메뉴 건너뛰기




Volumn 1, Issue 1, 2010, Pages 195-201

IGF-IR and its inhibitors in gastrointestinal carcinomas

Author keywords

Cancer therapy; Gastrointestinal carcinoma; Monoclonal antibody; Type I insulin like growth factor receptor; Tyrosine kinase inhibitor

Indexed keywords

BVP 51004; CASPASE 3; CETUXIMAB; CISPLATIN; CP 751871; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLUINDOSTATIN; FLUOROURACIL; IMC A12; IMMUNOGLOBULIN G1; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MESSENGER RNA; MK 0646; NAVELBINE; NORDIHYDROGUAIARETIC ACID; NVP AEW 541; PHOSPHATIDYLINOSITOL 3 KINASE; PODOPHYLLIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SOMATOMEDIN B RECEPTOR; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C RECEPTOR; TAMOXIFEN; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 77955753972     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol_00000036     Document Type: Review
Times cited : (2)

References (66)
  • 1
    • 38849088141 scopus 로고    scopus 로고
    • The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer
    • Ryan PD and Goss PE: The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer. Oncologist 13: 16-24, 2008.
    • (2008) Oncologist , vol.13 , pp. 16-24
    • Ryan, P.D.1    Goss, P.E.2
  • 2
    • 28544444712 scopus 로고    scopus 로고
    • Type I insulin-like growth factor receptor as a therapeutic target in cancer
    • Miller BS and Yee D: Type I insulin-like growth factor receptor as a therapeutic target in cancer. Cancer Res 65: 10123-10127, 2005.
    • (2005) Cancer Res , vol.65 , pp. 10123-10127
    • Miller, B.S.1    Yee, D.2
  • 3
    • 0028579733 scopus 로고
    • Oncogenes and the strategy of growth factors
    • Baserga R: Oncogenes and the strategy of growth factors. Cell 79: 927-930, 1994.
    • (1994) Cell , vol.79 , pp. 927-930
    • Baserga, R.1
  • 4
    • 33748416494 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor as a candidate for a novel molecular target in the gastrointestinal cancers
    • Adachi Y, Yamamoto H, Imsumran A, et al: Insulin-like growth factor-I receptor as a candidate for a novel molecular target in the gastrointestinal cancers. Dig Endosc 18: 245-251, 2006.
    • (2006) Dig Endosc , vol.18 , pp. 245-251
    • Adachi, Y.1    Yamamoto, H.2    Imsumran, A.3
  • 5
    • 0036111682 scopus 로고    scopus 로고
    • Insulin-like growth factors and cancer
    • Furstenberger G and Senn HJ: Insulin-like growth factors and cancer. Lancet Oncol 3: 298-302, 2002.
    • (2002) Lancet Oncol , vol.3 , pp. 298-302
    • Furstenberger, G.1    Senn, H.J.2
  • 6
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD and Cantley LC: AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274, 2007.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 7
    • 0037032817 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways mediated by ER K, JNK and p38 protein kinases
    • Johnson GL and Lapadat R: Mitogen-activated protein kinase pathways mediated by ER K, JNK and p38 protein kinases. Science 298: 1911-1912, 2002.
    • (2002) Science , vol.298 , pp. 1911-1912
    • Johnson, G.L.1    Lapadat, R.2
  • 8
    • 0037110602 scopus 로고    scopus 로고
    • Overexpression of the insulin-like growth factor I receptor in human colon carcinomas
    • Weber MM, Fottner C, Liu SB, Jung MC, Engelhardt D and Baretton GB: Overexpression of the insulin-like growth factor I receptor in human colon carcinomas. Cancer 95: 2086-2095, 2002.
    • (2002) Cancer , vol.95 , pp. 2086-2095
    • Weber, M.M.1    Fottner, C.2    Liu, S.B.3    Jung, M.C.4    Engelhardt, D.5    Baretton, G.B.6
  • 9
    • 19944369418 scopus 로고    scopus 로고
    • A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer
    • Jiang Y, Wang L, Gong W, Wei D, Le X, Yao J, Ajani J, Abbruzzese JL, Huang S and Xie K: A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer. Clin Exp Metastasis 21: 755-764, 2004.
