-
1
-
-
0025999111
-
Identification and characterization of two distinct kyotorphin- hydrolyzing enzymes in rat brain
-
Akasaki, K., Nakamura, A., Shiomi, H., Tsuji, H., 1991. Identification and characterization of two distinct kyotorphin-hydrolyzing enzymes in rat brain. Neuropeptides 20, 103-107.
-
(1991)
Neuropeptides
, vol.20
, pp. 103-107
-
-
Akasaki, K.1
Nakamura, A.2
Shiomi, H.3
Tsuji, H.4
-
2
-
-
23844467052
-
Characterization of rPEPT2-mediated Gly-Sar transport parameters in the rat kidney proximal tubule cell line SKPT-0193 cl.2 cultured in basic growth media
-
Bravo, S. A., Nielsen, C. U., Frokjaer, S., Brodin, B., 2005. Characterization of rPEPT2-mediated Gly-Sar transport parameters in the rat kidney proximal tubule cell line SKPT-0193 cl.2 cultured in basic growth media. Mol. Pharm. 2, 98-108.
-
(2005)
Mol. Pharm.
, vol.2
, pp. 98-108
-
-
Bravo, S.A.1
Nielsen, C.U.2
Frokjaer, S.3
Brodin, B.4
-
3
-
-
1242272750
-
The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology
-
Daniel, H., Kottra, G., 2004. The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Pflugers Arch. 447, 610-618.
-
(2004)
Pflugers Arch.
, vol.447
, pp. 610-618
-
-
Daniel, H.1
Kottra, G.2
-
4
-
-
0036193784
-
Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide
-
Fischer, H. S., Zernig, G., Hauser, K. F., Gerard, C., Hersh, L. B., Saria, A., 2002. Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide. J. Mol. Neurosci. 18, 129-134.
-
(2002)
J. Mol. Neurosci.
, vol.18
, pp. 129-134
-
-
Fischer, H.S.1
Zernig, G.2
Hauser, K.F.3
Gerard, C.4
Hersh, L.B.5
Saria, A.6
-
5
-
-
0347985817
-
Functional characterization of brain peptide transporter in rat cerebral cortex: Identification of the high-affinity type H+/peptide transporter PEPT2
-
Fujita, T., Kishida, T., Wada, M., Okada, N., Yamamoto, A., Leibach, F. H., Ganapathy, V., 2004. Functional characterization of brain peptide transporter in rat cerebral cortex: identification of the high-affinity type H+/peptide transporter PEPT2. Brain Res. 997, 52-61.
-
(2004)
Brain Res.
, vol.997
, pp. 52-61
-
-
Fujita, T.1
Kishida, T.2
Wada, M.3
Okada, N.4
Yamamoto, A.5
Leibach, F.H.6
Ganapathy, V.7
-
6
-
-
0001336717
-
Astrocytes in the primary culture
-
Pfeiffer, S. E. Ed., CRL Press, Boca Raton
-
Hertz, L., Juurilink, B. H. L., Fosmark, H., Schouboe, A., 1982. Astrocytes in the primary culture. In: Pfeiffer, S. E. (Ed.), Neuroscience Approached Through Cell Culture, Vol. 1. CRL Press, Boca Raton, pp. 175-186.
-
(1982)
Neuroscience Approached Through Cell. Culture
, vol.1
, pp. 175-186
-
-
Hertz, L.1
Juurilink, B.H.L.2
Fosmark, H.3
Schouboe, A.4
-
7
-
-
0027324899
-
Transport of bestatin in rat renal brush-border membrane vesicles
-
Hori, R., Tomita, Y., Katsura, T., Yasuhara, M., Inui, K., Takano, M., 1993. Transport of bestatin in rat renal brush-border membrane vesicles. Biochem. Pharmacol. 45, 1763-1768.
-
(1993)
Biochem. Pharmacol.
, vol.45
, pp. 1763-1768
-
-
Hori, R.1
Tomita, Y.2
Katsura, T.3
Yasuhara, M.4
Inui, K.5
Takano, M.6
-
8
-
-
0035941131
-
Functional and molecular characterization of a peptide transporter in the rat PC12 neuroendocrine cell line
-
Hussain, I., Zanic-Grubisic, T., Kudo, Y., Boyd, C. A., 2001. Functional and molecular characterization of a peptide transporter in the rat PC12 neuroendocrine cell line. FEBS Lett. 508, 350-354.
-
(2001)
FEBS Lett.
