메뉴 건너뛰기




Volumn 15, Issue 5, 2010, Pages 753-759

Hsp90 modulates CAG repeat instability in human cells

Author keywords

Homologous recombination; Hsp90 chaperone; Repeat instability; Stress induced mutation

Indexed keywords

CHAPERONE; HEAT SHOCK PROTEIN 90; RAD51 PROTEIN; SMALL INTERFERING RNA;

EID: 77955716080     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-010-0191-0     Document Type: Article
Times cited : (34)

References (47)
  • 1
    • 0347993069 scopus 로고    scopus 로고
    • Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress
    • 10.1074/jbc.M309054200 1:CAS:528:DC%2BD3sXpvFGjsLo%3D 14570880
    • SJ Arlander AK Eapen BT Vroman RJ McDonald DO Toft LM Karnitz 2003 Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress J Biol Chem 278 52572 52577 10.1074/jbc.M309054200 1:CAS:528:DC%2BD3sXpvFGjsLo%3D 14570880
    • (2003) J Biol Chem , vol.278 , pp. 52572-52577
    • Arlander, S.J.1    Eapen, A.K.2    Vroman, B.T.3    McDonald, R.J.4    Toft, D.O.5    Karnitz, L.M.6
  • 2
    • 58849160500 scopus 로고    scopus 로고
    • Heat shock protein 90 as a drug target: Some like it hot
    • 10.1158/1078-0432.CCR-08-0132 1:CAS:528:DC%2BD1MXhs1Cjug%3D%3D 19118027
    • U Banerji 2009 Heat shock protein 90 as a drug target: some like it hot Clin Cancer Res 15 9 14 10.1158/1078-0432.CCR-08-0132 1:CAS:528: DC%2BD1MXhs1Cjug%3D%3D 19118027
    • (2009) Clin Cancer Res , vol.15 , pp. 9-14
    • Banerji, U.1
  • 4
    • 34547689351 scopus 로고    scopus 로고
    • Inhibition of Hsp90: A multitarget approach to radiosensitization
    • 10.1158/1078-0432.CCR-07-0632 1:CAS:528:DC%2BD2sXotlGqsL4%3D 17671112
    • K Camphausen PJ Tofilon 2007 Inhibition of Hsp90: a multitarget approach to radiosensitization Clin Cancer Res 13 4326 4330 10.1158/1078-0432.CCR-07-0632 1:CAS:528:DC%2BD2sXotlGqsL4%3D 17671112
    • (2007) Clin Cancer Res , vol.13 , pp. 4326-4330
    • Camphausen, K.1    Tofilon, P.J.2
  • 5
    • 33846208233 scopus 로고    scopus 로고
    • STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90alpha and beta in multiple myeloma cells, which critically contribute to tumor-cell survival
    • 10.1182/blood-2006-05-024372 1:CAS:528:DC%2BD2sXivVyrs7c%3D 17003370
    • M Chatterjee S Jain T Stuhmer M Andrulis U Ungethum RJ Kuban H Lorentz K Bommert M Topp D Kramer HK Muller-Hermelink H Einsele A Greiner RC Bargou 2007 STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90alpha and beta in multiple myeloma cells, which critically contribute to tumor-cell survival Blood 109 720 728 10.1182/blood-2006-05-024372 1:CAS:528: DC%2BD2sXivVyrs7c%3D 17003370
    • (2007) Blood , vol.109 , pp. 720-728
    • Chatterjee, M.1    Jain, S.2    Stuhmer, T.3    Andrulis, M.4    Ungethum, U.5    Kuban, R.J.6    Lorentz, H.7    Bommert, K.8    Topp, M.9    Kramer, D.10    Muller-Hermelink, H.K.11    Einsele, H.12    Greiner, A.13    Bargou, R.C.14
  • 7
    • 32044431688 scopus 로고    scopus 로고
    • Induction of nitric oxide synthase-dependent telomere shortening after functional inhibition of Hsp90 in human tumor cells
