메뉴 건너뛰기




Volumn 83, Issue 3, 2010, Pages 347-358

Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo

Author keywords

Blastocyst; Cavity formation; Cdx2; Cell polarity; Early development; Epithelium; Gene regulation; Nanog; Paracellular permeability seal; PRKCZ (aPKCzeta); Tead4; TJP1 (ZO 1); Trophoblast

Indexed keywords

PROTEIN KINASE C; PROTEIN KINASE C ZETA; PROTEIN PARD6B; PROTEIN TEAD4; PROTEIN ZO1; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX2; UNCLASSIFIED DRUG;

EID: 77956126193     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.110.084400     Document Type: Article
Times cited : (120)

References (54)
  • 1
    • 39849084922 scopus 로고    scopus 로고
    • Tight junction biogenesis during early development
    • Eckert JJ, Fleming TP. Tight junction biogenesis during early development. Biochim Biophys Acta 2008; 1778:717-728.
    • (2008) Biochim Biophys Acta , vol.1778 , pp. 717-728
    • Eckert, J.J.1    Fleming, T.P.2
  • 3
    • 2442495047 scopus 로고    scopus 로고
    • Deletion of the Na/K-ATPase α1-subunit gene (Atp1a1) does not prevent cavitation of the preimplantation mouse embryo
    • Barcroft LC, Moseley AE, Lingrel JB, Watson AJ. Deletion of the Na/K-ATPase α1-subunit gene (Atp1a1) does not prevent cavitation of the preimplantation mouse embryo. Mech Dev 2004; 121:417-426.
    • (2004) Mech Dev , vol.121 , pp. 417-426
    • Barcroft, L.C.1    Moseley, A.E.2    Lingrel, J.B.3    Watson, A.J.4
  • 5
    • 34249708977 scopus 로고    scopus 로고
    • Na/K-ATPase β1 subunit expression is required for blastocyst formation and normal assembly of trophectoderm tight junction-associated proteins
    • DOI 10.1074/jbc.M700696200
    • Madan P, Rose K, Watson AJ. Na/K-ATPase β1 subunit expression is required for blastocyst formation and normal assembly of trophectoderm tight junction-associated proteins. J Biol Chem 2007; 282:12127-12134. (Pubitemid 47100727)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.16 , pp. 12127-12134
    • Madan, P.1    Rose, K.2    Watson, A.J.3
  • 6
    • 52049087791 scopus 로고    scopus 로고
    • Blastomeres of the mouse embryo lose totipotency after the fifth cleavage division: Expression of Cdx2 and Oct4 and developmental potential of inner and outer blastomeres of 16- and 32-cell embryos
    • Suwińska A, Czołowska R, Ozdzeński W, Tarkowski AK. Blastomeres of the mouse embryo lose totipotency after the fifth cleavage division: expression of Cdx2 and Oct4 and developmental potential of inner and outer blastomeres of 16- and 32-cell embryos. Dev Biol 2008; 322:133-144.
    • (2008) Dev Biol , vol.322 , pp. 133-144
    • Suwińska, A.1    Czołowska, R.2    Ozdzeński, W.3    Tarkowski, A.K.4
  • 7
    • 3242667728 scopus 로고    scopus 로고
    • Lineage allocation and cell polarity during mouse embryogenesis
    • DOI 10.1016/j.semcdb.2004.04.002, PII S108495210400045X
    • Johnson MH, McConnell JML. Lineage allocation and cell polarity during mouse embryogenesis. Semin Cell Dev Biol 2004; 15:583-597. (Pubitemid 38953955)
    • (2004) Seminars in Cell and Developmental Biology , vol.15 , Issue.5 , pp. 583-597
    • Johnson, M.H.1    McConnell, J.M.L.2
  • 8
    • 70349288430 scopus 로고    scopus 로고
    • Establishment of trophectoderm and inner cell mass lineages in the mouse embryo
    • Marikawa Y, Alarcón VB. Establishment of trophectoderm and inner cell mass lineages in the mouse embryo. Mol Reprod Dev 2009; 76:1019-1032.
    • (2009) Mol Reprod Dev , vol.76 , pp. 1019-1032
    • Marikawa, Y.1    Alarcón, V.B.2
  • 10
    • 65549115574 scopus 로고    scopus 로고
    • Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse
    • Rossant J, Tam PP. Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development 2009; 136: 701-713.