    • (2004) Clin Exp Metastasis , vol.21 , pp. 755-764
    • Jiang, Y.1    Wang, L.2    Gong, W.3    Wei, D.4    Le, X.5    Yao, J.6    Ajani, J.7    Abbruzzese, J.L.8    Huang, S.9    Xie, K.10
  • 10
    • 34447095442 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor as a marker for prognosis and a therapeutic target in human esophageal squamous cell carcinoma
    • Imsumran A, Adachi Y, Yamamoto H, et al: Insulin-like growth factor-I receptor as a marker for prognosis and a therapeutic target in human esophageal squamous cell carcinoma. Carcinogenesis 28: 947-956, 2007.
    • (2007) Carcinogenesis , vol.28 , pp. 947-956
    • Imsumran, A.1    Adachi, Y.2    Yamamoto, H.3
  • 11
    • 0028997487 scopus 로고
    • Insulin-like growth factor I overexpression in human pancreatic cancer: Evidence for autocrine and paracrine roles
    • Bergmann U, Funatomi H, Yokoyama M, Beger HG and Korc M: Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles. Cancer Res 55: 2007-2011, 1995.
    • (1995) Cancer Res , vol.55 , pp. 2007-2011
    • Bergmann, U.1    Funatomi, H.2    Yokoyama, M.3    Beger, H.G.4    Korc, M.5
  • 12
  • 13
    • 33846874575 scopus 로고    scopus 로고
    • The role of the IGF system in cancer growth and metastasis: Overview and recent insights
    • Samani AA, Yakar S, LeRoith D and Brodt P: The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocrine 28: 20-47, 2007.
    • (2007) Endocrine , vol.28 , pp. 20-47
    • Samani, A.A.1    Yakar, S.2    LeRoith, D.3    Brodt, P.4
  • 15
    • 60549112878 scopus 로고    scopus 로고
    • Insulin receptor substrate-2- mediated insulin-like growth factor-I receptor overexpression in pancreatic adenocarcinoma through protein kinase Cdelta
    • Kwon J, Stephan S, Mukhopadhyay A, Muders MH, Dutta SK, Lau JS and Mukhopadhyay D: Insulin receptor substrate-2- mediated insulin-like growth factor-I receptor overexpression in pancreatic adenocarcinoma through protein kinase Cdelta. Cancer Res 69: 1350-1357, 2009.
    • (2009) Cancer Res , vol.69 , pp. 1350-1357
    • Kwon, J.1    Stephan, S.2    Mukhopadhyay, A.3    Muders, M.H.4    Dutta, S.K.5    Lau, J.S.6    Mukhopadhyay, D.7
  • 16
    • 0028068826 scopus 로고
    • The insulin-like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer
    • Almeida A, Muleris M, Dutrillaux B and Malfoy B: The insulin-like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer. Genes Chromosomes Cancer 11: 63-65, 1994.
    • (1994) Genes Chromosomes Cancer , vol.11 , pp. 63-65
    • Almeida, A.1    Muleris, M.2    Dutrillaux, B.3    Malfoy, B.4
  • 17
    • 0026605211 scopus 로고
    • Sporadic amplifi cation of the insulin-like growth factor 1 receptor gene in human breast tumors
    • Berns EM, Klijn JG, van Staveren IL, Portengen H and Foekens JA: Sporadic amplifi cation of the insulin-like growth factor 1 receptor gene in human breast tumors. Cancer Res 52: 1036-1039, 1992.
    • (1992) Cancer Res , vol.52 , pp. 1036-1039
    • Berns, E.M.1    Klijn, J.G.2    van Staveren, I.L.3    Portengen, H.4    Foekens, J.A.5
  • 18
    • 0033991993 scopus 로고    scopus 로고
    • DNA copy number changes and evaluation of MYC, IGF1R and FES amplifi cation in xenografts of pancreatic adenocarcinoma
    • Armengol G, Knuutila S, Lluís F, Capellà G, Miró R and Caballín MR: DNA copy number changes and evaluation of MYC, IGF1R and FES amplifi cation in xenografts of pancreatic adenocarcinoma. Cancer Genet Cytogenet 116: 133-141, 2000.