, vol.508
, pp. 350-354
-
-
Hussain, I.1
Zanic-Grubisic, T.2
Kudo, Y.3
Boyd, C.A.4
-
9
-
-
0026591754
-
H+coupled active transport of bestatin via the dipeptide transport system in rabbit intestinal brush-border membranes
-
Inui, K., Tomita, Y., Katsura, T., Okano, T., Takano, M., Hori, R., 1992. H+coupled active transport of bestatin via the dipeptide transport system in rabbit intestinal brush-border membranes. J. Pharmacol. Exp. Ther. 260, 482-486.
-
(1992)
J. Pharmacol. Exp. Ther.
, vol.260
, pp. 482-486
-
-
Inui, K.1
Tomita, Y.2
Katsura, T.3
Okano, T.4
Takano, M.5
Hori, R.6
-
10
-
-
65549083451
-
Enhanced antinociceptive response to intracerebroventricular kyotorphin in Pept2 null mice
-
Jiang, H., Hu, Y., Keep, R. F., Smith, D. E., 2009. Enhanced antinociceptive response to intracerebroventricular kyotorphin in Pept2 null mice. J. Neurochem. 109, 1536-1543.
-
(2009)
J. Neurochem.
, vol.109
, pp. 1536-1543
-
-
Jiang, H.1
Hu, Y.2
Keep, R.F.3
Smith, D.E.4
-
11
-
-
56149103172
-
Role and relevance of PEPT2 in drug disposition, dynamics, and toxicity
-
Kamal, M. A., Keep, R. F., Smith, D. E., 2008. Role and relevance of PEPT2 in drug disposition, dynamics, and toxicity. Drug Metab. Pharmacokinet. 23, 236-242.
-
(2008)
Drug Metab. Pharmacokinet.
, vol.23
, pp. 236-242
-
-
Kamal, M.A.1
Keep, R.F.2
Smith, D.E.3
-
12
-
-
0021123684
-
Hydrolytic deactivation of kyotorphin by the rodent brain homogenates and sera
-
Matsubayashi, K., Kojima, C., Kawajiri, S., Ono, K., Takegoshi, T., Ueda, H., Takagi, H., 1984. Hydrolytic deactivation of kyotorphin by the rodent brain homogenates and sera. J. Pharmacobiodyn. 7, 479-484.
-
(1984)
J. Pharmacobiodyn.
, vol.7
, pp. 479-484
-
-
Matsubayashi, K.1
Kojima, C.2
Kawajiri, S.3
Ono, K.4
Takegoshi, T.5
Ueda, H.6
Takagi, H.7
-
13
-
-
0022930828
-
Inactivation and metabolism of neuropeptides
-
McKelvy, J. F., Blumberg, S., 1986. Inactivation and metabolism of neuropeptides. Annu. Rev. Neurosci. 9, 415-434.
-
(1986)
Annu. Rev. Neurosci.
, vol.9
, pp. 415-434
-
-
McKelvy, J.F.1
Blumberg, S.2
-
14
-
-
0026718361
-
Dipeptidase activities in rat brain synaptosomes can be distinguished on the basis of inhibition by bestatin and amastatin: Identification of a kyotorphin (Tyr-Arg)-degrading enzyme
-
Orawski, A. T., Simmons, W. H., 1992. Dipeptidase activities in rat brain synaptosomes can be distinguished on the basis of inhibition by bestatin and amastatin: identification of a kyotorphin (Tyr-Arg)-degrading enzyme. Neurochem. Res. 17, 817-820.
-
(1992)
Neurochem. Res.
, vol.17
, pp. 817-820
-
-
Orawski, A.T.1
Simmons, W.H.2
-
15
-
-
0027475050
-
Neutral endopeptidase 24.11: Structure, inhibition, and experimental and clinical pharmacology
-
Roques, B. P., Noble, F., Dauge, V., Fournie-Zaluski, M. C., Beaumont, A., 1993. Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology. Pharmacol. Rev. 45, 87-146.
-
(1993)
Pharmacol. Rev.
, vol.45
, pp. 87-146
-
-
Roques, B.P.1
Noble, F.2
Dauge, V.3
Fournie-Zaluski, M.C.4
Beaumont, A.5
-
16
-
-
0030756672
-
Opioid-related changes in nociceptive threshold and in tissue levels of enkephalins after target disruption of the gene for neutral endopeptidase (EC 3.4.24.11) in mice
-
Saria, A., Hauser, K. F., Traurig, H. H., Turbek, C. S., Hersh, L., Gerard, C., 1997. Opioid-related changes in nociceptive threshold and in tissue levels of enkephalins after target disruption of the gene for neutral endopeptidase (EC 3.4.24.11) in mice. Neurosci. Lett. 234, 27-30.
-
(1997)
Neurosci. Lett.