    • (2009) Development , vol.136 , pp. 701-713
    • Rossant, J.1    Tam, P.P.2
  • 11
    • 0032582513 scopus 로고    scopus 로고
    • Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
    • DOI 10.1016/S0092-8674(00)81769-9
    • Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, Schöler H, Smith A. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 1998; 95:379-391. (Pubitemid 28507326)
    • (1998) Cell , vol.95 , Issue.3 , pp. 379-391
    • Nichols, J.1    Zevnik, B.2    Anastassiadis, K.3    Niwa, H.4    Klewe-Nebenius, D.5    Chambers, I.6    Scholer, H.7    Smith, A.8
  • 12
    • 0025291459 scopus 로고
    • Oct-4: A germline-specific transcription factor mapping to the mouse t-complex
    • Schöler HR, Dressler GR, Balling R, Rohdewohld H, Gruss P. Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J 1990; 9:2185-2195. (Pubitemid 20198962)
    • (1990) EMBO Journal , vol.9 , Issue.7 , pp. 2185-2195
    • Scholer, H.R.1    Dressler, G.R.2    Balling, R.3    Rohdewohld, H.4    Gruss, P.5
  • 13
    • 0027959928 scopus 로고
    • Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation
    • DOI 10.1006/dbio.1994.1312
    • Palmieri SL, Peter W, Hess H, Schöler HR. Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev Biol 1994; 166:259-267. (Pubitemid 24374763)
    • (1994) Developmental Biology , vol.166 , Issue.1 , pp. 259-267
    • Palmieri, S.L.1    Peter, W.2    Hess, H.3    Scholer, H.R.4
  • 14
    • 0028879331 scopus 로고
    • Expression of Cdx-2 in the mouse embryo and placenta: Possible role in patterning of the extraembryonic membranes
    • Beck F, Erler T, Russell A, James R. Expression of Cdx-2 in the mouse embryo and placenta: possible role in patterning of the extraembryonic membranes. Dev Dyn 1995; 204:219-227.
    • (1995) Dev Dyn , vol.204 , pp. 219-227
    • Beck, F.1    Erler, T.2    Russell, A.3    James, R.4
  • 15
    • 19744365010 scopus 로고    scopus 로고
    • Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
    • DOI 10.1242/dev.01801
    • Strumpf D, Mao CA, Yamanaka Y, Ralston A, Chawengsaksophak K, Beck F, Rossant J. Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development 2005; 132:2093-2102. (Pubitemid 40744469)
    • (2005) Development , vol.132 , Issue.9 , pp. 2093-2102
    • Strumpf, D.1    Mao, C.-A.2    Yamanaka, Y.3    Ralston, A.4    Chawengsaksophak, K.5    Beck, F.6    Rossant, J.7
  • 16
    • 38049095768 scopus 로고    scopus 로고
    • Stochastic patterning in the mouse preimplantation embryo
    • Dietrich JE, Hiiragi T. Stochastic patterning in the mouse preimplantation embryo. Development 2007; 134:4219-4231.
    • (2007) Development , vol.134 , pp. 4219-4231
    • Dietrich, J.E.1    Hiiragi, T.2
  • 17
  • 18
    • 38049045708 scopus 로고    scopus 로고
    • Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo
    • Ralston A, Rossant J. Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo. Dev Biol 2008; 313:614-629.
    • (2008) Dev Biol , vol.313 , pp. 614-629
    • Ralston, A.1    Rossant, J.2
  • 19
    • 36549062015 scopus 로고    scopus 로고
    • Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development
    • DOI 10.1242/dev.010223
    • Yagi R, Kohn MJ, Karavanova I, Kaneko KJ, Vullhorst D, DePamphilis ML, Buonanno A. Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development. Development 2007; 134:3827-3836. (Pubitemid 350187342)
    • (2007) Development , vol.134 , Issue.21 , pp. 3827-3836
    • Yagi, R.1    Kohn, M.J.2    Karavanova, I.3    Kaneko, K.J.4    Vullhorst, D.5    DePamphilis, M.L.6    Buonanno, A.7
  • 22
    • 20444400205 scopus 로고    scopus 로고
    • Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction
    • DOI 10.1016/j.ydbio.2005.03.001, PII S0012160605001405
    • Vinot S, Le T, Ohno S, Pawson T, Maro B, Louvet-Vallée S. Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction. Dev Biol 2005; 282:307-319. (Pubitemid 40799323)
    • (2005) Developmental Biology , vol.282 , Issue.2 , pp. 307-319
    • Vinot, S.1    Le, T.2    Ohno, S.3    Pawson, T.4    Maro, B.5    Louvet-Vallee, S.6
  • 23
    • 14344250090 scopus 로고    scopus 로고
    • PAR proteins and the establishment of cell polarity during C. elegans development
    • Nance J. PAR proteins and the establishment of cell polarity during C. elegans development. BioEssays 2005; 27:126-135.