    • (2000) Cancer Genet Cytogenet , vol.116 , pp. 133-141
    • Armengol, G.1    Knuutila, S.2    Lluís, F.3    Capellà, G.4    Miró, R.5    Caballín, M.R.6
  • 20
    • 49649092885 scopus 로고    scopus 로고
    • Alterations in RN A-binding activities of IRES -regulatory proteins as a mechanism for physiological variability and pathological dys-regulation of IGF-IR translational control in human breast tumor cells
    • Meng Z, Jackson NL, Choi H, King PH, Emanuel PD and Blume SW: Alterations in RN A-binding activities of IRES -regulatory proteins as a mechanism for physiological variability and pathological dys-regulation of IGF-IR translational control in human breast tumor cells. J Cell Physiol 217: 172-183, 2008.
    • (2008) J Cell Physiol , vol.217 , pp. 172-183
    • Meng, Z.1    Jackson, N.L.2    Choi, H.3    King, P.H.4    Emanuel, P.D.5    Blume, S.W.6
  • 22
    • 0036112482 scopus 로고    scopus 로고
    • Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3 and risk of colorectal cancer: A prospective study in northern Sweden
    • Palmqvist R, Hallmans G, Rinaldi S, Biessy C, Stenling R, Riboli E and Kaaks R: Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3 and risk of colorectal cancer: a prospective study in northern Sweden. Gut 50: 642-646, 2002.
    • (2002) Gut , vol.50 , pp. 642-646
    • Palmqvist, R.1    Hallmans, G.2    Rinaldi, S.3    Biessy, C.4    Stenling, R.5    Riboli, E.6    Kaaks, R.7
  • 23
    • 19944425991 scopus 로고    scopus 로고
    • Low levels of insulin-like growth factor type 1 receptor expression at cancer cell membrane predict liver metastasis in Dukes' C human colorectal cancers
    • Nakamura M, Miyamoto S, Maeda H, Zhang SC, Sangai T, Ishii G G, Hasebe T, Endoh Y, Saito N, Asaka M and Ochiai A: Low levels of insulin-like growth factor type 1 receptor expression at cancer cell membrane predict liver metastasis in Dukes' C human colorectal cancers. Clin Cancer Res 10: 8434-8441, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 8434-8441
    • Nakamura, M.1    Miyamoto, S.2    Maeda, H.3    Zhang, S.C.4    Sangai, T.5    Ishii, G.6    Hasebe, T.7    Endoh, Y.8    Saito, N.9    Asaka, M.10    Ochiai, A.11
  • 24
    • 33645989468 scopus 로고    scopus 로고
    • The insulin-like growth factor receptor 1 is a promising target for novel treatment approaches in neuroendocrine gastrointestinal tumours
    • Höpfner M, Baradari V, Huether A, Schöfl C and Scherübl H: The insulin-like growth factor receptor 1 is a promising target for novel treatment approaches in neuroendocrine gastrointestinal tumours. Endocr Relat Cancer 13: 135-149, 2006.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 135-149
    • Höpfner, M.1    Baradari, V.2    Huether, A.3    Schöfl, C.4    Scherübl, H.5
  • 25
    • 33750139113 scopus 로고    scopus 로고
    • Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer
    • Hopfner M, Sutter AP, Huether A, Baradari V and Scherubl H: Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer. World J Gastroenterol 12: 5635-5643, 2006.
