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Volumn 25, Issue 3, 2008, Pages 512-520

Drug elimination kinetics following subconjunctival injection using dynamic contrast-enhanced magnetic resonance imaging

Author keywords

Drug transport barrier; Magnetic resonance imaging; Ocular pharmacokinetics; Subconjunctival injection; Transscleral drug delivery

Indexed keywords

CONTRAST MEDIUM; GADOLINIUM ALBUMIN; GADOLINIUM PENTETATE; GALBUIM; UNCLASSIFIED DRUG;

EID: 40549145573     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9408-z     Document Type: Article
Times cited : (62)

References (34)
  • 1
    • 7044238939 scopus 로고    scopus 로고
    • A review of evidence guiding the use of corticosteroids in the treatment of intraocular inflammation
    • 1. P. A. Gaudio 2004 A review of evidence guiding the use of corticosteroids in the treatment of intraocular inflammation Ocul. Immunol. Inflamm. 12 169 192 15385194 10.1080/092739490500192 1:CAS:528:DC%2BD2cXhtVenu7%2FJ P. A. Gaudio. A review of evidence guiding the use of corticosteroids in the treatment of intraocular inflammation. Ocul. Immunol. Inflamm. 12:169–192 (2004).
    • (2004) Ocul. Immunol. Inflamm. , vol.12 , pp. 169-192
    • Gaudio, P.A.1
  • 2
    • 0024847923 scopus 로고
    • Subconjunctival injections of antibiotics are used increasingly at the conclusion of intraocular and extraocular procedures
    • 2. R. J. Morris D. McLeod Z. J. Gregor 1989 Subconjunctival injections of antibiotics are used increasingly at the conclusion of intraocular and extraocular procedures Eye 3 Pt 6 860 861 2630371 R. J. Morris, D. McLeod, and Z. J. Gregor. Subconjunctival injections of antibiotics are used increasingly at the conclusion of intraocular and extraocular procedures. Eye 3 (Pt 6):860–861 (1989).
    • (1989) Eye , vol.3 , Issue.Pt 6 , pp. 860-861
    • Morris, R.J.1    McLeod, D.2    Gregor, Z.J.3
  • 3
    • 0001338538 scopus 로고
    • An autoradiographic study of the penetration of subconjunctivally injected hydrocortisone into the normal and inflamed rabbit eye
    • 3. H. J. McCartney I. O. Drysdale A. G. Gornall P. K. Basu 1965 An autoradiographic study of the penetration of subconjunctivally injected hydrocortisone into the normal and inflamed rabbit eye Invest. Ophthalmol. 4 297 302 14326615 1:CAS:528:DyaF2MXksVSgtrc%3D H. J. McCartney, I. O. Drysdale, A. G. Gornall, and P. K. Basu. An autoradiographic study of the penetration of subconjunctivally injected hydrocortisone into the normal and inflamed rabbit eye. Invest. Ophthalmol. 4:297–302 (1965).
    • (1965) Invest. Ophthalmol. , vol.4 , pp. 297-302
    • McCartney, H.J.1    Drysdale, I.O.2    Gornall, A.G.3    Basu, P.K.4
  • 4
    • 0032799705 scopus 로고    scopus 로고
    • High concentration of dexamethasone in aqueous and vitreous after subconjunctival injection
    • 4. O. Weijtens E. J. Feron R. C. Schoemaker A. F. Cohen E. G. Lentjes F. P. Romijn J. C. Meurs van 1999 High concentration of dexamethasone in aqueous and vitreous after subconjunctival injection Am. J. Ophthalmol. 128 192 197 10458175 10.1016/S0002-9394(99)00129-4 1:CAS:528:DyaK1MXlslylsL8%3D O. Weijtens, E. J. Feron, R. C. Schoemaker, A. F. Cohen, E. G. Lentjes, F. P. Romijn, and J. C. van Meurs. High concentration of dexamethasone in aqueous and vitreous after subconjunctival injection. Am. J. Ophthalmol. 128:192–197 (1999).