    • (2005) BioEssays , vol.27 , pp. 126-135
    • Nance, J.1
  • 24
    • 0024284814 scopus 로고
    • Identification of genes required for cytoplasmic localization in early C. elegans embryos
    • Kemphues KJ, Priess JR, Morton DG, Cheng NS. Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell 1988; 52:311-320.
    • (1988) Cell , vol.52 , pp. 311-320
    • Kemphues, K.J.1    Priess, J.R.2    Morton, D.G.3    Cheng, N.S.4
  • 25
    • 0029850113 scopus 로고    scopus 로고
    • Par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3
    • Watts JL, Etemad-Moghadam B, Guo S, Boyd L, Draper BW, Mello CC, Priess JR, Kemphues KJ. par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3. Development 1996; 122:3133-3140.
    • (1996) Development , vol.122 , pp. 3133-3140
    • Watts, J.L.1    Etemad-Moghadam, B.2    Guo, S.3    Boyd, L.4    Draper, B.W.5    Mello, C.C.6    Priess, J.R.7    Kemphues, K.J.8
  • 26
    • 0031674842 scopus 로고    scopus 로고
    • Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans
    • Tabuse Y, Izumi Y, Piano F, Kemphues KJ, Miwa J, Ohno S. Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans. Development 1998; 125:3607-3614.
    • (1998) Development , vol.125 , pp. 3607-3614
    • Tabuse, Y.1    Izumi, Y.2    Piano, F.3    Kemphues, K.J.4    Miwa, J.5    Ohno, S.6
  • 27
    • 33645746316 scopus 로고    scopus 로고
    • The PAR-aPKC system: Lessons in polarity
    • Suzuki A, Ohno S. The PAR-aPKC system: lessons in polarity. J Cell Sci 2006; 119:979-987.
    • (2006) J Cell Sci , vol.119 , pp. 979-987
    • Suzuki, A.1    Ohno, S.2
  • 28
    • 35549001736 scopus 로고    scopus 로고
    • The PAR Proteins: Fundamental Players in Animal Cell Polarization
    • DOI 10.1016/j.devcel.2007.10.007, PII S1534580707003851
    • Goldstein B, Macara IG. The PAR proteins: fundamental players in animal cell polarization. Dev Cell 2007; 13:609-622. (Pubitemid 350011991)
    • (2007) Developmental Cell , vol.13 , Issue.5 , pp. 609-622
    • Goldstein, B.1    Macara, I.G.2
  • 29
    • 52049125202 scopus 로고    scopus 로고
    • Regulation of epithelial and endothelial junctions by PAR proteins
    • Ebnet K, Iden S, Gerke V, Suzuki A. Regulation of epithelial and endothelial junctions by PAR proteins. Front Biosci 2008; 13:6520-6536.
    • (2008) Front Biosci , vol.13 , pp. 6520-6536
    • Ebnet, K.1    Iden, S.2    Gerke, V.3    Suzuki, A.4
  • 30
    • 70349484847 scopus 로고    scopus 로고
    • Inactivation of aPKClambda reveals a context dependent allocation of cell lineages in preimplantation mouse embryos
    • Dard N, Le T, Maro B, Louvet-Vallée S. Inactivation of aPKClambda reveals a context dependent allocation of cell lineages in preimplantation mouse embryos. PLoS One 2009; 4:e7117.
    • (2009) PLoS One , vol.4
    • Dard, N.1    Le, T.2    Maro, B.3    Louvet-Vallée, S.4
  • 31
    • 0034253536 scopus 로고    scopus 로고
    • The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    • Joberty G, Petersen C, Gao L, Macara IG. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol 2000; 2: 531-539.
    • (2000) Nat Cell Biol , vol.2 , pp. 531-539
    • Joberty, G.1    Petersen, C.2    Gao, L.3    Macara, I.G.4
  • 32
    • 33845345893 scopus 로고    scopus 로고
    • Transcription profile in mouse four-cell, morula, and blastocyst: Genes implicated in compaction and blastocoel formation
    • Cui XS, Li XY, Shen XH, Bae YJ, Kang JJ, Kim NH. Transcription profile in mouse four-cell, morula, and blastocyst: genes implicated in compaction and blastocoel formation. Mol Reprod Dev 2007; 74:133-143.
