A silk platform that enables electrophysiology and targeted drug delivery in brain astroglial cells

Biomaterials

Volumn 31, Issue 31, 2010, Pages 7883-7891

  Benfenati, Valentina ^a   Toffanin, Stefano ^a   Capelli, Raffaella ^a   Camassa, Laura M A ^b   Ferroni, Stefano ^c   Kaplan, David L ^d   Omenetto, Fiorenzo G ^d   Muccini, Michele ^a   Zamboni, Roberto ^a  

^a CNR   (Italy)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d Tufts University   (United States)

Author keywords

Astrocytes; Biocompatibility; Guanosine; Patch clamp; Potassium channels; Silk platform

Indexed keywords

ASTROCYTES; ASTROGLIOSIS; BIOMEDICAL APPLICATIONS; BRAIN IMPLANTS; CELL SURVIVAL; CELL TYPES; CHANNEL CONDUCTANCE; COATED GLASS; COMPARATIVE ANALYSIS; CURRENT INCREASE; DIRECT MODULATION; ELECTRONIC INTERFACE; GLASS SURFACES; GLIAL CELLS; GUANOSINES; HYPERPOLARIZED; IN-VITRO; IN-VIVO; INPUT RESISTANCE; INWARD-RECTIFYING; ION CHANNEL; MECHANISTIC STUDIES; MEMBRANE POLARIZATION; MEMBRANE POTENTIALS; MOLECULAR TARGETS; NEOCORTICAL ASTROGLIAL CELLS; NEURAL CELLS; PATCH CLAMP; PHYSIOLOGICAL FUNCTIONS; POLY D LYSINES; POTASSIUM CHANNELS; SPECIFIC CONDUCTANCE; TARGETED DRUG DELIVERY; UP-REGULATION;

ADHESION; AMINO ACIDS; BIOCOMPATIBILITY; BIOMOLECULES; BIOPOLYMERS; CELL ADHESION; CELLS; DISTILLATION; DRUG DELIVERY; ELECTROPHYSIOLOGY; FUNCTIONAL POLYMERS; GLASS; IMPLANTS (SURGICAL);

SILK;

BIOMATERIAL; GLASS; ION CHANNEL; POLYLYSINE; POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; ASTROCYTE; ASTROCYTOSIS; BRAIN CELL; CELL ADHESION; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ELECTROPHYSIOLOGY; GLIA CELL; IMPLANT; IN VITRO STUDY; IN VIVO STUDY; NERVE CELL; NONHUMAN; PATCH CLAMP; PHYSIOLOGY; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SILK; UPREGULATION; WHOLE CELL;

ANIMALS; ASTROCYTES; BOMBYX; BRAIN; CELL PROLIFERATION; DRUG DELIVERY SYSTEMS; ELECTROPHYSIOLOGICAL PHENOMENA; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GUANOSINE; INDOLES; ION CHANNEL GATING; MICROSCOPY, CONFOCAL; NEOCORTEX; POLYLYSINE; RATS; SILK;

EID: 77956012440     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.07.013     Document Type: Article

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