, vol.234
, pp. 27-30
-
-
Saria, A.1
Hauser, K.F.2
Traurig, H.H.3
Turbek, C.S.4
Hersh, L.5
Gerard, C.6
-
17
-
-
0013068816
-
Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus
-
Shen, H., Smith, D. E., Keep, R. F., Xiang, J., Brosius 3rd, F. C., 2003. Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus. J. Biol. Chem. 278, 4786-4791.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 4786-4791
-
-
Shen, H.1
Smith, D.E.2
Keep, R.F.3
Xiang, J.4
Brosius III, F.C.5
-
18
-
-
4644239463
-
Immunolocalization of the proton-coupled oligopeptide transporter PEPT2 in developing rat brain
-
Shen, H., Smith, D. E., Keep, R. F., Brosius 3rd, F. C., 2004. Immunolocalization of the proton-coupled oligopeptide transporter PEPT2 in developing rat brain. Mol. Pharm. 1, 248-256.
-
(2004)
Mol. Pharm.
, vol.1
, pp. 248-256
-
-
Shen, H.1
Smith, D.E.2
Keep, R.F.3
Brosius III, F.C.4
-
19
-
-
27744552573
-
PEPT2 (Slc15a2)-mediated unidirectional transport of cefadroxil from cerebrospinal fluid into choroid plexus
-
Shen, H., Keep, R. F., Hu, Y., Smith, D. E., 2005. PEPT2 (Slc15a2)-mediated unidirectional transport of cefadroxil from cerebrospinal fluid into choroid plexus. J. Pharmacol. Exp. Ther. 315, 1101-1108.
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.315
, pp. 1101-1108
-
-
Shen, H.1
Keep, R.F.2
Hu, Y.3
Smith, D.E.4
-
20
-
-
34250738921
-
Impact of genetic knockout of PEPT2 on cefadroxil pharmacokinetics, renal tubular reabsorption, and brain penetration in mice
-
Shen, H., Ocheltree, S. M., Hu, Y., Keep, R. F., Smith, D. E., 2007. Impact of genetic knockout of PEPT2 on cefadroxil pharmacokinetics, renal tubular reabsorption, and brain penetration in mice. Drug Metab. Dispos. 35, 1209-1216.
-
(2007)
Drug Metab. Dispos
, vol.35
, pp. 1209-1216
-
-
Shen, H.1
Ocheltree, S.M.2
Hu, Y.3
Keep, R.F.4
Smith, D.E.5
-
21
-
-
1942452552
-
Peptide and peptide analog transport systems at the blood-CSF barrier
-
Smith, D. E., Johanson, C. E., Keep, R. F., 2004. Peptide and peptide analog transport systems at the blood-CSF barrier. Adv. Drug Deliv. Rev. 56, 1765-1791.
-
(2004)
Adv. Drug Deliv. Rev.
, vol.56
, pp. 1765-1791
-
-
Smith, D.E.1
Johanson, C.E.2
Keep, R.F.3
-
22
-
-
17644363389
-
Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability
-
Stamatovic, S. M., Shakui, P., Keep, R. F., Moore, B. B., Kunkel, S. L., Van Rooijen, N., Andjelkovic, A. V., 2005. Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability. J. Cereb. Blood Flow Metab. 25, 593-606.
-
(2005)
J. Cereb. Blood Flow Metab.
, vol.25
, pp. 593-606
-
-
Stamatovic, S.M.1
Shakui, P.2
Keep, R.F.3
Moore, B.B.4
Kunkel, S.L.5
Van Rooijen, N.6
Andjelkovic, A.V.7
-
23
-
-
0027320505
-
Dipeptidyl peptidase II in astrocytes of the rat brain. Meningeal cells increase enzymic activity in cultivated astrocytes
-
Struckhoff, G., 1993. Dipeptidyl peptidase II in astrocytes of the rat brain. Meningeal cells increase enzymic activity in cultivated astrocytes. Brain Res. 620, 49-57.
-
(1993)
Brain Res.
, vol.620
, pp. 49-57
-
-
Struckhoff, G.1
-
24
-
-
0018755730
-
Morphine-like analgesia by a new dipeptide, L-tyrosyl-L-arginine (Kyotorphin) and its analogue
-
Takagi, H., Shiomi, H., Ueda, H., Amano, H., 1979a. Morphine-like analgesia by a new dipeptide, L-tyrosyl-L-arginine (Kyotorphin) and its analogue. Eur. J. Pharmacol. 55, 109-111.
-
(1979)
Eur. J. Pharmacol.
, vol.55
, pp. 109-111
-
-
Takagi, H.1
Shiomi, H.2
Ueda, H.3
Amano, H.4
-
25
-
-
0018582692
-
A novel analgesic dipeptide from bovine brain is a possible Met-enkephalin releaser
-
Takagi, H., Shiomi, H., Ueda, H., Amano, H., 1979b. A novel analgesic dipeptide from bovine brain is a possible Met-enkephalin releaser. Nature 282, 410-412.
