Normal physiological and pathophysiological effects of trypan blue on the retinas of albino rabbits

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 8, 2010, Pages 4187-4194

  Heilweil, Gad ^a   Komarowska, Izabela ^b   Zemel, Esther ^b   Loewenstein, Anat ^a,c   Perlman, Ido ^b  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM CHLORIDE; TRYPAN BLUE; COLORING AGENT;

A WAVE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B WAVE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRORETINOGRAPHY; EVOKED VISUAL RESPONSE; EYE TOXICITY; FOLLOW UP; HISTOPATHOLOGY; MICROSCOPY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RABBIT; RETINA; TIME; ANIMAL; DOSE RESPONSE; DRUG EFFECT; EPIRETINAL MEMBRANE; INJECTION; VITRECTOMY; VITREOUS BODY;

ANIMALS; COLORING AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRORETINOGRAPHY; EPIRETINAL MEMBRANE; EVOKED POTENTIALS, VISUAL; FOLLOW-UP STUDIES; INJECTIONS; RABBITS; RETINA; TIME FACTORS; TRYPAN BLUE; VITRECTOMY; VITREOUS BODY;

EID: 77955860726     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-4675     Document Type: Article

References (31)

1. Goldstein M, Zemel E, Loewenstein A, Perlman I. Retinal toxicity of indocyanine green in albino rabbits. Invest Ophthalmol Vis Sci. 2006;47:2100-2107.
2. Querques G, Prascina F, Iaculli C, Noci ND. Retinal toxicity of indocyanine green. Int Ophthalmol. 2008;28:115-118.
3. Tsuiki E, Fujikawa A, Miyamura N, Yamada K, Mishima K, Kitaoka T. Visual field defects after macular hole surgery with indocyanine green-assisted internal limiting membrane peeling. Am J Ophthalmol. 2007;143:704-705.
4. Feron EJ, Veckeneer M, Ginderdeuren RPV, et al. Trypan blue staining of epiretinal membrane in proliferative vitreoretinopathy. Arch Ophthalmol. 2002;120:141-144.
5. Li K, Wong D, Hiscott P et al. Trypan blue staining of internal limiting membrane and epiretinal membrane during vitrectomy: visual results and histopathological findings. Br J Ophthalmol. 2003;87:216-219.
6. Haritoglou C, Eibl K, Schaumberger M, et al. Functional outcome after trypan blue-assisted vitrectomy for macular pucker: a prospective, randomized, comparative trial. Am J Ophthalmol. 2004; 138:1-5.
7. Melles GR, de Waard PW, Pameyer JH, Houdijn Beekhuis W. Trypan blue capsule staining to visualize the capsulorrhexis in cataract surgery. J Cataract Refract Surg. 1999;25:7-9.
8. Jacob S, Agarwal A, Agarwal A, Agarwal S, Chowdhary R, Bagmar AA. Trypan blue as an adjunct for safe phacoemulsification in eyes with white cataract. J Cataract Refract Surg. 2002;28:1819-1825.
9. van Dooren BT, Beekhuis WH, Pels E. Biocompatibility of trypan blue with human corneal cells. Arch Ophthalmol. 2004;122:736-742.
10. Chang Y-S, Tseng S-Y, Tseng S-H, Chen Y-T, Hsiao J-H. Comparison of dyes for cataract surgery, 1: cytotoxicity to corneal endothelial cells in a rabbit model. J Cataract Refract Surg. 2005;31:792-798.
11. Haritoglou C, Gandorfer A, Schaumberger M et al. Trypan blue in macular pucker surgery: an evaluation of histology and functional outcome. Retina. 2004;24:582-590.
12. Gale JS, Proulx AA, Gonder JR, et al. Comparison of the in vitro toxicity of indocyanine green to that of trypan blue in human retinal pigment epithelium cell cultures. Am J Ophthalmol. 2004; 138:64-69.
