Significance of manipulating tumour hypoxia and radiation dose rate in terms of local tumour response and lung metastatic potential, referring to the response of quiescent cell populations

British Journal of Radiology

Volumn 83, Issue 993, 2010, Pages 776-784

  Masunaga, Shin Ichiro ^a   Matsumoto, Y ^b   Kashino, G ^a   Hirayama, R ^b   Liu, Y ^a   Tanaka, H ^b   Sakurai, Y ^b   Suzuki, M ^a   Kinashi, Y ^b   Maruhashi, A ^b   Ono, K ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; NICOTINAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CANCER RADIOTHERAPY; CELL ISOLATION; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINESIS; FEMALE; GAMMA IRRADIATION; HYPERTHERMIA; HYPOXIA; IMMUNOFLUORESCENCE; INTERMETHOD COMPARISON; IRRADIATION; LUNG METASTASIS; MELANOMA B16; METASTASIS POTENTIAL; MICRONUCLEUS; MOUSE; NONHUMAN; OXYGENATION; QUIESCENT TUMOR CELL; RADIATION DOSE; RADIOSENSITIVITY; STAINING; TEMPERATURE; TUMOR BLOOD FLOW; TUMOR CELL; TUMOR CELL LINE; TUMOR HYPOXIA;

ANIMALS; BROMODEOXYURIDINE; CELL HYPOXIA; COMBINED MODALITY THERAPY; FEMALE; GAMMA RAYS; LUNG NEOPLASMS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NIACINAMIDE; RADIOTHERAPY DOSAGE; TEMPERATURE; TUMOR CELLS, CULTURED;

EID: 77956002433     PISSN: 00071285     EISSN: None     Source Type: Journal    
DOI: 10.1259/bjr/57015642     Document Type: Article

References (24)

1. Masunaga S, Ono K. Significance of the response of quiescent cell populations within solid tumors in cancer therapy. J Radiat Res 2002;43:11-25. (Pubitemid 135693382)
2. Boyd D. Invasion and metastasis. Cancer Metastasis Rev 1996;15:77-89.
3. Fidler IJ. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003;3:453-845.
4. Cairns BA, Kalliomaki T, Hill RP. Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors. Cancer Res 2001;61:8903-8.
5. Rofstad EK, Galappathi K, Mathiesen B, Ruud E-BM. Fluctuating and diffusion-limited hypoxia in hypoxia-induced metastasis. Clin Cancer Res 2007;13:1971-8.
6. Masunaga S, Matsumoto Y, Hirayama R, Kashino G, Tanaka H, Suzuki M, et al. Significance of hypoxia manipulation in solid tumors in the effect on lung metastases in radiotherapy, with reference to its effect on the sensitivity of intratumor quiescent cells. Clin Exp Metastasis 2009;26:693-700.
7. Masunaga S, Hirayama R, Uzawa A, Kashini G, Takata T, Suzuki M, et al. Influence of manipulating hypoxia in solid tumors on radiation dose-rate effect in vivo, referring to that in quiescent cell population. Jpn J Radiol 2010;28:132-42.
8. Song CW, Park H, Griffin RJ. Improvement of tumor oxygenation by mild hyperthermia. Radiat Res 2001;155:512-28.
9. Masunaga S, Ono K, Suzuki M, Nishimura Y, Hiraoka M, Kinashi Y, et al. Alteration of the hypoxic fraction of quiescent cell populations by hyperthermia at mild temperatures. Int J Hyperthermia 1997;13:401-11. (Pubitemid 27363894)
10. Masunaga S, Takahashi A, Ohnishi K, Ohnishi T, Nagata K, Suzuki M, et al. Effects of mild temperature hyperthermia and p53 status on the size of hypoxic fractions in solid tumors, with reference to the effect in intratumor quiescent cell populations. Int J Radiat Oncol Biol Phys 2004;60:570-7.
11. Duan X, Zhang H, Liu B, et al. Apoptosis of murine melanoma cells induced by heavy-ion radiation combined with Tp53 gene transfer. Int J Radiat Biol 2008;84:211-17.
12. Nishimura Y, Ono K, Hiraoka M, Masunaga S, Jo S, Shibamoto, et al. Treatment of murine SCC VII tumors with localized hyperthermia and temperature-sensitive liposomes containing cisplatin. Radiat Res 1990;122:161-7.
13. Masunaga S, Ono K, Abe M. The method for selective detection of radiosensitivity of quiescent cells in solid tumors - combination of immunofluorescence staining to BUdR and micronucleus assay. Radiat Res 1991;125:243-7.
14. De Jaeger K, Kavanagh M-C, Hill RP. Relationship of hypoxia to metastatic ability in rodent tumours. Br J Cancer 2001;84:1280-5.
15. Brown JM. Evidence of acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation. Br J Radiol 1979;52:650-6.
16. Chaplin DJ, Horsman MR, Trotter MJ. Effect of nicotinamide on the microregional heterogeneity of oxygen delivery within a murine tumor. J Natl Cancer Inst 1990;82:672-6.
17. Griffin RJ, Okajima K, Ogawa A, Song CW. Radiosensitization of two murine tumours with mild temperature hyperthermia and carbogen breathing. Int J Radiat Biol 1999;75:1299-1306. (Pubitemid 29500013)
18. Masunaga S, Ono K, Akaboshi M, Nishimura Y, Suzuki M, Kinashi Y, et al. Reduction of hypoxic cells in solid tumours induced by mild hyperthermia: special reference to differences in changes in the hypoxic fraction between total and quiescent cell populations. Br J Cancer 1997;76:588-93.
19. Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer PM, Powell S, et al. Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance. Cancer Res 2008;68:605-14.
20. Sprong D, Janssen HL, Vens C, Begg AC. Resistance of hypoxic cells to ionizing radiation is influenced by homologous recombination status. Int J Radiat Oncol Biol Phys 2006;64:562-72. (Pubitemid 43083446)
21. Masunaga S, Nagata K, Suzuki M, Kashino G, Kinashi Y, Ono K. Inhibition of repair from radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations. Radiat Med 2007;25:417-25.
22. Vaupel P. Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 2004;14:197-275.
23. Rofstad EK. Microenvironment-induced cancer metastasis. Int J Radiat Biol 2000;76:589-605.
24. Moller MG, Lewis J M, Dessureault S, Zager JS. Toxicities associated with hyperthermic isolated limb perfusion and isolated limb infusion in the treatment of melanoma and sarcoma. Int J Hyperthermia 2008;24:275-89. (Pubitemid 351517160)