Norepinephrine and N(ω)-monomethyl-L-arginine in porcine septic shock: Effects on hepatic O2 exchange and energy balance

American Journal of Respiratory and Critical Care Medicine

Volumn 159, Issue 6, 1999, Pages 1758-1765

  Träger, Karl ^a,b   Radermacher, Peter ^a,b   Rieger, Karen M ^a,b   Vlatten, Arnim ^a,b   Vogt, Josef ^a,b   Iber, Thomas ^a,b   Adler, Jens ^a,b   Wachter, Ulrich ^a,b   Grover, Robert ^a,b   Georgieff, Michael ^a,b   Šantak, Borislav ^a,b  

^a UNIVERSITY OF ULM   (Germany)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; N(G) METHYLARGININE; NORADRENALIN; ENZYME INHIBITOR; GLUCOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ENERGY BALANCE; ENERGY METABOLISM; FLUID THERAPY; GLUCONEOGENESIS; HEART OUTPUT; INFUSION; LIVER BLOOD FLOW; MEAN ARTERIAL PRESSURE; NONHUMAN; OXYGEN SATURATION; OXYGEN TRANSPORT; PATHOGENESIS; PRIORITY JOURNAL; SEPTIC SHOCK; SYSTEMIC VASCULAR RESISTANCE; ANIMAL; BIOSYNTHESIS; BLOOD PRESSURE; COMPARATIVE STUDY; DRUG EFFECT; FEMALE; LIVER; LIVER CIRCULATION; MALE; METABOLISM; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; SWINE; VASCULAR RESISTANCE;

ANIMALS; BLOOD PRESSURE; ENDOTOXINS; ENERGY METABOLISM; ENZYME INHIBITORS; FEMALE; GLUCOSE; LIVER; LIVER CIRCULATION; MALE; NOREPINEPHRINE; OMEGA-N-METHYLARGININE; OXYGEN CONSUMPTION; SHOCK, SEPTIC; SWINE; VASCULAR RESISTANCE;

EID: 0032587255     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.159.6.9808040     Document Type: Article

References (35)

