메뉴 건너뛰기




Volumn 18, Issue 9, 2010, Pages 1203-1210

P38γ mitogen-activated protein kinase suppresses chondrocyte production of MMP-13 in response to catabolic stimulation

Author keywords

Articular cartilage; Cell signaling; Chondrocyte; Cytokines; Integrins; Matrix metalloproteinase

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; COLLAGENASE 3; DORAMAPIMOD; FIBRONECTIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 11; MITOGEN ACTIVATED PROTEIN KINASE 12; MITOGEN ACTIVATED PROTEIN KINASE 13; MITOGEN ACTIVATED PROTEIN KINASE 14; OSTEOGENIC PROTEIN 1; SOMATOMEDIN C; PEPTIDE FRAGMENT; SIGNAL PEPTIDE;

EID: 77956010447     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2010.05.016     Document Type: Article
Times cited : (26)

References (36)
  • 1
    • 0142026209 scopus 로고    scopus 로고
    • P38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases
    • Kumar S., Boehm J., Lee J.C. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov 2003, 2:717-726.
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 717-726
    • Kumar, S.1    Boehm, J.2    Lee, J.C.3
  • 2
    • 0028605318 scopus 로고
    • A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    • Lee J.C., Laydon J.T., McDonnell P.C., Gallagher T.F., Kumar S., Green D., et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994, 372:739-746.
    • (1994) Nature , vol.372 , pp. 739-746
    • Lee, J.C.1    Laydon, J.T.2    McDonnell, P.C.3    Gallagher, T.F.4    Kumar, S.5    Green, D.6
  • 3
    • 0029982565 scopus 로고    scopus 로고
    • Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)
    • Jiang Y., Chen C., Li Z., Guo W., Gegner J.A., Lin S., et al. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem 1996, 271:17920-17926.
    • (1996) J Biol Chem , vol.271 , pp. 17920-17926
    • Jiang, Y.1    Chen, C.2    Li, Z.3    Guo, W.4    Gegner, J.A.5    Lin, S.6
  • 4
    • 0030581626 scopus 로고    scopus 로고
    • The primary structure of p38 gamma: a new member of p38 group of MAP kinases
    • Li Z., Jiang Y., Ulevitch R.J., Han J. The primary structure of p38 gamma: a new member of p38 group of MAP kinases. Biochem Biophys Res Commun 1996, 228:334-340.
    • (1996) Biochem Biophys Res Commun , vol.228 , pp. 334-340
    • Li, Z.1    Jiang, Y.2    Ulevitch, R.J.3    Han, J.4
  • 5
    • 0030828701 scopus 로고    scopus 로고
    • Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta
    • Jiang Y., Gram H., Zhao M., New L., Gu J., Feng L., et al. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta. J Biol Chem 1997, 272:30122-30128.
    • (1997) J Biol Chem , vol.272 , pp. 30122-30128
    • Jiang, Y.1    Gram, H.2    Zhao, M.3    New, L.4    Gu, J.5    Feng, L.6
  • 6
    • 0033569125 scopus 로고    scopus 로고
    • Potential regulation of cartilage metabolism in osteoarthritis by fibronectin fragments
    • Homandberg G.A. Potential regulation of cartilage metabolism in osteoarthritis by fibronectin fragments. Front Biosci 1999, 4:D713-730.
    • (1999) Front Biosci , vol.4
    • Homandberg, G.A.1
  • 7
    • 0030032444 scopus 로고    scopus 로고
    • Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage
    • Mitchell P.G., Magna H.A., Reeves L.M., Lopresti-Morrow L.L., Yocum S.A., Rosner P.J., et al. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J Clin Invest 1996, 97:761-768.
    • (1996) J Clin Invest , vol.97 , pp. 761-768
    • Mitchell, P.G.1    Magna, H.A.2    Reeves, L.M.3    Lopresti-Morrow, L.L.4    Yocum, S.A.5    Rosner, P.J.6
  • 8
    • 0035002353 scopus 로고    scopus 로고
    • Analysis of the cell infiltrate and expression of matrix metalloproteinases and granzyme B in paired synovial biopsy specimens from the cartilage-pannus junction in patients with RA
    • Smeets T.J., Kraan M.C., Galjaard S., Youssef P.P., Smith M.D., Tak P.P. Analysis of the cell infiltrate and expression of matrix metalloproteinases and granzyme B in paired synovial biopsy specimens from the cartilage-pannus junction in patients with RA. Ann Rheum Dis 2001, 60:561-565.
