Ocular pharmacokinetic study of a corticosteroid by 19F MR

Experimental Eye Research

Volumn 91, Issue 3, 2010, Pages 347-352

  Liu, Xin ^a   Kevin Li, S ^b   Jeong, Eun Kee ^c  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

19F MR; Corticosteroid; Ocular pharmacokinetics; TAP

Indexed keywords

CORTICOSTEROID; TRIAMCINOLONE ACETONIDE PHOSPHATE; UNCLASSIFIED DRUG; DROCINONIDE; FLUORINE; GLUCOCORTICOID; TRIAMCINOLONE ACETONIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ELIMINATION; DRUG HALF LIFE; FLUORINE NUCLEAR MAGNETIC RESONANCE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; ANALOGS AND DERIVATIVES; ANIMAL; BIOAVAILABILITY; CONJUNCTIVA; HALF LIFE TIME; INJECTION; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; RABBIT; VITREOUS BODY;

ANIMALS; BIOLOGICAL AVAILABILITY; CONJUNCTIVA; FLUORINE; GLUCOCORTICOIDS; HALF-LIFE; INJECTIONS; MAGNETIC RESONANCE IMAGING; RABBITS; TRIAMCINOLONE ACETONIDE; VITREOUS BODY;

EID: 77955845113     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2010.05.022     Document Type: Article

References (29)

