Extrastriatal dopamine D2 receptor occupancy in olanzapine-treated patients with schizophrenia

European Archives of Psychiatry and Clinical Neuroscience

Volumn 260, Issue 4, 2010, Pages 345-350

  Arakawa, Ryosuke ^a,b   Ito, Hiroshi ^a   Okumura, Masaki ^a,b   Takano, Akihiro ^a   Takahashi, Hidehiko ^a   Takano, Harumasa ^a   Okubo, Yoshiro ^b   Suhara, Tetsuya ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Dopamine D2receptor occupancy; Extrastriatum; Olanzapine; Positron emission tomography; Schizophrenia

Indexed keywords

ANTIPARKINSON AGENT; BENZODIAZEPINE; DOPAMINE 2 RECEPTOR; OLANZAPINE; BENZODIAZEPINE DERIVATIVE; CARBON; DOPAMINE RECEPTOR BLOCKING AGENT; ISOREMOXIPRIDE; PYRROLIDINE DERIVATIVE; SALICYLAMIDE DERIVATIVE; SEROTONIN UPTAKE INHIBITOR;

ADULT; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CORPUS STRIATUM; FEMALE; HUMAN; MALE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; SCHIZOPHRENIA; TEMPORAL CORTEX; BLOOD; DOSE RESPONSE; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; METHODOLOGY; MIDDLE AGED; PROTEIN BINDING; PSYCHOLOGICAL RATING SCALE; SCINTISCANNING;

ADULT; BENZODIAZEPINES; CARBON ISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CORPUS STRIATUM; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; PSYCHIATRIC STATUS RATING SCALES; PYRROLIDINES; RECEPTORS, DOPAMINE D2; SALICYLAMIDES; SCHIZOPHRENIA; SEROTONIN UPTAKE INHIBITORS; YOUNG ADULT;

EID: 77955908534     PISSN: 09401334     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00406-009-0082-5     Document Type: Article

References (35)

