PEPT2 (Slc15a2)-mediated unidirectional transport of cefadroxil from cerebrospinal fluid into choroid plexus

Journal of Pharmacology and Experimental Therapeutics

Volumn 315, Issue 3, 2005, Pages 1101-1108

  Shen, Hong ^a   Keep, Richard F ^a   Hu, Yongjun ^a   Smith, David E ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CEFADROXIL; PEPTIDE DERIVATIVE; PEPTIDE TRANSPORTER 1; PEPTIDE TRANSPORTER 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; BLOOD CEREBROSPINAL FLUID BARRIER; CELL CULTURE; CEREBROSPINAL FLUID; CHOROID PLEXUS; CONTROLLED STUDY; DRUG TRANSPORT; EPITHELIUM CELL; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; WILD TYPE;

ANIMALS; ANIMALS, NEWBORN; ANTI-BACTERIAL AGENTS; BIOLOGICAL TRANSPORT, ACTIVE; CEFADROXIL; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CEREBROSPINAL FLUID; CHOROID PLEXUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC IMPEDANCE; EPITHELIAL CELLS; FEMALE; HYDROGEN-ION CONCENTRATION; MALE; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PREGNANCY; RATS; SYMPORTERS; TIME FACTORS;

EID: 27744552573     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.090654     Document Type: Article

References (36)

