Synthesis, antiviral activity, and mode of action of some 3-substituted 2,5,6-trichloroindole 2′- and 5″-deoxyribonucleosides

Journal of Medicinal Chemistry

Volumn 47, Issue 23, 2004, Pages 5773-5782

  Williams, John D ^a   Ptak, Roger G ^a,b   Drach, John C ^a   Townsend, Leroy B ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 ACETYL 2,5,6 TRICHLORO 1 (2 DEOXY BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 CYANO 2,5,6 TRICHLORO 1 (2 DEOXY BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 CYANO 2,5,6 TRICHLORO 1 (5 DEOXY BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 CYANO 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 FORMYL 2,5,6 TRICHLORO 1 (2 DEOXY BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 FORMYL 2,5,6 TRICHLORO 1 (5 DEOXY BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 FORMYL 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; INDOLE DERIVATIVE; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CHEMICAL MODIFICATION; DATA ANALYSIS; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GLYCOSYLATION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IC 50;

ANTIVIRAL AGENTS; CELL LINE; CYTOMEGALOVIRUS; DEOXYRIBONUCLEOSIDES; HERPESVIRUS 1, HUMAN; HUMANS; INDOLES; MOLECULAR CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 7444238718     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0400606     Document Type: Article

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