The peptides mimicking the third intracellular loop of 5-hydroxytryptamine receptors of the types 1B and 6 selectively activate G proteins and receptor-specifically inhibit serotonin signaling via the adenylyl cyclase system

International Journal of Peptide Research and Therapeutics

Volumn 16, Issue 2, 2010, Pages 95-105

  Shpakov, Alexander O ^a   Shpakova, Elena A ^b   Tarasenko, Irina I ^b   Derkach, Kira V ^a   Vlasov, Gennady P ^b  

^a SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

^b INSTITUTE OF MACROMOLECULAR COMPOUNDS   (Russian Federation)

Author keywords

5 hydroxytryptamine receptor; Adenylyl cyclase; Brain; G protein; Intracellular loop; Serotonin

Indexed keywords

ADENYLATE CYCLASE; CHOLERA TOXIN; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; SEROTONIN 1B RECEPTOR; SEROTONIN 6 RECEPTOR; SEROTONIN RECEPTOR; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; SYNTHETIC PEPTIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; MALE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SYNAPTIC MEMBRANE;

RATTUS;

EID: 77955919591     PISSN: 15733149     EISSN: 15733904     Source Type: Journal    
DOI: 10.1007/s10989-010-9208-x     Document Type: Article

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