Bone mineral density and body composition in adolescents with childhood-onset growth hormone deficiency

Hormone Research

Volumn 71, Issue 6, 2009, Pages 364-371

  Boot, Annemieke M ^a   Van Der Sluis, Inge M ^b   Krenning, Eric P ^d   De Muinck Keizer Schrama, Sabine M P F ^c  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b Division of Pediatric Haemato Oncology   (Netherlands)

^c SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^d ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Body composition; Bone mineral density; Growth hormone deficiency; Lean body mass; Transition

Indexed keywords

GROWTH HORMONE;

ADOLESCENT; ARTICLE; BODY COMPOSITION; BODY FAT; BODY HEIGHT; BODY MASS; BONE DENSITY; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GROWTH HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; LEAN BODY WEIGHT; LUMBAR SPINE; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADOLESCENT; BODY HEIGHT; BONE DENSITY; FEMALE; FOLLOW-UP STUDIES; GROWTH DISORDERS; HORMONE REPLACEMENT THERAPY; HUMAN GROWTH HORMONE; HUMANS; MALE; RECOMBINANT PROTEINS;

EID: 66449098302     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000223422     Document Type: Article

References (43)

1. Molitch ME, Clemmons DR, Malozowski S, Merriam GR, Shalet SM, Vance ML, Endocrine Society's Clinical Guidelines Subcommittee, Stephens PA: Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2006;91: 1621-1634.
2. Wuster C, Abs R, Bengtsson BA, Bennmar- ker H, Feldt-Rasmussen U, Hernberg-Ståhl E, Monson JP, Westberg B, Wilton P, KIMS Study Group and the KIMS International Board: Pharmacia & Upjohn International Metabolic Database: The influence of growth hormone deficiency, growth hormone replacement therapy, and other aspects of hy- popituitarism on fracture rate and bone mineral density. J Bone Miner Res 2001; 16: 398-405.
3. Coloa A, Di Somma C, Salerno M, Spinelli L, Orio F, Lombardi G: The cardiovascular risk of GH-deficient adolescents. J Clin Endocri- nol Metab 2002;87:3650-3655.
4. Rosen T, Bengtsson BA: Premature mortality due to cardiovascular disease in hypopitu-itarism. Lancet 1990; 336: 285-288.
5. Woodhouse LJ, Mukherjee A, Shalet SM, Ez- zat S: The influence of growth hormone status on physical impairments, functional limitations, and health-related quality of life in adults. Endocr Rev 2006;27:287-317.
6. Baroncelli GI, Bertelloni S, Ceccarelli C, Saggese G: Measurement of volumetric bone mineral density accurately determines degree of lumbar undermineralization in children with growth hormone deficiency. J Clin Endocrinol Metab 1998; 83: 3150-3154.
7. Boot AM, Engels MA, Boerma GJ, Krenning EP, De Muinck Keizer-Schrama SM: Changes in bone mineral density, body composition, and lipid metabolism during growth hormone (GH) treatment in children with GH deficiency. J Clin Endocrinol Metab 1997; 82: 2423-2428.
8. van der Sluis IM, Boot AM, Hop WC, De Rijke YB, Krenning EP, de Muinck Keizer- Schrama SM: Long-term effects of growth hormone therapy on bone mineral density, body composition, and serum lipid levels in growth hormone deficient children: a 6-year follow-up study. Horm Res 2002;58:207-214.
9. Baroncelli GI, Bertelloni S, Sodini F, Saggese G: Lumbar bone mineral density at final height and prevalence of fractures in treated children with GH deficiency. J Clin Endocri-nol Metab 2002; 87: 3624-3631.
10. Baroncelli GI, Bertelloni S, Sodini F, Saggese G: Longitudinal changes of lumbar bone mineral density (BMD) in patients with GH deficiency after discontinuation of treatment at final height; timing and peak values for lumbar BMD. Clin Endocrinol 2004;60: 175-184.
11. Benbassat CA, Eshed V, Kamjin M, Laron Z: Are adult patients with Laron syndrome os- teopenic? A comparison between dual-energy X-ray absorptiometry and volumetric bone densities. J Clin Endocrinol Metab 2003;88: 4586-4589.