-
(1979)
Nature
, vol.282
, pp. 410-412
-
-
Takagi, H.1
Shiomi, H.2
Ueda, H.3
Amano, H.4
-
26
-
-
0034858814
-
PEPT2-mediated uptake of neuropeptides in rat choroid plexus
-
Teuscher, N. S., Keep, R. F., Smith, D. E., 2001. PEPT2-mediated uptake of neuropeptides in rat choroid plexus. Pharm. Res. 18, 807-813.
-
(2001)
Pharm. Res.
, vol.18
, pp. 807-813
-
-
Teuscher, N.S.1
Keep, R.F.2
Smith, D.E.3
-
27
-
-
56149085072
-
Stimulation of Na+/Cl-coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2
-
Thakkar, S. V., Miyauchi, S., Prasad, P. D., Ganapathy, V., 2008. Stimulation of Na+/Cl-coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2. Drug Metab. Pharmacokinet. 23, 254-262.
-
(2008)
Drug Metab. Pharmacokinet.
, vol.23
, pp. 254-262
-
-
Thakkar, S.V.1
Miyauchi, S.2
Prasad, P.D.3
Ganapathy, V.4
-
28
-
-
36348975209
-
Glutamate transporters: Confining runaway excitation by shaping synaptic transmission
-
Tzingounis, A. V., Wadiche, J. I., 2007. Glutamate transporters: confining runaway excitation by shaping synaptic transmission. Nat. Rev. Neurosci. 8, 935-947.
-
(2007)
Nat. Rev. Neurosci.
, vol.8
, pp. 935-947
-
-
Tzingounis, A.V.1
Wadiche, J.I.2
-
29
-
-
0018893084
-
Regional distribution of a novel analgesic dipeptide kyotorphin (Tyr-Arg) in the rat brain and spinal cord
-
Ueda, H., Shiomi, H., Takagi, H., 1980. Regional distribution of a novel analgesic dipeptide kyotorphin (Tyr-Arg) in the rat brain and spinal cord. Brain Res. 198, 460-464.
-
(1980)
Brain Res.
, vol.198
, pp. 460-464
-
-
Ueda, H.1
Shiomi, H.2
Takagi, H.3
-
30
-
-
0020077256
-
Analgesic dipeptide, kyotorphin (Tyr-Arg), is highly concentrated in the synaptosomal fraction of the rat brain
-
Ueda, H., Tatsumi, K., Shiomi, H., Takagi, H., 1982. Analgesic dipeptide, kyotorphin (Tyr-Arg), is highly concentrated in the synaptosomal fraction of the rat brain. Brain Res. 231, 222-224.
-
(1982)
Brain Res.
, vol.231
, pp. 222-224
-
-
Ueda, H.1
Tatsumi, K.2
Shiomi, H.3
Takagi, H.4
-
31
-
-
0021880607
-
Degradation of kyotorphin by a purified membrane-bound-aminopeptidase from monkey brain: Potentiation of kyotorphin-induced analgesia by a highly effective inhibitor, bestatin
-
Ueda, H., Ming, G., Hazato, T., Katayama, T., Takagi, H., 1985. Degradation of kyotorphin by a purified membrane-bound-aminopeptidase from monkey brain: potentiation of kyotorphin-induced analgesia by a highly effective inhibitor, bestatin. Life Sci. 36, 1865-1871.
-
(1985)
Life Sci.
, vol.36
, pp. 1865-1871
-
-
Ueda, H.1
Ming, G.2
Hazato, T.3
Katayama, T.4
Takagi, H.5
-
32
-
-
33644687617
-
Role of PEPT2 in glycylsarcosine transport in astrocyte and glioma cultures
-
Xiang, J., Chiang, P. P., Hu, Y., Smith, D. E., Keep, R. F., 2006a. Role of PEPT2 in glycylsarcosine transport in astrocyte and glioma cultures. Neurosci. Lett. 396, 225-229.
-
(2006)
Neurosci. Lett.
, vol.396
, pp. 225-229
-
-
Xiang, J.1
Chiang, P.P.2
Hu, Y.3
Smith, D.E.4
Keep, R.F.5
-
33
-
-
33750711999
-
PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes
-
Xiang, J., Hu, Y., Smith, D. E., Keep, R. F., 2006b. PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes. Brain Res. 1122, 18-23.
-
(2006)
Brain Res.
, vol.1122
, pp. 18-23
-
-
Xiang, J.1
Hu, Y.2
Smith, D.E.3
Keep, R.F.4
|