Testing retinal toxicity of drugs in animal models using electrophysiological and morphological techniques

Documenta Ophthalmologica

Volumn 118, Issue 1, 2009, Pages 3-28

  Perlman, Ido ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Drug toxicity; Electroretinogram; Retina; Visual evoked potential

Indexed keywords

AZTREONAM; CILASTATIN PLUS IMIPENEM; GENTAMICIN; GLIAL FIBRILLARY ACIDIC PROTEIN; INDOCYANINE GREEN; LIDOCAINE; METHYLPREDNISOLONE ACETATE; TIENAM 500; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG;

ANESTHESIA MECHANISM; CONFERENCE PAPER; DOSE RESPONSE; DRUG CONTRAINDICATION; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG FORMULATION; DRUG INDUCED DISEASE; DRUG MEGADOSE; ELECTRORETINOGRAM; EVOKED VISUAL RESPONSE; EXPERIMENTAL DESIGN; EXPERIMENTAL RABBIT; EXPERIMENTAL RAT; EYE TOXICITY; HUMAN; IMMUNOREACTIVITY; LIGHT ABSORPTION; NONHUMAN; PHOTORECEPTOR; RETINAL TOXICITY; SYNAPTIC TRANSMISSION; TOXICITY TESTING;

ANIMALS; CONTROL GROUPS; DRUG EVALUATION; DRUG TOXICITY; ELECTRORETINOGRAPHY; EVOKED POTENTIALS, VISUAL; EYE DISEASES; HUMANS; IMMUNOHISTOCHEMISTRY; INJECTIONS; MACACA MULATTA; MODELS, ANIMAL; RABBITS; RATS; RETINA;

EID: 59049106323     PISSN: 00124486     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10633-008-9153-6     Document Type: Conference Paper

References (66)

