Characterization of a clinical polymer-drug conjugate using multiscale modeling

Biopolymers

Volumn 93, Issue 11, 2010, Pages 936-951

  Peng, Lili X ^a   Ivetac, Anthony ^b   Chaudhari, Akshay S ^a   Van, Sang ^c   Zhao, Gang ^c   Yu, Lei ^c   Howell, Stephen B ^d   McCammon, J Andrew ^b   Gough, David A ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Biomedical Group   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Amphiphilic; Drug delivery; Multiscale modeling; Paclitaxel; Polymer

Indexed keywords

CIRCULAR DICHROISM SPECTROSCOPY; COMPUTER SIMULATION; DICHROISM; DRUG DELIVERY; MOLECULAR DYNAMICS; POLYMERS;

AMPHIPHILIC POLYMERS; AMPHIPHILICS; COARSE-GRAINED; COIL GEOMETRIES; COIL SHAPE; DRUG-CONJUGATES; EFFECTIVE TIME; FORM COIL; HYDROPHOBIC AND HYDROPHILIC; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATIONS; MULTI-SCALE MODELING; PACLITAXEL; POTENTIAL VALUES; SHAPE AND SIZE; SPATIAL ARRANGEMENTS; STATISTICAL EQUILIBRIUM; TARGET CELLS; THERAPEUTIC AGENTS; THERAPEUTIC DELIVERY;

CONFORMATIONS;

PACLITAXEL; POLY GAMMA GLUTAMYLGLUTAMATE; POLY GAMMA GLUTAMYLGLUTAMATE PACLITAXEL; POLYGLUTAMIC ACID; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; POLY(GAMMA-GLUTAMYLGLUTAMINE)PACLITAXEL; PROTEIN;

ARTICLE; CIRCULAR DICHROISM; DRUG CONJUGATION; DRUG FORMULATION; DRUG SYNTHESIS; HYDROPHILICITY; HYDROPHOBICITY; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG DELIVERY SYSTEM;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CIRCULAR DICHROISM; DRUG DELIVERY SYSTEMS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; PACLITAXEL; PROTEINS;

EID: 77956135362     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.21474     Document Type: Article

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