Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels

Journal of Physiology

Volumn 588, Issue 16, 2010, Pages 2999-3009

  Kolbe, Katrin ^a   Schönherr, Roland ^a   Gessner, Guido ^a   Sahoo, Nirakar ^a   Hoshi, Toshinori ^b   Heinemann, Stefan H ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; GLUCOSE; HYDROGEN PEROXIDE; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL HERG1; REACTIVE OXYGEN METABOLITE; TOSYLCHLORAMIDE SODIUM; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CELL STRESS; CONTROLLED STUDY; GENE DELETION; HUMAN; HUMAN CELL; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; WHOLE CELL; CHANNEL GATING; GENE; HEK293 CELL LINE; HERG1 GENE; HYPERGLYCEMIA; MUTAGENESIS; OXIDATIVE STRESS; PROTEIN DOMAIN; PROTEIN FUNCTION; WHOLE CELL PATCH CLAMP;

CELL LINE; CYSTEINE; ETHER-A-GO-GO POTASSIUM CHANNELS; GLUCOSE; HUMANS; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXIDANTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL REAGENTS; TRANSFECTION;

EID: 77955731294     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2010.192468     Document Type: Article

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