Modulation of the glycemic response using insulin attenuates the pulmonary response in an animal trauma model

Journal of Trauma - Injury, Infection and Critical Care

Volumn 63, Issue 2, 2007, Pages 351-357

  Donnelly, Michael ^a,b   Condron, Claire ^a   Murray, Pariac ^a   Bouchier Hayes, David ^a  

^a BEAUMONT HOSPITAL   (Ireland)

^b WATERFORD REGIONAL HOSPITAL   (Ireland)

Author keywords

Hyperglycemia; Insulin; Neutrophil function; Trauma

Indexed keywords

GLUCOSE; INSULIN; NEUTRAL INSULIN; PROTEIN; SODIUM CHLORIDE;

ANESTHESIA; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; BLOOD SAMPLING; CELL FUNCTION; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; FEMUR FRACTURE; GLUCOSE BLOOD LEVEL; HYPOTHESIS; LEUKOCYTE; LUNG; LUNG EDEMA; LUNG ENDOTHELIUM; LUNG INJURY; LUNG LAVAGE; LUNG SEQUESTRATION; LUNG WEIGHT; MALE; MODULATION; NEUTROPHIL; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; RATING SCALE; RESPIRATORY BURST; STATISTICAL SIGNIFICANCE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ANIMALS; BLOOD GLUCOSE; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; FEMORAL FRACTURES; GLYCEMIC INDEX; INFLAMMATION MEDIATORS; INSULIN; LUNG; MALE; ORGAN SIZE; PROBABILITY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 34547891115     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/01.ta.0000251599.80602.d1     Document Type: Article

References (35)