    • (1999) Am. J. Ophthalmol. , vol.128 , pp. 192-197
    • Weijtens, O.1    Feron, E.J.2    Schoemaker, R.C.3    Cohen, A.F.4    Lentjes, E.G.5    Romijn, F.P.6    Meurs, J.C.7
  • 5
    • 0017339674 scopus 로고
    • Regional differences in ocular concentration of gentamicin after subconjunctival and retrobulbar injection in the rabbit
    • 5. M. Barza A. Kane J. L. Baum 1977 Regional differences in ocular concentration of gentamicin after subconjunctival and retrobulbar injection in the rabbit Am. J. Ophthalmol. 83 407 413 848547 1:CAS:528:DyaE2sXhs1Gjt7w%3D M. Barza, A. Kane, and J. L. Baum. Regional differences in ocular concentration of gentamicin after subconjunctival and retrobulbar injection in the rabbit. Am. J. Ophthalmol. 83:407–413 (1977).
    • (1977) Am. J. Ophthalmol. , vol.83 , pp. 407-413
    • Barza, M.1    Kane, A.2    Baum, J.L.3
  • 6
    • 0023835180 scopus 로고
    • Intraocular penetration kinetics of prednisolone after subconjunctival injection in rabbits
    • 6. A. Tsuji I. Tamai K. Sasaki 1988 Intraocular penetration kinetics of prednisolone after subconjunctival injection in rabbits Ophthalmic Res. 20 31 43 3380524 1:CAS:528:DyaL1cXhvFymtb8%3D 10.1159/000266253 A. Tsuji, I. Tamai, and K. Sasaki. Intraocular penetration kinetics of prednisolone after subconjunctival injection in rabbits. Ophthalmic Res. 20:31–43 (1988).
    • (1988) Ophthalmic Res. , vol.20 , pp. 31-43
    • Tsuji, A.1    Tamai, I.2    Sasaki, K.3
  • 7
    • 0036272393 scopus 로고    scopus 로고
    • Intraocular distribution of 70-kDa dextran after subconjunctival injection in mice
    • 7. T. W. Kim J. D. Lindsey M. Aihara T. L. Anthony R. N. Weinreb 2002 Intraocular distribution of 70-kDa dextran after subconjunctival injection in mice Invest. Ophthalmol. Vis. Sci. 43 1809 1816 12036983 T. W. Kim, J. D. Lindsey, M. Aihara, T. L. Anthony, and R. N. Weinreb. Intraocular distribution of 70-kDa dextran after subconjunctival injection in mice. Invest. Ophthalmol. Vis. Sci. 43:1809–1816 (2002).
    • (2002) Invest. Ophthalmol. Vis. Sci. , vol.43 , pp. 1809-1816
    • Kim, T.W.1    Lindsey, J.D.2    Aihara, M.3    Anthony, T.L.4    Weinreb, R.N.5
  • 8
    • 0028850531 scopus 로고
    • Biochemical quantification of triamcinolone in subconjunctival depots
    • 8. P. H. Kalina J. C. Erie L. Rosenbaum 1995 Biochemical quantification of triamcinolone in subconjunctival depots Arch. Ophthalmol. 113 867 869 7605276 1:STN:280:DyaK2MzivFShuw%3D%3D P. H. Kalina, J. C. Erie, and L. Rosenbaum. Biochemical quantification of triamcinolone in subconjunctival depots. Arch. Ophthalmol. 113:867–869 (1995).
    • (1995) Arch. Ophthalmol. , vol.113 , pp. 867-869
    • Kalina, P.H.1    Erie, J.C.2    Rosenbaum, L.3
  • 9
    • 0017898309 scopus 로고
    • The kinetics of subconjunctival injections
    • 9. D. M. Maurice Y. Ota 1978 The kinetics of subconjunctival injections Jpn. J. Ophthalmol. 22 95 100 D. M. Maurice, and Y. Ota. The kinetics of subconjunctival injections. Jpn. J. Ophthalmol. 22:95–100 (1978).
