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Volumn 49, Issue 6, 2010, Pages 373-384

In vitro interactions between aged garlic extract and drugs used for the treatment of cardiovascular and diabetic patients

Author keywords

Aged garlic extract; Caco 2 cell monolayers; Drugs; Interactions; Intestinal transporters; Rat intestine

Indexed keywords

ATENOLOL; ATORVASTATIN; BREAST CANCER RESISTANCE PROTEIN; CIPROFLOXACIN; DIGOXIN; FUROSEMIDE; GARLIC EXTRACT; GLIBENCLAMIDE; GLIPIZIDE; GLYCOPROTEIN P; HYDROCHLOROTHIAZIDE; LOSARTAN; MONOCARBOXYLATE TRANSPORTER 1; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER; PEPTIDE TRANSPORTER 1; PRAVASTATIN; PRAZOSIN; RHODAMINE 123; ROSUVASTATIN; SILDENAFIL; VALACICLOVIR; VALSARTAN;

EID: 77955851957     PISSN: 14366207     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00394-010-0095-x     Document Type: Article
Times cited : (22)

References (46)
  • 1
    • 0035126826 scopus 로고    scopus 로고
    • Historical perspective on the use of garlic
    • 1:CAS:528:DC%2BD3MXhvVOitbs%3D
    • RS Rivlin 2001 Historical perspective on the use of garlic J Nutr 131 3S 951S 954S 1:CAS:528:DC%2BD3MXhvVOitbs%3D
    • (2001) J Nutr , vol.131 , Issue.S3
    • Rivlin, R.S.1
  • 2
    • 0030029823 scopus 로고    scopus 로고
    • Therapeutic actions of garlic constituents
    • DOI 10.1002/(SICI)1098-1128(199601)16:1<111::AID-MED4>3.0.CO;2-5
    • KC Agarwal 1996 Therapeutic actions of garlic constituents Med Res Rev 16 111 124 10.1002/(SICI)1098-1128(199601)16:1<111::AID-MED4>3.0.CO;2-5 1:CAS:528:DyaK28XhtFyls7o%3D (Pubitemid 26037077)
    • (1996) Medicinal Research Reviews , vol.16 , Issue.1 , pp. 111-124
    • Agarwal, K.C.1
  • 3
    • 0041522647 scopus 로고    scopus 로고
    • Extract of garlic (Allium Sativum) in cancer chemoprevention
    • 1:CAS:528:DC%2BD3sXntVSrtrg%3D
    • S Ejaz LC Woong A Ejaz 2003 Extract of garlic (Allium Sativum) in cancer chemoprevention Exp Oncol 25 93 97 1:CAS:528:DC%2BD3sXntVSrtrg%3D
    • (2003) Exp Oncol , vol.25 , pp. 93-97
    • Ejaz, S.1    Woong, L.C.2    Ejaz, A.3
  • 4
    • 0035120035 scopus 로고    scopus 로고
    • Cholesterol-lowering effect of garlic extracts and organosulfur compounds: Human and animal studies
    • 1:CAS:528:DC%2BD3MXhvVOiur0%3D
    • YY Yeh L Liu 2001 Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies J Nutr 131 3S 989S 993S 1:CAS:528:DC%2BD3MXhvVOiur0%3D
    • (2001) J Nutr , vol.131 , Issue.S3
    • Yeh, Y.Y.1    Liu, L.2
  • 5
    • 33644835000 scopus 로고    scopus 로고
    • Clarifying the real bioactive constituents of garlic
    • 1:CAS:528:DC%2BD28XitFCmtrw%3D
    • H Amagase 2006 Clarifying the real bioactive constituents of garlic J Nutr 136 716S 725S 1:CAS:528:DC%2BD28XitFCmtrw%3D
    • (2006) J Nutr , vol.136
    • Amagase, H.1
  • 6
    • 0034620261 scopus 로고    scopus 로고
    • Herb-drug interactions
    • 10.1016/S0140-6736(99)06457-0 1:CAS:528:DC%2BD3cXptleluw%3D%3D
    • A Fugh-Berman 2000 Herb-drug interactions Lancet 355 134 138 10.1016/S0140-6736(99)06457-0 1:CAS:528:DC%2BD3cXptleluw%3D%3D
    • (2000) Lancet , vol.355 , pp. 134-138
    • Fugh-Berman, A.1
  • 7
    • 17644380257 scopus 로고    scopus 로고
    • Predicting drug disposition via application of BCS: Transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system
    • DOI 10.1007/s11095-004-9004-4