    • (2001) Ann Rheum Dis , vol.60 , pp. 561-565
    • Smeets, T.J.1    Kraan, M.C.2    Galjaard, S.3    Youssef, P.P.4    Smith, M.D.5    Tak, P.P.6
  • 9
    • 0033851463 scopus 로고    scopus 로고
    • Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3
    • Mengshol J.A., Vincenti M.P., Coon C.I., Barchowsky A., Brinckerhoff C.E. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum 2000, 43:801-811.
    • (2000) Arthritis Rheum , vol.43 , pp. 801-811
    • Mengshol, J.A.1    Vincenti, M.P.2    Coon, C.I.3    Barchowsky, A.4    Brinckerhoff, C.E.5
  • 10
    • 0036746088 scopus 로고    scopus 로고
    • Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes
    • Forsyth C.B., Pulai J., Loeser R.F. Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes. Arthritis Rheum 2002, 46:2368-2376.
    • (2002) Arthritis Rheum , vol.46 , pp. 2368-2376
    • Forsyth, C.B.1    Pulai, J.2    Loeser, R.F.3
  • 11
    • 0042090276 scopus 로고    scopus 로고
    • Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway
    • Loeser R.F., Forsyth C.B., Samarel A.M., Im H.J. Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway. J Biol Chem 2003, 278:24577-24585.
    • (2003) J Biol Chem , vol.278 , pp. 24577-24585
    • Loeser, R.F.1    Forsyth, C.B.2    Samarel, A.M.3    Im, H.J.4
  • 12
    • 50949116784 scopus 로고    scopus 로고
    • The cartilage chondrolytic mechanism of fibronectin fragments involves MAP kinases: comparison of three fragments and native fibronectin
    • Ding L., Guo D., Homandberg G.A. The cartilage chondrolytic mechanism of fibronectin fragments involves MAP kinases: comparison of three fragments and native fibronectin. Osteoarthritis Cartilage 2008, 16:1253-1262.
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. 1253-1262
    • Ding, L.1    Guo, D.2    Homandberg, G.A.3
  • 13
    • 33749370145 scopus 로고    scopus 로고
    • Differential tissue expression and activation of p38 MAPK alpha, beta, gamma, and delta isoforms in rheumatoid arthritis
    • Korb A., Tohidast-Akrad M., Cetin E., Axmann R., Smolen J., Schett G. Differential tissue expression and activation of p38 MAPK alpha, beta, gamma, and delta isoforms in rheumatoid arthritis. Arthritis Rheum 2006, 54:2745-2756.
    • (2006) Arthritis Rheum , vol.54 , pp. 2745-2756
    • Korb, A.1    Tohidast-Akrad, M.2    Cetin, E.3    Axmann, R.4    Smolen, J.5    Schett, G.6
  • 14
    • 4344586823 scopus 로고    scopus 로고
    • Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways
    • Masuko-Hongo K., Berenbaum F., Humbert L., Salvat C., Goldring M.B., Thirion S. Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways. Arthritis Rheum 2004, 50:2829-2838.
    • (2004) Arthritis Rheum , vol.50 , pp. 2829-2838
    • Masuko-Hongo, K.1    Berenbaum, F.2    Humbert, L.3    Salvat, C.4    Goldring, M.B.5    Thirion, S.6
  • 15
    • 38149135837 scopus 로고    scopus 로고
    • Cathepsins B, K, and L are regulated by a defined collagen type II peptide via activation of classical protein kinase C and p38 MAP kinase in articular chondrocytes
    • Ruettger A., Schueler S., Mollenhauer J.A., Wiederanders B. Cathepsins B, K, and L are regulated by a defined collagen type II peptide via activation of classical protein kinase C and p38 MAP kinase in articular chondrocytes. J Biol Chem 2008, 283:1043-1051.
    • (2008) J Biol Chem , vol.283 , pp. 1043-1051
    • Ruettger, A.1    Schueler, S.2    Mollenhauer, J.A.3    Wiederanders, B.4
  • 16
    • 21244476768 scopus 로고    scopus 로고
    • BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo
    • Kuma Y., Sabio G., Bain J., Shpiro N., Marquez R., Cuenda A. BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo. J Biol Chem 2005, 280:19472-19479.
    • (2005) J Biol Chem , vol.280 , pp. 19472-19479