    • 10.1128/MCB.26.4.1452-1462.2006 1:CAS:528:DC%2BD28XhsFeqsbY%3D 16449656
    • SA Compton LW Elmore K Haydu CK Jackson-Cook SE Holt 2006 Induction of nitric oxide synthase-dependent telomere shortening after functional inhibition of Hsp90 in human tumor cells Mol Cell Biol 26 1452 1462 10.1128/MCB.26.4.1452- 1462.2006 1:CAS:528:DC%2BD28XhsFeqsbY%3D 16449656
    • (2006) Mol Cell Biol , vol.26 , pp. 1452-1462
    • Compton, S.A.1    Elmore, L.W.2    Haydu, K.3    Jackson-Cook, C.K.4    Holt, S.E.5
  • 8
    • 25844530060 scopus 로고    scopus 로고
    • Hsp90 potentiates the rapid evolution of new traits: Drug resistance in diverse fungi
    • 10.1126/science.1118370 1:CAS:528:DC%2BD2MXhtVeksbbI 16195452
    • LE Cowen S Lindquist 2005 Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi Science 309 2185 2189 10.1126/science.1118370 1:CAS:528:DC%2BD2MXhtVeksbbI 16195452
    • (2005) Science , vol.309 , pp. 2185-2189
    • Cowen, L.E.1    Lindquist, S.2
  • 9
    • 33749469341 scopus 로고    scopus 로고
    • Inhibition of hsp90 compromises the DNA damage response to radiation
    • 10.1158/0008-5472.CAN-06-2181 1:CAS:528:DC%2BD28Xps1aiu7k%3D 16982765
    • H Dote WE Burgan K Camphausen PJ Tofilon 2006 Inhibition of hsp90 compromises the DNA damage response to radiation Cancer Res 66 9211 9220 10.1158/0008-5472.CAN-06-2181 1:CAS:528:DC%2BD28Xps1aiu7k%3D 16982765
    • (2006) Cancer Res , vol.66 , pp. 9211-9220
    • Dote, H.1    Burgan, W.E.2    Camphausen, K.3    Tofilon, P.J.4
  • 10
    • 11144230088 scopus 로고    scopus 로고
    • Molecular origins of rapid and continuous morphological evolution
    • 10.1073/pnas.0408118101 1:CAS:528:DC%2BD2MXjsl2nug%3D%3D 15596718
    • JW Fondon III HR Garner 2004 Molecular origins of rapid and continuous morphological evolution Proc Natl Acad Sci U S A 101 18058 18063 10.1073/pnas.0408118101 1:CAS:528:DC%2BD2MXjsl2nug%3D%3D 15596718
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 18058-18063
    • Fondon Iii, J.W.1    Garner, H.R.2
  • 11
    • 0037150683 scopus 로고    scopus 로고
    • Disassembly of transcriptional regulatory complexes by molecular chaperones
    • 10.1126/science.1073051 1:CAS:528:DC%2BD38XkvFGht7w%3D 12077419
    • BC Freeman KR Yamamoto 2002 Disassembly of transcriptional regulatory complexes by molecular chaperones Science 296 2232 2235 10.1126/science.1073051 1:CAS:528:DC%2BD38XkvFGht7w%3D 12077419
    • (2002) Science , vol.296 , pp. 2232-2235
    • Freeman, B.C.1    Yamamoto, K.R.2
  • 12
    • 47349107760 scopus 로고    scopus 로고
    • ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
    • 10.1016/j.molcel.2008.05.017 1:CAS:528:DC%2BD1cXpsFOgt7c%3D 18657500
    • AA Goodarzi AT Noon D Deckbar Y Ziv Y Shiloh M Lobrich PA Jeggo 2008 ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin Mol Cell 31 167 177 10.1016/j.molcel.2008.05.017 1:CAS:528:DC%2BD1cXpsFOgt7c%3D 18657500
    • (2008) Mol Cell , vol.31 , pp. 167-177
    • Goodarzi, A.A.1    Noon, A.T.2    Deckbar, D.3    Ziv, Y.4    Shiloh, Y.5    Lobrich, M.6    Jeggo, P.A.7
