Histologic evidence: Growth hormone completely prevents reduction in cortical bone gain and partially prevents cancellous osteopenia in the tibia of hypophysectomized rats

Anatomical Record

Volumn 249, Issue 2, 1997, Pages 163-172

  Chen, Meng Meng ^a   Yeh, James K ^a,b   Aloia, John F ^a,b  

^a WINTHROP UNIVERSITY HOSPITAL   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Bone turnover; Bone volume; Growth hormone; Hypophysectomy; Osteoporosis

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE GROWTH; BONE MASS; BONE MINERAL; BONE TURNOVER; CANCELLOUS BONE; CONTROLLED STUDY; CORTICAL BONE; CYTOARCHITECTURE; GASTROCNEMIUS MUSCLE; GROWTH HORMONE RELEASE; HISTOLOGY; HYPOPHYSECTOMY; NONHUMAN; OSTEOPENIA; PRIORITY JOURNAL; RAT; TIBIA SHAFT; TISSUE SECTION;

ANIMALS; BODY WEIGHT; BONE DEVELOPMENT; BONE DISEASES, METABOLIC; FEMALE; FEMUR; GROWTH HORMONE; GROWTH PLATE; HYPOPHYSECTOMY; IMAGE PROCESSING, COMPUTER-ASSISTED; INSULIN-LIKE GROWTH FACTOR I; MOTOR ACTIVITY; MUSCLE, SKELETAL; RATS; RATS, SPRAGUE-DAWLEY; TIBIA;

ANIMALIA;

EID: 0030881639     PISSN: 0003276X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0185(199710)249:2<163::AID-AR2>3.0.CO;2-Z     Document Type: Article

References (45)

