Inhibition of nitric oxide synthase during sepsis: Revival because of isoform selectivity?

Shock

Volumn 34, Issue 3, 2010, Pages 321-322

  Stahl, Wolfgang ^a   Matejovic, Martin ^b   Radermacher, Peter ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 (4 METHOXYPYRIDIN 2 YL)ETHYL] 3H IMIDAZOL[4,5 B]PYRIDINE; ADENOSINE TRIPHOSPHATE; BYK 191023; CALCIUM; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOENZYME; LACTIC ACID; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; N(G) METHYLARGININE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NORADRENALIN; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; BACTEREMIA; ENDOTOXEMIA; ENZYME INHIBITION; HUMAN; LACTATE BLOOD LEVEL; LUNG GAS EXCHANGE; NONHUMAN; NOTE; ORGAN BLOOD FLOW; PERITONITIS; PULMONARY HYPERTENSION; RESUSCITATION; SEPSIS; SEPTIC SHOCK; SURVIVAL;

ACIDOSIS; ANIMALS; BLOOD CIRCULATION; CLINICAL TRIALS, PHASE II AS TOPIC; EARLY TERMINATION OF CLINICAL TRIALS; ENDOTOXEMIA; FLUID THERAPY; HUMANS; IMIDAZOLES; MICE; MICE, KNOCKOUT; MOLSIDOMINE; NITRIC OXIDE SYNTHASE TYPE II; NOREPINEPHRINE; OMEGA-N-METHYLARGININE; PROTEIN ISOFORMS; PYRIDINES; SEPSIS; SHOCK, SEPTIC; SWINE;

EID: 77955983138     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3181d758b5     Document Type: Note

References (35)

