Timing of growth hormone treatment affects trabecular bone microarchitecture and mineralization in growth hormone deficient mice

Bone

Volumn 47, Issue 2, 2010, Pages 295-300

  Kristensen, Erika ^a,b   Hallgrímsson, Benedikt ^a,b   Morck, Douglas W ^a   Boyd, Steven K ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Ghrhr little mice; Growth hormone deficiency; Growth hormone treatment; Micro computed tomography; Trabecular microarchitecture

Indexed keywords

GROWTH HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MASS; BONE MINERALIZATION; BONE STRUCTURE; CONTROLLED STUDY; EARLY INTERVENTION; FEMALE; GROWTH HORMONE DEFICIENCY; HETEROZYGOSITY; HOMOZYGOSITY; IN VIVO STUDY; LUMBAR VERTEBRA; MALE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; STRUCTURE ANALYSIS; THERAPY DELAY; TRABECULAR BONE; ANIMAL; BONE; DEFICIENCY; DRUG EFFECTS; HOMOZYGOTE; METABOLISM; NORMAL DISTRIBUTION; ORGAN SIZE; PATHOLOGY; TIME;

ANIMALS; BONE AND BONES; BONE DENSITY; CALCIFICATION, PHYSIOLOGIC; GROWTH HORMONE; HOMOZYGOTE; MICE; NORMAL DISTRIBUTION; ORGAN SIZE; TIME FACTORS;

EID: 77955983782     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2010.04.587     Document Type: Article

References (34)