1. Loewenstein A, Zemel E, Lazar M, Perlman I (1991) The effects of depo-medrol preservative (MGP) on the rabbit visual system. Invest Ophthalmol Vis Sci 32:3053-3060
2. Zemel E, Loewenstein A, Lazar M, Perlman I (1993) The effects of myristyl γ-picolinium chloride on the rabbit retina: Morphologic observations. Invest Ophthalmol Vis Sci 34:2360-2366
3. Lai TY, Ngai JW, Chan WM, Lam DS (2006) Visual field and multifocal electroretinography and their correlation in patients on hydroxychloroquine therapy. Doc Ophthalmol 112:177-187. doi: 10.1007/ s10633-006-9006-0
4. Tzekov R (2005) Ocular toxicity due to chloroquine and hydroxychloroquine: Electrophysiological and visual function correlates. Doc Ophthalmol 110:111-120. doi: 10.1007/s10633-005-7349-6
5. Ivanina TA, Zueva MV, Lebedeva MN, Bogoslovsky AI, Bunin AJ (1983) Ultrastructural alterations in rat and cat retina and pigment epithelium induced by chloroquine. Graefes Arch Clin Exp Ophthalmol 220:32-38. doi: 10.1007/BF02307013
6. Harding GF, Robertson K, Spencer EL, Holliday I (2002) Vigabatrin: Its effects on the electrophysiology of vision. Doc Ophthalmol 104:213-229. doi: 10.1023/A:1014643528474
7. Sankar R, Wasterlain CG (1999) Is the devil we know the lesser of two evils? Vigabatrin and visual fields. Neurology 52:1537-1538
8. Butler WH, Ford GP, Newberne JW (1987) A study on the effects of vigabatrin on the central nervous system and retina of Sprague Dawley and Lister-Hooded rats. Toxicol Pathol 15:143-148
9. Kjellström U, Kjelleström S, Bruum A, Andreasson S, Ponjavic V (2006) Retinal function in rabbits does not improve 4-5 months after terminating treatment with vigabatrin. Doc Ophthalmol 112:35-41. doi: 10.1007/s10633-006-0004-z
10. Tano Y, Chandler DB, Machemer R (1980) Treatment of intraocular proliferation with intravitreal injection of triamcinolone acetonide. Am J Ophthalmol 90:810-816
11. Martidis A, Duker JS, Greenberg PB, Rogers AH, Puliafito CA, Reichel E, Baumal C (2002) Intravitreal triamcinolone for refractory diabetic macular edema. Ophthalmology 109:920-927
12. Danis RP, Ciulla TA, Pratt LM, Anliker W (2000) Intravitreal triamcinolone acetonide in exudative age-related macular degeneration. Retina 20:244-250. doi: 10.1097/00006982-200005000-00003
13. Bashshur ZF, Haddad ZA, Schakal A, Jaafar RF, Saab M, Noureddin BN (2008) Intravitreal bevacizumab for treatment of neovascular age-related macular degeneration: A one-year prospective study. Am J Ophthalmol 145:249-256. doi: 10.1016/j.ajo.2007.09.031
14. Rosenfeld PJ, Moshfeghi AA, Puliafito CA (2005) Optical coherence tomography findings after an intravitreal injection of bevacizumab (avastin) for neovascular age-related macular degeneration. Ophthal Surg Laser Imaging 36:331-335
15. Armington JC (1974) The electroretinogram. Academic Press, New York
16. Berson EL (1981) Electrical phenomena in the retina. In: Moses RA (ed) Adler's physiology of the eye. Mosby, St. Louis, pp 466-529
17. Granit R (1933) The components of the retinal action potential in mammals and their relation to the discharge in the optic nerve. J Physiol 77:207-239
18. Ripps H, Witkovsky P (1985) Neuron-glia interaction in the brain and retina. In: Osborne NN, Chader GJ (eds) Prog. Retinal Res. Pergamon, Oxford, pp 181-219
19. Green DG, Kapousta-Bruneau NV (1999) A dissection of the electroretinogram from the isolated rat retina with microelectrodes and drugs. Vis Neurosci 16:727-741. doi: 10.1017/S0952523899164125
20. Lei B, Perlman I (1999) The contribution of voltage- and time-dependent potassium conductances to the electroretinogram in rabbits. Vis Neurosci 16:743-754. doi: 10.1017/S0952523899164137
21. Robson JG, Frishman LJ (1995) Response linearity and kinetics of the cat retina: The bipolar cell component of the dark-adapted electroretinogram. Vis Neurosci 12:837-850
22. Stockton A, Slaughter MM (1989) B-wave of the electroretinogram. A reflection of ON-bipolar cell activity. J Gen Physiol 93:101-122. doi: 10.1085/jgp.93.1.101
23. Heynen H, Wachtmeister L, van Norren D (1985) Origin of the oscillatory potentials in the primate retina. Vision Res 25:1365-1373. doi: 10.1016/ 0042-6989(85)90214-7