    • (1978) Jpn. J. Ophthalmol. , vol.22 , pp. 95-100
    • Maurice, D.M.1    Ota, Y.2
  • 10
    • 17644426066 scopus 로고    scopus 로고
    • Assessment of subconjunctival delivery with model ionic permeants and magnetic resonance imaging
    • 10. S. K. Li S. A. Molokhia E. K. Jeong 2004 Assessment of subconjunctival delivery with model ionic permeants and magnetic resonance imaging Pharm. Res. 21 2175 2184 15648248 10.1007/s11095-004-7669-3 1:CAS:528:DC%2BD2MXjslOqtw%3D%3D S. K. Li, S. A. Molokhia, and E. K. Jeong. Assessment of subconjunctival delivery with model ionic permeants and magnetic resonance imaging. Pharm. Res. 21:2175–2184 (2004).
    • (2004) Pharm. Res. , vol.21 , pp. 2175-2184
    • Li, S.K.1    Molokhia, S.A.2    Jeong, E.K.3
  • 11
    • 0027164037 scopus 로고
    • The use of magnetic resonance imaging to track controlled drug release and transport in the brain
    • 11. B. Reisfeld S. Blackband V. Calhoun S. Grossman S. Eller K. Leong 1993 The use of magnetic resonance imaging to track controlled drug release and transport in the brain Magn. Reson. Imaging 11 247 252 8455434 10.1016/0730-725X(93)90029-D 1:STN:280:DyaK3s3gsVKntg%3D%3D B. Reisfeld, S. Blackband, V. Calhoun, S. Grossman, S. Eller, and K. Leong. The use of magnetic resonance imaging to track controlled drug release and transport in the brain. Magn. Reson. Imaging. 11:247–252 (1993).
    • (1993) Magn. Reson. Imaging , vol.11 , pp. 247-252
    • Reisfeld, B.1    Blackband, S.2    Calhoun, V.3    Grossman, S.4    Eller, S.5    Leong, K.6
  • 12
    • 0025937971 scopus 로고
    • Blood–retinal barrier breakdown investigated by real-time magnetic resonance imaging after gadolinium-diethylenetriaminepentaacetic acid injection
    • 12. B. A. Berkowitz Y. Sato C. A. Wilson E. Juan de 1991 Blood–retinal barrier breakdown investigated by real-time magnetic resonance imaging after gadolinium-diethylenetriaminepentaacetic acid injection Invest. Ophthalmol. Vis. Sci. 32 2854 2860 1917389 1:STN:280:DyaK38%2FhtVKktA%3D%3D B. A. Berkowitz, Y. Sato, C. A. Wilson, and E. de Juan. Blood–retinal barrier breakdown investigated by real-time magnetic resonance imaging after gadolinium-diethylenetriaminepentaacetic acid injection. Invest. Ophthalmol. Vis. Sci. 32:2854–2860 (1991).
    • (1991) Invest. Ophthalmol. Vis. Sci. , vol.32 , pp. 2854-2860
    • Berkowitz, B.A.1    Sato, Y.2    Wilson, C.A.3    Juan, E.4
  • 13
    • 0028854568 scopus 로고
    • High-resolution magnetic resonance imaging evaluation of blood–retinal barrier integrity following transscleral diode laser treatment
    • 13. E. L. Arrindell J. C. Wu M. D. Wolf S. Nanda D. P. Han E. C. Wong G. W. Abrams W. F. Mieler J. S. Hyde 1995 High-resolution magnetic resonance imaging evaluation of blood–retinal barrier integrity following transscleral diode laser treatment Arch. Ophthalmol. 113 96 102 7826300 1:STN:280:DyaK2M7is1yksQ%3D%3D E. L. Arrindell, J. C. Wu, M. D. Wolf, S. Nanda, D. P. Han, E. C. Wong, G. W. Abrams, W. F. Mieler, and J. S. Hyde. High-resolution magnetic resonance imaging evaluation of blood–retinal barrier integrity following transscleral diode laser treatment. Arch. Ophthalmol. 113:96–102 (1995).