12. Maheshwari HG, Bouillon R, Nijs J, Oganov VS, Bakulin AV, Baumann G: The impact of congenital, severe, untreated growth hormone (GH) deficiency on bone size and density in young adults: insights from genetic GH-releasing hormone receptor deficiency. J Clin Endocrinol Metab 2003; 88: 2614-2618.
13. Murray RD, Adams JE, Shalet SM: A densi- tometric and morphometric analysis of the skeleton in adults with varying degrees of growth hormone deficiency. J Clin Endocri-nol Metab 2006; 91: 432-438.
14. Matkovic V, Jelic T, Wardlaw GM, Ilich JZ, Goel PK, Wright JK, Andon MB, Smith KT, Heany RP: Timing of peak bone mass in Caucasian females and its implication for the prevention of osteoporosis. Inference from a cross-sectional model. J Clin Invest 1994;93: 799-780.
15. Lu PW, Briody JN, Ogle GD, Morley K, Humphries IR, Allen J, Howman-Giles R, Sillence D, Cowell CT: Bone mineral density of total body, spine and femoral neck in children and young adults: a cross-sectional and longitudinal study. J Bone Miner Res 1994;9: 1451-1458.
16. Gordon CL, Halton JM, Atkinson SA, Webber CE: The contributions of growth and puberty to peak bone mass. Growth Dev Aging 1991; 55: 257-262.
17. Schönau E, Werhahn E, Schiedermaier U, Mokow E, Schiessl H, Scheidhauer K, Mi- chalk D: Influence of muscle strength on bone strength during childhood and adolescence. Horm Res 1996; 45: 63-66.
18. Abs R: Update on the diagnosis of GH deficiency in adults. Eur J Endocrinol 2003; 148(suppl 2):S3-S8.
19. Clayton PE, Cuneo RC, Juul A, Monson JP, Shalet SM, Tauber M, European Society of Paediatric Endocrinology: Consensus statement on the management of the GH-treated adolescent in the transition to adult care. Eur J Endocrinol 2005; 152: 165-170.
20. Fredriks AM, van Buuren S, Burgmeijer RJ, Meulmeester JF, Beuker RJ, Brugman E, Roede MJ, Verloove-Vanhorick SP, Wit JM: Continuing positive secular growth change in The Netherlands 1955-1997. Pediatr Res 2000;47: 316-323.
21. Crabtree NJ, Shaw NJ, Boivin CM, Oldroyd B, Truscott JG: Pediatric in vivo cross-calibration between the GE Lunar Prodigy and DPX-L bone densitometers. Osteoporos Int 2005;16: 2157-2167.
22. Johnson J, Dawson-Hughes B: Precision and stability of dual-energy X-ray absorptiometry measurements. Calcif Tissue Int 1991;49: 174-178.
23. Shepherd JA, Fan B, Lu Y, Lewiecki EM, Miller P, Genant HK: Comparison of BMD precision for Prodigy and Delphi spine and femur scans. Osteoporos Int 2006; 17:1303-1308.
24. Margulies L, Horlick M, Thornton JC, Wang J, Ioannidou E, Heymsfield SB: Reproduc- ibility of pediatric whole body bone and body composition measures by dual-energy X-ray absorptiometry using the GE Lunar Prodigy. J Clin Densitom 2005;8:298-304.
25. Kroger H, Vainio P, Nieminen J, Kotaniemi A: Comparison of different models for interpreting bone mineral density measurements using DXA and MRI technology. Bone 1995; 17:157-159.
26. van der Sluis IM, de Ridder MA, Boot AM, Krenning EP, de Muinck Keizer-Schrama SM: Reference data for bone density and body composition measured with dual energy X ray absorptiometry in white children and young adults. Arch Dis Child 2002;87: 341-347.
27. Hokken-Koelega AC, Hackeng WH, Stijnen T, Wit JM, de Muinck Keizer-Schrama SM, Drop SL: Twenty-four-hour plasma growth hormone (GH) profiles, urinary GH excretion, and plasma insulin-like growth factor-I and -II levels in prepubertal children with chronic renal insufficiency and severe growth retardation. J Clin Endocrinol Metab 1990;71:688-695.
28. Elmlinger MW, Kuhnel W, Weber MM, Ran- ke MB: Reference ranges for two automated chemiluminescent assays for serum insulinlike growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3). Clin Chem Lab Med 2004;42:654-664.