    • (2006) World J Gastroenterol , vol.12 , pp. 5635-5643
    • Hopfner, M.1    Sutter, A.P.2    Huether, A.3    Baradari, V.4    Scherubl, H.5
  • 26
    • 49849098247 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas
    • Piao W, Wang Y, Adachi Y, et al: Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas. Mol Cancer Ther 7: 1483-1493, 2008.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1483-1493
    • Piao, W.1    Wang, Y.2    Adachi, Y.3
  • 27
    • 33748310896 scopus 로고    scopus 로고
    • Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells
    • Bauer TW, Somcio RJ, Fan F, Liu W, Johnson M, Lesslie DP, Evans DB, Gallick GE and Ellis LM: Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells. Mol Cancer Ther 5: 1676-1682, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1676-1682
    • Bauer, T.W.1    Somcio, R.J.2    Fan, F.3    Liu, W.4    Johnson, M.5    Lesslie, D.P.6    Evans, D.B.7    Gallick, G.E.8    Ellis, L.M.9
  • 29
    • 0032850369 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death-proliferative and anti-apoptotic effects
    • Gooch JL, van Den Berg CL and Yee D: Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death-proliferative and anti-apoptotic effects. Breast Cancer Res Treat 56: 1-10, 1999.
    • (1999) Breast Cancer Res Treat , vol.56 , pp. 1-10
    • Gooch, J.L.1    van Den Berg, C.L.2    Yee, D.3
  • 30
    • 0033768157 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor antagonism augments response to chemoradiation therapy in colon cancer cells
    • Perer ES, Madan AK, Shurin A, Zakris E, Romeguera K, Pang Y and Beech DJ: Insulin-like growth factor I receptor antagonism augments response to chemoradiation therapy in colon cancer cells. J Surg Res 94: 1-5, 2000.
    • (2000) J Surg Res , vol.94 , pp. 1-5
    • Perer, E.S.1    Madan, A.K.2    Shurin, A.3    Zakris, E.4    Romeguera, K.5    Pang, Y.6    Beech, D.J.7
  • 31
    • 20244366701 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts
    • Min Y, Adachi Y, Yamamoto H, Imsumran A, Arimura Y, Endo T, Hinoda Y, Lee CT, Nadaf S, Carbone DP and Imai K: Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts. Gut 54: 591-600, 2005.
    • (2005) Gut , vol.54 , pp. 591-600
    • Min, Y.1    Adachi, Y.2    Yamamoto, H.3    Imsumran, A.4    Arimura, Y.5    Endo, T.6    Hinoda, Y.7    Lee, C.T.8    Nadaf, S.9    Carbone, D.P.10    Imai, K.11
  • 32
    • 0022800838 scopus 로고
    • Insulin-like growth factor I receptor primary structure: Comparison with insulin receptor suggests structural determinants that defi ne functional specifi city
    • Ullrich A, Gray A, Tam AW, et al: Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that defi ne functional specifi city. EMBO J 5: 2503-2512, 1986.
    • (1986) EMBO J , vol.5 , pp. 2503-2512
    • Ullrich, A.1    Gray, A.2    Tam, A.W.3
  • 33
    • 23044493251 scopus 로고    scopus 로고
    • Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer
    • Hofmann F and Garcia-Echeverria C: Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer. Drug Discov Today 10: 1041-1047, 2005.
    • (2005) Drug Discov Today , vol.10 , pp. 1041-1047
    • Hofmann, F.1    Garcia-Echeverria, C.2
  • 34
    • 0142117228 scopus 로고    scopus 로고
    • Increased expression of the mannose 6-phosphate/insulin-like growth factor-II receptor in breast cancer cells alters tumorigenic properties in vitro and in vivo
    • Lee JS, Weiss J, Martin JL and Scott CD: Increased expression of the mannose 6-phosphate/insulin-like growth factor-II receptor in breast cancer cells alters tumorigenic properties in vitro and in vivo. Int J Cancer 107: 564-570, 2003.
    • (2003) Int J Cancer , vol.107 , pp. 564-570
    • Lee, J.S.1    Weiss, J.2    Martin, J.L.3    Scott, C.D.4
  • 35
    • 0036682286 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein-1 (IGFBP-1) inhibits breast cancer cell motility
    • Zhang X and Yee D: Insulin-like growth factor binding protein-1 (IGFBP-1) inhibits breast cancer cell motility. Cancer Res 62: 4369-4375, 2002.