    • (1995) Arch. Ophthalmol. , vol.113 , pp. 96-102
    • Arrindell, E.L.1    Wu, J.C.2    Wolf, M.D.3    Nanda, S.4    Han, D.P.5    Wong, E.C.6    Abrams, G.W.7    Mieler, W.F.8    Hyde, J.S.9
  • 14
    • 3142543143 scopus 로고    scopus 로고
    • Dynamic contrast-enhanced MRI measurements of passive permeability through blood retinal barrier in diabetic rats
    • 14. B. A. Berkowitz R. Roberts H. Luan J. Peysakhov X. Mao K. A. Thomas 2004 Dynamic contrast-enhanced MRI measurements of passive permeability through blood retinal barrier in diabetic rats Invest. Ophthalmol. Vis. Sci. 45 2391 2398 15223822 10.1167/iovs.03-1381 B. A. Berkowitz, R. Roberts, H. Luan, J. Peysakhov, X. Mao, and K. A. Thomas. Dynamic contrast-enhanced MRI measurements of passive permeability through blood retinal barrier in diabetic rats. Invest. Ophthalmol. Vis. Sci. 45:2391–2398 (2004).
    • (2004) Invest. Ophthalmol. Vis. Sci. , vol.45 , pp. 2391-2398
    • Berkowitz, B.A.1    Roberts, R.2    Luan, H.3    Peysakhov, J.4    Mao, X.5    Thomas, K.A.6
  • 15
    • 0023893839 scopus 로고
    • Quantitative magnetic resonance imaging in assessment of the blood–retinal barrier
    • 15. W. E. Plehwe D. W. McRobbie R. A. Lerski E. M. Kohner 1988 Quantitative magnetic resonance imaging in assessment of the blood–retinal barrier Invest. Ophthalmol. Vis. Sci. 29 663 670 3366561 1:CAS:528:DyaL1cXks12muro%3D W. E. Plehwe, D. W. McRobbie, R. A. Lerski, and E. M. Kohner. Quantitative magnetic resonance imaging in assessment of the blood–retinal barrier. Invest. Ophthalmol. Vis. Sci. 29:663–670 (1988).
    • (1988) Invest. Ophthalmol. Vis. Sci. , vol.29 , pp. 663-670
    • Plehwe, W.E.1    McRobbie, D.W.2    Lerski, R.A.3    Kohner, E.M.4
  • 16
    • 3242885512 scopus 로고    scopus 로고
    • Controlled drug release from an ocular implant: an evaluation using dynamic three-dimensional magnetic resonance imaging
    • 16. H. Kim M. R. Robinson M. J. Lizak G. Tansey R. J. Lutz P. Yuan N. S. Wang K. G. Csaky 2004 Controlled drug release from an ocular implant: an evaluation using dynamic three-dimensional magnetic resonance imaging Invest. Ophthalmol. Vis. Sci. 45 2722 2731 15277497 10.1167/iovs.04-0091 H. Kim, M. R. Robinson, M. J. Lizak, G. Tansey, R. J. Lutz, P. Yuan, N. S. Wang, and K. G. Csaky. Controlled drug release from an ocular implant: an evaluation using dynamic three-dimensional magnetic resonance imaging. Invest. Ophthalmol. Vis. Sci. 45:2722–2731 (2004).
