7-hydroxyfrullanolide, a sesquiterpene lactone, inhibits pro-inflammatory cytokine production from immune cells and is orally efficacious in animal models of inflammation

European Journal of Pharmacology

Volumn 644, Issue 1-3, 2010, Pages 220-229

  Fonseca, Lyle C ^a   Dadarkar, Shruta S ^a   Lobo, Aurelio S ^a   Suthar, Ashish C ^a   Chauhan, Vijay S ^a   Chandrababu, Shanthi ^b   Sharma, Somesh D ^a   Dagia, Nilesh M ^a   Padigaru, Muralidhara ^a  

^a Piramal Enterprises Limited   (India)

^b VIT UNIVERSITY   (India)

Author keywords

Colitis; IL 6; Rheumatoid arthritis; Sepsis; Sesquiterpene lactone; TNF

Indexed keywords

7 HYDROXYFRULLANOLIDE; ANTIINFLAMMATORY AGENT; CARRAGEENAN; COLLAGEN; DEXTRAN SULFATE; ENDOTOXIN; INTERLEUKIN 6; METHANOL; SESQUITERPENE LACTONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; ASTERACEAE; BONE EROSION; CELL ISOLATION; CHRONIC DISEASE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG ISOLATION; ENDOTOXEMIA; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FRUIT; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INFLAMMATORY CELL; INFLAMMATORY DISEASE; JOINT DESTRUCTION; LYMPHOCYTIC INFILTRATION; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; NORMAL HUMAN; PAW EDEMA; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RECTUM HEMORRHAGE; SPHAERANTHUS INDICUS; SYNOVIOCYTE; WEIGHT REDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; ASTERACEAE; COLITIS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-6; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; RATS; RATS, WISTAR; SESQUITERPENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77955774623     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.06.052     Document Type: Article

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