Changes in fibroblast mechanostat set point and mechanosensitivity: An adaptive response to mechanical stress in floppy eyelid syndrome

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 8, 2010, Pages 3853-3863

  Ezra, Daniel G ^a,b   Ellis, James S ^a   Beaconsfield, Michèle ^b   Collin, Richard ^b   Bailly, Maryse ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MOORFIELDS EYE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN AND CALCIUM BINDING EPIDERMAL GROWTH FACTOR DOMAINS 1 PROTEIN; CYCLIN D1; CYCLIN D2; DIPEPTIDYL PEPTIDASE IV; EPIDERMAL GROWTH FACTOR CONTAINING FIBULIN LIKE EXTRACELLULAR MATRIX PROTEIN 1; GENE PRODUCT; GROWTH ARREST SPECIFIC PROTEIN 6; HISTONE H2BK; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER; MONOCARBOXYLATE TRANSPORTER 5; MOTOPSIN; PHOSPHOPROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT C; SCLEROPROTEIN; SMALL NUCLEOLAR RNA; SMALL NUCLEOLAR RNA 3A; THYMOCYTE SELECTION ASSOCIATED HIGH MOBILITY GROUP BOX PROTEIN; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VERSICAN; X RAY RADIATION RESISTANCE ASSOCIATED 1 PROTEIN; ACTIN; ALPHA SMA PROTEIN, HUMAN; ALPHA-SMA PROTEIN, HUMAN; CARRIER PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PPP1R3C PROTEIN, HUMAN;

ARTICLE; CCBE1 GENE; CCND1 GENE; CCND2 GENE; CONTROLLED STUDY; DPP4 GENE; EFEMP1 GENE; EYELID DISEASE; EYELID MUSCLE; EYELID RECONSTRUCTION; FIBROBLAST; FIBROBLAST CULTURE; FLOPPY EYELID SYNDROME; GENE; GENE EXPRESSION PROFILING; HIST1HBK GENE; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LL22NC03 GENE; MECHANICAL STRESS; MECHANOTRANSDUCTION; MICROARRAY ANALYSIS; MUSCLE CONTRACTILITY; MUSCLE RELAXATION; MUSCLE STRESS; MUSCLE STRETCHING; MUSCLE TONE; NUCLEOTIDE SEQUENCE; ORBICULARIS OCULI MUSCLE; PPP1R3C GENE; PRIORITY JOURNAL; PRSS12 GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SLC16A4 GENE; SNORD3A GENE; TOX GENE; UPREGULATION; VCAM1 GENE; VCAN GENE; XRRA1 GENE; ADAPTATION; CONFOCAL MICROSCOPY; DNA MICROARRAY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUSCLE CONTRACTION; MUSCLE HYPOTONIA; PATHOPHYSIOLOGY; PHYSIOLOGY; SYNDROME;

ACTINS; ADAPTATION, PHYSIOLOGICAL; CARRIER PROTEINS; EYELID DISEASES; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; HUMANS; MECHANOTRANSDUCTION, CELLULAR; MICROSCOPY, CONFOCAL; MUSCLE CONTRACTION; MUSCLE HYPOTONIA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHOPROTEIN PHOSPHATASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STRESS, MECHANICAL; SYNDROME; VASCULAR CELL ADHESION MOLECULE-1;

EID: 77955913439     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-4724     Document Type: Article

References (51)