1. Yendamuri S, Fulda GJ, Tinkoff GH. Admission hyperglycemia as a prognostic indicator in trauma. J Trauma. 2003;55:33-38.
2. Sung J, Bochicchio GV, Joshi M, Bochicchio K, Tracy K, Scalea TM. Admission hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma. 2005;59:80-83.
3. Bochicchio GV, Salzano L, Joshi M, Bochicchio K, Scalea TM. Admission preoperative glucose is predictive of morbidity and mortality in trauma patients who require immediate operative intervention. Am Surg. 2005;71:171-174.
4. Yang SY, Zhang S, Wang ML. Clinical significance of admission hyperglycemia and factors related to it in patients with acute severe head injury. Surg Neurol. 1995;44:373-377.
5. Walia S, Sutcliffe AJ. The relationship between blood glucose, mean arterial pressure and outcome after severe head injury: an observational study. Injury. 2002;33:339-344.
6. Norhammar AM, Ryden L, Malmberg K. Admission plasma glucose: independent risk factor for long term prognosis after myocardial infarction even in non-diabetic patients. Diabetes Care. 1999;22:1827-1831.
7. Zindrou D, Taylor KM, Bagger JP. Admission plasma glucose: an independent risk factor in non-diabetic woman after coronary artery bypass grafting. Diabetes Care. 2001;24:1634-1639.
8. Mesotten D, Van den Berghe G. Clinical potential of insulin therapy in critically ill patients. Drugs. 2003;63:625-636.
9. Hill M, McCallum R. Altered transcriptional regulation of phosphoenolpyruvate carboxykinase in rats following endotoxin treatment. J Clin Invest. 1991;88:811-816.
10. Khani S, Tayek JA. Cortisol increases gluconeogenesis in humans: its role in the metabolic syndrome. Clin Sci (Lond). 2001;101:739-747.
11. Watt MJ, Howlett KF, Febbraio MA, Spriet LL, Hargreaves M. Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans. J Physiol. 2001;534:269-278.
12. Flores EA, Istfan N, Pomposelli JJ, Blackburn GL, Bistrian BR. Effect of interleukin-1 and tumour necrosis factor/cachectin on glucose turnover in the rat. Metabolism. 1990;39:738-743.
13. Lang CH, Dobrescu C, Bagby GJ. Tumour necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology. 1992;130:43-52.
14. Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001;345:1359-1367.
15. Fraker DL, Merino MJ, Norton JA. Reversal of the toxic effects of cachectin by concurrent insulin administration. Am J Physiol. 1989;256:E725-E731.
16. Das UN. Essential fatty acids: biology and their clinical implications. Asia Pac J Pharmacol. 1991;6:317.
17. Das UN. Hypertension and ascorbic acid. Lancet. 2000;355:1273-1274.
18. Das UN. Beneficial effects of n-3 fatty acids in cardiovascular disease: but why and how? Prostaglandins Leukot Essent Fatty Acids. 2000;63:351-363.
19. Kuboki K, Jiang ZY, Takahara N. Regulation of endothelial constitutative nitric oxide synthase gene expression in endothelial cells and in vivo a specific vascular action of insulin. Circulation. 2000;101:676-681.
20. Beal AL, Cerra FB. Multiple organ failure syndrome in the 1990s. Systemic inflammatory response and organ dysfunction. JAMA. 1994;271:226-233.
21. Pasquale MD, Cipolle MD, Monaco J, Simon N. Early inflammatory responses correlate with the severity of injury. Crit Care Med. 1996;24:1238-1242.
22. Diehl KH, Hull R, Morton D, et al. A good practice guide to the administration of substances and removal of blood, including routes and volumes. J Appl Toxicol. 2001;21:15-23.
23. Tien H, Chu P, Brenneman F. Causes of death following multiple trauma. Curr Orthop. 2004;18:304-310.
24. Giannoudis PV. Current concepts of the inflammatory response after major trauma: an update. Injury. 2003;34:397-404.
25. Lucas CE, Ledgerwood AM. Pulmonary response to massive steroids in seriously injured patients. Ann Surg. 1981;194:256-261.
26. Sprung CL, Caralis PV, Marcial EH, et al. The effects of high dose corticosteroids in patients with septic shock. A prospective controlled study. N Engl J Med. 1984;311:1137-1143.
27. Spagnoli A, Spadoni GL, Sesti G, Del Principe D, Germani D, Boscherini B. Effect of insulin by hydrogen peroxide production by human polymorphonuclear leukocytes. Studies with monoclonal antiinsulin receptor antibodies, and an agonist and an inhibitor of protein kinase C. Horm Res. 1995;43:286-293.
28. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med. 2003;348:138-150.
29. Swanton BJ, Iohom G, Wang JH, Redmond HP, Shorten GD. The effect of lidocaince on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation. Eur J Anaesthesiol. 2001;18:524-529.
30. Giannoudis PV, Hildebrand F, Pape HC. Inflammatory serum markers in patients with multiple trauma. Can they predict outcome? J Bone Joint Surg Br. 2004;86:313-323.
31. Andersen SK, Gjedsted J, Christiansen C, Tønnesen E. The roles of insulin and hyperglycemia in sepsis pathogenesis. J Leukoc Biol. 2004;75:413-421.
32. Marfella R, Siniscalchi M, Esposito K, et al. Effects of stress hyperglycemia on acute myocardial infarction: role of inflammatory immune process in functional cardiac outcome. Diabetes Care. 2003;26:3129-3135.
33. MacKay F, Rothe J, Bluethmann H, Loetscher H, Lesslauer W. Differential responses of fibroblasts from wild-type and TNF-R55 deficient mice to mouse and human TNF-alpha activation. J Immunol. 1994;153:5274-5284.
34. Puente Navazo MD, Chettab K, Duhault J, Koenig-Berard E, McGregor JL. Glucose and insulin modulate the capacity of endothelial cells (HUVEC) to express P-selectin and bind a monocytic cell line (L937). Thromb Haemost. 2001;86:680-685.
35. Marfella R, Esposito K, Giunta R, et al. Circulating adhesion molecules in humans: role of hyperglycemia and hyperinsulinaemia. Circulation. 2000;101:2247-2251.