    • (2004) Invest. Ophthalmol. Vis. Sci. , vol.45 , pp. 2722-2731
    • Kim, H.1    Robinson, M.R.2    Lizak, M.J.3    Tansey, G.4    Lutz, R.J.5    Yuan, P.6    Wang, N.S.7    Csaky, K.G.8
  • 17
    • 33847710274 scopus 로고    scopus 로고
    • Assessment of subconjunctival and intrascleral drug delivery to the posterior segment using dynamic contrast-enhanced magnetic resonance imaging
    • 17. S. H. Kim C. J. Galban R. J. Lutz R. L. Dedrick K. G. Csaky M. J. Lizak N. S. Wang G. Tansey M. R. Robinson 2007 Assessment of subconjunctival and intrascleral drug delivery to the posterior segment using dynamic contrast-enhanced magnetic resonance imaging Invest. Ophthalmol. Vis. Sci. 48 808 814 17251481 10.1167/iovs.06-0670 S. H. Kim, C. J. Galban, R. J. Lutz, R. L. Dedrick, K. G. Csaky, M. J. Lizak, N. S. Wang, G. Tansey, and M. R. Robinson. Assessment of subconjunctival and intrascleral drug delivery to the posterior segment using dynamic contrast-enhanced magnetic resonance imaging. Invest. Ophthalmol. Vis. Sci. 48:808–814 (2007).
    • (2007) Invest. Ophthalmol. Vis. Sci. , vol.48 , pp. 808-814
    • Kim, S.H.1    Galban, C.J.2    Lutz, R.J.3    Dedrick, R.L.4    Csaky, K.G.5    Lizak, M.J.6    Wang, N.S.7    Tansey, G.8    Robinson, M.R.9
  • 18
    • 17044362175 scopus 로고    scopus 로고
    • Study of ocular transport of drugs released from an intravitreal implant using magnetic resonance imaging
    • 18. H. Kim M. J. Lizak G. Tansey K. G. Csaky M. R. Robinson P. Yuan N. S. Wang R. J. Lutz 2005 Study of ocular transport of drugs released from an intravitreal implant using magnetic resonance imaging Ann. Biomed. Eng. 33 150 164 15771269 10.1007/s10439-005-8974-7 H. Kim, M. J. Lizak, G. Tansey, K. G. Csaky, M. R. Robinson, P. Yuan, N. S. Wang, and R. J. Lutz. Study of ocular transport of drugs released from an intravitreal implant using magnetic resonance imaging. Ann. Biomed. Eng. 33:150–164 (2005).
    • (2005) Ann. Biomed. Eng. , vol.33 , pp. 150-164
    • Kim, H.1    Lizak, M.J.2    Tansey, G.3    Csaky, K.G.4    Robinson, M.R.5    Yuan, P.6    Wang, N.S.7    Lutz, R.J.8
  • 19
    • 31344468895 scopus 로고    scopus 로고
    • A rabbit model for assessing the ocular barriers to the transscleral delivery of triamcinolone acetonide
    • 19. M. R. Robinson S. S. Lee H. Kim S. Kim R. J. Lutz C. Galban P. M. Bungay P. Yuan N. S. Wang J. Kim K. G. Csaky 2006 A rabbit model for assessing the ocular barriers to the transscleral delivery of triamcinolone acetonide Exp. Eye Res. 82 479 487 16168412 10.1016/j.exer.2005.08.007 1:CAS:528:DC%2BD28Xos1aktw%3D%3D M. R. Robinson, S. S. Lee, H. Kim, S. Kim, R. J. Lutz, C. Galban, P. M. Bungay, P. Yuan, N. S. Wang, J. Kim, and K. G. Csaky. A rabbit model for assessing the ocular barriers to the transscleral delivery of triamcinolone acetonide. Exp. Eye Res. 82:479–487 (2006).
    • (2006) Exp. Eye Res. , vol.82 , pp. 479-487
    • Robinson, M.R.1    Lee, S.S.2    Kim, H.3    Kim, S.4    Lutz, R.J.5    Galban, C.6    Bungay, P.M.7    Yuan, P.8    Wang, N.S.9    Kim, J.10    Csaky, K.G.11
  • 20
    • 0025287316 scopus 로고
    • Effect of molecular weight on the lymphatic absorption of water-soluble compounds following subcutaneous administration
    • 20. A. Supersaxo W. R. Hein H. Steffen 1990 Effect of molecular weight on the lymphatic absorption of water-soluble compounds following subcutaneous administration Pharm. Res. 7 167 169 2137911 10.1023/A:1015880819328 1:CAS:528:DyaK3cXhtlOit7o%3D A. Supersaxo, W. R. Hein, and H. Steffen. Effect of molecular weight on the lymphatic absorption of water-soluble compounds following subcutaneous administration. Pharm. Res. 7:167–169 (1990).
