Novel nucleosides as potent influenza viral inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 17, 2010, Pages 6329-6339

  Vedula, Manohar Sharma ^a   Jennepalli, Sreenu ^a   Aryasomayajula, Ratnakar ^a   Rondla, Subhash Reddy ^a   Musku, Madanmohan Reddy ^a   Kura, Rathnakar Reddy ^a   Bandi, Parthasaradhi Reddy ^a  

^a Hetero Drugs Limited   (India)

Author keywords

Influenza virus; Nucleosides; SAR

Indexed keywords

((2,3,4) 3 BENZOYLOXY 4 FLUORO 4 METHYL 5 OXO TETRAHYDROFURAN 2 YL)METHYL BENZOATE; ((2,3,4,5) 3 ACETOXY 4 FLUORO 3,4 DIMETHYL 5 (5 METHYL 2,4 DIOXO 3,4 DIHYDROPYRIMIDIN 1 (2H) YL)TETRAHYDROFURAN 2 YL)METHYL BENZOATE; ((2,3,4,5) 3 ACETOXY 4 FLUORO 3,4 DIMETHYL 5 (6 (4 METHYLPIPERAZIN 1 YL) 9H PURIN 9 YL)TETRAHYDROFURAN 2 YL)METHYL BENZOATE; ((2,3,4,5) 3 ACETOXY 4 FLUORO 5 (5 FLUORO 2,4 DIOXO 3,4 DIHYDROPYRIMIDIN 1(2H) YL) 3,4 DIMETHYLTETRAHYDROFURAN 2 YL)METHYL BENZOATE; ((2,3,4,5) 3 ACETOXY 4 FLUORO 5 (6 (4 FLUOROBENZYLAMINO) 9H PURIN 9 YL) 3,4 DIMETHYLTETRAHYDROFURAN 2 YL)METHYL BENZOATE; ((2,3,4,5) 3 ACETOXY 4 FLUORO 5 (6 (FURAN 2 YLMETHYLAMINO) 9H PURIN 9 YL) 3,4 DIMETHYLTETRAHYDROFURAN 2 YL)METHYL BENZOATE; ((2,3,4,5) 3 ACETOXY 4 FLUORO 5 (6 HYDROXY 9H PURIN 9 YL) 3,4 DIMETHYLTETRAHYDROFURAN 2 YL)METHYL BENZOATE; ((2,3,4,5) 3 ACETOXY 5 (2,4 DIOXO 3,4 DIHYDROPYRIMIDIN 1 (2H) YL) 4 FLUORO 3,4 DIMETHYLTETRAHYDROFURAN 2 YL)METHYL BENZOATE; ((2,3,4,5) 3 ACETOXY 5 (4 BENZAMIDO 2 OXOPYRIMIDIN 1(2H) YL) 4 FLUORO 3,4 DIMETHYL TETRAHYDROFURAN 2 YL)METHYL BENZOATE; ((2,3,4,5) 3 ACETOXY 5 (6 (CYCLOBUTYLAMINO) 9H PURIN 9 YL) 4 FLUORO 3,4 DIMETHYLTETRAHYDROFURAN 2 YL)METHYL BENZOATE; ((2,3,4,5) 3 ACETOXY 5 (6 (CYCLOPROPYLAMINO) 9H PURIN 9 YL) 4 FLUORO 3,4 DIMETHYLTETRAHYDROFURAN 2 YL)METHYL BENZOATE; ((2,3,4,5) 3 ACETOXY 5 (6 (CYCLOPROPYLMETHYLAMINO) 9H PURIN 9 YL) 4 FLUORO 3,4 DIMETHYLTETRAHYDROFURAN 2 YL)METHYL BENZOATE; ((2,3,4,5) 3 ACETOXY 5 (6 CHLORO 9H PURIN 9 YL) 4 FLUORO 3,4 DIMETHYLTETRAHYDROFURAN 2 YL)METHYL BENZOATE; ((2,3,4,5) 3 ACETOXY 5 (6 ETHOXY 9H PURIN 9 YL) 4 FLUORO 3,4 DIMETHYLTETRAHYDROFURAN 2 YL)METHYL BENZOATE; (2,3,4,5) 3 ACETOXY 4 FLUORO 3,4 DIMETHYL 5 (6 MORPHOLINO 9H PURIN 9 YL)TETRAHYDROFURAN 2 YL)METHYL BENZOATE; AMANTADINE; ANTIVIRUS AGENT; OSELTAMIVIR; PERAMIVIR; RIMANTADINE; UNCLASSIFIED DRUG; ZANAMIVIR;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CROSS COUPLING REACTION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; INFLUENZA VIRUS; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS STRAIN;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DOGS; HUMANS; INFLUENZA A VIRUS; INFLUENZA B VIRUS; INFLUENZA, HUMAN; PURINE NUCLEOSIDES; PYRIMIDINE NUCLEOSIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

ORTHOMYXOVIRIDAE;

EID: 77955984256     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.07.017     Document Type: Article

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