1. 2 receptor occupancy in patients with schizophrenia. Psychopharmacology (Berl) 197:229-235
2. Asselin MC, Montgomery AJ, Grasby PM, Hume SP (2007) Quantification of PET studies with the very high-affinity dopamine D2/D3 receptor ligand [11C]FLB 457: re-evaluation of the validity of using a cerebellar reference region. J Cereb Blood Flow Metab 27:378-392
3. Bigliani V, Mulligan RS, Acton PD, Ohlsen RI, Pike VW, Ell PJ, Gacinovic S, Kerwin RW, Pilowsky LS (2000) Striatal and temporal cortical D2/D3 receptor occupancy by olanzapine and sertindole in vivo:a[123I]epidepride single photon emissiontomography (SPET) study. Psychopharmacology (Berl) 150:132-140
4. Bressan RA, Erlandsson K, Jones HM, Mulligan R, Flanagan RJ, Ell PJ, Pilowsky LS (2003) Is regionally selective D2/D3 dopamine occupancy sufficient for atypical antipsychotic effect? An in vivo quantitative [123I]epidepride SPET study of amisulpride treated patients. Am J Psychiatry 160:1413-1420
5. Bressan RA, Erlandsson K, Jones HM, Mulligan RS, Ell PJ, Pilowsky LS (2003) Optimizing limbic selective D2/D3 receptor occupancy by risperidone: a [123I]-epidepride SPET study. J Clin Psychopharmacol 23:5-14
6. Bymaster FP, Calligaro DO, Falcone JF, Marsh RD, Moore NA, Tye NC, Seeman P, Wong DT (1996) Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology 14:87-96
7. Duggan L, Fenton M, Rathbone J, Dardennes R, El-Dosoky A, Indran S (2005) Olanzapine for schizophrenia. Cochrane Database Syst Rev CD001359
8. Farde L, Nordstrom AL, Wiesel FA, Pauli S, Halldin C, Sedvall G (1992) Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine: relation to extrapyramidal side effects. Arch Gen Psychiatry 49:538-544
9. Grunder G, Landvogt C, Vernaleken I, Buchholz HG, Ondracek J, Siessmeier T, Hartter S, Schreckenberger M, Stoeter P, Hiemke C, Rosch F, Wong DF, Bartenstein P (2006) The striatal and extrastriatal D2/D3 receptor-binding profile of clozapine in patients with schizophrenia. Neuropsychopharmacology 31:1027-1035
10. 11C]FLB 457 binding to extrastriatal D2 dopamine receptors in the human brain. Neuroimage 13:531-539
11. Ito H, Arakawa R, Takahashi H, Takano H, Okumura M, Otsuka T, Ikoma Y, Shidahara M, Suhara T (2009) No regional difference in dopamine D2 receptor occupancy by the second-generation antipsychotic drug risperidone in humans: a positron emission tomography study. Int J Neuropsychopharmacol 12:667-675
12. Kaasinen V, Nagren K, Hietala J, Farde L, Rinne JO (2001) Sex differences in extrastriatal dopamine d2-like receptors in the human brain. Am J Psychiatry 158:308-311
13. Kapur S, Zipursky RB, Remington G, Jones C, Da Silva J, Wilson AA, Houle S (1998) 5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation. Am J Psychiatry 155:921-928
14. Kapur S, Zipursky R, Jones C, Remington G, Houle S (2000) Relationship between dopamine D2 occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia. Am J Psychiatry 157:514-520
15. Kessler RM, Whetsell WO, Ansari MS, Votaw JR, de Paulis T, Clanton JA, Schmidt DE, Mason NS, Manning RG (1993) Identification of extrastriatal dopamine D2 receptors in post mortem human brain with [125I]epidepride. Brain Res 609:237-243
16. Kessler RM, Ansari MS, Riccardi P, Li R, Jayathilake K, Dawant B, Meltzer HY (2005) Occupancy of striatal and extrastriatal dopamine D2/D3 receptors by olanzapine and haloperidol. Neuropsychopharmacology 30:2283-2289
17. Kessler RM, Ansari MS, Riccardi P, Li R, Jayathilake K, Dawant B, Meltzer HY (2006) Occupancy of striatal and extrastriatal dopamine D2 receptors by clozapine and quetiapine. Neuropsychopharmacology 31:1991-2001
18. Lammertsma AA, Hume SP (1996) Simplified reference tissue model for PET receptor studies. Neuroimage 4:153-158
19. Meisenzahl EM, Schmitt G, Grunder G, Dresel S, Frodl T, la Fougere C, Scheuerecker J, Schwarz M, Boerner R, Stauss J, Hahn K, Moller HJ (2008) Striatal D2/D3 receptor occupancy, clinical response and side effects with amisulpride: an iodine-123-iodobenzamide SPET study. Pharmacopsychiatry 41:169-175
20. Nordstrom AL, Farde L, Wiesel FA, Forslund K, Pauli S, Halldin C, Uppfeldt G (1993) Central D2-dopamine receptor occupancy in relation to antipsychotic drug effects: a double-blind PET study of schizophrenic patients. Biol Psychiatry 33:227-235
21. Olsson H, Farde L (2001) Potentials and pitfalls using high affinity radioligands in PET and SPET determinations on regional drug induced D2 receptor occupancy-a simulation study based on experimental data. Neuroimage 14:936-945
22. Olsson H, Halldin C, Farde L (2004) Differentiation of extrastriatal dopamine D2 receptor density and affinity in the human brain using PET. Neuroimage 22:794-803
23. Pilowsky LS, Mulligan RS, Acton PD, Ell PJ, Costa DC, Kerwin RW (1997) Limbic selectivity of clozapine. Lancet 350:490-491
24. Robertson GS, Fibiger HC (1996) Effects of olanzapine on regional C-Fos expression in rat forebrain. Neuropsychopharmacology 14:105-110
25. Schroder J, Silvestri S, Bubeck B, Karr M, Demisch S, Scherrer S, Geider FJ, Sauer H (1998) D2 dopamine receptor up-regulation, treatment response, neurological soft signs, and extrapyramidal side effects in schizophrenia: a follow-up study with 123I-iodobenzamide single photon emission computed tomography in the drug-naive state and after neuroleptic treatment. Biol Psychiatry 43:660-665
26. 123I]-epidepride single photon emission tomography (SPET) study. Br J Psychiatry 177:408-415
27. Stockton ME, Rasmussen K (1996) Electrophysiological effects of olanzapine, a novel atypical antipsychotic, on A9 and A10 dopamine neurons. Neuropsychopharmacology 14:97-105
28. Suhara T, Sudo Y, Okauchi T, Maeda J, Kawabe K, Suzuki K, Okubo Y, Nakashima Y, Ito H, Tanada S, Halldin C, Farde L (1999) Extrastriatal dopamine D2 receptor density and affinity in the human brain measured by 3D PET. Int J Neuropsychopharmcol 2:73-82
29. Suhara T, Okubo Y, Yasuno F, Sudo Y, Inoue M, Ichimiya T, Nakashima Y, Nakayama K, Tanada S, Suzuki K, Halldin C, Farde L (2002) Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia. Arch Gen Psychiatry 59:25-30 (Pubitemid 34044401)
30. Takano A, Suhara T, Ikoma Y, Yasuno F, Maeda J, Ichimiya T, Sudo Y, Inoue M, Okubo Y (2004) Estimation of the time-course of dopamine D2 receptor occupancy in living human brain from plasma pharmacokinetics of antipsychotics. Int J Neuropsychopharmacol 7:19-26
31. Takano A, Suhara T, Yasuno F, Suzuki K, Takahashi H, Morimoto T, Lee YJ, Kusuhara H, Sugiyama Y, Okubo Y (2006) The antipsychotic sultopride is overdosed-a PET study of druginduced receptor occupancy in comparison with sulpiride. Int J Neuropsychopharmacol 9:539-545
32. 11C]FLB 457. Am J Psychiatry 158:926-930
33. Talvik M, Nordstrom AL, Olsson H, Halldin C, Farde L (2003) Decreased thalamic D2/D3 receptor binding in drug-naive patients with schizophrenia: a PET study with [11C]FLB 457. Int J Neuropsychopharmacol 6:361-370
34. Xiberas X, Martinot JL, Mallet L, Artiges E, Loc HC, Maziere B, Paillere-Martinot ML (2001) Extrastriatal and striatal D2 dopamine receptor blockade with haloperidol or new antipsychotic drugs in patients with schizophrenia. Br J Psychiatry 179:503-508 (Pubitemid 34031674)
35. Yasuno F, Suhara T, Okubo Y, Sudo Y, Inoue M, Ichimiya T, Tanada S (2001) Dose relationship of limbic-cortical D2-dopamine receptor occupancy with risperidone. Psychopharmacology (Berl) 154:112-114