13. Jackson TL, Hillenkamp J, Knight BC, et al. Safety testing of indocyanine green and trypan blue using retinal pigment epithelium and glial cell cultures. Invest Ophthalmol Vis Sci. 2004;45:2778-2785.
14. Kwok AKH, Yeung CK, Lai TYY, et al. Effects of trypan blue on cell viability and gene expression in human retinal pigment epithelial cells. Br J Ophthalmol. 2004;88:1590-1594.
15. Kodjukian L, Richter T, Halberstadt M, et al. Toxic effects of indocyanine green, infracyanine green, and trypan blue on the human retinal pigmented epithelium. Graefes Arch Clin Exp Ophthalmol. 2005;243:917-925.
16. Veckeneer M, Overdam K, Monzer J, et al. Ocular toxicity study of trypan blue injected into the vitreous cavity of rabbit eyes. Graefes Arch Clin Exp Ophthalmol. 2001;239:698-704.
17. Maia M, Penha F, Rodrigues EB, et al. Effects of subretinal injection of patent blue and trypan blue in rabbits. Curr Eye Res. 2007;32: 309-317.
18. Penha FM, Maia M, Farah ME, et al. Effects of subretinal injections of indocyanine green, trypan blue and glucose in rabbit eyes. Ophthalmology. 2007;114:899-908.
19. Loewenstein A, Zemel E, Lazar M, Perlman I. Drug-induced retinal toxicity in albino rabbits: the effects of imipenem and aztreonam. Invest Ophthalmol Vis Sci. 1993;34:3466-476.
20. Hood DC, Birch DG. A computational model of the amplitude and implicit time of the b-wave of the human ERG. Vis Neurosci. 1992;107-126.
21. Perlman I. Testing retinal toxicity of drugs in animal models using electrophysiological and morphological techniques. Doc Ophthalmol. 2009;118:3-28.
22. Perlman I. Relationship between the amplitude of the b wave and the a wave as a useful index for evaluating the electroretinogram. Br J Ophthalmol. 1983;67:443-448.
23. Ripps H, Witkovsky P. Neuron-glia interaction in the brain and retina. In: Osborne NV, Chandler GJ, eds. Progress in Retinal Research. New York: Pergamon Press; 1985:181-219.
24. Lei B, Perlman I. The contribution of voltage- and time-dependent potassium conductance to the electroretinogram in rabbits. Vis Neurosci. 1999;16:743-754.
25. Karwoski CJ, Xu X. Current source-density analysis of light-evoked field potentials in rabbit retina. Vis Neurosci. 1999;16:369-377.
26. Roseth S, Fykse EM, Fonnum F. Uptake of L-glutamate into synaptic vesicles: competitive inhibition by dyes with biphenyl and aminoand sulphonic acid-substituted naphthyl groups. Biochem Pharmacol. 1998;56:1243-1249.
27. Bellocchino EE, Reimer RJ, Fremeau RT Jr, Edwards RH. Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. Science. 2000;289:957-960.
28. Schäfer MK-H, Varoqui H, Defamie N, Weihe E, Erickson JD. Molecular cloning and functional identification of mouse vesicular glutamate transporter 3 and its expression in subsets of novel excitatory neurons. J Biol Chem. 2002;277:50734-50748.
29. Mackenzie B, Illing AC, Morris MEK, Varoqui H, Erickson JD. Analysis of a vesicular glutamate transporter (VGLUT2) supports a cell-leakage mode in addition to vesicular packaging. Neurochem Res. 2008;33:238-247.
30. Johnson J, Fremeau RT Jr, Duncan JL, et al. Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions. J Neurosci. 2007;27:7245-7255.
31. Vorwerk CK, Naskar R, Schuettauf F, et al. Depression of retinal glutamate transporter function leads to elevated intravitreal glutamate levels and ganglion cell death. Invest Ophthalmol Vis Sci. 2000;41:3615-3621.