Nutrigenomics and IBD: The intestinal microbiota at the cross-road between inflammation and metabolism

Journal of Clinical Gastroenterology

Volumn 44, Issue SUPPL. 1, 2010, Pages

  Haller, Dirk ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

endoplasmic reticulum stress; inflammation; metabolism; microbiota

Indexed keywords

INTERLEUKIN 10; PROTEOME; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

AEROBIC METABOLISM; CELLULAR STRESS RESPONSE; CONFERENCE PAPER; CROHN DISEASE; DISEASE COURSE; ENTERITIS; ENVIRONMENTAL FACTOR; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; HUMAN; IMMUNOREGULATION; INSULIN RESISTANCE; INTESTINE FLORA; MICROORGANISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRIGENOMICS; NUTRITION; NUTRITIONAL PARAMETERS; PATHOGENESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEOMICS; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS; ULCERATIVE COLITIS;

ANIMALS; GENETIC PREDISPOSITION TO DISEASE; HOMEOSTASIS; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINES; METAGENOME; NUTRIGENOMICS; NUTRITIONAL STATUS; PHENOTYPE; RISK ASSESSMENT; RISK FACTORS;

EID: 77956062579     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/MCG.0b013e3181dd8b76     Document Type: Conference Paper

References (36)

1. Clavel T, Haller D. Bacteria- and host-derived mechanisms to control intestinal epithelial cell homeostasis: implications for chronic inflammation. Inflamm Bowel Dis. 2007;13:1153-1164.
2. Barrett JC, Hansoul S, Nicolae DL, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet. 2008;40:955-962.
3. Halfvarson J, Bodin L, Tysk C, et al. Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics. Gastroenterology. 2003;124:1767-1773.
4. Frank DN, St Amand AL, Feldman RA, et al. Molecularphylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A. 2007;104:13780-13785.
5. Frank DN, Pace NR. Gastrointestinal microbiology enters the metagenomics era. Curr Opin Gastroenterol. 2008;24:4-10.
6. Sartor RB. Microbial influences in inflammatory bowel diseases. Gastroenterology. 2008;134:577-594.
7. Kim SC, Tonkonogy SL, Karrasch T, et al. Dual-association of gnotobiotic IL-10-/- mice with 2 nonpathogenic commensal bacteria induces aggressive pancolitis. Inflamm Bowel Dis. 2007;13:1457-1466.
8. Kim SC, Tonkonogy SL, Albright CA, et al. Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria. Gastroenterology. 2005;128:891-906.
9. Hormannsperger G, Haller D. Molecular crosstalk of probiotic bacteria with the intestinal immune system: clinical relevance in the context of inflammatory bowel disease. Int J Med Microbiol. 2010;300:63-73.
10. Kaput J, Perlina A, Hatipoglu B, et al. Nutrigenomics: concepts and applications to pharmacogenomics and clinical medicine. Pharmacogenomics. 2007;8:369-390.
11. Werner T, Haller D. Intestinal epithelial cell signalling and chronic inflammation: from the proteome to specific molecular mechanisms. Mutat Res. 2007;622:42-57.
12. Ley RE, Turnbaugh PJ, Klein S, et al. Microbial ecology: human gut microbes associated with obesity. Nature. 2006; 444:1022-1023.
13. Ley RE, Backhed F, Turnbaugh P, et al. Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A. 2005;102: 11070-11075.
14. Roediger WE. The colonic epithelium in ulcerative colitis: an energy-deficiency disease? Lancet. 1980;2:712-715.
15. Fukushima K, Fiocchi C. Paradoxical decrease of mitochondrial DNA deletions in epithelial cells of active ulcerative colitis patients. Am J Physiol Gastrointest Liver Physiol. 2004; 286:G804-G813.
16. Shkoda A, Ruiz PA, Daniel H, et al. Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation. Gastroenterology. 2007;132: 190-207.
17. Heazlewood CK, Cook MC, Eri R, et al. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med. 2008;5:e54.
18. Kaser A, Lee AH, Franke A, et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 2008;134:743-756.
19. Xu C, Bailly-Maitre B, Reed JC. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest. 2005;115:2656-2664.
20. Pahl HL. Signal transduction from the endoplasmic reticulum to the cell nucleus. Physiol Rev. 1999;79:683-701.
21. Wu J, Kaufman RJ. From acute ER stress to physiological roles of the Unfolded Protein Response. Cell Death Differ. 2006;13:374-384.
22. Zhang K, Kaufman RJ. The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology. 2006;66:S102-S109.
23. Messlik A, Schmechel S, Kisling S, et al. Loss of Toll-like receptor 2 and 4 leads to differential induction of endoplasmic reticulum stress and proapoptotic responses in the intestinal epithelium under conditions of chronic inflammation. J Proteome Res. 2009;8:4406-4417.
24. Werner T, Hoermannsperger G, Schuemann K, et al. Intestinal epithelial cell proteome from wild-type and TNFDeltaARE/ WT mice: effect of iron on the development of chronic ileitis. J Proteome Res. 2009;8:3252-3264.
25. Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol. 2008;8:923-934.
26. Nathan C. Epidemic inflammation: pondering obesity. Mol Med. 2008;14:485-492.
27. Shi H, Kokoeva MV, Inouye K, et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006;116:3015-3025.
28. Membrez M, Blancher F, Jaquet M, et al. Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice. Faseb J. 2008;22:2416-2426.
29. Cani PD, Bibiloni R, Knauf C, et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in highfat diet-induced obesity and diabetes in mice. Diabetes. 2008; 57:1470-1481.
30. Creely SJ, McTernan PG, Kusminski CM, et al. Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab. 2007;292:E740-E747.
31. Martin FP, Rezzi S, Philippe D, et al. Metabolic assessment of gradual development of moderate experimental colitis in IL-10 deficient mice. J Proteome Res. 2009;8:2376-2387.
32. Beltran B, Nos P, Dasi F, et al. Mitochondrial dysfunction, persistent oxidative damage, and catalase inhibition in immune cells of naive and treated Crohn's disease. Inflamm Bowel Dis. 2009;16:76-86.
33. Restivo NL, Srivastava MD, Schafer IA, et al. Mitochondrial dysfunction in a patient with Crohn's disease: possible role in pathogenesis. J Pediatr Gastroenterol Nutr. 2004;38:534-538.
34. Werner T, Shkoda A, Haller D. Intestinal epithelial cell proteome in IL-10 deficient mice and IL-10 receptor reconstituted epithelial cells: impact on chronic inflammation. J Proteome Res. 2007;6:3691-3704.
35. Shkoda A, Werner T, Daniel H, et al. Differential protein expression profile in the intestinal epithelium from patients with inflammatory bowel disease. J Proteome Res. 2007;6: 1114-1125.
36. Aldridge JE, Horibe T, Hoogenraad NJ. Discovery of genes activated by the mitochondrial unfolded protein response (mtUPR) and cognate promoter elements. PLoS One. 2007;2:e874.