  • 13
    • 0038044708 scopus 로고    scopus 로고
    • Selectable system for monitoring the instability of CTG/CAG triplet repeats in mammalian cells
    • 10.1128/MCB.23.13.4485-4493.2003 1:CAS:528:DC%2BD3sXltVSitrY%3D 12808091
    • V Gorbunova A Seluanov V Dion Z Sandor JL Meservy JH Wilson 2003 Selectable system for monitoring the instability of CTG/CAG triplet repeats in mammalian cells Mol Cell Biol 23 4485 4493 10.1128/MCB.23.13.4485-4493.2003 1:CAS:528:DC%2BD3sXltVSitrY%3D 12808091
    • (2003) Mol Cell Biol , vol.23 , pp. 4485-4493
    • Gorbunova, V.1    Seluanov, A.2    Dion, V.3    Sandor, Z.4    Meservy, J.L.5    Wilson, J.H.6
  • 14
    • 9744253732 scopus 로고    scopus 로고
    • Genome-wide demethylation destabilizes CTG-CAG trinucleotide repeats in mammalian cells
    • 10.1093/hmg/ddh317 1:CAS:528:DC%2BD2cXhtVSkt7bF 15459182
    • V Gorbunova A Seluanov D Mittelman JH Wilson 2004 Genome-wide demethylation destabilizes CTG-CAG trinucleotide repeats in mammalian cells Hum Mol Genet 13 2979 2989 10.1093/hmg/ddh317 1:CAS:528:DC%2BD2cXhtVSkt7bF 15459182
    • (2004) Hum Mol Genet , vol.13 , pp. 2979-2989
    • Gorbunova, V.1    Seluanov, A.2    Mittelman, D.3    Wilson, J.H.4
  • 15
    • 33744930829 scopus 로고    scopus 로고
    • Flow cytometric detection of tandem repeat mutations induced by various chemical classes
    • 1:CAS:528:DC%2BD28XlsFGkur8%3D 16516933
    • C Healy M Wade A McMahon A Williams DA Johnson C Parfett 2006 Flow cytometric detection of tandem repeat mutations induced by various chemical classes Mutat Res 598 85 102 1:CAS:528:DC%2BD28XlsFGkur8%3D 16516933
    • (2006) Mutat Res , vol.598 , pp. 85-102
    • Healy, C.1    Wade, M.2    McMahon, A.3    Williams, A.4    Johnson, D.A.5    Parfett, C.6
  • 16
    • 23344453535 scopus 로고    scopus 로고
    • Rad51 siRNA delivered by HVJ envelope vector enhances the anti-cancer effect of cisplatin
    • 10.1002/jgm.753 1:CAS:528:DC%2BD2MXhtVCksLbF 15756713
    • M Ito S Yamamoto K Nimura K Hiraoka K Tamai Y Kaneda 2005 Rad51 siRNA delivered by HVJ envelope vector enhances the anti-cancer effect of cisplatin J Gene Med 7 1044 1052 10.1002/jgm.753 1:CAS:528:DC%2BD2MXhtVCksLbF 15756713
    • (2005) J Gene Med , vol.7 , pp. 1044-1052
    • Ito, M.1    Yamamoto, S.2    Nimura, K.3    Hiraoka, K.4    Tamai, K.5    Kaneda, Y.6
  • 17
    • 0034102420 scopus 로고    scopus 로고
    • Meiotic instability of CAG repeat tracts occurs by double-strand break repair in yeast
    • 10.1073/pnas.040460297 1:CAS:528:DC%2BD3cXhslKhtr0%3D 10681451
    • C Jankowski F Nasar DK Nag 2000 Meiotic instability of CAG repeat tracts occurs by double-strand break repair in yeast Proc Natl Acad Sci U S A 97 2134 2139 10.1073/pnas.040460297 1:CAS:528:DC%2BD3cXhslKhtr0%3D 10681451
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 2134-2139
    • Jankowski, C.1    Nasar, F.2    Nag, D.K.3
  • 18
    • 0141484615 scopus 로고    scopus 로고
    • A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
    • 10.1038/nature01913 1:CAS:528:DC%2BD3sXnsV2kt7w%3D 14508491