    • Kuma, Y.1    Sabio, G.2    Bain, J.3    Shpiro, N.4    Marquez, R.5    Cuenda, A.6
  • 17
    • 0030050396 scopus 로고    scopus 로고
    • 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region
    • Leahy D.J., Aukhil I., Erickson H.P. 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region. Cell 1996, 84:155-164.
    • (1996) Cell , vol.84 , pp. 155-164
    • Leahy, D.J.1    Aukhil, I.2    Erickson, H.P.3
  • 20
    • 17844363020 scopus 로고    scopus 로고
    • NF-κB mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments
    • Pulai J.I., Chen H., Im H.J., Kumar S., Hanning C., Hegde P.S., et al. NF-κB mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments. J Immunol 2005, 174:5781-5788.
    • (2005) J Immunol , vol.174 , pp. 5781-5788
    • Pulai, J.I.1    Chen, H.2    Im, H.J.3    Kumar, S.4    Hanning, C.5    Hegde, P.S.6
  • 21
    • 0345803000 scopus 로고    scopus 로고
    • Alterations in subcellular localization of p38 MAPK potentiates endothelin-stimulated COX-2 expression in glomerular mesangial cells
    • Pratt P.F., Bokemeyer D., Foschi M., Sorokin A., Dunn M.J. Alterations in subcellular localization of p38 MAPK potentiates endothelin-stimulated COX-2 expression in glomerular mesangial cells. J Biol Chem 2003, 278:51928-51936.
    • (2003) J Biol Chem , vol.278 , pp. 51928-51936
    • Pratt, P.F.1    Bokemeyer, D.2    Foschi, M.3    Sorokin, A.4    Dunn, M.J.5
  • 22
    • 0036549872 scopus 로고    scopus 로고
    • Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3)
    • Court N.W., dos Remedios C.G., Cordell J., Bogoyevitch M.A. Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3). J Mol Cell Cardiol 2002, 34:413-426.
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 413-426
    • Court, N.W.1    dos Remedios, C.G.2    Cordell, J.3    Bogoyevitch, M.A.4
  • 23
    • 35748932065 scopus 로고    scopus 로고
    • P38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response
    • Qi X., Pohl N.M., Loesch M., Hou S., Li R., Qin J.Z., et al. p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response. J Biol Chem 2007, 282:31398-31408.
    • (2007) J Biol Chem , vol.282 , pp. 31398-31408
    • Qi, X.1    Pohl, N.M.2    Loesch, M.3    Hou, S.4    Li, R.5    Qin, J.Z.6
  • 24
    • 0033030207 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase inhibitors-mechanisms and therapeutic potentials
    • Lee J.C., Kassis S., Kumar S., Badger A., Adams J.L. p38 mitogen-activated protein kinase inhibitors-mechanisms and therapeutic potentials. Pharmacol Ther 1999, 82:389-397.
    • (1999) Pharmacol Ther , vol.82 , pp. 389-397
    • Lee, J.C.1    Kassis, S.2    Kumar, S.3    Badger, A.4    Adams, J.L.5
  • 25
    • 0031024646 scopus 로고    scopus 로고
    • Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)
    • Cuenda A., Cohen P., Buee-Scherrer V., Goedert M. Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). EMBO J 1997, 16:295-305.
    • (1997) EMBO J , vol.16 , pp. 295-305
    • Cuenda, A.1    Cohen, P.2    Buee-Scherrer, V.3    Goedert, M.4
  • 26
    • 12344300194 scopus 로고    scopus 로고
    • Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta
    • Fan Z., Bau B., Yang H., Soeder S., Aigner T. Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta. Arthritis Rheum 2005, 52:136-143.
    • (2005) Arthritis Rheum , vol.52 , pp. 136-143
    • Fan, Z.1    Bau, B.2    Yang, H.3    Soeder, S.4    Aigner, T.5
  • 27
    • 0038491555 scopus 로고    scopus 로고
    • Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes
    • Im H.J., Pacione C., Chubinskaya S., Van Wijnen A.J., Sun Y., Loeser R.F. Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes. J Biol Chem 2003, 278:25386-25394.
    • (2003) J Biol Chem , vol.278 , pp. 25386-25394
    • Im, H.J.1    Pacione, C.2    Chubinskaya, S.3    Van Wijnen, A.J.4    Sun, Y.5    Loeser, R.F.6
  • 28
    • 34547809513 scopus 로고    scopus 로고