    • (2002) Cancer Res , vol.62 , pp. 4369-4375
    • Zhang, X.1    Yee, D.2
  • 36
    • 4344591505 scopus 로고    scopus 로고
    • Growth inhibition of human prostate cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice by a ligand-specific antibody to human insulin-like growth factors
    • Goya M, Miyamoto S, Nagai K, et al: Growth inhibition of human prostate cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice by a ligand-specific antibody to human insulin-like growth factors. Cancer Res 64: 6252-6258, 2004.
    • (2004) Cancer Res , vol.64 , pp. 6252-6258
    • Goya, M.1    Miyamoto, S.2    Nagai, K.3
  • 37
    • 54349093798 scopus 로고    scopus 로고
    • Insulin, insulin-like growth factors and neoplasia
    • Pollak M: Insulin, insulin-like growth factors and neoplasia. Best Pract Res Clin Endocrinol Metab 22: 625-638, 2008.
    • (2008) Best Pract Res Clin Endocrinol Metab , vol.22 , pp. 625-638
    • Pollak, M.1
  • 38
    • 54049108939 scopus 로고    scopus 로고
    • Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: Lessons from the first clinical trials
    • Rodon J, DeSantos V, Ferry RJ Jr and Kurzrock R: Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials. Mol Cancer Ther 7: 2575-2588, 2008.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2575-2588
    • Rodon, J.1    Desantos, V.2    Ferry Jr., R.J.3    Kurzrock, R.4
  • 42
    • 9144234724 scopus 로고    scopus 로고
    • A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo
    • Burtrum D, Zhu Z, Lu D, et al: A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res 63: 8912-8921, 2003.
    • (2003) Cancer Res , vol.63 , pp. 8912-8921
    • Burtrum, D.1    Zhu, Z.2    Lu, D.3
  • 44
    • 33845959800 scopus 로고    scopus 로고
    • Antibody targeting of the insulin-like growth factor I receptor enhances the anti-tumor response of multiple myeloma to chemotherapy through inhibition of tumor proliferation and angiogenesis
    • Wu KD, Zhou L, Burtrum D, Ludwig DL and Moore MA: Antibody targeting of the insulin-like growth factor I receptor enhances the anti-tumor response of multiple myeloma to chemotherapy through inhibition of tumor proliferation and angiogenesis. Cancer Immunol Immunother 56: 343-357, 2007.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 343-357
    • Wu, K.D.1    Zhou, L.2    Burtrum, D.3    Ludwig, D.L.4    Moore, M.A.5
  • 45
    • 34848902796 scopus 로고    scopus 로고
    • IMC-A12 enhances the efficacy of cetuximab + gemcitabine therapy in human pancreatic carcinoma xenografts
    • Prewett M, Damoci C, Bassi R, Ludwig DL, Hicklin DJ and Tonra JR: IMC-A12 enhances the efficacy of cetuximab + gemcitabine therapy in human pancreatic carcinoma xenografts. Proc Am Assoc Cancer Res 48: 652, 2007.
    • (2007) Proc Am Assoc Cancer Res , vol.48 , pp. 652
    • Prewett, M.1    Damoci, C.2    Bassi, R.3    Ludwig, D.L.4    Hicklin, D.J.5    Tonra, J.R.6
  • 47
    • 10344247119 scopus 로고    scopus 로고
    • A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the anti-tumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts
    • Goetsch L, Gonzalez A, Leger O, Beck A, Pauwels PJ, Haeuw JF and Corvaia N: A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the anti-tumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts. Int J Cancer 113: 316-328, 2005.
    • (2005) Int J Cancer , vol.113 , pp. 316-328
    • Goetsch, L.1    Gonzalez, A.2    Leger, O.3    Beck, A.4    Pauwels, P.J.5    Haeuw, J.F.6    Corvaia, N.7
  • 48
    • 64249110119 scopus 로고    scopus 로고
    • Molecular mechanisms involved in activity of h7C10, a humanized monoclonal antibody, to IGF-1 receptor
    • Broussas M, Dupont J, Gonzalez A, Blaecke A, Fournier M, Corvaïa N and Goetsch L: Molecular mechanisms involved in activity of h7C10, a humanized monoclonal antibody, to IGF-1 receptor. Int J Cancer 124: 2281-2293, 2009.