24. Speros P, Prise J (1981) Oscillatory potentials: History, techniques and potential use in the evaluation of disturbances of retinal circulation. Surv Ophthalmol 25:237-252. doi: 10.1016/0039-6257(81)90093-X
25. Wachtmeister L (1987) Basic research and clinical aspects of the oscillatory potentials of the electroretinogram. Doc Ophthalmol 66:187-194. doi: 10.1007/BF00145232
26. Sieving PA, Murayama K, Naarendorp F (1994) Push-pull model of the primate photopic electroretinogram: A role for hyperpolarizing neurons in shaping the b-wave. Vis Neurosci 11:519-532
27. Ueno S, Kondo M, Ueno M, Miyata K, Terasaki H, Miyake Y (2006) Contribution of retinal neurons to d-wave of primate photopic electroretinogram. Vision Res 46:658-664. doi: 10.1016/ j.visres.2005.05.026
28. Holder GE (2001) Pattern electroretinography (PERG) and an integrated approach to visual pathway diagnosis. In: Osborne NN, Chader GJ (eds) Prog. Retinal Eye Res. Elsevier, Amsterdam, pp 531-561
29. Ben-Shlomo G, Bakalash S, Lambrou GN, Latour E, Dawson WW, Schwartz M, Ofri R (2005) Pattern electroretinography in a rat model of ocular hypertension: Functional evidence for early detection of inner retinal damage. Exp Eye Res 81:340-349
30. Feghali JG, Jin J-C, Odom JV (1991) Effects of short-term intraocular pressure elevation on the rabbit electroretinogram. Invest Ophthalmol Vis Sci 32:2184-2189
31. Viswanathan S, Frishman LJ, Robson JG, Walters JW (2001) The photopic negative response of the flash electroretinogram in primary open angle glaucoma. Invest Ophthalmol Vis Sci 42:514-522
32. Viswanathan S, Frishman LJ, Robson JG, Harwerth RS, Smith ELIII (1999) The photopic negative response of the macaque electroretinogram: Reduction by experimental glaucoma. Invest Ophthalmol Vis Sci 40:1124-1136
33. Li B, Barnes GE, Holt WF (2005) The decline of the photopic negative response (PhNR) in the rat after optic nerve transection. Doc Ophthalmol 111:23-31. doi: 10.1007/s10633-005-2629-8
34. Mojumder DK, Sherry DM, Frishman LJ (2008) Contribution of voltage-gated sodium channels to the b-wave of the mammalian flash electroretinogram. J Physiol 586:2551-2580. doi: 10.1113/jphysiol.2008.150755
35. Fulton AB, Hansen RM (1988) Scotopic stimulus/response relations of the b-wave of the electroretinogram. Doc Ophthalmol 68:193-304. doi: 10.1007/ BF00156435
36. Fulton AB, Rushton WAH (1978) The human rod ERG: Correlationship with psychophysical responses in light and dark adaptation. Vision Res 18:793-800. doi: 10.1016/0042-6989(78)90119-0
37. Hood DC, Birch DG (1992) A computational model of the amplitude and implicit time of the b-wave of the human ERG. Vis Neurosci 8:107-126
38. Cone RA (1963) Quantum relations of the rat electroretinogram. J Gen Physiol 46:1267-1286. doi: 10.1085/jgp.46.6.1267
39. Perlman I (1983) Relationship between the amplitudes of the b wave and the a wave as a useful index for evaluating the electroretinogram. Br J Ophthalmol 67:443-448. doi: 10.1136/bjo.67.7.443
40. Loewenstein A, Zemel E, Lazar M, Perlman I (1993) Drug-induced retinal toxicity in albino rabbits: Effects of imipenem and aztreonam. Invest Ophthalmol Vis Sci 34:3466-3476
41. Bignami A, Dahl D (1979) The radial glia of Müller in the rat retina and their response to injury: An immunofluorescence study with antibodies to the glial fibrillary acidic (GFA) protein. Exp Eye Res 28:63-69. doi: 10.1016/0014-4835(79)90106-4
42. Li Q, Zemel E, Miller B, Perlman I (2002) Early retinal damage in experimental diabetes: Electroretinographical and morphological observations. Exp Eye Res 74:615-625. doi: 10.1006/exer.2002.1170
43. Miller NM, Oberdorfer M (1981) Neuronal and neuroglial responses following retinal lesions in the neonatal rat. J Comp Neurol 202:493-504. doi: 10.1002/cne.902020404
44. Penn JS, Thum KA, Rhem MN, Dell SJ (1988) Effects of oxygen rearing on the electroretinogram and GFA-protein in the rat. Invest Ophthalmol Vis Sci 29:1623-1630