1. Lindsay R., Feldkamp M., Harris D., Robertson J., Rallison M. Utah Growth Study: growth standards and the prevalence of growth hormone deficiency. J Pediatr 1994, 125:29-35.
2. Shalet S.M., Toogood A., Rahim A., Brennan B.M. The diagnosis of growth hormone deficiency in children and adults. Endocr Rev 1998, 19:203-223.
3. Hyer S.L., Rodin D.A., Tobias J.H., Leiper A., Nussey S.S. Growth hormone deficiency during puberty reduces adult bone mineral density. Arch Dis Child 1992, 67:1472-1474.
4. Bouillon R., Koledova E., Bezlepkina O., Nijs J., Shavrikhova E., Nagaeva E., et al. Bone status and fracture prevalence in Russian adults with childhood-onset growth hormone deficiency. J Clin Endocrinol Metab 2004, 89:4993-4998.
5. Kaufman J.M., Taelman P., Vermeulen A., Vandeweghe M. Bone mineral status in growth hormone-deficient males with isolated and multiple pituitary deficiencies of childhood onset. J Clin Endocrinol Metab 1992, 74:118-123.
6. Saggese G., Baroncelli G.I., Bertelloni S., Barsanti S. The effect of long-term growth hormone (GH) treatment on bone mineral density in children with GH deficiency. Role of GH in the attainment of peak bone mass. J Clin Endocrinol Metab 1996, 81:3077-3083.
7. Boot A.M., van der Sluis I.M., Krenning E.P., de Muinck Keizer-Schrama S.M.P.F. Bone mineral density and body composition in adolescents with childhood-onset growth hormone deficiency. Horm Res 2009, 71:364-371.
8. Murray R.D., Adams J.E., Shalet S.M. A densitometric and morphometric analysis of the skeleton in adults with varying degrees of growth hormone deficiency. J Clin Endocrinol Metab 2006, 91:432-438.
9. van der Sluis I.M., Boot A.M., Hop W.C., De Rijke Y.B., Krenning E.P., de Muinck Keizer-Schrama S.M. Long-term effects of growth hormone therapy on bone mineral density, body composition, and serum lipid levels in growth hormone deficient children: a 6-year follow-up study. Horm Res 2002, 58:207-214.
10. Bravenboer N., Holzmann P.J., ter Maaten J.C., Stuurman L.M., Roos J.C., Lips P. Effect of long-term growth hormone treatment on bone mass and bone metabolism in growth hormone-deficient men. J Bone Miner Res 2005, 20:1778-1784.
11. Carter D.R., Bouxsein M.L., Marcus R. New approaches for interpreting projected bone densitometry data. J Bone Miner Res 1992, 7:137-145.
12. Arends N.J., Boonstra V.H., Mulder P.G., Odink R.J., Stokvis-Brantsma W.H., Rongen-Westerlaken C., et al. GH treatment and its effect on bone mineral density, bone maturation and growth in short children born small for gestational age: 3-year results of a randomized, controlled GH trial. Clin Endocrinol (Oxf) 2003, 59:779-787.
13. Schweizer R., Martin D.D., Schwarze C.P., Binder G., Georgiadou A., Ihle J., et al. Cortical bone density is normal in prepubertal children with growth hormone (GH) deficiency, but initially decreases during GH replacement due to early bone remodeling. J Clin Endocrinol Metab 2003, 88:5266-5272.
14. Schweizer R., Martin D.D., Haase M., Roth J., Trebar B., Binder G., et al. Similar effects of long-term exogenous growth hormone (GH) on bone and muscle parameters: a pQCT study of GH-deficient and small-for-gestational-age (SGA) children. Bone 2007, 41:875-881.
15. Bravenboer N., Holzmann P., de Boer H., Blok G.J., Lips P. Histomorphometric analysis of bone mass and bone metabolism in growth hormone deficient adult men. Bone 1996, 18:551-557.
16. Chen M.M., Yeh J.K., Aloia J.F. Histologic evidence: growth hormone completely prevents reduction in cortical bone gain and partially prevents cancellous osteopenia in the tibia of hypophysectomized rats. Anat Rec 1997, 249:163-172.
17. Kasukawa Y., Baylink D.J., Guo R., Mohan S. Evidence that sensitivity to growth hormone (GH) is growth period and tissue type dependent: studies in GH-deficient lit/lit mice. Endocrinology 2003, 144:3950-3957.
18. Osteoporosis prevention, diagnosis, and therapy. Jama 2001, 285:785-795.
19. van der Linden J.C., Weinans H. Effects of microarchitecture on bone strength. Curr Osteoporos Rep 2007, 5:56-61.
20. Eicher E.M., Beamer W.G. Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6. J Heredity 1976, 67:87-91.
21. Groesbeck M.D., Parlow A.F., Daughaday W.H. Stimulation of supranormal growth in prepubertal, adult plateaued, and hypophysectomized female rats by large doses of rat growth hormone: physiological effects and adverse consequences. Endocrinology 1987, 120:1963-1975.
22. Mohan S., Richman C., Guo R., Amaar Y., Donahue L.R., Wergedal J., et al. Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormone-dependent and -independent mechanisms. Endocrinology 2003, 144:929-936.
23. Danilovich N., Wernsing D., Coschigano K.T., Kopchick J.J., Bartke A. Deficits in female reproductive function in GH-R-KO mice; role of IGF-I. Endocrinology 1999, 140:2637-2640.
24. Ahima R.S., Dushay J., Flier S.N., Prabakaran D., Flier J.S. Leptin accelerates the onset of puberty in normal female mice. J Clin Invest 1997, 99:391-395.
25. Buie H.R., Moore C.P., Boyd S.K. Postpubertal architectural developmental patterns differ between the L3 vertebra and proximal tibia in three inbred strains of mice. J Bone Miner Res 2008, 23:2048-2059.
26. Miller L.M., Little W., Schirmer A., Sheik F., Busa B., Judex S. Accretion of bone quantity and quality in the developing mouse skeleton. J Bone Miner Res 2007, 22:1037-1045.
27. Brouwers J.E., van Rietbergen B., Huiskes R. No effects of in vivo micro-CT radiation on structural parameters and bone marrow cells in proximal tibia of Wistar rats detected after eight weekly scans. J Orthop Res 2007, 25:1325-1332.
28. Klinck R.J., Campbell G.M., Boyd S.K. Radiation effects on bone architecture in mice and rats resulting from in vivo micro-computed tomography scanning. Med Eng Phys 2008, 30:888-895.
29. Laperre K., Depypere M., van Gastel N., Torrekens S., Maes F., Carmeliet G. Effect of in vivo micro-CT radiation on trabecular bone morphology in mice. J Bone Miner Res 2009, 24(Suppl 1). Available at: http://www.asbmr.org/Meetings/AnnualMeeting/AbstractDetail.aspx?aid=a183a17d-4c94-4406-b636-cc7ccb47cdd0. Accessed: Nov 30 2009.
30. Nishiyama K.K., Campbell G.M., Klinck R.J., Boyd S.K. Reproducibility of bone micro-architecture measurements in rodents by in vivo micro-computed tomography is maximized with three-dimensional image registration. Bone 2010, 46:155-161.
31. Roux J., Wegrzyn J., Arlot M., Guyen O., Delmas P., Chapurlat R., et al. Contribution of trabecular and cortical components to biomechanical behavior of human vertebrae: an ex-vivo study. J Bone Miner Res 2010, 25:356-361.
32. Marini J.C., Hopkins E., Glorieux F.H., Chrousos G.P., Reynolds J.C., Gundberg C.M., et al. Positive linear growth and bone responses to growth hormone treatment in children with types III and IV osteogenesis imperfecta: high predictive value of the carboxyterminal propeptide of type I procollagen. J Bone Miner Res 2003, 18:237-243.
33. Guo X.E., Kim C.H. Mechanical consequence of trabecular bone loss and its treatment: a three-dimensional model simulation. Bone 2002, 30:404-411.
34. Mosekilde L., Thomsen J.S., Orhii P.B., Kalu D.N. Growth hormone increases vertebral and femoral bone strength in osteopenic, ovariectomized, aged rats in a dose-dependent and site-specific manner. Bone 1998, 23:343-352.