Drug Delivery to the Posterior Segment of the Eye II: Development and Validation of a Simple Pharmacokinetic Model for Subconjunctival Injection

Journal of Ocular Pharmacology and Therapeutics

Volumn 20, Issue 1, 2004, Pages 43-53

  Lee, Thomas Wai Yip ^a,b   Robinson, Joseph R ^a,c  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PREDNISOLONE;

ARTICLE; CURVE FITTING; DRUG DELIVERY SYSTEM; DRUG ELIMINATION; MODEL; POSTERIOR EYE CHAMBER; VALIDATION PROCESS; VITREOUS BODY;

EID: 1042277993     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/108076804772745455     Document Type: Article

References (21)

1. Kalsi, G.S., Gudauskas, G., Bussanich, N., Freeman, D.J., and Rootman, J. Ocular pharmacokinetics of subconjunctivally administered cyclosporine in the rabbit. Can. J. Ophthalmol. 26:200-205, 1991.
2. Gudauskas, G., Kumi, C. Dedhar, C., Bussanich, N., and Rootman, J. Ocular pharmacokinetics of subconjunctivally versus intravenously administered 6-mercaptopurine. Can. J. Ophthalmol. 20:110-113, 1985.
3. Tsuji, A., Tamai, I. and Sasaki, K. Intraocular penetration kinetics of prednisolone after subconjunctival injection in rabbits. Ophthalmic Res. 20:31-43, 1988.
4. Slovin, E.M. In vivo swelling kinetics of series of hydrogel polymers in the gastrointestinal tract of the cannulated canine, Ph.D. Thesis, 1997, University of Wisconsin-Madison.
5. Norris, D.A., Leesman, G.D., Sinko, P.J., and Grass, G.M. Development of predictive pharmacokinetic simulation models for drug discovery. J. Control Release 65:55-62, 2000.
6. Grass, G.M., Bozarth, C.A., and Vallner, J.J. Evaluation of the performance of controlled release dosage forms of ticlopidine using in vitro intestinal permeability and computer simulations. J. Drug Target 2:23-33, 1994.
7. Grass, G.M., and Lee, V.H. A model to predict aqueous humor and plasma pharmacokinetics of ocularly applied drugs. Invest. Ophthalmol. Vis. Sci. 34:2251-2259, 1993.
8. Conrad, J.M. Ocular drug disposition from subconjunctival injection in the albino rabbit, Ph.D. Thesis, 1979, University of Wisconsin-Madison.
9. Lee, T.W., and Robinson, J.R. Drug delivery to the posterior segment of the eye: some insights on the penetration pathways after subconjunctival injection. J. Ocul. Pharmacol. Ther. 17:565-72, 2001.
10. Gabrielsson, J., and Weiner, D. Basic pharmacokinetic and dynamic concepts, In Pharmacokinetic and Pharmacodynamic Data Analysis, Swedish Pharmaceutical Press: Stockholm, Sweden. 1994, pp. 41-100.
11. Makoid, M.C., and Robinson, J.R. Pharmacokinetics of topically applied pilocarpine in the albino rabbit eye. J. Pharm. Sci. 68:435-443, 1979.
12. Ahmed, I., Francoeur, M.L., Thombre, A.G., and Patton, T.F. The kinetics of timolol in the rabbit lens: implications for ocular drug delivery. Pharm Res. 6:772-778, 1989.
13. Kojima, M., Shui, Y.B., and Sasaki, K. Topographic distribution of prednisolone in the lens after organ culture. Ophthalmic Res. 27 (Suppl 1):25-33, 1995.
14. Lindsey, J.K., and Jones, B. Choosing among generalized linear models applied to medical data. Stat. Med. 17:59-68, 1998.
15. Koehler, A.B., and Murphree, E.S. A comparison of the Akaike and Schwarz Criteria for selecting model order. Appl. Statist. 37:187-195, 1988.
16. Schwarz, G. Estimating the dimension of a model. Ann Stat. 6:461-464, 1978.
17. Maurice, D.M. Injection of drugs into the vitreous body, In Symposium on Ocular Therapy, B. R.P., Ed., John Wiley and Sons, Inc., New York, 1976, pp. 59-71.
18. Scholes, G.N., O'Brien, W.J. Abrams, G.W., and Kubicek, M.F. Clearance of triamcinolone from vitreous. Arch. Ophthalmol. 103:1567-1569, 1985.
19. Graham, R.O., and Peyman, G.A. Intravitreal injection of dexamethasone. Treatment of experimentally induced endophthalmitis. Arch. Ophthalmol. 92:149-154, 1974.
20. Cochereau-Massin, I., Marrakchi-Benjaafar, S., Bauchet, J., Vallois, J.M., Faurisson, F., and Pocidalo, J.J. Kinetics and tolerability of intravitreal pefloxacin in rabbits. J. Antimicrob. Chemother. 33:231-242, 1994.
21. Levine, N.D., and Aronson, S.B. Orbital infusion of steroids in the rabbit. Arch. Ophthalmol. 83:599-607, 1970.