Efficient nucleic acid transduction with lipoplexes containing novel piperazine- and polyamine-conjugated cholesterol derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 1, 2009, Pages 100-103

  Islam, Rafique Ul ^a,b   Hean, Justin ^a   van Otterlo, Willem A L ^b   de Koning, Charles B ^b   Arbuthnot, Patrick ^a  

^a UNIVERSITY OF THE WITWATERSRAND MEDICAL SCHOOL   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

Cholesterol; Cyclen; DNA; Lipoplex; Piperazine; RNA; Transfection

Indexed keywords

CARBAMIC ACID; CHOLESTEROL DERIVATIVE; DNA; LIPOPLEX; NANOPARTICLE; NUCLEIC ACID; PIPERAZINE DERIVATIVE; POLYAMINE DERIVATIVE; RNA; SMALL INTERFERING RNA;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DNA BINDING; DNA TRANSFECTION; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; DRUG SYNTHESIS; GENE SILENCING; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; NONVIRAL GENE DELIVERY SYSTEM; NUCLEOTIDE SEQUENCE; SUBSTITUTION REACTION;

ANIMALS; CATIONS; CELLS; CHOLESTEROL ESTERS; DNA; HETEROCYCLIC COMPOUNDS; HUMANS; LIPIDS; PIPERAZINES; POLYAMINES; RNA; RNA, SMALL INTERFERING; TRANSDUCTION, GENETIC;

EID: 57749098534     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.11.009     Document Type: Article

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