1. Andreassen, T.T., P.H. Jorgensen, A. Flyvbjerg, H. Orskov, and H. Oxlund 1995 Growth hormone stimulates bone formation and strength of cortical bone in aged rats. J. Bone Miner. Res., 10:1057-1067.
2. Balducci, R., V. Toscano, A.M. Pasquino, A. Mangiantini, G. Municchi, P. Armenise, S. Terracina, G. Prossomariti, and B. Boscherini 1995 Bone turnover and bone mineral density in young adult patients with panhypopituitarism before and after long-term growth hormone therapy. Eur. J. Endocrinol., 132:42-46.
3. Barnes, C.D., and L.G. Eltherington 1973 Drug Dosage in Laboratory Animals. Rev. Ed. Univ. of California Press, Berkeley.
4. Baron, R., R. Tross, and A. Vignery 1984 Evidence of sequential remodeling in rat trabecular bone: Morphology, dynamic histomorphometry, and changes during skeletal maturation. Anat. Rec., 208:137-145.
5. Bing-You, R.G., M.C. Denis, and C.J. Rosen 1993 Low bone mineral density in adults with previous hypothalamic-pituitary tumors: Correlations with serum growth hormone responses to GH-releasing hormone, insulin-like factor I, and IGF binding protein 3. Calcif. Tissue Int., 52:183-187.
6. Binnerts, A., G.R. Swart, J.H. Paul-Wilson, N. Hooger-Brugge, H.A. Pols, J.C. Birkenhager, and W.J. Lamberts 1992 The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as body composition. Clin. Endocrinol., 37:79-87.
7. Brixen, K., M. Kassem, H.K. Nielsen, A.G. Loft, A. Flyvbjerg, and L. Mosekilde 1995 Short-term treatment with growth hormone stimulates osteoblastic and osteoclastic activity in osteopenic postmenopausal women: A dose response study. J. Bone Miner. Res., 10:1865-1874.
8. Chen, M.M., J.K. Yeh, and J.F. Aloia 1995 Skeletal alterations in hypophysectomized rats. II: A histomorphometric study on tibial cortical bone. Anat. Rec., 241:513-518.
9. De Boer, H., G.J. Blok, A. Van Lingen, G.J.J. Teule, P. Lips, and E.A. Van Der Veen 1994 Consequences of childhood-onset growth hormone deficiency for adult bone mass. J. Bone Miner. Res., 9:1319-1326.
10. Denis, I., E. Zerath, and A. Pointillart 1994 Effects of exogenous growth hormone on bone mineralization and remodeling and on plasma calcitriol in intact pigs. Bone, 15:419-424.
11. Doyle, F., J. Brown, and C. Lachance 1970 Relation between bone mass and muscle weight. Lancet, 1:391-393.
12. Eden, S. 1976 Age- and sex-related differences in episodic growth hormone secretion in the rat. Endocrinology, 105:555-560.
13. Ernst, M., and E.R. Froesch 1988 Growth hormone dependent stimulation of osteoblast-like cells in serum-free cultures via local synthesis of insulin-like growth factor I. Biochem. Biophys. Res. Commun., 151:142-147.
14. Frost, H.M., and W.S.S Jee 1992 On the rat model of human osteopenias and osteoporosis. Bone Miner., 18:227-236.
15. Frost, H.M., and W.S.S. Jee 1994a Perspectives: A vital biomechanical model of the endochondral ossification mechanism. Anat. Rec., 240:435-446.
16. Frost, H.M., and W.S.S. Jee 1994b Perspectives: Applications of a biomechanical model of the endochondral ossification mechanism. Anat. Rec., 240:447-455.
17. Groesbeck, M.D., and A.F. Parlow 1987 Highly improved precision of the hypophysectomized female rat body weight gain bioassay for growth hormone by increased frequency of injections, avoidance of antibody formation, and other simple modifications. Endocrinology, 120:2582-2590.
18. Groesbeck, M.D., A.F. Parlow, and W.H. Daughaday 1987 Stimulation of supranormal growth in prepubertal, adult plateaued, and hypophysectomized female rats by large doses of rat growth hormone: Physiological effects and adverse consequences. Endocrinology, 120:1963-1975.
19. Guler, H.P., J. Zapf, E. Scheiwiller, and E.R. Froesch 1988 Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats. Proc. Natl. Acad. Sci., 85:4889-4893.
20. Halloran, B.P., D.D. Bikle, J. Harris, C.P. Autry, P.A. Currier, S. Tanner, P. Patterson-Buckendahl, and E. Morey-Holton 1995 Skeletal unloading induces selective resistance to the anabolic actions of growth hormone on bone. J. Bone Miner. Res., 10:1168-1176.
21. Harris, W.H., R.P. Heaney, J. Jowsey, J. Cockin, C. Akins, J. Graham, and E.H. Weinberg 1972 Growth hormone: The effect of skeletal mass on skeletal renewal in the adult dog. I. Morphometric studies. Calcif. Tissue Res., 10:1-13.
22. Hock, J.M., and J. Fonseca 1990 Anabolic effect of human synthetic parathyroid hormone (1-34) depends on growth hormone. Endocrinology, 127:1804-1810.