    • CY Wu LZ Benet 2005 Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutical drug disposition classification system Pharm Res 22 11 23 10.1007/s11095-004-9004-4 1:CAS:528:DC%2BD2MXhtlCks70%3D (Pubitemid 40558141)
    • (2005) Pharmaceutical Research , vol.22 , Issue.1 , pp. 11-23
    • Wu, C.-Y.1    Benet, L.Z.2
  • 8
    • 0037332007 scopus 로고    scopus 로고
    • The effect of food components on the absorption of P-gp substrates: A review
    • DOI 10.1211/002235702603
    • S Deferme P Augustijns 2003 The effect of food components on the absorption of Pgp substrates: a review J Pharm Pharmacol 55 153 162 10.1211/002235702603 1:CAS:528:DC%2BD3sXisVOjs7c%3D (Pubitemid 36277751)
    • (2003) Journal of Pharmacy and Pharmacology , vol.55 , Issue.2 , pp. 153-162
    • Deferme, S.1    Augustijns, P.2
  • 13
    • 65249173973 scopus 로고    scopus 로고
    • Aged garlic extract stimulates P-glycoprotein and multidrug resistance associated protein 2 mediated effluxes
    • 10.1248/bpb.32.694 1:CAS:528:DC%2BD1MXmsVSksLc%3D
    • K Berginc D Uršič S Žakelj A Kristl 2009 Aged garlic extract stimulates P-glycoprotein and multidrug resistance associated protein 2 mediated effluxes Biol Pharm Bull 32 694 699 10.1248/bpb.32.694 1:CAS:528:DC%2BD1MXmsVSksLc%3D
    • (2009) Biol Pharm Bull , vol.32 , pp. 694-699
    • Berginc, K.1    Uršič, D.2    Žakelj, S.3    Kristl, A.4
  • 14
    • 0035126237 scopus 로고    scopus 로고
    • Determination of allicin, S-allylcysteine and volatile metabolites of garlic in breath, plasma or simulated gastric fluids
    • 1:CAS:528:DC%2BD3MXhvVOitbY%3D
    • RT Rosen RD Hiserodt EK Fukuda RJ Ruiz Z Zhou J Lech SL Rosen TG Hartman 2001 Determination of allicin, S-allylcysteine and volatile metabolites of garlic in breath, plasma or simulated gastric fluids J Nutr 131 3S 968S 971S 1:CAS:528:DC%2BD3MXhvVOitbY%3D
    • (2001) J Nutr , vol.131 , Issue.S3
    • Rosen, R.T.1    Hiserodt, R.D.2    Fukuda, E.K.3    Ruiz, R.J.4    Zhou, Z.5    Lech, J.6    Rosen, S.L.7    Hartman, T.G.8
  • 15
    • 0035119877 scopus 로고    scopus 로고
    • Intake of garlic and its bioactive components
    • 1:CAS:528:DC%2BD3MXhvVOitbg%3D
    • H Amagase BL Petesch H Matsuura S Kasuga 2001 Intake of garlic and its bioactive components J Nutr 131 S3 955S 962S 1:CAS:528:DC%2BD3MXhvVOitbg%3D
    • (2001) J Nutr , vol.131 , Issue.S3
    • Amagase, H.1    Petesch, B.L.2    Matsuura, H.3    Kasuga, S.4
  • 16
    • 0030782511 scopus 로고    scopus 로고
    • Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities
    • 10.1111/j.1432-1033.1997.00130.x 1:CAS:528:DyaK2sXnslGgt7o%3D
    • AB Shapiro V Ling 1997 Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities Eur J Biochem 250 130 137 10.1111/j.1432-1033.1997.00130.x 1:CAS:528:DyaK2sXnslGgt7o%3D
    • (1997) Eur J Biochem , vol.250 , pp. 130-137
    • Shapiro, A.B.1    Ling, V.2
  • 17
    • 0033328139 scopus 로고    scopus 로고
    • The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions
    • 10.1177/00912709922012006 1:CAS:528:DC%2BD3cXisVaktA%3D%3D
    • DK Yu 1999 The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions J Clin Pharmacol 39 1203 1211 10.1177/00912709922012006 1:CAS:528:DC%2BD3cXisVaktA%3D%3D
    • (1999) J Clin Pharmacol , vol.39 , pp. 1203-1211
    • Yu, D.K.1
  • 19
    • 9044245300 scopus 로고    scopus 로고
    • Inhibition of intestinal digoxin absorption and exsorption by quinidine
    • 1:CAS:528:DyaK28XhtFCrsrg%3D