    • (2009) Int J Cancer , vol.124 , pp. 2281-2293
    • Broussas, M.1    Dupont, J.2    Gonzalez, A.3    Blaecke, A.4    Fournier, M.5    Corvaïa, N.6    Goetsch, L.7
  • 49
    • 34248170187 scopus 로고    scopus 로고
    • Functional responses and in vivo anti-tumour activity of h7C10: A humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors
    • Pandini G, Wurch T, Akla B, et al: Functional responses and in vivo anti-tumour activity of h7C10: a humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors. Eur J Cancer 43: 1318-1327, 2007.
    • (2007) Eur J Cancer , vol.43 , pp. 1318-1327
    • Pandini, G.1    Wurch, T.2    Akla, B.3
  • 52
    • 51049095723 scopus 로고    scopus 로고
    • Nordihydroguaiaretic acid, a cytotoxic insulin-like growth factor-I receptor/HER2 inhibitor in trastuzumab-resistant breast cancer
    • Rowe DL, Ozbay T, Bender LM and Nahta R: Nordihydroguaiaretic acid, a cytotoxic insulin-like growth factor-I receptor/HER2 inhibitor in trastuzumab-resistant breast cancer. Mol Cancer Ther 7: 1900-1908, 2008.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1900-1908
    • Rowe, D.L.1    Ozbay, T.2    Bender, L.M.3    Nahta, R.4
  • 53
    • 38549094538 scopus 로고    scopus 로고
    • A pilot dose-escalation study of the effects of nordihydroguareacetic acid on hormone and prostate specific antigen levels in patients with relapsed prostate cancer
    • Ryan CJ, Harzstark AH, Rosenberg J, Lin A, Claros C, Goldfine ID, Kerner JF, Small EJ and Youngren JF: A pilot dose-escalation study of the effects of nordihydroguareacetic acid on hormone and prostate specific antigen levels in patients with relapsed prostate cancer. BJU Int 101: 436-439, 2008.
    • (2008) BJU Int , vol.101 , pp. 436-439
    • Ryan, C.J.1    Harzstark, A.H.2    Rosenberg, J.3    Lin, A.4    Claros, C.5    Goldfine, I.D.6    Kerner, J.F.7    Small, E.J.8    Youngren, J.F.9
  • 54
    • 12144285705 scopus 로고    scopus 로고
    • In vivo antitumor activity of NVP-AEW541 - a novel, potent and selective inhibitor of the IGF-IRkinase
    • Garcia-Echeverria C, Pearson MA, Marti A, et al: In vivo antitumor activity of NVP-AEW541 - a novel, potent and selective inhibitor of the IGF-IRkinase. Cancer Cell 53: 231-239, 2004.
    • (2004) Cancer Cell , vol.53 , pp. 231-239
    • Garcia-Echeverria, C.1    Pearson, M.A.2    Marti, A.3
  • 55
    • 46049100584 scopus 로고    scopus 로고
    • Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis
    • Moser C, Schachtschneider P, Lang SA, Gaumann A, Mori A, Zimmermann J, Schlitt HJ, Geissler EK and Stoeltzing O: Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis. Eur J Cancer 44: 1577-1586, 2008.
    • (2008) Eur J Cancer , vol.44 , pp. 1577-1586
    • Moser, C.1    Schachtschneider, P.2    Lang, S.A.3    Gaumann, A.4    Mori, A.5    Zimmermann, J.6    Schlitt, H.J.7    Geissler, E.K.8    Stoeltzing, O.9
  • 56
    • 33646040417 scopus 로고    scopus 로고
    • Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells
    • Höpfner M, Huether A, Sutter AP, Baradari V, Schuppan D and Scherübl H: Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells. Bio Chem Pharmacol 71: 1435-1448, 2006.