    • A Kamal L Thao J Sensintaffar L Zhang MF Boehm LC Fritz FJ Burrows 2003 A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors Nature 425 407 410 10.1038/nature01913 1:CAS:528:DC%2BD3sXnsV2kt7w%3D 14508491
    • (2003) Nature , vol.425 , pp. 407-410
    • Kamal, A.1    Thao, L.2    Sensintaffar, J.3    Zhang, L.4    Boehm, M.F.5    Fritz, L.C.6    Burrows, F.J.7
  • 19
    • 42649105426 scopus 로고    scopus 로고
    • The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer
    • 10.1016/j.yexcr.2008.02.013 1:CAS:528:DC%2BD1cXlsF2qsrc%3D 18377894
    • JC Ko JH Hong LH Wang YW Lin 2008 The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer Exp Cell Res 314 1881 1891 10.1016/j.yexcr.2008.02.013 1:CAS:528: DC%2BD1cXlsF2qsrc%3D 18377894
    • (2008) Exp Cell Res , vol.314 , pp. 1881-1891
    • Ko, J.C.1    Hong, J.H.2    Wang, L.H.3    Lin, Y.W.4
  • 20
    • 0035863398 scopus 로고    scopus 로고
    • Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures
    • 1:CAS:528:DC%2BD3MXht1Gnu7Y%3D 11212225
    • CY Li JB Little K Hu W Zhang L Zhang MW Dewhirst Q Huang 2001 Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures Cancer Res 61 428 432 1:CAS:528:DC%2BD3MXht1Gnu7Y%3D 11212225
    • (2001) Cancer Res , vol.61 , pp. 428-432
    • Li, C.Y.1    Little, J.B.2    Hu, K.3    Zhang, W.4    Zhang, L.5    Dewhirst, M.W.6    Huang, Q.7
  • 21
    • 34548204316 scopus 로고    scopus 로고
    • Transcription-induced CAG repeat contraction in human cells is mediated in part by transcription-coupled nucleotide excision repair
    • 10.1128/MCB.00739-07 1:CAS:528:DC%2BD2sXpvFGgt7g%3D 17591697
    • Y Lin JH Wilson 2007 Transcription-induced CAG repeat contraction in human cells is mediated in part by transcription-coupled nucleotide excision repair Mol Cell Biol 27 6209 6217 10.1128/MCB.00739-07 1:CAS:528: DC%2BD2sXpvFGgt7g%3D 17591697
    • (2007) Mol Cell Biol , vol.27 , pp. 6209-6217
    • Lin, Y.1    Wilson, J.H.2
  • 22
    • 32244438870 scopus 로고    scopus 로고
    • Transcription promotes contraction of CAG repeat tracts in human cells
    • 10.1038/nsmb1042 1:CAS:528:DC%2BD28XhtFajsLs%3D 16388310
    • Y Lin V Dion JH Wilson 2006 Transcription promotes contraction of CAG repeat tracts in human cells Nat Struct Mol Biol 13 179 180 10.1038/nsmb1042 1:CAS:528:DC%2BD28XhtFajsLs%3D 16388310
    • (2006) Nat Struct Mol Biol , vol.13 , pp. 179-180
    • Lin, Y.1    Dion, V.2    Wilson, J.H.3
  • 23
    • 76249098186 scopus 로고    scopus 로고
    • R loops stimulate genetic instability of CTG-CAG repeats
    • 10.1073/pnas.0909740107 1:CAS:528:DC%2BC3cXhtFCmsrg%3D 20080737
    • Y Lin SY Dent JH Wilson RD Wells M Napierala 2010 R loops stimulate genetic instability of CTG-CAG repeats Proc Natl Acad Sci U S A 107 692 697 10.1073/pnas.0909740107 1:CAS:528:DC%2BC3cXhtFCmsrg%3D 20080737
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 692-697
    • Lin, Y.1    Dent, S.Y.2    Wilson, J.H.3    Wells, R.D.4    Napierala, M.5
  • 24
    • 0037405845 scopus 로고    scopus 로고
