Folic acid consumption reduces resistin level and restores blunted acetylcholine-induced aortic relaxation in obese/diabetic mice

Journal of Nutritional Biochemistry

Volumn 21, Issue 9, 2010, Pages 872-880

  Seto, Sai Wang ^a   Lam, Tsz Yan ^a   Or, Penelope Mei Yu ^a   Lee, Wayne Yuk Wai ^a   Au, Alice Lai Shan ^a   Poon, Christina Chui Wa ^a   Li, Rachel Wai Sum ^b   Chan, Shun Wan ^c   Yeung, John Hok Keung ^a   Leung, George Pak Heng ^b   Lee, Simon Ming Yuen ^d   Ngai, Sai Ming ^e   Kwan, Yiu Wa ^a,e  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^d University of Macau   (Macao)

^e CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Acetylcholine; ENOS; Folic acid; PTEN; Relaxation

Indexed keywords

ACETYLCHOLINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FOLIC ACID; GELDANAMYCIN; GLUTATHIONE; GLUTATHIONE DISULFIDE; HEAT SHOCK PROTEIN 90; N NITRO L ARGININE METHYL ESTER, 2 (4 MORPHOLINYL) 8 PHENYL 1 BENZOPYRAN 4 ONE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PROTEIN KINASE B; RESISTIN; TRICIRIBINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; DRUG SENSITIVITY; FEMALE; MOUSE; NONHUMAN; OBESITY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; VASODILATATION; VITAMIN SUPPLEMENTATION;

MUS;

EID: 77955847141     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2009.06.015     Document Type: Article

References (46)