1. 1. Nussler, A. K., M. Di Silvio, T. R. Billiar, R. A. Hoffman, D. A. Geller, R. Selby, J. Madariaga, and R. L. Simmons. 1992. Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. J. Exp. Med. 176:261-264.
2. 2. Moncada, S., and A. Higgs. 1993. The L-arginine nitric oxide pathway. N. Engl. J. Med. 329:2002-2012.
3. 3. Gómez-Jiménez, J., A. Salgado, M. Mourelle, M. C. Martin, R. M. Segura, R. Peracaula, and S. Moncada. 1995. L-Arginine: nitric oxide pathway in endotoxemia and human septic shock. Crit. Care Med. 23:253-258.
4. 4. Fleming, I., G. Joulou-Schaeffer, and G. Gray. 1991. Evidence that an L-arginine/nitric oxide dependent elevation of tissue cyclic GMP content is involved in depression of vascular reactivity by endotoxin. Br. J. Pharmacol. 103:1047-1052.
5. 5. Petros, A., G. Lamb, A. Leone, S. Moncada, D. Bennett, and P. Vallance. 1994. Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc. Res. 28:34-39.
6. 6. Meyer, J., M. Booke, R. Waurick, T. Prien, and H. van Aken. 1996. Nitric oxide synthase inhibition restores vasopressor effects of norepinephrine in ovine hyperdynamic sepsis. Anesth. Analg. 83:1009-1013.
7. 7. Booke, M., F. Hinder, R. McGuire, L. D. Traber, and D. L. Traber. 1996. Nitric oxide synthase inhibition versus norepinephrine for the treatment of hyperdynamic sepsis in sheep. Crit. Care Med. 24:835-844.
8. 8. Booke, M., F. Hinder, R. McGuire, L. D. Traber, and D. L. Traber. 1996. Nitric oxide synthase inhibition versus norepinephrine in ovine sepsis: effects on regional blood flow. Shock 5:362-370.
9. 9. Offner, P. J., F. M. Robertson, and B. A. Pruitt. 1995. Effects of nitric oxide synthase inhibition on regional blood flow in a porcine model of endotoxic shock. J. Trauma 39:338-343.
10. 10. Gundersen, Y., T. Sætre, H. Carlsen, T. Scholz, P. Lilleaasen, and A. O. Aasen. 1997. Modulators of nitric oxide in porcine endotoxemia: effects on hepatic oxygen delivery and consumption. Eur. Surg. Res. 29:237-245.
11. 11. Henderson, J. L., R. Statman, J. N. Cunningham, W. Cheng, P. Damiani, A. Sinconolfy, and J. H. Horovitz. 1994. The effects of nitric oxide inhibition on regional hemodynamics during hyperdynamic endotoxemia. Arch. Surg. 129:1271-1275.
12. 12. Wright, C. E., D. D. Rees, and S. Moncada. 1992. Protective and pathological roles of nitric oxide in endotoxin shock. Cardiovasc. Res. 26:48-57.
13. 13. Kilbourn, R. G., C. Szabó, and D. L. Traber. 1997. Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: lessons learned from experimental and clinical studies. Shock 7:235-246.
14. 14. Harbrecht, B. G., T. R. Billiar, J. Stadler, A. J. Demetris, J. B. Ochoa, K. D. Curran, and R. L. Simmons. 1992. Nitric oxide synthesis serves to reduce hepatic damage during acute murine endotoxemia. Crit. Care Med. 20:1568-1574.
15. 15. Pastor, C. M., M. R. Losser, and D. Payen. 1995. Nitric oxide donor prevents hepatic and systemic perfusion decrase induced by endotoxin in anesthetized rabbits. Hepatology 22:1547-1553.
16. 2 extraction capabilities during endotoxic shock. J. Appl. Physiol. 83:1164-1173.
17. 17. Takala, J., K. Guntupalli, J. Donaldson, and D. Watson. 1997. Multicentre, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88 in patients with septic shock: effect on early non-cardiovascular organ function (abstract). Intensive Care Med. 23:S51.
18. 18. Šantak, B., P. Radermacher, J. Adler, T. Iber, K. M. Rieger, U. Wachter, J. Vogt, M. Georgieff, and K. Träger. 1998. Effect of increased cardiac output on liver blood flow, oxygen exchange and metabolic rate during longterm endotoxin-induced shock in pigs. Br. J. Pharmacol. 124:1689-1697.
19. 19. Temmesfeld-Wollbrück, B., A. Szalay, K, Mayer, H. Olschewski, W. Seeger, and F. Grimminger. 1998. Abnormalities of gastric mucosal oxygenation in septic shock - partial responsiveness to dopexamine. Am. J. Respir. Crit. Care Med. 157:1586-1592.
20. 20. Villamor, E., F. Pérez-Vizcaíno, T. Ruiz, J. C. Leza, M. Moro, and J. Tamargo. 1995. Group B streptococcus and E. coli LPS-induced NO-dependent hyporesponsiveness to noradrenaline in isolated intrapulmonary arteries of neonatal pigs. Br. J. Pharmacol. 115:261-266.
21. 3-infusion. Br. J. Pharmacol. 122:1605-1610.
22. 22. Fink, M. P., and S. O. Heard. 1990. Laboratory models of sepsis and septic shock. J. Surg. Res. 49:186-196.
23. 23. MacGregor, D. A., R. C. Prielipp, J. F. Butterworth, R. L. James, and R. L. Royster. 1996. Relative efficacy and potency of β-adrenoceplor agonists for generating cAMP in human lymphocytes. Chest 109:194-200.
24. 24. Kubes, P., and D. N. Granger. 1992. Nitric oxide modulates microvascular permeability. Am. J. Physiol. 262:H611-H615.
25. 25. Fink, M. 1997. Cytopathic hypoxia in sepsis. Acta Anaesthesiol. Scand. 110:87-95.
26. 26. Meier-Hellmann, A., M. Specht, L. Hannemann, H. Hassel, D. L. Bredle, and K. Reinhart. 1996. Splanchnic blood flow is greater in septic shock treated with norepinephrine than in severe sepsis. Intensive Care Med. 22:1354-1359.
27. 27. Reinelt, H., P, Radermacher, P. Kiefer, G. Fischer, U. Wachter, J. Vogt, and M. Georgieff. 1999. Impact of exogenous β-adrenoceptor stimulation on hepatosplanchnic oxygen kinetics and metabolic activity in septic shock. Crit. Care Med. 27:325-331.
28. 28. Horton, R. A., E, D. Ceppi, R. G. Knowles, and M. A. Titheradge. 1994. Inhibition of hepatic gluconeogenesis by nitric oxide: a comparison with endotoxin shock. Biochem. J. 299:735-739.
29. 29. Wolfe, R. R. 1982. Stable isotope approaches for study of energy substrate metabolism. Fed. Proc. 41:2692-2697.
30. 30. Dahn, M. S., R. A. Mitchell, M. P. Lange, S. Smith, and L. A. Jacobs. 1995. Hepatic metabolic response to injury and sepsis. Surgery 117:520-530.
31. 31. Reinelt, H., P. Radermacher, G. Fischer, W. Geisser, U. Wachter, H. Wiedeck, M. Georgieff, and J. Vogt. 1997. Effects of a dobutamine-induced increase in splanchnic blood flow on hepatic metabolic activity in patients with septic shock. Anesthesiology 86:818-824.
32. 32. Wilmore, D. W., C. W. Goodwin, L. H. Aulick, M. C. Powanda, A. D. Mason, and P. A. Pruitt. 1980. Effect of injury and infection on visceral metabolism and circulation. Ann. Surg. 192:491-500.
33. 33. Stumvoll, M., U. Chintalapudi, G. Periello, S. Welle, O. Gutierrez, and J. Gerich. 1995. Uptake and release of glucose by the human kidney: postabsorptive rates and responses to epinephrine. J. Clin. Invest. 96:2528-2533.
34. 34. Hotchkiss, R. S., and I. E. Karl. 1992. Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. J.A.M.A. 267:1503-1510.
35. 35. Mészáros, K., J. Bojta, A. P. Bautista, C. H. Lang, and J. J. Spitzer. 1991. Glucose utilization by Kupffer cells, endothelial cells, and granulocytes in endotoxemic rat liver. Am. J. Physiol. 260:G7-G12.