    • Long CTG tracts from the myotonic dystrophy gene induce deletions and rearrangements during recombination at the APRT locus in CHO cells
    • 10.1128/MCB.23.9.3152-3162.2003 1:CAS:528:DC%2BD3sXjt1Gls7Y%3D 12697816
    • JL Meservy RG Sargent RR Iyer F Chan GJ McKenzie RD Wells JH Wilson 2003 Long CTG tracts from the myotonic dystrophy gene induce deletions and rearrangements during recombination at the APRT locus in CHO cells Mol Cell Biol 23 3152 3162 10.1128/MCB.23.9.3152-3162.2003 1:CAS:528:DC%2BD3sXjt1Gls7Y%3D 12697816
    • (2003) Mol Cell Biol , vol.23 , pp. 3152-3162
    • Meservy, J.L.1    Sargent, R.G.2    Iyer, R.R.3    Chan, F.4    McKenzie, G.J.5    Wells, R.D.6    Wilson, J.H.7
  • 25
    • 67649858822 scopus 로고    scopus 로고
    • Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cells
    • 10.1073/pnas.0902420106 1:CAS:528:DC%2BD1MXotFCqurw%3D 19482946
    • D Mittelman C Moye J Morton K Sykoudis Y Lin D Carroll JH Wilson 2009 Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cells Proc Natl Acad Sci U S A 106 9607 9612 10.1073/pnas.0902420106 1:CAS:528:DC%2BD1MXotFCqurw%3D 19482946
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9607-9612
    • Mittelman, D.1    Moye, C.2    Morton, J.3    Sykoudis, K.4    Lin, Y.5    Carroll, D.6    Wilson, J.H.7
  • 26
    • 0030667932 scopus 로고    scopus 로고
    • In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone
    • 10.1073/pnas.94.24.12949 1:CAS:528:DyaK2sXnvFamsrY%3D 9371781
    • DF Nathan MH Vos S Lindquist 1997 In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone Proc Natl Acad Sci U S A 94 12949 12956 10.1073/pnas.94.24.12949 1:CAS:528:DyaK2sXnvFamsrY%3D 9371781
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 12949-12956
    • Nathan, D.F.1    Vos, M.H.2    Lindquist, S.3
  • 27
    • 0742287264 scopus 로고    scopus 로고
    • Heat shock protein 90
    • 10.1097/00001622-200311000-00003 1:CAS:528:DC%2BD3sXptVCmsbg%3D 14624223
    • L Neckers SP Ivy 2003 Heat shock protein 90 Curr Opin Oncol 15 419 424 10.1097/00001622-200311000-00003 1:CAS:528:DC%2BD3sXptVCmsbg%3D 14624223
    • (2003) Curr Opin Oncol , vol.15 , pp. 419-424
    • Neckers, L.1    Ivy, S.P.2
  • 28
    • 33750696349 scopus 로고    scopus 로고
    • Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin
    • 10.1016/j.bbrc.2006.10.094 1:CAS:528:DC%2BD28Xht1SmsbfP 17083915
    • M Noguchi D Yu R Hirayama Y Ninomiya E Sekine N Kubota K Ando R Okayasu 2006 Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin Biochem Biophys Res Commun 351 658 663 10.1016/j.bbrc.2006.10.094 1:CAS:528: DC%2BD28Xht1SmsbfP 17083915
    • (2006) Biochem Biophys Res Commun , vol.351 , pp. 658-663
    • Noguchi, M.1    Yu, D.2    Hirayama, R.3    Ninomiya, Y.4    Sekine, E.5    Kubota, N.6    Ando, K.7    Okayasu, R.8
  • 29
    • 42949165604 scopus 로고    scopus 로고
    • Chaperones as integrators of cellular networks: Changes of cellular integrity in stress and diseases
    • 10.1002/iub.8 1:CAS:528:DC%2BD1cXhtlKqu73N 18379988
