoids in the retina-a review of their possible role in preventing or limiting damage caused by light and oxygen. EXS 62, 280 298.
39. Snodderly, D. M. (1995) Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. Am. J. Clin. Nutr. 62, 1448S 1461S.
40. Snodderly, D. M., Auran, J. D. Delori, F. C. (1984a) The macular pigment. II. Spatial distribution in primate retinas. Invest. Ophthalmol. Vis. Sci. 25, 674 685.
41. Snodderly, D. M., Brown, P. K., Delori, F. C. Auran, J. D. (1984b) The macular pigment. I. Absorbance spectra, localization, and discrimination from other yellow pigments in primate retinas. Invest. Ophthalmol. Vis. Sci. 25, 660 673.
42. Snodderly, D. M. Hammond, B. R. (1999) In vivo psychophysical assessment of nutritional and environmental influences on human ocular tissues: lens and macular pigment. In : Nutritional and Environmental Influences on Vision (ed A. Taylor CRC Press, Boca Raton, pp. 251 273.
43. Stockman, A. Sharpe, L. T. (2000) The spectral sensitivities of the middle- and long-wavelength-sensitive cones derived from measurements in observers of known genotype. Vision Res. 40, 1711 1737.
44. Trieschmann, M., F. J. van Kuijk, R. Alexander, Hermans, P., Luthert, P., Bird, A. C. Pauleikhoff, D. (2008) Macular pigment in the human retina: histological evaluation of localization and distribution. Eye 22, 132 137.
45. van de Kraats, J., Berendschot, T. T., Valen, S. van Norren, D. (2006) Fast assessment of the central macular pigment density with natural pupil using the macular pigment reflectometer. J. Biomed. Opt. 11, 064031.
46. van de Kraats, J., Kanis, M. J., Genders, S. W. van Norren, D. (2008) Lutein and zeaxanthin measured separately in the living human retina with fundus reflectometry. Invest. Ophthalmol. Vis. Sci. 49, 5568 5573.
47. van de Kraats, J. van Norren, D. (2007) Optical density of the aging human ocular media in the visible and the UV. J. Opt. Soc. Am. A Opt. Image Sci. Vis. 24, 1842 1857.
48. van der Veen, R. L., Berendschot, T. T., Hendrikse, F., Carden, D., Makridaki, M. Murray, I. J. (2009) A new desktop instrument for measuring macular pigment optical density based on a novel technique for setting flicker thresholds. Ophthalmic Physiol. Opt. 29, 127 137.
49. Walkey, H. C., Barbur, J. L., Harlow, A. J. Makous, W. (2001) Measurements of Chromatic Sensitivity in the Mesopic Range. Color Res. Appl. 26, S36 S42.
50. Weale, R. A. (1988) Age and the transmittance of the human crystalline lens. J. Physiol. 395, 577 587.
51. Werner, J. S., Donnelly, S. K. Kliegl, R. (1987) Aging and human macular pigment density. Appended with translations from the work of Max Schultze and Ewald Hering. Vision Res. 27, 257 268.
52. Wolf-Schnurrbusch, U. E., Roosli, N., Weyermann, E., Heldner, M. R., Hohne, K. Wolf, S. (2007) Ethnic differences in macular pigment density and distribution. Invest. Ophthalmol. Vis. Sci. 48, 3783 3787.
53. Wolffsohn, J. S., Cochrane, A. L., Khoo, H., Yoshimitsu, Y. Wu, S. (2000) Contrast is enhanced by yellow lenses because of selective reduction of short-wavelength light. Optom. Vis. Sci. 77, 73 81.
54. Wooten, B. R. Hammond, B. R. (2002) Macular pigment: influences on visual acuity and visibility. Prog. Retin. Eye Res. 21, 225 240.
55. Wooten, B. R., Hammond, B. R. Jr., Land, R. I. Snodderly, D. M. (1999) A practical method for measuring macular pigment optical density. Invest. Ophthalmol. Vis. Sci. 40, 2481 2489.
56. Wooten, B. R., Hammond, B. R. Renzi, L. M. (2007) Using scotopic and photopic flicker to measure lens optical density. Ophthalmic Physiol. Opt. 27, 321 328.
57. Wustemeyer, H., Moessner, A., Jahn, C. Wolf, S. (2003) Macular pigment density in healthy subjects quantified with a modified confocal scanning laser ophthalmoscope. Graefes Arch. Clin. Exp. Ophthalmol. 241, 647 651.