1. Jones D. How do cells respond to the mechanical environment. In: Reglin G, ed. Wolff's Law and connective tissue regulation. Berlin Walterde Guyter. 1992:135-145.
2. Brown RA, Prajapati R, McGrouther DA, Yannas IV, Eastwood M. Tensional homeostasis in dermal fibroblasts: mechanical responses to mechanical loading in three-dimensional substrates. J Cell Physiol. 1998;175:323-332.
3. Wang N, Butler JP, Ingber DE. Mechanotransduction across the cell surface and through the cytoskeleton. Science. 1993;260:1124-1127.
4. Solon J, Levental I, Sengupta K, Georges PC, Janmey PA. Fibroblast adaptation and stiffness matching to soft elastic substrates. Biophys J. 2007;93:4453-4461.
5. Georges PC, Janmey PA. Cell type-specific response to growth on soft materials. J Appl Physiol. 2005;98:1547-1553.
6. Mizutani T, Haga H, Kawabata K. Cellular stiffness response to external deformation: tensional homeostasis in a single fibroblast. Cell Motil Cytoskeleton. 2004;59:242-248.
7. Frost HM. Bone. "mass" and the mechanostat: a proposal. Anat Rec. 1987;219:1-9.
8. Chicurel ME, Chen CS, Ingber DE. Cellular control lies in the balance of forces. Curr Opin Cell Biol. 1998;10:232-239.
9. Arnoczky SP, Lavagnino M, Egerbacher M, Caballero O, Gardner K, Shender MA. Loss of homeostatic strain alters mechanostat "set point" of tendon cells in vitro. Clin Orthop Relat Res. 2008;466: 1583-1591.
10. Donahue HJ. Gap junctional intercellular communication in bone: a cellular basis for the mechanostat set point. Calcif Tissue Int. 1998;62:85-88.
11. Ezra DG, Beaconsfield M, Collin JR. Surgical anatomy of the upper eyelid: old controversies, new concepts. Expert Rev Ophthalmol. 2009;4:47-57.
12. Culbertson WW, Ostler HB. The floppy eyelid syndrome. Am J Ophthalmol. 1981;92:568-575.
13. Schlotzer-Schrehardt U, Stojkovic M, Hofmann-Rummelt C, Cursiefen C, Kruse FE, Holbach LM. The pathogenesis of floppy eyelid syndrome: involvement of matrix metalloproteinases in elastic fiber degradation. Ophthalmology. 2005;112:694-704.
14. Goldberg R, Seiff S, McFarland J, Simons K, Shorr N. Floppy eyelid syndrome and blepharochalasis. Am J Ophthalmol. 1986;102: 376-381.
15. Culbertson WW, Tseng SC. Corneal disorders in floppy eyelid syndrome. Cornea. 1994;13:33-42.
16. Netland PA, Sugrue SP, Albert DM, Shore JW. Histopathologic features of the floppy eyelid syndrome: involvement of tarsal elastin. Ophthalmology. 1994;101:174-181.
17. Imbert P, Williamson W, Leger F, Gauthier L, Lagoutte F. Bilateral corneal neovascularization and floppy eyelid syndrome. A case report (in French). J Fr Ophtalmol. 1990;13:223-225.
18. Rossiter JD, Ellingham R, Hakin KN, Twomey JM. Corneal melt and perforation secondary to floppy eyelid syndrome in the presence of rheumatoid arthritis. Br J Ophthalmol. 2002;86:483.
19. Valenzuela AA, Sullivan TJ. Medial upper eyelid shortening to correct medial eyelid laxity in floppy eyelid syndrome: a new surgical approach. Ophthal Plast Reconstr Surg. 2005;21:259-263.
20. Ezra DG, Beaconsfield M, Sira M, et al. Long-term outcomes of surgical approaches to the treatment of floppy eyelid syndrome. Ophthalmology. 2010,117(4):839-846.
21. Ezra DG, Beaconsfield M, Sira M, Bunce C, Wormald R, Collin R. The Associations of floppy eyelid syndrome: a case control study. Ophthalmology. 2010;117(4):831-838.
22. Dahlmann-Noor AH, Martin-Martin B, Eastwood M, Khaw PT, Bailly M. Dynamic protrusive cell behaviour generates force and drives early matrix contraction by fibroblasts. Exp Cell Res. 2007;313: 4158-4169.
23. Eastwood M, McGrouther DA, Brown RA. A culture force monitor for measurement of contraction forces generated in human dermal fibroblast cultures: evidence for cell-matrix mechanical signalling. Biochim Biophys Acta. 1994;1201:186-192.
24. Eastwood M, Porter R, Khan U, McGrouther G, Brown R. Quantitative analysis of collagen gel contractile forces generated by dermal fibroblasts and the relationship to cell morphology. J Cell Physiol. 1996;166:33-42.
25. Bailly M, Macaluso F, Cammer M, Chan A, Segall JE, Condeelis JS. Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation. J Cell Biol. 1999;145:331-345.