    • (1990) Pharm. Res. , vol.7 , pp. 167-169
    • Supersaxo, A.1    Hein, W.R.2    Steffen, H.3
  • 21
    • 28644432836 scopus 로고    scopus 로고
    • Size-dependent disposition of nanoparticles and microparticles following subconjunctival administration
    • 21. A. C. Amrite U. B. Kompella 2005 Size-dependent disposition of nanoparticles and microparticles following subconjunctival administration J. Pharm. Pharmacol. 57 1555 1563 16354399 10.1211/jpp.57.12.0005 1:CAS:528:DC%2BD28Xit1Knu7s%3D A. C. Amrite, and U. B. Kompella. Size-dependent disposition of nanoparticles and microparticles following subconjunctival administration. J. Pharm. Pharmacol. 57:1555–1563 (2005).
    • (2005) J. Pharm. Pharmacol. , vol.57 , pp. 1555-1563
    • Amrite, A.C.1    Kompella, U.B.2
  • 22
    • 21744451953 scopus 로고    scopus 로고
    • Subcutaneous drug delivery and the role of the lymphatics
    • 22. D. N. McLennan C. J. H. Porter S. A. Charman 2005 Subcutaneous drug delivery and the role of the lymphatics Drug Discov Today: Technologies 2 89 10.1016/j.ddtec.2005.05.006 1:CAS:528:DC%2BD2MXpvFOmtL8%3D D. N. McLennan, C. J. H. Porter, and S. A. Charman. Subcutaneous drug delivery and the role of the lymphatics. Drug Discovery Today: Technologies. 2:89 (2005).
    • (2005) Drug Discov Today: Technologies , vol.2 , pp. 89
    • McLennan, D.N.1    Porter, C.J.H.2    Charman, S.A.3
  • 23
    • 0023179869 scopus 로고
    • Lymphoscintigraphy
    • 23. L. D. Samuels 1987 Lymphoscintigraphy Lymphology 20 4 9 3600035 1:STN:280:DyaL2s3ls1ajtQ%3D%3D L. D. Samuels. Lymphoscintigraphy. Lymphology. 20:4–9 (1987).
    • (1987) Lymphology , vol.20 , pp. 4-9
    • Samuels, L.D.1
  • 24
    • 0025186407 scopus 로고
    • Tc-99m human serum albumin lymphoscintigraphy in lymphedema of the lower extremities
    • 24. M. K. Nawaz M. M. Hamad H. M. Abdel-Dayem S. Sadek B. G. Eklof 1990 Tc-99m human serum albumin lymphoscintigraphy in lymphedema of the lower extremities Clin. Nucl. Med. 15 794 799 2292150 10.1097/00003072-199011000-00004 1:STN:280:DyaK3M7lt12hsQ%3D%3D M. K. Nawaz, M. M. Hamad, H. M. Abdel-Dayem, S. Sadek, and B. G. Eklof. Tc-99m human serum albumin lymphoscintigraphy in lymphedema of the lower extremities. Clin. Nucl. Med. 15:794–799 (1990).
    • (1990) Clin. Nucl. Med. , vol.15 , pp. 794-799
    • Nawaz, M.K.1    Hamad, M.M.2    Abdel-Dayem, H.M.3    Sadek, S.4    Eklof, B.G.5
  • 25
    • 0036186419 scopus 로고    scopus 로고
    • Quantification of lymphatic function for investigation of lymphedema: depot clearance and rate of appearance of soluble macromolecules in blood
    • 25. S. J. Pain R. S. Nicholas R. W. Barber J. R. Ballinger A. D. Purushotham P. S. Mortimer A. M. Peters 2002 Quantification of lymphatic function for investigation of lymphedema: depot clearance and rate of appearance of soluble macromolecules in blood J. Nucl. Med. 43 318 324 11884490 S. J. Pain, R. S. Nicholas, R. W. Barber, J. R. Ballinger, A. D. Purushotham, P. S. Mortimer, and A. M. Peters. Quantification of lymphatic function for investigation of lymphedema: depot clearance and rate of appearance of soluble macromolecules in blood. J. Nucl. Med. 43:318–324 (2002).
