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Volumn 125, Issue 20, 2003, Pages 6054-6055

The first conjugate addition reaction of terminal alkynes catalytic in copper: Conjugate addition of alkynes in water

Author keywords

[No Author keywords available]

Indexed keywords

ALKYNE; COPPER DERIVATIVE; WATER;

EID: 0037613482     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja035311z     Document Type: Article
Times cited : (153)

References (46)
  • 19
    • 0025133581 scopus 로고
    • Conjugate addition reactions of terminal acetylenes using late transition-metal catalysts (Rh, Ru) have been documented. However, these reactions are limited to unsubstituted vinyl ketones, see: Kovalev, I. P.; Nikishin, G. I. Tetrahedron Lett. 1990, 31, 7063-7064. (b) Chang, S.; Na, Y.; Choi, E.; Kim, S. Org. Lett. 2001, 3, 2089-2091.
    • (1990) Tetrahedron Lett. , vol.31 , pp. 7063-7064
    • Kovalev, I.P.1    Nikishin, G.I.2
  • 20
    • 0000793297 scopus 로고    scopus 로고
    • Conjugate addition reactions of terminal acetylenes using late transition-metal catalysts (Rh, Ru) have been documented. However, these reactions are limited to unsubstituted vinyl ketones, see: Kovalev, I. P.; Nikishin, G. I. Tetrahedron Lett. 1990, 31, 7063-7064. (b) Chang, S.; Na, Y.; Choi, E.; Kim, S. Org. Lett. 2001, 3, 2089-2091.
    • (2001) Org. Lett. , vol.3 , pp. 2089-2091
    • Chang, S.1    Na, Y.2    Choi, E.3    Kim, S.4
  • 35
    • 0344814478 scopus 로고
    • For reviews of Meldrum's acid. see: Chen, B. C. Heterocycles 1991, 32, 529-597.
    • (1991) Heterocycles , vol.32 , pp. 529-597
    • Chen, B.C.1
  • 41
    • 0001155299 scopus 로고
    • Glaser, C. Ber. 1869, 2, 422.
    • (1869) Ber. , vol.2 , pp. 422
    • Glaser, C.1
  • 44
    • 0037798578 scopus 로고    scopus 로고
    • note
    • At the current level of development, aliphatic substituted alkynes afford 5-10% yield adduct with 1b, and enynes such as 2-methyl-1-buten-3-yne furnish 20% yield of the corresponding adduct.
  • 45
    • 0038475264 scopus 로고    scopus 로고
    • note
    • In our current working model, we believe that a Cu-acetylide is the key reactive intermediate. Preliminary observations involving the effect on the reaction of adding known ligands for copper are consistent with such a species.
  • 46
    • 0038813053 scopus 로고    scopus 로고
    • note
    • Prices quoted are those for bulk quantities of material.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.