    • P38alpha and p38delta mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells
    • Junttila M.R., Ala-Aho R., Jokilehto T., Peltonen J., Kallajoki M., Grenman R., et al. p38alpha and p38delta mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells. Oncogene 2007, 26:5267-5279.
    • (2007) Oncogene , vol.26 , pp. 5267-5279
    • Junttila, M.R.1    Ala-Aho, R.2    Jokilehto, T.3    Peltonen, J.4    Kallajoki, M.5    Grenman, R.6
  • 29
    • 0038363324 scopus 로고    scopus 로고
    • P38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity
    • Pramanik R., Qi X., Borowicz S., Choubey D., Schultz R.M., Han J., et al. p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity. J Biol Chem 2003, 278:4831-4839.
    • (2003) J Biol Chem , vol.278 , pp. 4831-4839
    • Pramanik, R.1    Qi, X.2    Borowicz, S.3    Choubey, D.4    Schultz, R.M.5    Han, J.6
  • 30
    • 33846808922 scopus 로고    scopus 로고
    • Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription
    • Askari N., Diskin R., Avitzour M., Capone R., Livnah O., Engelberg D. Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription. J Biol Chem 2007, 282:91-99.
    • (2007) J Biol Chem , vol.282 , pp. 91-99
    • Askari, N.1    Diskin, R.2    Avitzour, M.3    Capone, R.4    Livnah, O.5    Engelberg, D.6
  • 31
    • 33746214777 scopus 로고    scopus 로고
    • MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis
    • Hegen M., Gaestel M., Nickerson-Nutter C.L., Lin L.L., Telliez J.B. MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis. J Immunol 2006, 177:1913-1917.
    • (2006) J Immunol , vol.177 , pp. 1913-1917
    • Hegen, M.1    Gaestel, M.2    Nickerson-Nutter, C.L.3    Lin, L.L.4    Telliez, J.B.5
  • 32
    • 57549091806 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology
    • Jones S.W., Brockbank S.M., Clements K.M., Le Good N., Campbell D., Read S.J., et al. Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology. Osteoarthritis Cartilage 2009, 17:124-131.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 124-131
    • Jones, S.W.1    Brockbank, S.M.2    Clements, K.M.3    Le Good, N.4    Campbell, D.5    Read, S.J.6
  • 33
    • 33748743740 scopus 로고    scopus 로고
    • Multiple activation mechanisms of p38alpha mitogen-activated protein kinase
    • Kang Y.J., Seit-Nebi A., Davis R.J., Han J. Multiple activation mechanisms of p38alpha mitogen-activated protein kinase. J Biol Chem 2006, 281:26225-26234.
    • (2006) J Biol Chem , vol.281 , pp. 26225-26234
    • Kang, Y.J.1    Seit-Nebi, A.2    Davis, R.J.3    Han, J.4
  • 34
    • 0034653850 scopus 로고    scopus 로고
    • Molecular determinants that mediate selective activation of p38 MAP kinase isoforms
    • Enslen H., Brancho D.M., Davis R.J. Molecular determinants that mediate selective activation of p38 MAP kinase isoforms. EMBO J 2000, 19:1301-1311.
    • (2000) EMBO J , vol.19 , pp. 1301-1311
    • Enslen, H.1    Brancho, D.M.2    Davis, R.J.3
  • 35
    • 0034704178 scopus 로고    scopus 로고
    • Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength
    • Alonso G., Ambrosino C., Jones M., Nebreda A.R. Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength. J Biol Chem 2000, 275:40641-40648.
    • (2000) J Biol Chem , vol.275 , pp. 40641-40648
    • Alonso, G.1    Ambrosino, C.2    Jones, M.3    Nebreda, A.R.4
  • 36
    • 55849133703 scopus 로고    scopus 로고
    • Reduced limb length and worsened osteoarthritis in adult mice after genetic inhibition of p38 MAP kinase activity in cartilage
    • Namdari S., Wei L., Moore D., Chen Q. Reduced limb length and worsened osteoarthritis in adult mice after genetic inhibition of p38 MAP kinase activity in cartilage. Arthritis Rheum 2008, 58:3520-3529.
    • (2008) Arthritis Rheum , vol.58 , pp. 3520-3529
    • Namdari, S.1    Wei, L.2    Moore, D.3    Chen, Q.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.