    • (2007) Mol Reprod Dev , vol.74 , pp. 133-143
    • Cui, X.S.1    Li, X.Y.2    Shen, X.H.3    Bae, Y.J.4    Kang, J.J.5    Kim, N.H.6
  • 35
    • 1842532909 scopus 로고    scopus 로고
    • Specific Gene Silencing in the Pre-Implantation Stage Mouse Embryo by an siRNA Expression Vector System
    • DOI 10.1002/mrd.20047
    • Haraguchi S, Saga Y, Naito K, Inoue H, Seto A. Specific gene silencing in the preimplantation stage mouse embryo by an siRNA expression vector system. Mol Reprod Dev 2004; 68:17-24. (Pubitemid 38420515)
    • (2004) Molecular Reproduction and Development , vol.68 , Issue.1 , pp. 17-24
    • Haraguchi, S.1    Saga, Y.2    Naito, K.3    Inoue, H.4    Seto, A.5
  • 36
    • 44849131273 scopus 로고    scopus 로고
    • Spatial alignment of the mouse blastocyst axis across the first cleavage plane is caused by mechanical constraint rather than developmental bias among blastomeres
    • DOI 10.1002/mrd.20856
    • Alarcón VB, Marikawa Y. Spatial alignment of the mouse blastocyst axis across the first cleavage plane is caused by mechanical constraint rather than developmental bias among blastomeres. Mol Reprod Dev 2008; 75: 1143-1153. (Pubitemid 351799528)
    • (2008) Molecular Reproduction and Development , vol.75 , Issue.7 , pp. 1143-1153
    • Alarcon, V.B.1    Marikawa, Y.2
  • 37
    • 12944302580 scopus 로고    scopus 로고
    • A maternal store of macroH2A is removed from pronuclei prior to onset of somatic macroH2A expression in preimplantation embryos
    • DOI 10.1016/j.ydbio.2004.11.032, PII S0012160604008115
    • Chang CC, Ma Y, Jacobs S, Tian XC, Yang X, Rasmussen TP. A maternal store of macroH2A is removed from pronuclei prior to onset of somatic macroH2A expression in preimplantation embryos. Dev Biol 2005; 278: 367-380. (Pubitemid 40175036)
    • (2005) Developmental Biology , vol.278 , Issue.2 , pp. 367-380
    • Chang, C.-C.1    Ma, Y.2    Jacobs, S.3    Tian, X.C.4    Yang, X.5    Rasmussen, T.P.6
  • 38
    • 39449102987 scopus 로고    scopus 로고
    • Preimplantation embryo programming: Transcription epigenetics, and culture environment
    • DOI 10.1530/REP-07-0324
    • Duranthon V, Watson AJ, Lonergan P. Preimplantation embryo programming: transcription, epigenetics, and culture environment. Reproduction 2008; 135:141-150. (Pubitemid 351267385)
    • (2008) Reproduction , vol.135 , Issue.2 , pp. 141-150
    • Duranthon, V.1    Watson, A.J.2    Lonergan, P.3
  • 40
    • 0017681593 scopus 로고
    • +-ATPase-linked mechanism in blastocysts
    • +-ATPase-linked mechanism in blastocysts. Dev Biol 1977; 59:198-205.
    • (1977) Dev Biol , vol.59 , pp. 198-205
    • DiZio, S.M.1    Tasca, R.J.2
  • 41
    • 0024511857 scopus 로고
    • Blastocoel expansion in the preimplantation mouse embryo: Role of extracellular sodium and chloride and possible apical routes of their entry
    • Manejwala FM, Cragoe EJ Jr, Schultz RM. Blastocoel expansion in the preimplantation mouse embryo: role of extracellular sodium and chloride and possible apical routes of their entry. Dev Biol 1989; 133:210-220.
    • (1989) Dev Biol , vol.133 , pp. 210-220
    • Manejwala, F.M.1    Cragoe Jr., E.J.2    Schultz, R.M.3
  • 42
    • 36549003561 scopus 로고    scopus 로고
    • Tight junctions containing claudin 4 and 6 are essential for blastocyst formation in preimplantation mouse embryos
    • DOI 10.1016/j.ydbio.2007.09.049, PII S0012160607013991
    • Moriwaki K, Tsukita S, Furuse M. Tight junctions containing claudin 4 and 6 are essential for blastocyst formation in preimplantation mouse embryos. Dev Biol 2007; 312:509-522. (Pubitemid 350183973)
    • (2007) Developmental Biology , vol.312 , Issue.2 , pp. 509-522
    • Moriwaki, K.1    Tsukita, S.2    Furuse, M.3
  • 43
    • 43449121222 scopus 로고    scopus 로고
    • Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse
    • Wang H, Ding T, Brown N, Yamamoto Y, Prince LS, Reese J, Paria BC. Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev Biol 2008; 318:112-125.
