Effect of disruption of Akt-1 of lin-c-kit+ stem cells on myocardial performance in infarcted heart

Cardiovascular Research

Volumn 87, Issue 4, 2010, Pages 704-712

  Tseng, Andy ^a   Stabila, Joan ^a   McGonnigal, Beth ^a   Yano, Naohiro ^a   Yang, Mao Jing ^a   Tseng, Yi Tang ^a   Davol, Pamela A ^b   Lum, Lawrence G ^c,d   Padbury, James F ^a   Zhao, Ting C ^a,b  

^a BROWN UNIVERSITY   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d WAYNE STATE UNIVERSITY   (United States)

Author keywords

Akt 1; Heart; Mouse; Myocardial infarction; Stem cells

Indexed keywords

PROTEIN KINASE B; PROTEIN KINASE B ALPHA; STEM CELL FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN ANTIBODY;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CONTROLLED STUDY; FEMALE; GENE; GENETIC MARKER; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART PERFORMANCE; HEART VENTRICLE HYPERTROPHY; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; ISOLATED HEART; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SRY3 GENE; THORACOTOMY; WILD TYPE; Y CHROMOSOME;

ANIMALS; ANTIBODIES, BISPECIFIC; CARDIOMEGALY; CELL ADHESION; CELL LINEAGE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, SCID; MYOCARDIAL INFARCTION; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-KIT; RECOVERY OF FUNCTION; STEM CELL TRANSPLANTATION; STEM CELLS; TIME FACTORS; VASCULAR CELL ADHESION MOLECULE-1; VENTRICULAR FUNCTION, LEFT;

EID: 77955869523     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvq110     Document Type: Article

References (32)

1. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997;276:71-74.
2. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001;410:701-705.
3. Deb A, Wang S, Skelding KA, Miller D, Simper D, Caplice NM. Bone marrow-derived cardiomyocytes are present in adult human heart: a study of gender-mismatched bone marrow transplantation patients. Circulation 2003;107:1247-1249.
4. Lee RJ, Fang Q, Davol PA, Gu Y, Sievers RE, Grabert RC et al. Antibody targeting of stem cells to infarcted myocardium. Stem Cells 2007;25:712-717.
5. Bodine DM, Seidel NE, Gale MS, Nienhuis AW, Orlic D. Efficient retrovirus transduc-tion of mouse pluripotent hematopoietic stem cells mobilized into the peripheral blood by treatment with granulocyte colony-stimulating factor and stem cell factor. Blood 1994;84:1482-1491.
6. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964-967.
7. Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci USA 2001;98:10344-10349.
8. Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL, Robbins RC. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 2004;428:668-673.
9. Murry CE, Soonpaa MH, Reinecke H, Nakajima H, Nakajima HO, Rubart M et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 2004;428:664-668.
10. Schächinger V, Erbs S, Elsässer A, Haberbosch W, Hambrecht R, Hölschermann H et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 2006;355:1210-1221.
11. Assmus B, Honold J, Schächinger V, Britten MB, Fischer-Rasokat U, Lehmann R et al. Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 2006;355:1222-1232. (Pubitemid 44427446)
12. Lunde K, Solheim S, Aakhus S, Arnesen H, Abdelnoor M, Egeland T et al. Intracoron-ary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med 2006;355:1199-1209.
13. Rosenzweig A. Cardiac cell therapy-mixed results from mixed cells. N Engl J Med 2006;355:1274-1277.
14. + hematopoietic stem cells with anti-CD45 x anti-myosin light chain bispecific antibody preserves cardiac function in myocardial infarction. J Appl Physiol 2008;104: 1793-1800.
15. Tseng YT, Yano N, Rojan A, Stabila JP, McGonnigal BG, Ianus V et al. Ontogeny of phosphoinositide 3-kinase signaling in developing heart: effect of acute beta-adrenergic stimulation. Am J Physiol Heart Circ Physiol 2005;289:H1834-H1842.
16. Shiojima I, Yefremashvili M, Luo Z, Kureishi Y, Takahashi A, Tao J et al. Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem 2002;277:37670-37677.
17. Fujio Y, Nguyen T, Wencker D, Kitsis RN, Walsh K. Akt promotes survival of cardi-omyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 2000;101:660-667.
18. Matsui T, Tao J, del Monte F, Lee KH, Li L, Picard M et al. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation 2001;104:330-335.
19. Shiraishi I, Melendez J, Ahn Y, Skavdahl M, Murphy E, Welch S et al. Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ Res 2004;94: 884-891.
20. Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS et al. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 2003;9:1195-1201.
21. Wang Y, Ahmad N, Wani MA, Ashraf M. Hepatocyte growth factor prevents ventricular remodeling and dysfunction in mice via Akt pathway and angiogenesis. J Mol Cell Cardiol 2004;37:1041-1052.
22. Gnecchi M, He H, Liang OD, Melo LG, Morello F, Mu H et al. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med 2005;11:367-368.
23. Guo Y, Jones WK, Xuan YT, Tang XL, Bao W, Wu WJ et al. The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene. Proc Natl Acad Sci USA 1999;96:11507-11512.
24. Zhao TC, Kukreja RC. Protein kinase C-delta mediates adenosine A3 receptor-induced delayed cardioprotection in mouse. Am J Physiol Heart Circ Physiol 2003; 285:H434-H441.
25. + hematopoietic stem cells with bispecific antibodies to injured myocardium. Blood Cells Mol Dis 2004;32:82-87.
26. Freeman WM, Walker SJ, Vrana KE. Quantitative RT-PCR: pitfalls and potential. Biotechniques 1999;26:112-122.
27. Quaini F, Urbanek K, Beltrami AP, Finato N, Beltrami CA, Nadal-Ginard B et al. Chimerism of the transplanted heart. N Engl J Med 2002;346:5-15.
28. Haqq CM, King CY, Ukiyama E, Falsafi S, Haqq TN, Donahoe PK et al. Molecular basis of mammalian sexual determination: activation of Mullerian inhibiting substance gene expression by SRY. Science 1994;266:1494-1500.
29. Taylor PB, Cerny FJ. Evaluation of the isolated paced rat heart. J Appl Physiol 1976;41: 328-331.
30. Zhao TC, Kukreja RC. Rapid pacing-induced preconditioning in mouse heart: role of phosphatidylinositol 3 kinase-eNOs pathway. Circulation (Suppl.) 2002;106:II57.
31. Guo J, Lin GS, Bao CY, Hu ZM, Hu MY. Anti-inflammation role for mesenchymal stem cells transplantation in myocardial infarction. Inflammation 2007;30:97-104.
32. Hudlicka O, Brown M, Egginton S. Angiogenesis in skeletal and cardiac muscle. Physiol Rev 1992;72:369-417.