1. 2 balance during endotoxemia in pigs. Intensive Care Med 31:985-992, 2005.
2. Siegemund M, Van Bommel J, Sinaasappel M, Schwarte LA, Studer W, Girard T, Vollebregt K, Ince C: The NO donor SIN-1 improves intestinal-arterial PCO2 gap in experimental endotoxemia: an animal study. Acta Anaesthesiol Scand 51:693-700, 2007.
3. Hollenberg SM, Cinel I: Bench-to-bedside review: nitric oxide in critical illnessVupdate 2008. Crit Care 13:218, 2009.
4. Hauser B, Bracht H, Matejovic M, Radermacher P, Venkatesh B: Nitric oxide synthase inhibition in sepsis? Lessons learned from large-animal studies. Anesth Analg 101:488-498, 2005.
5. Lange M, Enkhbaatar P, Nakano Y, Traber DL: Role of nitric oxide in shock: the large animal perspective. Front Biosci 14:1979-1989, 2009.
6. Grover R, Zaccardelli D, Colice G, Guntupalli K, Watson D, Vincent JL: An open-label dose escalation study of the nitric oxide synthase inhibitor, N(G)-methyl-l-arginine hydrochloride (546C88), in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group. Crit Care Med 27:913-922, 1999.
7. López A, Lorente JA, Steingrub J, Bakker J, McLuckie A, Willatts S, Brockway M, Anzueto A, Holzapfel L, Breen D, et al.: Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 32:21-30, 2004.
8. Dellinger P, Parrillo JE: Mediator modulation therapy of severe sepsis and septic shock: does it work? Crit Care Med 32:282-286, 2004.
9. Schlag G, Redl H, Gasser H, Khakpour Z, Davies J: Successful administration of the NO synthase inhibitor 546C88 as a delayed continuous infusion in a baboon model of septic shock. In: Schlag G, Redl H, (eds.): Shock, Sepsis, and Organ FailureVScavenging of Nitric Oxide and Inhibition of its Production. Sixth Wiggers Bernard Conference 1997, Heidelberg, Germany: Springer, pp 23-43, 1999.
10. 2 exchange and energy balance. Am J Respir Crit Care Med 159:1758-1765, 1999.
11. Booke M, Hinder F, McGuire R, Traber LD, Traber DL: Nitric oxide synthase inhibition versus norepinephrine in ovine sepsis: effects on regional blood flow. Shock 5:362-370, 1996.
12. 5-monomethyl-L-arginine (L-NMMA): effects on haemodynamics and regional blood flow in healthy and septic sheep. Clin Sci 98:193-200, 2000.
13. Nicholson SC, Grobmyer SR, Shiloh MU, Brause JE, Potter S, MacMicking JD, Dinauer MC, Nathan CF: Lethality of endotoxin in mice genetically deficient in the respiratory burst oxidase, inducible nitric oxide synthase, or both. Shock 11:253-258, 1999.
14. Hollenberg SM, Easington CR, Osman J, Broussard M, Parrillo JE: Effects of nitric oxide synthase inhibition on mice microvascular reactivity in septic mice. Shock 12:262-267, 1999.
15. Ichinose F, Hataishi R, Wu JC, Kawai N, Rodrigues AC, Mallari C, Post JM, Parkinson JF, Picard MH, Bloch KD, et al.: A selective inducible NOS dimerization inhibitor prevents systemic, cardiac, and pulmonary hemody-namic dysfunction in endotoxemic mice. Am J Physiol Heart Circ Physiol 285: H2524-H2530, 2003.
16. Barth E, Radermacher P, Thiemermann C, Weber S, Georgieff M, Albuszies G: Role of inducible nitric oxide synthase in the reduced responsiveness of the myocardium to catecholamines in a hyperdynamic, murine model of septic shock. Crit Care Med 34:307-313, 2006.
17. Albuszies G, Vogt J, Wachter U, Thiemermann C, Leverve XM, Weber S, Georgieff M, Radermacher P, Barth E: The effect of iNOS deletion on hepatic gluconeogenesis in hyperdynamic murine septic shock. Intensive Care Med 33:1094-1101, 2007.
18. Hollenberg SM, Broussard M, Osman J, Parrillo JE: Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase. Circ Res 86:774-778, 2000.
19. 2-exchange and energy metabolism during hyper-dynamic porcine endotoxemia. Shock 16:203-210, 2001.
20. Matejovic M, Krouzecky A, Martinkova V, Rokyta R Jr, Kralova H, Treska V, Radermacher P, Novak I: Selective inducible nitric oxide synthase inhibition during long-term hyperdynamic porcine bacteremia. Shock 21:458-465, 2004.
21. Enkhbaatar P, Murakami K, Traber LD, Cox R, Parkinson JF, Westphal M, Esechie A, Morita N, Maybauer MO, Maybauer DM, et al.: The inhibition of inducible nitric oxide synthase in ovine sepsis model. Shock 25:522-527, 2006.
22. Matejovic M, Krouzecky A, Radej J, Rokyta R, Kralova H, Radermacher P, Novak I: Coagulation and endothelial dysfunction during long-term hyper-dynamic porcine bacteremiaVeffects of selective inducible nitric oxide syn-thase inhibition. Thromb Haemost 97:304-309, 2007.
23. Su F, Huang H, Kazuki A, Occhipinti G, Donadello K, Piagnerelli M, De Backer D, Vincent JL: Effects of a selective iNOS inhibitor versus norepi-nephrine in the treatment of septic shock. Shock (In press).
24. Barth E, Albuszies G, Baumgart K, Matejovic M, Wachter U, Vogt J, Radermacher P, Calzia E: Glucose metabolism and catecholamines. Crit Care Med 35(9 suppl):S508-S518, 2007.
25. Heemskerk S, Pickkers P, Bouw MPWJM, Draisma A, van der Hoeven JG, Peters WHM, Smits P, Russel FGM, Masereeuw R: Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury. Clin J Am Soc Nephrol 1:853-862, 2006.
26. Heemskerk S, Masereeuw R, Russel FGM, Pickkers P: Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury. Nat Rev Nephrol 5:629-640, 2009.
27. 6-(1-imiethyl)-lysine ion microcirculation and reactive nitrogen species generation in the kidney following lipopolysaccharide administration in mice. J Pharmacol Exp Ther 320:1061-1067, 2007.
28. Enkhbaatar P, Murakami K, Shimoda K, Mizutani A, Traber L, Phillips G, Parkinson J, Salsbury JR, Biondo N, Schmalstieg F, et al.: Inducible nitric oxide synthase dimerization inhibitor prevents cardiovascular and renal morbidity in sheep with combined burn and smoke inhalation injury. Am J Physiol Heart Circ Physiol 285:H2430-H2436, 2003.
29. Legrand M, Almac E, Mik EG, Johannes T, Kandil A, Bezemer R, Payen D, Ince C: L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats. Am J Physiol Renal Physiol 296:F1109-F1117, 2009.
30. Johannes T, Mik EG, Klingel K, Goedhart PT, Zanke C, Nohé B, Dieterich HJ, Unertl KE, Ince C: Effects of 1400W and/or nitroglycerin on renal oxygen-ation and kidney function during endotoxaemia in anaesthetised rats. Clin Exp Pharmacol Physiol 36:870-879, 2009.
31. Westphal M, Maybauer DM, Maybauer MO: Who is the bad guy in acute respiratory distress syndrome? Neuronal nitric oxide synthase, inducible nitric oxide synthase, or both? Crit Care Med 37:363-364, 2009.
32. EnkhbaatarP, Murakami K, Shimoda K, Mizutani A, McGuire R, Schmalstieg F, Cox R, Hawkins H, Jodoin J, Lee S, et al.: Inhibition of neuronal nitric oxide synthase by 7-nitroindazole attenuates acute lung injury in an ovine model. Am J Physiol Regul Integr Comp Physiol 285:R366-R372, 2003.
33. Enkhbaatar P, Lange M, Nakano Y, Hamahata A, Jonkam C, Wang J, Jaroch S, Traber L, Herndon D, Traber D: Role of neuronal nitric oxide synthase in ovine sepsis model. Shock 32:253-257, 2009.
34. Ichinose F, Buys ES, Neilan TG, Furutani EM, Morgan JG, Jassal DS, Graveline AR, Searles RJ, Lim CC, Kaneki M, et al.: Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock. Circ Res 100:130-139, 2007.
35. Bougaki M, Searles RJ, Kida K, De Yu J, Buys ES, Ichinose F: NOS3 protects against systemic inflammation and myocardial dysfunction in murine polymicrobial sepsis. Shock 2009 Dec 7. [Epub ahead of print]