    • SF Su JD Huang 1996 Inhibition of intestinal digoxin absorption and exsorption by quinidine Drug Metab Dispos 24 142 147 1:CAS:528: DyaK28XhtFCrsrg%3D
    • (1996) Drug Metab Dispos , vol.24 , pp. 142-147
    • Su, S.F.1    Huang, J.D.2
  • 20
    • 0034061961 scopus 로고    scopus 로고
    • Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and Caco-2 cell monolayers
    • 10.1038/sj.bjp.0703150 1:CAS:528:DC%2BD3cXit1egsL4%3D
    • A Soldner LZ Benet E Mutschler U Christians 2000 Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and Caco-2 cell monolayers Br J Pharmacol 129 1235 1243 10.1038/sj.bjp.0703150 1:CAS:528:DC%2BD3cXit1egsL4%3D
    • (2000) Br J Pharmacol , vol.129 , pp. 1235-1243
    • Soldner, A.1    Benet, L.Z.2    Mutschler, E.3    Christians, U.4
  • 21
    • 33745231761 scopus 로고    scopus 로고
    • Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptors in humans
    • 10.1124/dmd.105.008938 1:CAS:528:DC%2BD28XmsVKqsbw%3D
    • W Yamashiro K Maeda M Hirouchi Y Adachi Z Hu Y Sugiyama 2006 Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptors in humans Drug Metab Dispos 34 1247 1254 10.1124/dmd.105.008938 1:CAS:528:DC%2BD28XmsVKqsbw%3D
    • (2006) Drug Metab Dispos , vol.34 , pp. 1247-1254
    • Yamashiro, W.1    Maeda, K.2    Hirouchi, M.3    Adachi, Y.4    Hu, Z.5    Sugiyama, Y.6
  • 22
    • 0034072174 scopus 로고    scopus 로고
    • Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions
    • 1:CAS:528:DC%2BD3cXit1ehurk%3D
    • E Bakos R Evers E Sinko A Varadi P Borst B Sarkadi 2000 Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions Mol Pharmacol 57 760 768 1:CAS:528:DC%2BD3cXit1ehurk%3D
    • (2000) Mol Pharmacol , vol.57 , pp. 760-768
    • Bakos, E.1    Evers, R.2    Sinko, E.3    Varadi, A.4    Borst, P.5    Sarkadi, B.6
  • 23
    • 0034866642 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein
    • DOI 10.1023/A:1011036428972
    • E Wang CN Casciano RP Clement WW Johnson 2001 HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein Pharm Res 18 800 806 10.1023/A:1011036428972 1:CAS:528:DC%2BD3MXlt1Cqtbk%3D (Pubitemid 32783516)
    • (2001) Pharmaceutical Research , vol.18 , Issue.6 , pp. 800-806
    • Wang, E.-J.1    Casciano, C.N.2    Clement, R.P.3    Johnson, W.W.4
  • 24
    • 14644419054 scopus 로고    scopus 로고
    • Functional role of P-glycoprotein in limiting intestinal absorption of drugs: Contribution of passive permeability to P-glycoprotein mediated efflux transport
    • 10.1021/mp0499196
    • MVS Varma K Sateesh R Panchagnula 2004 Functional role of P-glycoprotein in limiting intestinal absorption of drugs: contribution of passive permeability to P-glycoprotein mediated efflux transport Mol Pharm 2 12 21 10.1021/mp0499196
    • (2004) Mol Pharm , vol.2 , pp. 12-21
    • Varma, M.V.S.1    Sateesh, K.2    Panchagnula, R.3
  • 26
    • 33645314628 scopus 로고    scopus 로고
    • Ciprofloxacin permeability and its active secretion through rat small intestine in vitro
    • 10.1016/j.ijpharm.2006.02.004
    • S Žakelj K Šturm A Kristl 2006 Ciprofloxacin permeability and its active secretion through rat small intestine in vitro Int J Pharm 313 175 180 10.1016/j.ijpharm.2006.02.004
    • (2006) Int J Pharm , vol.313 , pp. 175-180
    • Žakelj, S.1    Šturm, K.2    Kristl, A.3
  • 28
    • 46449138901 scopus 로고    scopus 로고
    • Closing the gaps: A full scan of the intestinal expression of P-glycoprotein, breast cancer resistance protein, and multidrug resistance-associated protein 2 in male and female rats
