Comparison of cyclooxygenase-1 crystal structures: Cross-talk between monomers comprising cyclooxygenase-1 homodimers

Biochemistry

Volumn 49, Issue 33, 2010, Pages 7069-7079

  Sidhu, Ranjinder S ^a   Lee, Jullia Y ^a   Yuan, Chong ^a   Smith, William L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; BIOCHEMISTRY; CROSSTALK; ENZYME INHIBITION; ENZYMES;

ALTERNATIVE ROUTES; BINDING LIGANDS; COX-2 INHIBITORS; CYCLOOXYGENASES; DIMER INTERFACE; ENDOPEROXIDES; HOMODIMERS; ISOFORMS; MEMBRANE BINDING; NONSTEROIDAL ANTI-INFLAMMATORY DRUGS; SYNTHASES;

MONOMERS;

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2 INHIBITOR; HOMODIMER; MONOMER; NONSTEROID ANTIINFLAMMATORY AGENT; PGHS 1 ENZYME; PROSTAGLANDIN; SYNTHETASE; UNCLASSIFIED DRUG; ACETYLSALICYLIC ACID; DICLOFENAC; FLURBIPROFEN; LIGAND; NIMESULIDE; PROTEIN BINDING; SULFONAMIDE;

ARTICLE; CATALYSIS; CRYSTALLIZATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STABILITY; ENZYME STRUCTURE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN SYNTHESIS; STOICHIOMETRY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; ENZYME ACTIVE SITE; METABOLISM; PROTEIN MULTIMERIZATION; SHEEP; X RAY CRYSTALLOGRAPHY;

OVIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2 INHIBITORS; DICLOFENAC; FLURBIPROFEN; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; SHEEP; SULFONAMIDES;

EID: 77955683189     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1003298     Document Type: Article

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