1. Varughese G.I., Tomson J., Lip G.Y. Type 2 diabetes mellitus: a cardiovascular perspective. Int J Clin Pract 2005, 59:798-816.
2. Lam T.Y., Seto S.W., Lau Y.M., Au L.S., Kwan Y.W., Ngai S.M. Impairment of the vascular relaxation and differential expression of caveolin-1 of the aorta of diabetic +db/+db mice. Eur J Pharmacol 2006, 546:134-141.
3. Miyata N., Tsuchida K., Tanaka M., Otomo S. Impairment of endothelium-dependent relaxation and changes in levels of cyclic GMP in carotid arteries from stroke-prone spontaneously hypertensive rats. J Pharm Pharmacol 1990, 42:763-766.
4. Chambers J.C., Ueland P.M., Obeid O.A., Wrigley J., Refsum H., Kooner J.S. Improved vascular endothelial function after oral B vitamins: an effect mediated through reduced concentrations of free plasma homocysteine. Circulation 2000, 102:2479-2483.
5. Woo K.S., Chook P., Lolin Y.I., Sanderson J.E., Metreweli C., Celermajer D.S. Folic acid improves arterial endothelial function in adults with hyperhomocystinemia. J Am Coll Cardiol 1999, 34:2002-2006.
6. Usui M., Matsuoka H., Miyazaki H., Ueda S., Okuda S., Imaizumi T. Endothelial dysfunction by acute hyperhomocyst(e)inaemia: restoration by folic acid. Clin Sci 1999, 96:235-239.
7. Mangoni A.A., Sherwood R.A., Asonganyi B., Ouldred E.L., Thomas S., Jackson S.H. Folic acid: a marker of endothelial function in type 2 diabetes?. Vasc Health Risk Manag 2005, 1:79-83.
8. Title L.M., Ur E., Giddens K., McQueen M.J., Nassar B.A. Folic acid improves endothelial dysfunction in type 2 diabetes - an effect independent of homocysteine-lowering. Vasc Med 2006, 11:101-109.
9. Doshi S.N., McDowell I.F., Moat S.J., Lang D., Newcombe R.G., Kredan M.B., et al. Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?. Arterioscler Thromb Vasc Biol 2001, 21:1196-1202.
10. Clark Z.L., Moat S.J., Miller A.L., Randall M.D., Lewis M.J., Lang D. Differential effects of low and high dose folic acid on endothelial dysfunction in a murine model of mild hyperhomocysteinaemia. Eur J Pharmacol 2006, 551:92-97.
11. Antoniades C., Shirodaria C., Warrick N., Cai S., de Bono J., Lee J. 5-Methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. Circulation 2006, 114:1193-1201.
12. Moat S.J., Madhavan A., Taylor S.Y., Payne N., Allen R.H., Stabler S.P., et al. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 2006, 36:850-859.
13. Holcomb I.N., Kabakoff R.C., Chan B., Baker T.W., Gurney A., Henzel W. FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J 2000, 19:4046-4055.
14. Kim K.H., Lee K., Moon Y.S., Sul H.S. A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J Biol Chem 2001, 276:11252-11256.
15. Steppan C.M., Lazar M.A. Resistin and obesity-associated insulin resistance. Trends Endocrinol Metab 2002, 13:18-23.
16. Rajala M.W., Qi Y., Patel H.R., Takahashi N., Banerjee R., Pajvani U.B., et al. Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting. Diabetes 2004, 53:1671-1679.
17. Asensio C., Cettour-Rose P., Theander-Carrillo C., Rohner-Jeanrenaud F., Muzzin P. Changes in glycemia by leptin administration or high-fat feeding in rodent models of obesity/type 2 diabetes suggest a link between resistin expression and control of glucose homeostasis. Endocrinology 2004, 145:2206-2213.
18. Fujita H., Fujishima H., Morii T., Koshimura J., Narita T., Kakei M., et al. Effect of metformin on adipose tissue resistin expression in db/db mice. Biochem Biophys Res Commun 2002, 298:345-349.
19. Maebuchi M., Machidori M., Urade R., Ogawa T., Moriyama T. Low resistin levels in adipose tissues and serum in high-fat fed mice and genetically obese mice: development of an ELISA system for quantification of resistin. Arch Biochem Biophys 2003, 416:164-170.
20. Way J.M., Görgün C.Z., Tong Q., Uysal K.T., Brown K.K., Harrington W.W., et al. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor γ agonists. J Biol Chem 2001, 276:25651-25653.
21. Gokce N., Vita J.A., McDonnell M., Forse A.R., Istfan N., Stoeckl M., et al. Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients. Am J Cardiol 2005, 95:266-268.
22. Dick G.M., Katz P.S., Farias M., Morris M., James J., Knudson J.D., et al. Resistin impairs endothelium-dependent dilation to bradykinin, but not acetylcholine, in the coronary circulation. Am J Physiol 2006, 291:2997-3002.
23. Bo S., Ciccone G., Durazzo M., Gambino R., Massarenti P., Baldi I. Efficacy of antioxidant treatment in reducing resistin serum levels: a randomized study. PLoS Clin Trials 2007, 2:17.
24. Nakano E., Higgins J.A., Powers H.J. Folate protects against oxidative modification of human LDL. Br J Nutr 2001, 86:637-639.
25. McCarty M.F. High-dose folate may improve platelet function in acute coronary syndrome and other pathologies associated with increased platelet oxidative stress. Med Hypotheses 2007, 69:12-19.
26. Okon E.B., Szado T., Laher I., McManus B., van Breemen C. Augmented contractile response of vascular smooth muscle in a diabetic mouse model. J Vasc Res 2003, 40:520-530.
27. Seto S.W., Lam T.Y., Leung G.P.H., Au A.L.S., Ngai S.M., Chan S.W. Comparison of vascular relaxation, lipolysis and glucose uptake by peroxisome proliferator-activated receptor-γ activation in +db/+m and +db/+db mice. Eur J Pharmacol 2007, 572:40-48.
28. Yeung J.H., Or P.M. Effects of polysaccharide peptides from COV-1 strain of Coriolus versicolor on glutathione and glutathione-related enzymes in the mouse. Food Chem Toxicol 2007, 45:953-961.
29. Akerboom T.P., Sies H. Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples. Methods Enzymol 1981, 77:373-382.
30. Lu Y., Yu Q., Liu J.H., Zhang J., Wang H., Koul D. Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades. J Biol Chem 2003, 278:40057-40066.
31. Oudit G.Y., Sun H., Kerfant B.G., Crackower M.A., Penninger J.M., Backx P.H. The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol 2004, 37:449-471.
32. Wang X.L., Zhang L., Youker K., Zhang M.X., Wang J., Le Maire S.A. Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase. Diabetes 2006, 55:2301-2310.
33. Shen Y.H., Zhang L., Utama B., Wang J., Gan Y., Wang X. Human cytomegalovirus inhibits Akt-mediated eNOS activation through upregulating PTEN (phosphatase and tensin homolog deleted on chromosome 10). Cardiovasc Res 2006, 69:502-511.
34. Hu Z., Lee I.H., Wang X., Sheng H., Du J., Mitch W.E. PTEN expression contributes to the regulation of muscle protein degradation in diabetes. Diabetes 2007, 56:2449-2456.
35. Northcott C.A., Poy M.N., Najjar S.M., Watts S.W. Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive rats. Circ Res 2002, 91:360-369.
36. Lei H., Venkatakrishnan A., Yu S., Kazlauskas A. Protein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetes. J Biol Chem 2007, 282:9364-9371.
37. Stalker T.J., Gong Y., Scalia R. The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes. Diabetes 2005, 54:1132-1140.
38. Feron O., Dessy C., Desager J.P., Balligand J.L. Hydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance. Circulation 2001, 103:113-118.
39. Jin L., Caldwell R.B., Li-Masters T., Caldwell R.W. Homocysteine induces endothelial dysfunction via inhibition of arginine transport. J Physiol Pharmacol 2007, 58:191-206.
40. Stroes E.S., van Faassen E.E., Yo M., Martasek P., Boer P., Govers R. Folic acid reverts dysfunction of endothelial nitric oxide synthase. Circ Res 2000, 86:1129-1134.
41. Fonseca-Alaniz M., Takada J., Alonso-Vale M.I., Lima F.B. Adipose tissue as an endocrine organ: from theory to practice. J Pediatr (Rio J) 2007, 83:S192-S203.
42. Hajer G.R., van Haeften T.W., Visseren F.L. Adipose tissue dysfunction in obesity, diabetes and vascular diseases. Eur Heart J 2008, 29:2959-2971.
43. Azuma K., Katsukawa F., Oguchi S., Murata M., Yamazaki H., Shimada A. Correlation between serum resistin level and adiposity in obese individuals. Obes Res 2003, 11:997-1001.
44. Vendrell J., Broch M., Vilarrasa N., Molina A., Gómez J.M., Gutiérrez C. Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity. Obes Res 2004, 12:962-971.
45. Shen Y.H., Zhang L., Gan Y., Wang X., Wang J., Le Maire S.A. Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome 10) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cells. J Biol Chem 2006, 281:7727-7736.
46. Kurlawalla-Martinez C., Stiles B., Wang Y., Devaskar S.U., Kahn B.B., Wu H. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol 2005, 25:2498-2510.