Estimation of the time-course of dopamine D2 receptor occupancy in living human brain from plasma pharmacokinetics of antipsychotics

International Journal of Neuropsychopharmacology

Volumn 7, Issue 1, 2004, Pages 19-26

  Takano, Akihiro ^a,b   Suhara, Tetsuya ^a,b   Ikoma, Yoko ^b,c   Yasuno, Fumihiko ^a,b   Maeda, Jun ^a,b   Ichimiya, Tetsuya ^a,b   Sudo, Yasuhiko ^a,b   Inoue, Makoto ^a,b   Okubo, Yoshiro ^d  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c WASEDA UNIVERSITY   (Japan)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Antipsychotics; Dopamine D2 receptor; Occupancy; Pharmacokinetics; Positron emission tomography

Indexed keywords

CARBON 11; DOPAMINE 2 RECEPTOR; ISOREMOXIPRIDE; NEUROLEPTIC AGENT; RISPERIDONE;

ADULT; ARTICLE; BRAIN; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG HALF LIFE; HUMAN; MALE; PLASMA; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; SCHIZOPHRENIA; SIMULATION;

ADULT; ALGORITHMS; ANTIPSYCHOTIC AGENTS; BRAIN; BRAIN CHEMISTRY; COMPUTER SIMULATION; DOPAMINE ANTAGONISTS; HALF-LIFE; HUMANS; MALE; MIDDLE AGED; PYRROLIDINES; RADIOLIGAND ASSAY; RADIOPHARMACEUTICALS; RECEPTORS, DOPAMINE D2; RISPERIDONE; SALICYLAMIDES; SCHIZOPHRENIA; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 1942475421     PISSN: 14611457     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1461145703003912     Document Type: Article

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