    • (2006) Bio Chem Pharmacol , vol.71 , pp. 1435-1448
    • Höpfner, M.1    Huether, A.2    Sutter, A.P.3    Baradari, V.4    Schuppan, D.5    Scherübl, H.6
  • 57
    • 66449091211 scopus 로고    scopus 로고
    • Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis
    • Kaulfuss S, Burfeind P, Gaedcke J and Scharf JG: Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis. Mol Cancer Ther 8: 821-833, 2009.
    • (2009) Mol Cancer Ther , vol.8 , pp. 821-833
    • Kaulfuss, S.1    Burfeind, P.2    Gaedcke, J.3    Scharf, J.G.4
  • 58
    • 0035185571 scopus 로고    scopus 로고
    • Structure and autoregulation of the insulin-like growth factor 1 receptor kinase
    • Favelyukis S, Till JH, Hubbard SR and Miller WT: Structure and autoregulation of the insulin-like growth factor 1 receptor kinase. Nat Struct Biol 8: 1058-1063, 2001.
    • (2001) Nat Struct Biol , vol.8 , pp. 1058-1063
    • Favelyukis, S.1    Till, J.H.2    Hubbard, S.R.3    Miller, W.T.4
  • 59
    • 1642494838 scopus 로고    scopus 로고
    • Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth
    • Girnita A, Girnita L, del Prete F, Bartolazzi A, Larsson O and Axelson M: Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res 64: 236-242, 2004.
    • (2004) Cancer Res , vol.64 , pp. 236-242
    • Girnita, A.1    Girnita, L.2    del Prete, F.3    Bartolazzi, A.4    Larsson, O.5    Axelson, M.6
  • 60
    • 7644223079 scopus 로고    scopus 로고
    • The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway
    • Vasilcanu D, Girnita A, Girnita L, Vasilcanu R, Axelson M and Larsson O: The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway. Oncogene 23: 7854-7862, 2004.
    • (2004) Oncogene , vol.23 , pp. 7854-7862
    • Vasilcanu, D.1    Girnita, A.2    Girnita, L.3    Vasilcanu, R.4    Axelson, M.5    Larsson, O.6
  • 63
    • 34548699650 scopus 로고    scopus 로고
    • Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: Beneficial effects on tumor growth, angiogenesis, bone disease and survival
    • Menu E, Jernberg-Wiklund H, de Raeve H, et al: Targeting the IGF-1R using picropodophyllin in the therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival. Int J Cancer 121: 1857-1861, 2007.
    • (2007) Int J Cancer , vol.121 , pp. 1857-1861
    • Menu, E.1    Jernberg-Wiklund, H.2    de Raeve, H.3
  • 64
    • 40449095393 scopus 로고    scopus 로고
    • Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: Potential mechanistic involvement of Mdm2 and beta-arrestin1
    • Vasilcanu R, Vasilcanu D, Rosengren L, Natalishvili N, Sehat B, Yin S, Girnita A, Axelson M, Girnita L and Larsson O: Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1. Oncogene 27: 1629-1638, 2008.
    • (2008) Oncogene , vol.27 , pp. 1629-1638
    • Vasilcanu, R.1    Vasilcanu, D.2    Rosengren, L.3    Natalishvili, N.4    Sehat, B.5    Yin, S.6    Girnita, A.7    Axelson, M.8    Girnita, L.9    Larsson, O.10
  • 65
    • 40849131149 scopus 로고    scopus 로고
    • Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin
    • Vasilcanu R, Vasilcanu D, Sehat B, Yin S, Girnita A, Axelson M and Girnita L: Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin. Mol Pharmacol 73: 930-939, 2008.
    • (2008) Mol Pharmacol , vol.73 , pp. 930-939
    • Vasilcanu, R.1    Vasilcanu, D.2    Sehat, B.3    Yin, S.4    Girnita, A.5    Axelson, M.6    Girnita, L.7
  • 66
    • 34047270772 scopus 로고    scopus 로고
    • Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-I receptor
    • Linder S, Shoshan MC and Gupta RS: Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-I receptor. Cancer Res 67: 2899-2900, 2007.
    • (2007) Cancer Res , vol.67 , pp. 2899-2900
    • Linder, S.1    Shoshan, M.C.2    Gupta, R.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.