    • R Palotai MS Szalay P Csermely 2008 Chaperones as integrators of cellular networks: changes of cellular integrity in stress and diseases IUBMB Life 60 10 18 10.1002/iub.8 1:CAS:528:DC%2BD1cXhtlKqu73N 18379988
    • (2008) IUBMB Life , vol.60 , pp. 10-18
    • Palotai, R.1    Szalay, M.S.2    Csermely, P.3
  • 30
    • 0038799991 scopus 로고    scopus 로고
    • Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
    • 1:STN:280:DyaK1M3os1eksA%3D%3D 10357855
    • F Paques JE Haber 1999 Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae Microbiol Mol Biol Rev 63 349 404 1:STN:280:DyaK1M3os1eksA%3D%3D 10357855
    • (1999) Microbiol Mol Biol Rev , vol.63 , pp. 349-404
    • Paques, F.1    Haber, J.E.2
  • 31
    • 0037030713 scopus 로고    scopus 로고
    • Hsp90 as a capacitor of phenotypic variation
    • 10.1038/nature749 1:CAS:528:DC%2BD38Xkt1ektrk%3D 12050657
    • C Queitsch TA Sangster S Lindquist 2002 Hsp90 as a capacitor of phenotypic variation Nature 417 618 624 10.1038/nature749 1:CAS:528: DC%2BD38Xkt1ektrk%3D 12050657
    • (2002) Nature , vol.417 , pp. 618-624
    • Queitsch, C.1    Sangster, T.A.2    Lindquist, S.3
  • 33
    • 0342965192 scopus 로고    scopus 로고
    • Double-strand break repair can lead to high frequencies of deletions within short CAG/CTG trinucleotide repeats
    • 10.1007/s004380050031 1:CAS:528:DyaK1MXks12mtLw%3D 10394925
    • GF Richard B Dujon JE Haber 1999 Double-strand break repair can lead to high frequencies of deletions within short CAG/CTG trinucleotide repeats Mol Gen Genet 261 871 882 10.1007/s004380050031 1:CAS:528:DyaK1MXks12mtLw%3D 10394925
    • (1999) Mol Gen Genet , vol.261 , pp. 871-882
    • Richard, G.F.1    Dujon, B.2    Haber, J.E.3
  • 34
    • 30444445118 scopus 로고    scopus 로고
    • Interplay between human DNA repair proteins at a unique double-strand break in vivo
    • 10.1038/sj.emboj.7600914 1:CAS:528:DC%2BD28Xis1Khtg%3D%3D 16395335
    • A Rodrigue M Lafrance MC Gauthier D McDonald M Hendzel SC West M Jasin JY Masson 2006 Interplay between human DNA repair proteins at a unique double-strand break in vivo EMBO J 25 222 231 10.1038/sj.emboj.7600914 1:CAS:528:DC%2BD28Xis1Khtg%3D%3D 16395335
    • (2006) EMBO J , vol.25 , pp. 222-231
    • Rodrigue, A.1    Lafrance, M.2    Gauthier, M.C.3    McDonald, D.4    Hendzel, M.5    West, S.C.6    Jasin, M.7    Masson, J.Y.8
  • 35
    • 0032569851 scopus 로고    scopus 로고
    • Hsp90 as a capacitor for morphological evolution
    • 10.1038/24550 1:CAS:528:DyaK1cXnvVaksLY%3D 9845070
    • SL Rutherford S Lindquist 1998 Hsp90 as a capacitor for morphological evolution Nature 396 336 342 10.1038/24550 1:CAS:528:DyaK1cXnvVaksLY%3D 9845070
    • (1998) Nature , vol.396 , pp. 336-342
    • Rutherford, S.L.1    Lindquist, S.2
  • 36
    • 84934439802 scopus 로고    scopus 로고
    • Hsp90 and developmental networks
    • 10.1007/978-0-387-39975-1-16 17205685
    • S Rutherford JR Knapp P Csermely 2007 Hsp90 and developmental networks Adv Exp Med Biol 594 190 197 10.1007/978-0-387-39975-1-16 17205685
    • (2007) Adv Exp Med Biol , vol.594 , pp. 190-197