    • DOI 10.1124/dmd.108.020859
    • C Maclean U Moenning A Reichel G Fricker 2008 Closing the gaps-A full scan of the intestinal expression of Pgp, Bcrp and Mrp2 in male and female rats Drug Metab Dispos 36 1249 1254 10.1124/dmd.108.020859 1:CAS:528: DC%2BD1cXotVegurk%3D (Pubitemid 351929307)
    • (2008) Drug Metabolism and Disposition , vol.36 , Issue.7 , pp. 1249-1254
    • MacLean, C.1    Moenning, U.2    Reichel, A.3    Fricker, G.4
  • 32
    • 33846034416 scopus 로고    scopus 로고
    • Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans
    • DOI 10.1007/s11095-006-9159-2
    • KT Kivistö M Niemi 2007 Influence of drug transporter polimorphism on pravastatin pharmacokinetics in humans Pharm Res 24 239 247 10.1007/s11095-006-9159-2 (Pubitemid 46072183)
    • (2007) Pharmaceutical Research , vol.24 , Issue.2 , pp. 239-247
    • Kivisto, K.T.1    Niemi, M.2
  • 33
    • 85009583484 scopus 로고    scopus 로고
    • Intestinal absorption of drugs mediated by drug transporters: Mechanisms and regulation
    • 10.2133/dmpk.18.1 1:CAS:528:DC%2BD3sXks1yrsrs%3D
    • T Katsura KI Inui 2003 Intestinal absorption of drugs mediated by drug transporters: mechanisms and regulation Drug Metab Pharmacokinet 18 1 15 10.2133/dmpk.18.1 1:CAS:528:DC%2BD3sXks1yrsrs%3D
    • (2003) Drug Metab Pharmacokinet , vol.18 , pp. 1-15
    • Katsura, T.1    Inui, K.I.2
  • 34
    • 15244353232 scopus 로고    scopus 로고
    • Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells
    • DOI 10.1016/j.ejps.2005.01.001
    • X Sha G Yan Y Wu J Li X Fang 2005 Effect of self-emulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells Eur J Pharm Sci 24 477 486 10.1016/j.ejps.2005.01.001 1:CAS:528:DC%2BD2MXisFGksbc%3D (Pubitemid 40387261)
    • (2005) European Journal of Pharmaceutical Sciences , vol.24 , Issue.5 , pp. 477-486
    • Sha, X.1    Yan, G.2    Wu, Y.3    Li, J.4    Fang, X.5
  • 35
    • 33644843461 scopus 로고    scopus 로고
    • Garlic and cardiovascular disease: A critical review
    • 1:CAS:528:DC%2BD28XitFCmtrs%3D
    • K Rahman GM Lowe 2006 Garlic and cardiovascular disease: a critical review J Nutr 136 3 736S 740S 1:CAS:528:DC%2BD28XitFCmtrs%3D
    • (2006) J Nutr , vol.136 , Issue.3
    • Rahman, K.1    Lowe, G.M.2
  • 36
    • 0030979588 scopus 로고    scopus 로고
    • Absolute bioavailability and pharmacokinetics of valsartan, an angiotensin II receptor antagonist, in man
    • DOI 10.1007/s002280050259
    • G Flesch PL Muller 1997 Absolute bioavailability and pharmacokinetics of valsaratn, an angiotensin II receptor antagonist, in man Eur J Clin Pharmacol 52 115 120 10.1007/s002280050259 1:CAS:528:DyaK2sXjsVCgu7w%3D (Pubitemid 27239595)
    • (1997) European Journal of Clinical Pharmacology , vol.52 , Issue.2 , pp. 115-120
    • Flesch, G.1    Muller, Ph.2    Lloyd, P.3
  • 37
    • 0029588499 scopus 로고
    • Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3174 in humans
    • DOI 10.1016/0009-9236(95)90020-9
    • MW Lo MR Goldberg JB McCrea H Lu C Furtek TD Bjornsson 1995 Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3174 in humans Clin Pharmacol Ther 58 641 649 10.1016/0009-9236(95)90020-9 1:CAS:528:DyaK28XhtVOgs7g%3D (Pubitemid 26018849)
    • (1995) Clinical Pharmacology and Therapeutics , vol.58 , Issue.6 , pp. 641-649
    • Lo, M.-W.1    Goldberg, M.R.2    McCrea, J.B.3    Lu, H.4    Furtek, C.I.5    Bjornsson, T.D.6
  • 38
