Exploring the role of the phospholipid ligand in endothelial protein C receptor: A molecular dynamics study

Proteins: Structure, Function and Bioinformatics

Volumn 78, Issue 12, 2010, Pages 2679-2690

  Chiappori, Federica ^a   Merelli, Ivan ^a   Milanesi, Luciano ^a   Rovida, Ermanna ^a  

^a CNR   (Italy)

Author keywords

Conformational sampling; Endothelial protein C receptor (EPCR); Free energy landscape (FEL); Ligand binding; Linear interaction energy (LIE) method; Molecular dynamics simulations; Mutants design; Principal components analysis; Protein structure stability

Indexed keywords

4 CARBOXYGLUTAMIC ACID; ENDOTHELIAL PROTEIN C RECEPTOR; PHOSPHOLIPID;

ARTICLE; CONFORMATION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; SIMULATION;

ANTIGENS, CD; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; PHOSPHOLIPIDS; PRINCIPAL COMPONENT ANALYSIS; PROTEIN BINDING; PROTEIN C; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; RECEPTORS, CELL SURFACE;

EID: 77955819961     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22782     Document Type: Article

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