1. Barza M., Kane A., Baum J. The effects of infection and probenecid on the transport of carbenicillin from the rabbit vitreous humor. Invest. Ophthalmol. Vis. Sci. 1982, 22:720-726.
2. Barza M., Lynch E., Baum J.L. Pharmacokinetics of newer cephalosporins after subconjunctival and intravitreal injection in rabbits. Arch. Ophthalmol. 1993, 111:121-125.
3. Berkowitz B.A., Roberts R., Luan H., Peysakhov J., Mao X., Thomas K.A. Dynamic contrast-enhanced MRI measurements of passive permeability through blood retinal barrier in diabetic rats. Invest. Ophthalmol. Vis. Sci. 2004, 45:2391-2398.
4. Berthe P., Baudouin C., Garraffo R., Hofmann P., Taburet A.M., Lapalus P. Toxicologic and pharmacokinetic analysis of intravitreal injections of foscarnet, either alone or in combination with ganciclovir. Invest. Ophthalmol. Vis. Sci. 1994, 35:1038-1045.
5. Cheng L., Banker A.S., Martin M., Kozak I., Freeman W.R. Triamcinolone acetonide concentration of aqueous humor after decanted 20-mg intravitreal injection. Ophthalmology 2009, 116:1356-1359.
6. Friedrich S., Cheng Y.L., Saville B. Drug distribution in the vitreous humor of the human eye: the effects of intravitreal injection position and volume. Curr. Eye Res. 1997, 16:663-669.
7. Friedrich S., Cheng Y.L., Saville B. Finite element modeling of drug distribution in the vitreous humor of the rabbit eye. Ann. Biomed. Eng. 1997, 25:303-314.
8. Ghate D., Brooks W., McCarey B.E., Edelhauser H.F. Pharmacokinetics of intraocular drug delivery by periocular injections using ocular fluorophotometry. Invest. Ophthalmol. Vis. Sci. 2007, 48:2230-2237.
9. Graham R.O., Peyman G.A. Intravitreal injection of dexamethasone. Treatment of experimentally induced endophthalmitis. Arch. Ophthalmol. 1974, 92:149-154.
10. Kiernan D.F., Mieler W.F. The use of intraocular corticosteroids. Expert Opin. Pharmacother. 2009, 10:2511-2525.
11. Kim H., Robinson M.R., Lizak M.J., Tansey G., Lutz R.J., Yuan P., Wang N.S., Csaky K.G. Controlled drug release from an ocular implant: an evaluation using dynamic three-dimensional magnetic resonance imaging. Invest. Ophthalmol. Vis. Sci. 2004, 45:2722-2731.
12. Kim S.H., Csaky K.G., Wang N.S., Lutz R.J. Drug elimination kinetics following subconjunctival injection using dynamic contrast-enhanced magnetic resonance imaging. Pharm. Res. 2008, 25:512-520.
13. Kwak H.W., D'Amico D.J. Evaluation of the retinal toxicity and pharmacokinetics of dexamethasone after intravitreal injection. Arch. Ophthalmol. 1992, 110:259-266.
14. Lee T.W., Robinson J.R. Drug delivery to the posterior segment of the eye: some insights on the penetration pathways after subconjunctival injection. J. Ocul. Pharmacol. Ther. 2001, 17:565-572.
15. Lee T.W., Robinson J.R. Drug delivery to the posterior segment of the eye II: development and validation of a simple pharmacokinetic model for subconjunctival injection. J. Ocul. Pharmacol. Ther. 2004, 20:43-53.
16. Lee V.H.L., Robinson J.R. Disposition of pilocarpine in the pigmented rabbit eye. Int. J. Pharm. 1982, 11:155-165.
17. Li S.K., Molokhia S.A., Jeong E.K. Assessment of subconjunctival delivery with model ionic permeants and magnetic resonance imaging. Pharm. Res. 2004, 21:2175-2184.
18. Maren T.H., Jankowska L. Ocular pharmacology of sulfonamides: the cornea as barrier and depot. Curr. Eye Res. 1985, 4:399-408.
19. Maurice D. Review: practical issues in intravitreal drug delivery. J. Ocul. Pharmacol. Ther. 2001, 17:393-401.
20. Oishi M., Maeda S., Hashida N., Ohguro N., Tano Y., Kurokawa N. Pharmacokinetic behavior of intravitreal triamcinolone acetonide prepared by a hospital pharmacy. Jpn. J. Ophthalmol. 2008, 52:489-492.
21. Sugrue M.F. The preclinical pharmacology of dorzolamide hydrochloride, a topical carbonic anhydrase inhibitor. J. Ocul. Pharmacol. Ther. 1996, 12:363-376.
22. Thuen M., Berry M., Pedersen T.B., Goa P.E., Summerfield M., Haraldseth O., Sandvig A., Brekken C. Manganese-enhanced MRI of the rat visual pathway: acute neural toxicity, contrast enhancement, axon resolution, axonal transport, and clearance of Mn(2+). J. Magn. Reson. Imaging 2008, 28:855-865.
23. Thuen M., Olsen O., Berry M., Pedersen T.B., Kristoffersen A., Haraldseth O., Sandvig A., Brekken C. Combination of Mn(2+)-enhanced and diffusion tensor MR imaging gives complementary information about injury and regeneration in the adult rat optic nerve. J. Magn. Reson. Imaging 2009, 29:39-51.
24. Urtti A. Challenges and obstacles of ocular pharmacokinetics and drug delivery. Adv. Drug Deliv. Rev. 2006, 58:1131-1135.
25. Watanabe T., Michaelis T., Frahm J. Mapping of retinal projections in the living rat using high-resolution 3D gradient-echo MRI with Mn2+-induced contrast. Magn. Reson. Med. 2001, 46:424-429.
26. Wiedmann T.S., Bhatia R., Wattenberg L.W. Drug solubilization in lung surfactant. J. Control. Release 2000, 65:43-47.
27. Worakul N., Robinson J.R. Ocular pharmacokinetics/pharmacodynamics. Eur. J. Pharm. Biopharm. 1997, 44:71-83.
28. Yang C.S., Khawly J.A., Hainsworth D.P., Chen S.N., Ashton P., Guo H., Jaffe G.J. An intravitreal sustained-release triamcinolone and 5-fluorouracil codrug in the treatment of experimental proliferative vitreoretinopathy. Arch. Ophthalmol. 1998, 116:69-77.
29. Yilmaz T., Weaver C.D., Gallagher M.J., Cordero-Coma M., Cervantes-Castaneda R.A., Klisovic D., Lavaque A.J., Larson R.J. Intravitreal triamcinolone acetonide injection for treatment of refractory diabetic macular edema: a systematic review. Ophthalmology 2009, 116:902-911. quiz 912-903.