    • (2008) Dev Biol , vol.318 , pp. 112-125
    • Wang, H.1    Ding, T.2    Brown, N.3    Yamamoto, Y.4    Prince, L.S.5    Reese, J.6    Paria, B.C.7
  • 44
    • 41549086164 scopus 로고    scopus 로고
    • Regulation of cell polarity during epithelial morphogenesis
    • Martin-Belmonte F, Mostov K. Regulation of cell polarity during epithelial morphogenesis. Curr Opin Cell Biol 2008; 20:227-234.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 227-234
    • Martin-Belmonte, F.1    Mostov, K.2
  • 45
    • 0038143611 scopus 로고    scopus 로고
    • Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells
    • Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, Smith A. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003; 113:643-655.
    • (2003) Cell , vol.113 , pp. 643-655
    • Chambers, I.1    Colby, D.2    Robertson, M.3    Nichols, J.4    Lee, S.5    Tweedie, S.6    Smith, A.7
  • 47
    • 54149088414 scopus 로고    scopus 로고
    • Tight junction protein ZO-2 expression and relative function of ZO-1 and ZO-2 during mouse blastocyst formation
    • Sheth B, Nowak RL, Anderson R, Kwong WY, Papenbrock T, Fleming TP. Tight junction protein ZO-2 expression and relative function of ZO-1 and ZO-2 during mouse blastocyst formation. Exp Cell Res 2008; 314: 3356-3368.
    • (2008) Exp Cell Res , vol.314 , pp. 3356-3368
    • Sheth, B.1    Nowak, R.L.2    Anderson, R.3    Kwong, W.Y.4    Papenbrock, T.5    Fleming, T.P.6
  • 48
    • 56749184887 scopus 로고    scopus 로고
    • Tight junction-based epithelial microenvironment and cell proliferation
    • Tsukita S, Yamazaki Y, Katsuno T, Tamura A, Tsukita S. Tight junction-based epithelial microenvironment and cell proliferation. Oncogene 2008; 27:6930-6938.
    • (2008) Oncogene , vol.27 , pp. 6930-6938
    • Tsukita, S.1    Yamazaki, Y.2    Katsuno, T.3    Tamura, A.4    Tsukita, S.5
  • 50
    • 0037022122 scopus 로고    scopus 로고
    • Assembly of epithelial tight junctions is negatively regulated by Par6
    • Gao L, Joberty G, Macara IG. Assembly of epithelial tight junctions is negatively regulated by Par6. Curr Biol 2002; 12:221-225.
    • (2002) Curr Biol , vol.12 , pp. 221-225
    • Gao, L.1    Joberty, G.2    Macara, I.G.3
  • 52
    • 34547811037 scopus 로고    scopus 로고
    • Polarity proteins PAR6 and aPKC regulate cell death through GSK-3β in 3D epithelial morphogenesis
    • Kim M, Datta A, Brakeman P, Yu W, Mostov KE. Polarity proteins PAR6 and aPKC regulate cell death through GSK-3β in 3D epithelial morphogenesis. J Cell Sci 2007; 120:2309-2317.
    • (2007) J Cell Sci , vol.120 , pp. 2309-2317
    • Kim, M.1    Datta, A.2    Brakeman, P.3    Yu, W.4    Mostov, K.E.5
  • 53
    • 46249098781 scopus 로고    scopus 로고
    • Ras- MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos
    • Lu CW, Yabuuchi A, Chen L, Viswanathan S, Kim K, Daley GQ. Ras- MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos. Nat Genet 2008; 40:921-926.
    • (2008) Nat Genet , vol.40 , pp. 921-926
    • Lu, C.W.1    Yabuuchi, A.2    Chen, L.3    Viswanathan, S.4    Kim, K.5    Daley, G.Q.6
  • 54
    • 72449171951 scopus 로고    scopus 로고
    • MAP kinase signaling antagonizes PAR-1 function during polarization of the early Caenorhabditis elegans embryo
    • Spilker AC, Rabilotta A, Zbinden C, LabbéJC, Gotta M. MAP kinase signaling antagonizes PAR-1 function during polarization of the early Caenorhabditis elegans embryo. Genetics 2009; 183:965-977.
    • (2009) Genetics , vol.183 , pp. 965-977
    • Spilker, A.C.1    Rabilotta, A.2    Zbinden, C.3    Labbé, J.C.4    Gotta, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.