    • 27144483358 scopus 로고    scopus 로고
    • Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists
    • DOI 10.1093/carcin/bgi139
    • B Ebert A Seidel A Lampen 2005 Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists Carcinogenesis 26 1754 1763 10.1093/carcin/bgi139 1:CAS:528:DC%2BD2MXhtVWnt7fN (Pubitemid 41487991)
    • (2005) Carcinogenesis , vol.26 , Issue.10 , pp. 1754-1763
    • Ebert, B.1    Seidel, A.2    Lampen, A.3
  • 39
    • 1242335471 scopus 로고    scopus 로고
    • The MRP-related and BCRP/ABCG2 multidrug resistance proteins: Biology, substrate specificity and regulation
    • DOI 10.2174/1389200043489199
    • A Heimeur G Conseil RG Deeley SPC Cole 2004 The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation Current drug metabolism 5 21 53 10.2174/1389200043489199 (Pubitemid 38294344)
    • (2004) Current Drug Metabolism , vol.5 , Issue.1 , pp. 21-53
    • Haimeur, A.1    Conseil, G.2    Deeley, R.G.3    Cole, S.P.C.4
  • 40
    • 33645829284 scopus 로고    scopus 로고
    • ATP-dependent transport of rosuvastatin in membrane vesicles expressing breast cancer resistance protein
    • 10.1124/dmd.105.007534 1:CAS:528:DC%2BD28Xks1Sks7c%3D
    • L Huang Y Wang S Grimm 2006 ATP-dependent transport of rosuvastatin in membrane vesicles expressing breast cancer resistance protein Drug Metab Dispos 34 738 743 10.1124/dmd.105.007534 1:CAS:528:DC%2BD28Xks1Sks7c%3D
    • (2006) Drug Metab Dispos , vol.34 , pp. 738-743
    • Huang, L.1    Wang, Y.2    Grimm, S.3
  • 42
    • 0346728708 scopus 로고    scopus 로고
    • Intestinal membrane transport of drugs and nutrients: Genomics of membrane transporters using expression microarrays
    • DOI 10.1016/S0928-0987(03)00169-6
    • P Anderle Y Huang W Sadee 2004 Intestinal membrane transport of drugs and nutrients: genomics of membrane transporters using expression microarrays Eur J Pharm Sci 21 17 24 10.1016/S0928-0987(03)00169-6 1:CAS:528:DC%2BD2cXovFSl (Pubitemid 38050201)
    • (2004) European Journal of Pharmaceutical Sciences , vol.21 , Issue.1 , pp. 17-24
    • Anderle, P.1    Huang, Y.2    Sadee, W.3
  • 44
    • 33746454653 scopus 로고    scopus 로고
    • Pharmacokinetics of sildenafil after intravenous and oral administration in rats: Hepatic and intestinal first-pass effects
    • DOI 10.1016/j.ijpharm.2006.04.005, PII S0378517306003280
    • HS Shin SK Bae MG Lee 2006 Pharmacokinetics of sildenafil after intravenous and oral administration of rats: hepatic and intestinal first-pass effects Int J Pharm 320 64 70 10.1016/j.ijpharm.2006.04.005 1:CAS:528: DC%2BD28XnsFCquro%3D (Pubitemid 44128707)
    • (2006) International Journal of Pharmaceutics , vol.320 , Issue.1-2 , pp. 64-70
    • Shin, H.S.1    Bae, S.K.2    Lee, M.G.3
  • 45
    • 1242340302 scopus 로고    scopus 로고
    • The SLC16 gene family - From monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond
    • DOI 10.1007/s00424-003-1067-2, The ABCs of Solute Carriers: Physiological, Pathological and Therapeutic Implications of Human Membrane Transport Proteins
    • AP Halestrap D Meredith 2004 The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond Pflugers Arch 447 5 619 628 10.1007/s00424-003-1067-2 1:CAS:528:DC%2BD2cXhtVygsL4%3D (Pubitemid 38241446)
    • (2004) Pflugers Archiv European Journal of Physiology , vol.447 , Issue.5 , pp. 619-628
    • Halestrap, A.P.1    Meredith, D.2


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