Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action

British Journal of Pharmacology

Volumn 161, Issue 1, 2010, Pages 162-175

  Oros, A ^a   Houtman, M J ^a   Neco, P ^b   Gomez, A M ^b   Rajamani, S ^c   Oosterhoff, P ^a   Attevelt, N J ^a   Beekman, J D ^a   Van Der Heyden, M A G ^a   Ver Donck, L ^d   Belardinelli, L ^c   Richard, S ^b   Antoons, G ^a   Vos, M A ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b INSERM   (France)

^c GILEAD SCIENCES   (United States)

^d JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

CAVB dog; drug induced TdP arrhythmias; flunarizine; safety pharmacology; ventricular repolarization; verapamil

Indexed keywords

CALCIUM ION; DOFETILIDE; FLUNARIZINE; LIDOCAINE; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CELL STRAIN HEK293; DOG; DRUG EFFECT; DRUG MECHANISM; ELECTROCARDIOGRAM; FEMALE; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART REPOLARIZATION; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; TORSADE DES POINTES;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CALCIUM SIGNALING; CELL LINE; DOGS; FLUNARIZINE; HUMANS; LIDOCAINE; MICE; MYOCYTES, CARDIAC; PHENETHYLAMINES; SULFONAMIDES; TORSADES DE POINTES; VERAPAMIL;

EID: 77955839656     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00883.x     Document Type: Article

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