Syntheses of 4′-C-ethynyl-β-D-arabino- and 4′-C-ethynyl-2′-deoxy-β-D-ribo-pentofuranosylpyrimidines and -purines and evaluation of their anti-HIV activity

Journal of Medicinal Chemistry

Volumn 43, Issue 23, 2000, Pages 4516-4525

  Ohrui, H ^a   Kohgo, S ^a   Kitano, K ^c   Sakata, S ^c   Kodama, E ^b   Yoshimura, K ^e   Matsuoka, M ^b   Shigeta, S ^d   Mitsuya, H ^e,f  

^a TOHOKU UNIVERSITY   (Japan)

^b YAMASA CORPORATION   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^e KUMAMOTO UNIVERSITY   (Japan)

^f NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4' ETHYNYL 2' DEOXY BETA DEXTRO RIBOPENTOFURANOSYLPYRIMIDINE; 4' ETHYNYL 2' DEOXYADENOSINE; 4' ETHYNYL 2' DEOXYCYTIDINE; 4' ETHYNYL 2,6 DIAMINO 2' DEOXYPURINE; 4' ETHYNYL BETA DEXTRO ARABINOPENTOFURANOSYLPYRIMIDINE; ABACAVIR; CYTIDINE DERIVATIVE; GLUCOSE; LAMIVUDINE; NUCLEOSIDE; PURINE; PURINE DERIVATIVE; PYRIMIDINE; PYRIMIDINE DERIVATIVE; STAVUDINE; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PURINE NUCLEOSIDE; PYRIMIDINE NUCLEOSIDE;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG POTENCY; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS; SYNTHESIS; ANTIBIOTIC RESISTANCE; CELL LINE; CHEMISTRY; DRUG EFFECT; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOLATION AND PURIFICATION; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; CELL LINE; DRUG RESISTANCE, MICROBIAL; HIV-1; PURINE NUCLEOSIDES; PYRIMIDINE NUCLEOSIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034676266     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000209n     Document Type: Article

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