23. Holloway, L., G. Butterfield, R.L. Hintz, N. Gesundheit, and R. Marcus 1994 Effects of recombinant human growth hormone on metabolic indices, body composition, and bone turnover in healthy elderly women. J. Clin. Endocrinol. Metab., 79:470-479.
24. Hulse, J.A., S.M. Rosenthal, L. Cuttler, S.L. Kaplan, and M.M. Grumbach 1986 The effect of pulsatile administration, continuous infusion, and diurnal variation on the growth hormone (GH) response to GH-releasing hormone in normal men. J. Clin. Endocrinol. Metab., 63:872-878.
25. Isaksson, O.G.P., A. Lindahl, A. Nilsson, and J. Isgaard 1987 Mechanism of the stimulatory effect of growth hormone on longitudinal bone growth. Endocrine Reviews, 8:426-438.
26. Jee, W.S.S., J. Inoue, K.W. Jee, and T. Haba 1983 Histomorphometric assay of the growing long bone. In: Handbook of Bone Morphology. H. Takahashi, ed. Nishimura, Niigata City, Japan, pp. 101-122.
27. Jorgensen, P.H., C. Bang, T.T. Andreassen, A. Flyvbjerg, and H. Orskov 1995 Dose-response study of the effect of growth hormone on mechanical properties of skin graft wounds. J. Surg. Res., 58:295-301.
28. Kassem, M., W. Blum, J. Ristelli, L. Mosekilde, and E.F. Eriksen 1993 Growth hormone stimulates proliferation and differentiation of normal human osteblast-like cells in vitro. Calcif. Tissue Int., 52:222-226.
29. Kaufman, J.M., P. Taelman, A. Vermeulen, and M. Vandeweghe 1992 Bone mineral status in growth hormone deficient males with isolated and multiple pituitary deficiencies of childhood onset. J. Clin. Endocrinol. Metab., 74:118-123.
30. Kimmel, D.B., and W.S.S. Jee 1980 A quantitative histologic analysis of the growing long bone metaphysis. Calcif. Tissue Int., 32:113-122.
31. Lewinson, D., P. Shenzer, and Z. Hochberg 1993 Growth hormone involvement in the regulation of tartrate-resistant acid phosphatase-positive cells that are active in cartilage and bone resorption. Calcif. Tissue Int., 52:216-221.
32. Martinez, D.A., A.C. Vailas, and R.E. Grindeland 1991 Cortical bone maturation in young hypophysectomized rats. Am. J. Physiol., 260:E690-E694.
33. Morel, G., P. Chavassieux, B. Barenton, P.M. Dubois, P.J. Meunier, and G. Boivin 1993 Evidence for a direct effect of growth hormone on osteoblasts. Cell Tissue Res., 273:279-286.
34. Nishiyama, K., T. Sugimoto, H. Kaji, M. Kanatani, T. Kobayashi, and K. Chihara 1996 Stimulatory effect of growth hormone on bone resorption and osteoclast differentiation. Endocrinology, 137: 35-41.
35. Nordin, M., and V.H. Frankel 1989 Basic Biomechanics of the Musculoskeletal System (2nd edn). Lea and Febiger, Philadelphia.
36. Ohlsson, C., J. Isgaard, J. Tornell, A. Nilsson, O.G.P. Isaksson, and A. Lindahl 1993 Endocrine regulation of longitudinal bone growth. Acta. Paediatr. Suppl., 391:33-40.
37. Parfitt, A.M., M.K. Drezner, F.H. Glorieux, J.A. Kanis, H. Malluche, P.J. Meunier, S.M. Ott, and R.R. Recker 1987 Bone histomorphometry: Standardization of nomenclature, symbols, and units. J. Bone Miner. Res., 2:595-610.
38. Saggese, G., G.I. Baroncelli, S. Bertelloni, L. Cinquanta, and G. DiNero 1993 Effects of long-term treatment with growth hormone in bone and mineral development in children with growth hormone deficiency. J. Pediatr., 122:37-45.
39. Saunders, A., L.C. Terry, J. Audet, P. Brazeau, and J.B. Martin 1976 Dynamic studies of growth hormone and prolactin secretion in the female rat. Neuroendocrinology, 21:193-203.
40. Schiltz, P.M., T. Ohta, D. Glass, S. Mohan, and D.J. Baylink 1992 Growth hormone stimulates cortical bone formation in immature hypophysectomized rats. Endocrine Res., 18:19-30.
41. Stracke, H., A. Schulz, D. Moeller, S. Rossol, and H. Schatz 1984 Effect of growth hormone on osteoblasts and demonstration of somatomedin-C/IGF-I in bone organ culture. Acta Endocrinol. (Copenh.), 107:16-24.
42. Ullman, M., and A. Oldfors 1989 Effects of growth hormone on skeletal muscle. I. Studies on normal adult rats. Acta Physiol. Scand., 135:531-536.
43. Yeh, J.K., J.F. Aloia, and M.M. Chen 1994 Growth hormone administration potentiates the effect of treadmill exercise on long bone formation but not on the vertebrae in middle-aged rats. Calcif. Tissue Int., 54:38-43.
44. Yeh, J.K., M.M. Chen, and J.F. Aloia 1995 Skeletal alterations in hypophysectomized rats. I. A histomorphometric study on tibial cancellous bone. Anat. Rec., 241:505-512.
45. Young, A., M. Stokes, and M. Crowe 1984 Size and strength of the quadriceps muscles of old and young women. Eur. J. Clin. Invest., 14:282-287.