29. Attanasio AF, Howell S, Bates PC, Frewer P, Chipman J, Blum WF, Shalet SM: Body composition, IGF-I and IGFBP-3 concentrations as outcome measures in severely GH-defi- cient (GHD) patients after childhood GH treatment: a comparison with adult onset GHD patients. J Clin Endocrinol Metab 2002;87: 3368-3372.
30. Maghnie M, Ambrosini L, Cappa M, Pozzo- bon G, Ghizzoni L, Ubertini MG, di Iorgi N, Tinelli C, Pilia S, Chiumello G, Lorini R, Loche S: Adult height in patients with permanent growth hormone deficiency with and without multiple pituitary hormone deficiencies. J Clin Endocrinol Metab 2006; 91: 2900-2905.
31. Tauber M, Jouret B, Cartault A, Lounis N, Gayrard M, Marcouyeux C, Pienkowski C, Oliver I, Moulin P, Otal P, Joffre F, Arnaud C, Rochiccioli P: Adolescents with partial growth hormone (GH) deficiency develop alterations of body composition after GH discontinuation and require follow-up. J Clin Endocrinol Metab 2003;88:5101-5106.
32. Aimaretti G, Corneli G, Rovere S, Granata R, Baldelli R, Grottoli S, Ghigo E: Insulin-like
33. growth factor I levels and the diagnosis of adult growth hormone deficiency. Horm Res 2004;62(suppl 1):26-33.
34. de Ridder MA, Stijnen T, Hokken-Koelega AC: Prediction of adult height in growth- hormone-treated children with growth hormone deficiency. J Clin Endocrinol Metab 2007;92: 925-931.
35. Ranke MB, Lindberg A, Price DA, Darende-liler F, Albertsson-Wikland K, Wilton P, Reiter EO, KIGS International Board: Age at growth hormone therapy start and first-year responsiveness to growth hormone are major determinants of height outcome in idio- pathic short stature. Horm Res 2007; 68: 53-62.
36. Hoos MB, Westerterp KR, Gerver WJ: Short- term effects of growth hormone on body composition as a predictor of growth J Clin Endocrinol Metab 2003; 88: 2569-2572.
37. Hulthén L, Bengtsson BA, Sunnerhagen KS, Hallberg L, Grimby G, Johannsson G: GH is needed for the maturation of muscle mass and strength in adolescents. J Clin Endocri- nol Metab 2001;86:4765-4770.
38. Mauras N, Pescovitz OH, Allada V, Messig M, Wajnrajch MP, Lippe B; Transition Study Group: Limited efficacy of growth hormone (GH) during transition of GH-deficient patients from adolescence to adulthood: a phase III multicenter, double-blind, randomized two-year trial. J Clin Endocrinol Metab 2005; 90:3946-3955.
39. Fisker S, Kristensen K, Rosenfalck AM, Pe- dersen SB, Ebdrup L, Richelsen B, Hilsted J, Christiansen JS, Jørgensen JO: Gene expression of a truncated and the full-length growth hormone (GH) receptor in subcutaneous fat and skeletal muscle in GH-defi- cient adults: impact of GH treatment. J Clin Endocrinol Metab 2001; 86:792-796.
40. Johannsson G, Albertsson-Wikland K, Bengtsson BA: Discontinuation of growth hormone (GH) treatment: metabolic effects in GH-deficient and GH-sufficient adolescent patients compared with control subjects. Swedish Study Group for Growth Hormone Treatment in Children. J Clin En-docrinol Metab 1999; 84:4516-4524.
41. Lustig RH, Post SR, Srivannaboon K, Rose SR, Danish RK, Burghen GA, Xiong X, Wu S, Merchant TE: Risk factors for the development of obesity in children surviving brain tumors. J Clin Endocrinol Metab 2003; 88: 611-616.
42. Fors H, Bjarnason R, Wirént L, Albertsson- Wikland K, Bosaeust L, Bengtsson BA, Jo- hannsson G: Currently used growth-promoting treatment of children results in normal bone mass and density. A prospective trial of discontinuing growth hormone treatment in adolescents. Clin Endocrinol 2001;55: 617-624.
43. Lu PW, Cowell CT, LLoyd-Jones SA, Briody JN, Howman-Giles R: Volumetric bone mineral density in normal subjects, aged 5-27 years. J Clin Endocrinol Metab 1996;81: 1586-1590.