    • Rutherford, S.1    Knapp, J.R.2    Csermely, P.3
  • 37
    • 40849150376 scopus 로고    scopus 로고
    • HSP90 affects the expression of genetic variation and developmental stability in quantitative traits
    • 10.1073/pnas.0712200105 1:CAS:528:DC%2BD1cXjtVSisbo%3D 18287065
    • TA Sangster N Salathia S Undurraga R Milo K Schellenberg S Lindquist C Queitsch 2008 HSP90 affects the expression of genetic variation and developmental stability in quantitative traits Proc Natl Acad Sci U S A 105 2963 2968 10.1073/pnas.0712200105 1:CAS:528:DC%2BD1cXjtVSisbo%3D 18287065
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2963-2968
    • Sangster, T.A.1    Salathia, N.2    Undurraga, S.3    Milo, R.4    Schellenberg, K.5    Lindquist, S.6    Queitsch, C.7
  • 38
    • 0026591855 scopus 로고
    • A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency
    • 10.1007/BF00220062 1:CAS:528:DyaK3sXkt1GmsLs%3D 1487231
    • DG Sculley PA Dawson BT Emmerson RB Gordon 1992 A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency Hum Genet 90 195 207 10.1007/BF00220062 1:CAS:528:DyaK3sXkt1GmsLs%3D 1487231
    • (1992) Hum Genet , vol.90 , pp. 195-207
    • Sculley, D.G.1    Dawson, P.A.2    Emmerson, B.T.3    Gordon, R.B.4
  • 39
    • 0035893241 scopus 로고    scopus 로고
    • Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange
    • 10.1101/gad.935501 1:CAS:528:DC%2BD38XivFyrsw%3D%3D 11751636
    • S Sigurdsson S Van Komen W Bussen D Schild JS Albala P Sung 2001 Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange Genes Dev 15 3308 3318 10.1101/gad.935501 1:CAS:528: DC%2BD38XivFyrsw%3D%3D 11751636
    • (2001) Genes Dev , vol.15 , pp. 3308-3318
    • Sigurdsson, S.1    Van Komen, S.2    Bussen, W.3    Schild, D.4    Albala, J.S.5    Sung, P.6
  • 40
    • 13944266820 scopus 로고    scopus 로고
    • The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
    • 10.1038/ncb1212 1:CAS:528:DC%2BD2MXpt1CjsA%3D%3D 15665856
    • CS Sorensen LT Hansen J Dziegielewski RG Syljuasen C Lundin J Bartek T Helleday 2005 The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair Nat Cell Biol 7 195 201 10.1038/ncb1212 1:CAS:528:DC%2BD2MXpt1CjsA%3D%3D 15665856
    • (2005) Nat Cell Biol , vol.7 , pp. 195-201
    • Sorensen, C.S.1    Hansen, L.T.2    Dziegielewski, J.3    Syljuasen, R.G.4    Lundin, C.5    Bartek, J.6    Helleday, T.7
  • 41
    • 76349117871 scopus 로고    scopus 로고
    • Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons
    • 10.1038/nature08739 1:CAS:528:DC%2BC3cXjsVaqsw%3D%3D 20062045
    • V Specchia L Piacentini P Tritto L Fanti R D'Alessandro G Palumbo S Pimpinelli MP Bozzetti 2010 Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons Nature 463 662 665 10.1038/nature08739 1:CAS:528:DC%2BC3cXjsVaqsw%3D%3D 20062045
    • (2010) Nature , vol.463 , pp. 662-665
    • Specchia, V.1    Piacentini, L.2    Tritto, P.3    Fanti, L.4    D'Alessandro, R.5    Palumbo, G.6    Pimpinelli, S.7    Bozzetti, M.P.8
  • 42
    • 1642268986 scopus 로고    scopus 로고
    • Hsp90 isoforms: Functions, expression and clinical importance
