PH1-derived bivalent bibodies and trivalent tribodies bind differentially to shed and tumour cell-associated MUC1

Protein Engineering, Design and Selection

Volumn 23, Issue 9, 2010, Pages 721-728

  Schoonooghe, Steve ^a,b,c   Burvenich, Ingrid ^a   Vervoort, Liesbet ^a   De Vos, Filip ^a   Mertens, Nico ^b   Grooten, Johan ^a  

^a GHENT UNIVERSITY   (Belgium)

^b FREE UNIVERSITY OF BRUSSELS   (Belgium)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

antibodies; antibody derivatives; bivalent; MUC1; trivalent

Indexed keywords

BIVALENT; CANCER-TARGETING; DISSOCIATION CONSTANT; FAB FRAGMENTS; FUNCTIONAL CHARACTERIZATION; HETERODIMERIZATION; MEMBRANE-BOUND; MUC1; PREFERENTIAL INTERACTION; RECOMBINANT ANTIBODY; SERUM STABILITY; TRIVALENT; TUMOUR CELLS; VARIABLE FRAGMENT;

DISSOCIATION; TUMORS;

ANTIBODIES;

ANTIBODY; DISULFIDE; IMMUNOGLOBULIN F(AB) FRAGMENT; MUCIN 1;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; IMMUNOASSAY; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; TUMOR CELL;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; BINDING SITES, ANTIBODY; CELL LINE, TUMOR; CLONING, MOLECULAR; ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; HEK293 CELLS; HUMANS; IMMOBILIZED PROTEINS; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; MUCIN-1; NEOPLASMS; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STABILITY;

EID: 77956044379     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzq044     Document Type: Article

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