    • (2002) J. Nucl. Med. , vol.43 , pp. 318-324
    • Pain, S.J.1    Nicholas, R.S.2    Barber, R.W.3    Ballinger, J.R.4    Purushotham, A.D.5    Mortimer, P.S.6    Peters, A.M.7
  • 26
    • 84914797341 scopus 로고
    • Studies of human peripheral blood flow; the effect of injection volume on the intramuscular radiosodium clearance rate
    • 26. G. F. Warner E. L. Dobson N. Pace M. E. Johnston C. R. Finney 1953 Studies of human peripheral blood flow; the effect of injection volume on the intramuscular radiosodium clearance rate Circulation 8 732 734 13106895 1:STN:280:DyaG2c%2Fislyitg%3D%3D G. F. Warner, E. L. Dobson, N. Pace, M. E. Johnston, and C. R. Finney. Studies of human peripheral blood flow; the effect of injection volume on the intramuscular radiosodium clearance rate. Circulation. 8:732–734 (1953).
    • (1953) Circulation , vol.8 , pp. 732-734
    • Warner, G.F.1    Dobson, E.L.2    Pace, N.3    Johnston, M.E.4    Finney, C.R.5
  • 27
    • 0005761858 scopus 로고
    • The determination of absorption rates from rat muscles: An experimental approach to kinetic descriptions
    • 27. R. B. Sund J. Schou 1964 The determination of absorption rates from rat muscles: An experimental approach to kinetic descriptions Acta. Pharm Toxicol. (Copenh) 21 313 325 1:CAS:528:DyaF2MXks1Sguw%3D%3D R. B. Sund, and J. Schou. The determination of absorption rates from rat muscles: An experimental approach to kinetic descriptions. Acta Pharm. Toxicol. (Copenh). 21:313–325 (1964).
    • (1964) Acta. Pharm Toxicol. (Copenh) , vol.21 , pp. 313-325
    • Sund, R.B.1    Schou, J.2
  • 28
    • 0025767720 scopus 로고
    • Interface-area-to-volume ratio of interstitial fluid in humans determined by pharmacokinetic analysis of netilmicin in small and large skin blisters
    • 28. J. Blaser H. L. Rieder R. Luthy 1991 Interface-area-to-volume ratio of interstitial fluid in humans determined by pharmacokinetic analysis of netilmicin in small and large skin blisters Antimicrob. Agents Chemother. 35 837 839 1854165 1:CAS:528:DyaK3MXitl2qsL4%3D J. Blaser, H. L. Rieder, and R. Luthy. Interface-area-to-volume ratio of interstitial fluid in humans determined by pharmacokinetic analysis of netilmicin in small and large skin blisters. Antimicrob. Agents. Chemother. 35:837–839 (1991).
    • (1991) Antimicrob. Agents Chemother. , vol.35 , pp. 837-839
    • Blaser, J.1    Rieder, H.L.2    Luthy, R.3
  • 29
    • 0019988419 scopus 로고
    • Studies on the absorption of practically water-insoluble drugs following injection V: Subcutaneous absorption in rats from solutions in water immiscible oils
    • 29. K. Hirano T. Ichihashi H. Yamada 1982 Studies on the absorption of practically water-insoluble drugs following injection V: Subcutaneous absorption in rats from solutions in water immiscible oils J. Pharm. Sci. 71 495 500 7097491 10.1002/jps.2600710505 1:CAS:528:DyaL38Xit1eit7o%3D K. Hirano, T. Ichihashi, and H. Yamada. Studies on the absorption of practically water-insoluble drugs following injection V: Subcutaneous absorption in rats from solutions in water immiscible oils. J. Pharm. Sci. 71:495–500 (1982).
