MGMT activity in mucosal epithelium and squamous cell carcinoma of the head and neck

Anticancer Research

Volumn 30, Issue 7, 2010, Pages 2561-2566

  Jacob, Roland ^a   Shafiei, Navid ^b   Nagel, Georg ^b   Welkoborsky, Hans Jürgen ^c   Mann, Wolf ^b   Kaina, Bernd ^b  

^a BUNDESWEHRZENTRALKRANKENHAUS KOBLENZ   (Germany)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^c NORDSTADT HOSPITAL   (Germany)

Author keywords

Alkyltransferase; Cancer therapy; Drug resistance; Field cancerization; MGMT; SCCHN

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; FEMALE; HEAD AND NECK CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MUCOSA; PERIPHERAL LYMPHOCYTE; PHARYNX; PRIORITY JOURNAL; PROGNOSIS; RECEPTOR DOWN REGULATION; RISK FACTOR; SMOKING; SQUAMOUS CELL CARCINOMA; SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK; TUMOR GROWTH;

ADULT; AGE FACTORS; ANEUPLOIDY; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; CELL GROWTH PROCESSES; DNA MODIFICATION METHYLASES; DNA REPAIR ENZYMES; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; MUCOUS MEMBRANE; SEX FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 77955778563     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Jacob R, Welkoborsky HJ, Mann WJ, Hofken F, Dienes HP and Freije JE: Heterogeneity of squamous cell carcinomas of the head and neck-analysis of tumor biologic factors and proliferation rates. Laryngoscope 106: 1170-1175, 1996. (Pubitemid 26304611)
2. Slaughter DP, Southwick HW and Smejkal W: Field cancerization in oral stratified squamous epithelium: clinical implications of multicentric origin. Cancer 6: 963-968, 1953.
3. Field JK, Spandidos DA, Malliri A, Gosney JR, Yiagnisis M and Stell PM: Elevated p53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck. Br J Cancer 64: 573-577, 1991.
4. Bongers V, Braakhuis BJ, Tobi H, Lubsen H and Snow GB: The relation between cancer incidence among relatives and the occurrence of multiple primary carcinomas following head and neck cancer. Cancer Epidemiol Biomarkers Prev 5: 595-8, 1996. (Pubitemid 26265152)
5. Hecht SS and Hoffmann D: The relevance of tobacco-specific nitrosamines to human cancer. Cancer Surv 8: 273-293, 1989.
6. Hooper SJ, Wilson MJ and Crean SJ: Exploring the link between microorganisms and oral cancer: a systematic review of the literature. Head and Neck 31: 1228-1239, 2009.
7. Lieber C, Baraona E, Leo MA and Garro A: International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC Working Paper No. 15/2. Metabolism and metabolic effects of ethanol, including interaction with drugs, carcinogens and nutrition. Mutation Res 186: 201-233, 1987.
8. 6-ethylguanine from rat liver DNA. Brit J Cancer 40: 809-813, 1979. (Pubitemid 10204804)
9. 6-alkylguanine-DNA alkyltrans-ferase variants. Chem Res Toxicol 17: 424-434, 2004.
10. Saffhill, R: In vitro miscoding of alkylthymines with DNA and RNA polymerases. Chem Biol Interact 13: 121-130, 1985.
11. 6-methylguanine is Bcl-2 and caspase-9/-3 regulated and Fas/caspase-8 independent. Cancer Res 60: 5815-5824, 2000.
12. 6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents. Carcinogenesis 12: 1857-1867, 1991.
13. + and methylation-tolerant mismatch repair compromised cells: facts and models. Mutation Res 381: 227-241, 1997. (Pubitemid 28015418)
14. 6-alkylguanine-DNA-alkyltransferase. Prog Nucleic Acid Res Mol Biol 51: 167-223, 1995.
15. 6-methylguanine-DNA methyltransferase in mammalian cells by DNA-damaging treatments. Mol Cell Biol 11: 4660-4668, 1991. (Pubitemid 21895863)
16. Grombacher T, Mitra S and Kaina B: Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes. Carcinogenesis 17: 2329-2336, 1996. (Pubitemid 26402229)
17. 6-alkylguanine-DNA alkyltransferase. Carcinogenesis 24: 625-635, 2003.
18. 6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 59: 793-797, 1999. (Pubitemid 29086728)
19. Yu CC, Woods AL and Levison DA: The assessment of cellular proliferation by immunohistochemistry: a review of currently available methods and their applications. Histochem J 24: 121-131, 1992.
20. Wiewrodt D, Nagel G, Dreimuller N, Hundsberger T, Perneczky A and Kaina B: MGMT in primary and recurrent human glioblastomas after radiation and chemotherapy and comparison with p53 status and clinical outcome. Int J Cancer 122: 1391-1399, 2008. (Pubitemid 351287241)
21. Janssen K, Grombacher U, Schlink K, Nitzsche S, Oesch F and Kaina B: Long-time expression of DNA repair enzymes MGMT and APE in human peripheral blood mononuclear cells. Arch Toxicol 75: 306-312, 2001. (Pubitemid 32702204)
22. Sawhney M, Rohatgi N, Kaur J, Gupta SD, Deo SV, Shukla NK and Ralhan R: MGMT expression in oral precancerous and cancerous lesions: correlation with progression, nodal metastasis and poor prognosis. Oral Oncol 43: 515-522, 2007. (Pubitemid 46561437)
23. Kato K, Hara A, Kuno T, Mori H, Yamashita T, Toida M and Shibata T: Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa. J Cancer Res Clin Oncol 132: 735-743, 2006. (Pubitemid 44337934)
24. Jahnke V, Matthias C, Bockmuhl U and Strange RC: Genetic predisposition for the development of head and neck carcinomas. Laryngorhinootologie 78: 24-27, 1999. (Pubitemid 29071457)
25. 6-methylguanine-DNA methyltransferase in relation to p53 Status and therapeutic response in ovarian cancer. Int J Cancer 84: 388-395, 1999. (Pubitemid 29337125)
26. Christmann M, Nagel G, Horn S, Krahn U, Wiewrodt D, Sommer C and Kaina B: MGMT activity, promoter methylation and immunohistochemistry of pre-treatment and recurrent malignant gliomas: A comparative study on astrocytoma and glioblastoma. Int J Cancer in press, 2010.
27. Russo AL, Thiagalingam A, Pan H, Califano J, Cheng KH, Ponte JF, Chinnappan D, Nemani P, Sidransky D and Thiagalingam S: Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer. Clin Cancer Res 11: 2466-2470, 2005. (Pubitemid 40569441)
28. Jacob R, Welkoborsky HJ, Bittinger F, Mann WJ and Amedee R: Histological grading, growth fraction and DNA-ploidy as criteria for the treatment of pharyngeal and supraglottic squamous cell carcinomas: a preliminary, prospective study. ORL J Otorhinolaryngol Relat Spec 63: 314-320, 2001. (Pubitemid 32786189)
29. Gluckman JL, Pavelic ZP, Welkoborsky HJ, Mann W, Stambrook P, Gleich L, Wilson K, Righi P, Portugal LG, McDonald J, Biddinger P, Steward D and Gartside P: Prognostic indicators for squamous cell carcinoma of the oral cavity: a clinicopathologic correlation. Laryngoscope 107: 1239-1244, 1997.
30. 6-Benzylguanine-mediated enhancement of chemotherapy. Mol Cancer Ther 1: 943-948, 2002.