Alteration in the hypoxic fraction of quiescent cell populations by hyperthermia at mild temperatures

International Journal of Hyperthermia

Volumn 13, Issue 4, 1997, Pages 401-411

  Masunaga, S ^a   Ono, K ^a   Suzuki, M ^a   Kinashi, Y ^a   Takagaki, M ^a   Akaboshi, M ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Carbogen inhalation; Hypoxic fraction; Mild hyperthermia; Nicotinamide; Quiescent cell

Indexed keywords

BROXURIDINE; CARBOGEN; CYTOCHALASIN B;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL HYPOXIA; CELL LABELING; CELL POPULATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; HYPERTHERMIA; IMMUNOFLUORESCENCE TEST; MICRONUCLEUS TEST; MOUSE; NONHUMAN; OXYGENATION; TUMOR CELL;

EID: 0030855660     PISSN: 02656736     EISSN: None     Source Type: Journal    
DOI: 10.3109/02656739709046541     Document Type: Article

References (28)

1. DETHLEFSEN, L. A., 1980, In quest of the quaint quiescent cells. Radiation Biology in Cancer Research, edited by R, E Meyn and H. R. Withers (New York, Raven Press), pp. 415-435.
2. DEWEY, W. C., 1994, Arrhenius relationship from the molecule and cell to clinic. International Journal of Hyperthermia, 10, 457-483.
3. FREYER, J. P., 1992, Spheroids in radiobiology research. Spheroid culture in cancer research, edited by R. Bjerkvik (London: CRC Press), pp. 217-275.
4. HERMENS, A. F., and BARENDSEN, G. W., 1978, The proliferative status and clonogenic capacity of tumor cells in a transplantable rhabdomyosarcoma of the rat before and after irradiation with 800 rad of x-rays. Cell Tissue Kinetics, 11, 83-100.
5. HORSMAN, M. R., CHAPLIN, D. J., and BROWN, J. M., 1989, Tumor radiosensitization by nicotinamide: a result of improved perfusion and oxygenation. Radiation Research, 118, 139-150.
6. HORSMAN, M. R., 1995, Nicotinamide and other benzamide analogues as agents for overcoming hypoxic cell radiation resistance in tumours. Acta Oncologica, 34, 571-587.
7. 2 can be increased markedly by mild hyperthermia. British Journal of Cancer, 74 (Suppl. XXVII) S217-S221.
8. JACKSON, R. C., 1989, The problem of the quiescent cancer cell. Advances in Enzyme Regulation, 29, 27-46.
9. KJELLEN, E., JOINER, M. C., COLLIER, J. M., JOHNS, H., and ROJAS, A., 1991, A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated X-ray treatments. Radiotherapy and Oncology, 22, 81-91.
10. LUK, C. K., and KENG, P. C., 1985, Regrowth and radiation sensitivity of quiescent cells isolated from EMT6/Ro-fed plateau monolayers. Cancer Research, 45, 1020-1025.
11. MASUNAGA, S., ONO, K., WANDL, E. O., FUSHIKI, M., and ABE, M., 1990, Use of micronucleus assay for the selective detection of radiosensitivity in BUdR-unincorporated cells after pulse labelling of exponentially growing tumour cells. International Journal of Radiation Biology, 58, 303-311.
12. MASUNAGA, S., ONO, K., and ABE, M., 1991, A method for selective measurement of the radiosensitivity of quiescent cells in solid tumors - combination of immunofluorescence staining to BrdU and micronucleus assay. Radiation Research, 125, 243-247.
13. MASUNAGA, S., ONO, K., and ABE, M., 1993, The detection and modification of the hypoxic fraction in quiescent cell populations in murine solid tumors. British Journal of Radiology, 66, 918-926.
14. MOULDER, J. E. and ROCKWELL, S., 1984, Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data. International Journal of Radiation Oncology, Biology and Physics, 10, 695-712.
15. NISHIMURA, Y., HIRAOKA, M., JO, S , AKUTA, K., YUKAWA, Y., SHIBAMOTO, Y., TAKAHASHI, M., and ABE, M., 1988, Microangiographic and histologic analysis of the effects of hyperthermia on murine tumor vasculature. International Journal of Radiation Oncology, Biology and Physics, 15, 411-420.
16. NISHIMURA, Y., ONO, K., HIRAOKA, M., MASUNAGA., S., JO, S., SHIBAMOTO, Y., SASAI, K., ABE, M., IGA, K., and OGAWA, Y., 1990, Treatment of murine SCC VII tumors with localized hyperthermia and temperature-sensitive liposomes containing cisplatin. Radiation Research, 122, 161-167.
17. OLESON, J. R., 1995, Hyperthermia from the clinic to the laboratory: hypothesis (Eugene Robinson Special Lecture). International Journal of Hyperthermia, 11, 315-322.
18. ONO, K., WANDL, E. O., TSUTSUI, K., SASAI, Y., and ABE, M., 1989, The correlation between cell survival curve and dose response curve of micronucleus (MN) frequency. Strahlentherapie und Onkologie, 165, 824-827.
19. ONO, K., MASUNAGA, S., AKUTA, K., AKABOSHI, M., and ABE, M., 1993, Radiosensitization of SCCVII tumours and normal tissues by nicotinamide and carbogen: analysis by micronucleus assay. Radiotherapy and Oncology, 28, 162-167.
20. OVERGAARD, J., 1989, Sensitization of hypoxic tumor cells - clinical experience. International Journal of Radiation Biology, 56, 801-811.
21. OVERGAARD, J., GONZALES, D. G., HULSHOR, M. C. C. M., ARCHANGELI, G., DAHL, O., MELLA, O., and BENTZEN, S. M., 1995, Randomized trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma. The Lancet, 345, 540-543.
22. OVERGAARD, J. and HORSMAN, M., 1996, Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers. Seminars in Radiation Oncology, 6, 10-21.
23. SECOMB, T. W., HSU, R., ONG, E. T., GROSS, J. F., and DEWHIRST, M. W., 1995, Analysis of the effect of oxygen supply and demand on hypoxic fraction in tumors. Acta Oncologica, 34, 313-316.
24. SONG, C. W., SHAKIL, A., OSBORN, J. L., and IWATA, K., 1996, Tumour oxygenation is increased by hyperthermia at mild temperatures. International Journal of Hyperthermia, 12, 367-373.
25. STEEL, G. G., 1977, Cell population kinetics of tumors in experimental animals. Growth Kinetics of Tumours, edited by G. G. Steel (Oxford: Clarendon Press, Inc.), pp. 146-216.
26. VAUPEL, P., 1990, Pathological mechanisms of hyperthermia in cancer therapy. Biological Basis for Oncologic Thermotherapy, edited by M. Gautherie (Heidelberg: Springer-Verlag), pp. 73-134.
27. WALLEN, C. A., RIDINGER, D. N., and DETHLEFSEN, L. A., 1985, Heterogeneity of X-ray cytotoxicity in proliferating and quiescent murine mammary carcinoma cells. Cancer Research, 45, 3064-3069.
28. WILSON, K. M., and KENG, P. C., 1989, Radiation-induced DNA damage and repair in quiescent and proliferating human tumor cells in vitro. International Journal of Radiation Biology, 55, 385-395.