    • (1982) J. Pharm. Sci. , vol.71 , pp. 495-500
    • Hirano, K.1    Ichihashi, T.2    Yamada, H.3
  • 30
    • 0031409699 scopus 로고    scopus 로고
    • The role of positron emission tomography in pharmacokinetic analysis
    • 30. A. J. Fischman N. M. Alpert J. W. Babich R. H. Rubin 1997 The role of positron emission tomography in pharmacokinetic analysis Drug. Metab. Rev. 29 923 956 9421680 10.3109/03602539709002238 1:CAS:528:DyaK1cXhtlGkug%3D%3D A. J. Fischman, N. M. Alpert, J. W. Babich, and R. H. Rubin. The role of positron emission tomography in pharmacokinetic analysis. Drug Metab. Rev. 29:923–956 (1997).
    • (1997) Drug. Metab. Rev. , vol.29 , pp. 923-956
    • Fischman, A.J.1    Alpert, N.M.2    Babich, J.W.3    Rubin, R.H.4
  • 31
    • 0035032805 scopus 로고    scopus 로고
    • Fundamentals of positron emission tomography and applications in preclinical drug development
    • 31. S. R. Cherry 2001 Fundamentals of positron emission tomography and applications in preclinical drug development J. Clin. Pharmacol. 41 482 491 11361044 10.1177/00912700122010357 1:CAS:528:DC%2BD3MXjvVaksbw%3D S. R. Cherry. Fundamentals of positron emission tomography and applications in preclinical drug development. J. Clin. Pharmacol. 41:482–491 (2001).
    • (2001) J. Clin. Pharmacol. , vol.41 , pp. 482-491
    • Cherry, S.R.1
  • 32
    • 8844242556 scopus 로고    scopus 로고
    • Methods to assess tissue-specific distribution and metabolism of drugs
    • 32. O. Langer M. Muller 2004 Methods to assess tissue-specific distribution and metabolism of drugs Curr. Drug Metab. 5 463 481 15578942 10.2174/1389200043335379 1:CAS:528:DC%2BD2cXhtVWhurnK O. Langer, and M. Muller. Methods to assess tissue-specific distribution and metabolism of drugs. Curr. Drug Metab. 5:463–481 (2004).
    • (2004) Curr. Drug Metab. , vol.5 , pp. 463-481
    • Langer, O.1    Muller, M.2
  • 33
    • 0033067830 scopus 로고    scopus 로고
    • Potential applications of PET imaging in developing novel cancer therapies
    • 33. R. Hustinx S. L. Eck A. Alavi 1999 Potential applications of PET imaging in developing novel cancer therapies J. Nucl. Med. 40 995 1002 10452317 1:STN:280:DyaK1MznvFertA%3D%3D R. Hustinx, S. L. Eck, and A. Alavi. Potential applications of PET imaging in developing novel cancer therapies. J. Nucl. Med. 40:995–1002 (1999).
    • (1999) J. Nucl. Med. , vol.40 , pp. 995-1002
    • Hustinx, R.1    Eck, S.L.2    Alavi, A.3
  • 34
    • 26944443535 scopus 로고    scopus 로고
    • Imaging drug delivery and drug responses in the lung
    • 34. M. Dolovich R. Labiris 2004 Imaging drug delivery and drug responses in the lung Proc. Am. Thorac. Soc. 1 329 337 16113454 10.1513/pats.200404-030MS 1:CAS:528:DC%2BD28XhsFGjsL0%3D M. Dolovich, and R. Labiris. Imaging drug delivery and drug responses in the lung. Proc. Am. Thorac. Soc. 1:329–337 (2004).
    • (2004) Proc. Am. Thorac. Soc. , vol.1 , pp. 329-337
    • Dolovich, M.1    Labiris, R.2


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