26. Irizarry RA, Hobbs B, Collin F, et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003;4:249-264.
27. Torre V, Ashmore JF, Lamb TD, Menini A. Transduction and adaptation in sensory receptor cells. J Neurosci. 1995;15:7757-7768.
28. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 2002;3:349-363.
29. Barron V, Brougham C, Coghlan K, et al. The effect of physiological cyclic stretch on the cell morphology, cell orientation and protein expression of endothelial cells. J Mater Sci Mater Med. 2007;18:1973-1981.
30. Yamamoto F, Yamamoto M. Scanning copy number and gene expression on the 18q21-qter chromosomal region by the systematic multiplex PCR and reverse transcription-PCR methods. Electrophoresis. 2007;28:1882-1895.
31. Marmorstein LY, McLaughlin PJ, Peachey NS, Sasaki T, Marmorstein AD. Formation and progression of sub-retinal pigment epithelium deposits in Efemp1 mutation knock-in mice: a model for the early pathogenic course of macular degeneration. Hum Mol Genet. 2007;16:2423-2432.
32. Chong NH, Keonin J, Luthert PJ, et al. Decreased thickness and integrity of the macular elastic layer of Bruch's membrane correspond to the distribution of lesions associated with age-related macular degeneration. Am J Pathol. 2005;166:241-251.
33. Gschwend TP, Krueger SR, Kozlov SV, Wolfer DP, Sonderegger P. Neurotrypsin, a novel multidomain serine protease expressed in the nervous system. Mol Cell Neurosci. 1997;9:207-219.
34. Ingber DE. Cellular mechanotransduction: putting all the pieces together again. FASEB J. 2006;20:811-827.
35. McBeath R, Pirone DM, Nelson CM, Bhadriraju K, Chen CS. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell. 2004;6:483-495.
36. Vogel V, Sheetz M. Local force and geometry sensing regulate cell functions. Nat Rev Mol Cell Biol. 2006;7:265-275.
37. Crawford AC, Evans MG, Fettiplace R. Activation and adaptation of transducer currents in turtle hair cells. J Physiol. 1989;419:405-434.
38. Burkhardt DA. Light adaptation and photopigment bleaching in cone photoreceptors in situ in the retina of the turtle. J Neurosci. 1994;14:1091-1105.
39. Bisson MA, Mudera V, McGrouther DA, Grobbelaar AO. The contractile properties and responses to tensional loading of Dupuytren's disease-derived fibroblasts are altered: a cause of the contracture? Plast Reconstr Surg. 2004;113:611-621, discussion 622-614.
40. Cohen PT. Protein phosphatase 1: targeted in many directions. J Cell Sci. 2002;115:241-256.
41. Doherty MJ, Young PR, Cohen PT. Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phosphatase 1. FEBS Lett. 1996;399:339-343.
42. Printen JA, Brady MJ, Saltiel AR. PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism. Science. 1997;275:1475-1478.
43. Fong NM, Jensen TC, Shah AS, Parekh NN, Saltiel AR, Brady MJ. Identification of binding sites on protein targeting to glycogen for enzymes of glycogen metabolism. J Biol Chem. 2000;275:35034-35039.
44. Greenberg CC, Danos AM, Brady MJ. Central role for protein targeting to glycogen in the maintenance of cellular glycogen stores in 3T3-L1 adipocytes. Mol Cell Biol. 2006;26:334-342.
45. Ueki S, Kihara J, Kato H, et al. Soluble vascular cell adhesion molecule-1 induces human eosinophil migration. Allergy. 2009;64: 718-724.
46. Katsumi A, Orr AW, Tzima E, Schwartz MA. Integrins in mechanotransduction. J Biol Chem. 2004;279:12001-12004.
47. Ezra DG, Beaconsfield M, Collin R. Floppy eyelid syndrome: stretching the limits. Surv Ophthalmol. 2010;55:35-46.
48. Smith KE, Metzler SA, Warnock JN. Cyclic strain inhibits acute pro-inflammatory gene expression in aortic valve interstitial cells. Biomech Model Mechanobiol. 2010;9:117-125.
49. Blann A, Kumar P, Krupinski J, McCollum C, Beevers DG, Lip GY. Soluble intercellular adhesion molecule-1, E-selectin, vascular cell adhesion molecule-1 and von Willebrand factor in stroke. Blood Coagul Fibrinolysis. 1999;10:277-284.
50. Nicolaou P, Rodriguez P, Ren X, et al. Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury. Circ Res. 2009;104:1012-1020.
51. Mills I, Murata K, Packer CS, Sumpio BE. Cyclic strain stimulates dephosphorylation of the 20kDa regulatory myosin light chain in vascular smooth muscle cells. Biochem Biophys Res Commun. 1994;205:79-84.