45. Tassignon M-J, Stempels N, Nguyen-Legros J, De Wilde F, Brihaye M (1991) The effects of wavelength on glial fibrillary acidic protein immunoreactivity in laser-induced lesions in rabbit retina. Graefes Arch Clin Exp Ophthalmol 229:380-388. doi: 10.1007/BF00170698
46. Ekstrom P, Sanyal S, Narfstrom K, Chader GJ, van Veen T (1988) Accumulation of glial fibrillary acidic protein in Müller radial glia during retinal degeneration. Invest Ophthalmol Vis Sci 29:1363-1371
47. Knowles RG, Palacois M, Palmer RM, Moncada S (1989) Formation of nitric oxide from L-arginine in the central nervous system: A transduction mechanism for stimulation of soluble guanylate cyclase. Proc Natl Acad Sci USA 86:5159-5162. doi: 10.1073/pnas.86.13.5159
48. Oku H, Yamaguchi H, Sugiyama T, Kojima S, Ota M, Azuma I (1997) Retinal toxicity of nitric oxide released by administration of a nitric oxide donor in the albino rabbit. Invest Ophthalmol Vis Sci 38:2540-2544
49. Sennlaub F, Courtois Y, Goureay O (2002) Inducible nitric oxide synthase mediates retinal apoptosis in ischemic proliferative retinopathy. J Neurosci 22:3987-3993
50. Barza M, McCue M (1983) Pharmacokinetics of aztreonam in rabbit eyes. Antimicrob Agents Chemother 24:468-473
51. Bui BV, Sinclair AJ, Vingrys AJ (1998) Electroretinograms of albino and pigmented guinea-pigs (Cavia porcellus). Aust N Z J Ophthalmol 26:S98-S100. doi: 10.1111/j.1442-9071.1998.tb01388.x
52. Green DG, Herreros de Tejada P, Glover MJ (1991) Are albino rats night blind? Invest Ophthalmol Vis Sci 32:2366-2371
53. Zemel E, Loewenstein A, Lei B, Lazar M, Perlman I (1995) Ocular pigmentation protects the rabbit retina from gentamicin-induced toxicity. Invest Ophthalmol Vis Sci 36:1875-1884
54. Barza M, Baum J, Kane A (1976) Inhibition of antibiotic activity in vitro by synthetic melanin. Antimicrob Agents Chemother 10:569-570
55. Zemel E, Loewenstein A, Lazar M, Perlman I (1995) The effects of lidocaine and bupivacaine on the rabbit retina. Doc Ophthalmol 90:189-199. doi: 10.1007/BF01203338
56. Chin GN, Almquist HT (1983) Bupivacaine and lidocaine retrobulbar anesthesia. A double blind clinical study. Ophthalmology 90:369-372
57. Loewenstein A, Zemel E, Vered Y, Lazar M, Perlman I (2001) Retinal toxicity of gentamicin after subconjunctival injection performed adjacent to thinned sclera. Ophthalmology 108:759-764
58. Goldstein M, Zemel E, Loewenstein A, Perlman I (2006) Retinal toxicity of indocyanine green in albino rabbits. Invest Ophthalmol Vis Sci 47:2100-2107. doi: 10.1167/iovs.05-0206
59. Burk SE, Da Mata AP, Snyder ME, Rosa RHJ, Foster RE (2000) Indocyanine green-assisted peeling of the retinal internal limiting membrane. Ophthalmology 107:2010-2014
60. Eshita T, Ishida S, Shinoda K, Kitamura S, Inoue M, Oguchi Y, Yamazaki K (2002) Indocyanine green can distinguish posterior vitreous cortex from internal limiting membrane during vitrectomy with removal of epiretinal membrane. Retina 22:104-106. doi: 10.1097/00006982-200202000-00018
61. Kwok AK, Li WW, Pang CP, Lai TY, Yam GH, Chan NR, Lam DS (2001) Indocyanine green staining and removal of internal limiting membrane in macular hole surgery: Histology and outcome. Am J Ophthalmol 132:178-183. doi: 10.1016/S0002-9394(01)00976-X
62. Lang Y, Zemel E, Miller B, Perlman I (2007) Retinal toxicity of intravitreal Kenalog in albino rabbits. Retina 27:778-788. doi: 10.1097/ IAE.0b013e318030c517
63. Lang Y, Leibu R, Shoham N, Miller B, Perlman I (2007) Evaluation of intravitreal Kenalog toxicity in humans. Ophthalmology 114:724-731
64. Izumi Y, Ishikawa M, Benz AM, Izumi M, Zorumski CF, Thio LL (2004) Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA. Epilepsia 45:1043-1048. doi: 10.1111/j.0013-9580.2004.01004.x
65. Frishman LJ, Saszik S, Harwerth RS, Viswanathan S, Li Y, Smith EL III, Robson JG, Barnes G (2000) Effects of experimental glaucoma in macaques on the multifocal ERG. Multifocal ERG in laser-induced glaucoma. Doc Ophthalmol 100:231-251. doi: 10.1023/A:1002735804029
66. Seeliger MW, Narfström K, Reinhardt J, Zrenner E, Sutter E (2000) Continuous monitoring of the stimulated area in multifocal ERG. Doc Ophthalmol 100:167-184. doi: 10.1023/A:1002731703120