Pharmacokinetics of sildenafil after intravenous and oral administration in rats: Hepatic and intestinal first-pass effects

International Journal of Pharmaceutics

Volumn 320, Issue 1-2, 2006, Pages 64-70

  Shin, Hyun S ^a   Bae, Soo K ^a   Lee, Myung G ^a  

^a Seoul National University   (South Korea)

Author keywords

Hepatic and intestinal first pass effects; Pharmacokinetics; Rats; Sildenafil

Indexed keywords

SILDENAFIL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG METABOLISM; FIRST PASS EFFECT; INTESTINE MUCOSA PERMEABILITY; LIVER METABOLISM; MALE; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; DOSE-RESPONSE RELATIONSHIP, DRUG; INFUSIONS, INTRAVENOUS; INTESTINES; INTUBATION, GASTROINTESTINAL; LIVER; MALE; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PURINES; RATS; RATS, SPRAGUE-DAWLEY; SULFONES;

EID: 33746454653     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.04.005     Document Type: Article

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