Abundance of a distinct cluster of telomere t-stumps in advanced breast cancer cell line

Oncology Letters

Volumn 1, Issue 2, 2010, Pages 339-343

  Pai, Rekha B ^a   Balakrishna Pai, S ^b   Yang, Lily ^a   Joshi, Harish C ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Cluster of t stumps; Immortalized cell line; Invasive metastatic cell line; Isogenic breast cancer cell lines; Telomerase reverse transcriptase; Telomere t stumps

Indexed keywords

CHROMOSOME PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN; PROGESTERONE; TELOMERASE;

ADVANCED CANCER; ARTICLE; BREAST CANCER; BREAST TUMOR; CANCER CELL CULTURE; CELL IMMORTALIZATION; CHROMOSOME ANALYSIS; CHROMOSOME SIZE; FEMALE; HUMAN; HUMAN CELL; MOLECULAR SIZE; PHENOTYPE; TARGET CELL; TELOMERE;

EID: 77955752584     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol_00000060     Document Type: Article

References (20)

1. Chu D and Lu J: Novel therapies in breast cancer: what is new from ASCO 2008. J Hematol Oncol 1: 16, 2008.
2. Pai SB, Steele VE and Nettesheim P: Neoplastic transformation of primary tracheal epithelial cell cultures. Carcinogenesis 4: 369-374, 1983.
3. Elenbaas B, Spirio L, Koerner F, Fleming MD, Zimonjic DB, Donaher JL, Popescu NC, Hahn WC and Weinberg RA: Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev 15: 50-65, 2001.
4. Rosen EM, Fan S and Isaacs C: BRCA1 in hormonal carcinogenesis: basic and clinical research. Endocr Relat Cancer 12: 533-548, 2005.
5. Greider CW and Blackburn EH: A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337: 331-337, 1989.
6. Blackburn EH: Switching and signaling at the telomere. Cell 106: 661-673, 2001.
7. Harley CB, Futcher AB and Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460, 1990.
8. Shay JW and Bacchetti S: A survey of telomerase activity in human cancer. Eur J Cancer 33: 787-791, 1997.
9. Zhu J, Wang H, Bishop JM and Blackburn EH: Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci USA 96: 3723-3728, 1999.
10. Pai RB, Pai SB, Kukhanova M, Dutschman GE, Guo X and Cheng YC: Telomerase from human leukemia cells: properties and its interaction with deoxynucleoside analogues. Cancer Res 58: 1909-1913, 1998.
11. Calado RT, Regal JA, Hills M, Yewdel WT, Dalmazoo LF, Zago MF, Zago MA, Lansdorp PM, Hogge D, Chanock SJ, Estey EJ, Falcao RP and Young NS: Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci USA 106: 1187-1192, 2009.
12. Xu L and Blackburn EH: Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres. Mol Cell 28: 315-327, 2007.
13. D'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, von Zglinicki T, Saretzki G, Carter NP and Jackson SP: A DNA damage checkpoint response in telomere-initiated senescence. Nature 426: 194-198, 2003.
14. Sarrio D, Rodriguez-Pimilla SM, Hardisson D, Cano A, Moreno-Bueno G and Palacios J: Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype. Cancer Res 68: 989-997, 2008.
15. Baird DM, Rowson J, Wynford-Thomas D and Kipling D: Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet 33: 203-207, 2003.
16. Liu ZB, Liu GY, Yang WT, Di GH, Lu JS, Shen KW, Shen ZZ, Shao ZM and Wu J: Triple-negative breast cancer types exhibit a distinct poor clinical characteristic in lymph node-negative Chinese patients. Oncol Rep 20: 987-994, 2008.
17. Hu M, Yao J, Carroll DK, Weremowicz S, Chen H, Carrasco D, Richardson A, Violette S, Nikolskaya T, Nikolsky Y, Bauerlein EL, Hahn WC, Gelman RS, Allred C, Bissell MJ, Schnitt S and Polyak K: Regulation of in situ to invasive breast carcinoma transition. Cancer Cell 13: 394-406, 2008.
18. Britt-Compton B, Capper R, Rowson J and Baird DM: Short telomeres are preferentially elongated by telomerase in human cells. FEBS Lett 583: 3076-3080, 2009.
19. Bianchi A and Shore D: Early replication of short telomeres in budding yeast. Cell 128: 1051-1062, 2007.
20. Morrish TA and Greider CW: Short telomeres initiate telomere recombination in primary and tumor cells. PLoS Genet 5: e1000357, 2009.