1. Berger UV and Hediger MA (1999) Distribution of peptide transporter PEPT2 mRNA in the rat nervous system. Anat Embryol 199:439-449.
2. +-dependent sugar transport in Caco-2 cells and human fetal colon. J Membr Biol 99:113-125.
3. Boll M, Herget M, Wagner M, Weber WM, Markovich D, Biber J, Clauss W, Murer H, and Daniel H (1996) Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter. Proc Natl Acad Sci USA 93:284-289.
4. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
5. Daniel H and Kottra G (2004) The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Pfluegers Arch Eur J Physiol 447:610-618.
6. Durand ML, Calderwood SB, Weber DJ, Miller SI, Southwick FS, Caviness VS Jr, and Swartz MN (1993) Acute bacterial meningitis in adults. A review of 493 episodes. N Engl J Med 328:21-28.
7. Ennis SR and Keep RF (2005) The effects of cerebral ischemia on the rat choroid plexus. J Cereb Blood Flow Metab, in press.
8. Fishman RA (1966) Blood-brain and CSF barriers to penicillin and related organic acids. Arch Neurol 15:113-124.
9. Hu Y, Ocheltree SM, H, Xiang J, Keep RF, and Smith DE (2005) Glycyl-L-glutamine disposition in rat choroid plexus epithelial cells in primary culture: role of PEPT2. Pharm Res 22:1281-1286.
10. Kottra G and Daniel H (2001) Bidirectional electrogenic transport of peptides by the proton-coupled carrier PEPT1 in Xenopus laevis oocytes: its asymmetry and symmetry. J Physiol (Lond) 536:495-503.
11. Kuroda M, Kusuhara H, Endou H, and Sugiyama Y (2005) Rapid elimination of cefaclor from the cerebrospinal fluid is mediated by a benzylpenicillin- sensitive mechanism distinct from organic anion transporter 3. J Pharmacol Exp Ther 314:855-861.
12. Kusuhara H and Sugiyama Y (2004) Efflux transport systems for organic anions and cations at the blood-CSF barrier. Adv Drug Deliv Rev 56:1741-1763.
13. Lutsar I and Friedland IR (2000) Pharmacokinetics and pharmacodynamics of cephalosporins in cerebrospinal fluid. Clin Pharmacokinet 39:335-343.
14. Nau R, Sorgel F, and Prange HW (1998) Pharmacokinetic optimisation of the treatment of bacterial central nervous system infections. Clin Pharmacokinet 35:223-246.
15. Norrby R (1978) A review of the penetration of antibiotics into CSF and its clinical significance. Scand J Infect Dis Suppl 14:296-309.
16. Novotny A, Xiang J, Stummer W, Teuscher NS, Smith DE, and Keep R (2000) Mechanisms of 5-aminolevulinic acid uptake at the choroid plexus. J Neurochem 75:321-328.
17. Ocheltree SM, Shen H, Hu Y, Xiang J, Keep RF, and Smith DE (2004a) Mechanisms of cefadroxil uptake in the choroid plexus: studies in wild-type and PEPT2 knockout mice. J Pharmacol Exp Ther 308:462-467.
18. Ocheltree SM, Shen H, Hu Y, Xiang J, Keep RF, and Smith DE (2004b) Role of PEPT2 in the choroid plexus uptake of glycylsarcosine and 5-aminolevulininc acid: studies in wild-type and null mice. Pharm Res 21:1680-1685.
19. Ogawa M, Suzuki H, Sawada Y, Hanano M, and Sugiyama Y (1994) Kinetics of active efflux via choroid plexus of beta-lactam antibiotics from the CSF into the circulation. Am J Physiol 266:R392-R399.
20. Petri WA Jr (2001) Antimicrobial agents (continued): penicillins, cephalosporins and other β-lactam antibiotics, in Goodman & Gilman's The Pharmacological Basis of Therapeutics (Hardman JG, Limbird LE, and Gilman AG eds) pp 1189-1218, McGraw-Hill Companies, New York.
21. +-coupled systems. J Pharmacol Exp Ther 271:1327-1333.
22. Rubio-Aliaga I, Frey I, Boll M, Groneberg D, Eichinger HM, Balling R, and Daniel H (2003) Targeted disruption of the peptide transporter Pept2 gene in mice defined its physiological role in the kidney. Mol Cell Biol 23:3247-3252.
23. Sakata K, Yamashita T, Maeda M, Moriyama Y, Shimada S, and Tohyama M (2001) Cloning of a lymphatic peptide/histidine transporter. Biochem J 356:53-60.
24. Shen H, Smith DE, Keep RF, and Brosius FC 3rd (2004) Immunolocalization of the proton-coupled oligopeptide transporter PEPT2 in developing rat brain. Mol Pharmacol 1:248-256.
25. Shen H, Smith DE, Keep RF, Xiang J, and Brosius FC 3rd (2003) Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus. J Biol Chem 278:4786-4791.
26. Shu C, Shen H, Teuscher NS, Lorenzi PJ, Keep RF, and Smith DE (2002) Role of PEPT2 in peptide/mimetic trafficking at the blood-cerebrospinal fluid barrier: studies in rat choroid plexus epithelial cells in primary culture. J Pharmacol Exp Ther 301:820-829.
27. Smith DE, Johanson CE, and Keep RF (2004) Peptide and peptide analog transport systems at the blood-CSF barrier. Adv Drug Deliv Rev 56:1765-1791.
28. Spector R and Lorenzo AV (1974) Inhibition of penicillin transport from the cerebrospinal fluid after intracisternal inoculation of bacteria. J Clin Investig 54:316-325.
29. Spector R (1986) Ceftriaxone pharmacokinetics in the central nervous system. J Pharmacol Exp Ther 236:380-383.
30. Sun H, Dai H, Shaik N, and Elmquist WF (2003) Drug efflux transporters in the CNS. Adv Drug Deliv Rev 55:83-105.
31. Suzuki H, Sawada Y, Sugiyama Y, Iga T, Hanano M, and Spector R (1989) Transport of imipenem, a novel carbapenem antibiotic, in the rat central nervous system. J Pharmacol Exp Ther 250:979-984.
32. Teuscher NS, Keep RF, and Smith DE (2001) PEPT2-mediated uptake of neuropeptides in rat choroid plexus. Pharm Res 18:807-813.
33. Teuscher NS, Novotny A, Keep RF, and Smith DE (2000) Functional evidence for presence of PEPT2 in rat choroid plexus: studies with glycylsarcosine. J Pharmacol Exp Ther 294:494-499.
34. Teuscher NS, Shu C, Xiang J, Keep RF, and Smith DE (2004) Carnosine uptake in rat choroid plexus primary cell cultures and choroid plexus whole tissue from PEPT2 null mice. J Neurochem 89:375-382.
35. +/peptide cotransporter PEPT2 using novel amino acid and dipeptide derivatives. Mol Pharmacol 61:214-221.
36. Yamashita T, Shimada S, Guo W, Sato K, Kohmura E, Hayakawa T, Takagi T, and Tohyama M (1997) Cloning and functional expression of a brain peptide/histidine transporter. J Biol Chem 272:10205-10211.