    • 10.1016/S0014-5793(04)00229-7 15069952
    • AS Sreedhar E Kalmar P Csermely YF Shen 2004 Hsp90 isoforms: functions, expression and clinical importance FEBS Lett 562 11 15 10.1016/S0014-5793(04) 00229-7 15069952
    • (2004) FEBS Lett , vol.562 , pp. 11-15
    • Sreedhar, A.S.1    Kalmar, E.2    Csermely, P.3    Shen, Y.F.4
  • 43
    • 0027741456 scopus 로고
    • Tissue-specific expression of heat shock proteins 70 and 90: Potential implication for differential sensitivity of tissues to glucocorticoids
    • 10.1016/0303-7207(93)90235-C 1:CAS:528:DyaK2cXht1GitbY%3D 8143913
    • NO Vamvakopoulos 1993 Tissue-specific expression of heat shock proteins 70 and 90: potential implication for differential sensitivity of tissues to glucocorticoids Mol Cell Endocrinol 98 49 54 10.1016/0303-7207(93)90235-C 1:CAS:528:DyaK2cXht1GitbY%3D 8143913
    • (1993) Mol Cell Endocrinol , vol.98 , pp. 49-54
    • Vamvakopoulos, N.O.1
  • 44
    • 66349113764 scopus 로고    scopus 로고
    • Unstable tandem repeats in promoters confer transcriptional evolvability
    • 10.1126/science.1170097 1:CAS:528:DC%2BD1MXmsVGisLg%3D 19478187
    • MD Vinces M Legendre M Caldara M Hagihara KJ Verstrepen 2009 Unstable tandem repeats in promoters confer transcriptional evolvability Science 324 1213 1216 10.1126/science.1170097 1:CAS:528:DC%2BD1MXmsVGisLg%3D 19478187
    • (2009) Science , vol.324 , pp. 1213-1216
    • Vinces, M.D.1    Legendre, M.2    Caldara, M.3    Hagihara, M.4    Verstrepen, K.J.5
  • 45
    • 25844519550 scopus 로고    scopus 로고
    • HSP90 and the chaperoning of cancer
    • 10.1038/nrc1716 1:CAS:528:DC%2BD2MXhtVGjs7bF 16175177
    • L Whitesell SL Lindquist 2005 HSP90 and the chaperoning of cancer Nat Rev Cancer 5 761 772 10.1038/nrc1716 1:CAS:528:DC%2BD2MXhtVGjs7bF 16175177
    • (2005) Nat Rev Cancer , vol.5 , pp. 761-772
    • Whitesell, L.1    Lindquist, S.L.2
  • 46
    • 35148815984 scopus 로고    scopus 로고
    • Hsp90 and the Fanconi anemia pathway: A molecular link between protein quality control and the DNA damage response
    • 1:CAS:528:DC%2BD2sXhtlKkt7rL 17881891
    • T Yamashita T Oda T Sekimoto 2007 Hsp90 and the Fanconi anemia pathway: a molecular link between protein quality control and the DNA damage response Cell Cycle 6 2232 2235 1:CAS:528:DC%2BD2sXhtlKkt7rL 17881891
    • (2007) Cell Cycle , vol.6 , pp. 2232-2235
    • Yamashita, T.1    Oda, T.2    Sekimoto, T.3
  • 47
    • 33947386313 scopus 로고    scopus 로고
    • Synergism between etoposide and 17-AAG in leukemia cells: Critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51
    • 10.1158/1078-0432.CCR-06-1750 1:CAS:528:DC%2BD2sXitlSjtLY%3D 17332306
    • Q Yao B Weigel J Kersey 2007 Synergism between etoposide and 17-AAG in leukemia cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51 Clin Cancer Res 13 1591 1600 10.1158/1078-0432.CCR-06-1750 1:CAS:528:DC%2BD2sXitlSjtLY%3D 17332306
    • (2007) Clin Cancer Res , vol.13 , pp. 1591-1600
    • Yao, Q.1    Weigel, B.2    Kersey, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.