Statistical challenges for genome-wide association studies of suicidality using family data

European Psychiatry

Volumn 25, Issue 5, 2010, Pages 307-309

  Lasky Su, J ^a,b   Lange, C ^a,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Candidate gene; Family based association methods; Genetics; Genome wide association; Psychiatric disorders; Suicidality

Indexed keywords

ARTICLE; EFFECT SIZE; ENVIRONMENTAL FACTOR; FAMILY STUDY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HUMAN GENOME; MATHEMATICAL ANALYSIS; METHODOLOGY; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL ANALYSIS; SUICIDAL BEHAVIOR; SUICIDE; FAMILY; GENETIC PREDISPOSITION; SOCIAL ENVIRONMENT; STATISTICS; STATISTICS AND NUMERICAL DATA;

FAMILY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; SOCIAL ENVIRONMENT; STATISTICS AS TOPIC; SUICIDE;

EID: 77955669139     PISSN: 09249338     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eurpsy.2009.12.019     Document Type: Article

References (20)

1. Bertram L., Lange C., Mullin K., Parkinson M., Hsiao M., Hogan M.F., et al. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet 2008, 83:623-632.
2. Chapman J.M., Cooper J.D., Todd J.A., Clayton D.G. Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum Hered 2003, 56:18-31.
3. Clayton D., Chapman J., Cooper J. Use of unphased multilocus genotype data in indirect association studies. Genet Epidemiol 2004, 27:415-428.
4. Herbert A., Gerry N.P., McQueen M.B., Heid I.M., Pfeufer A., Illig T., et al. A common genetic variant is associated with adult and childhood obesity. Science 2006, 312:279-283.
5. Horvath S., Xu X., Lake S.L., Silverman E.K., Weiss S.T., Laird N.M. Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol 2004, 26:61-69.
6. Ionita-Laza I., McQueen M.B., Laird N.M., Lange C. Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan. Am J Hum Genet 2007, 81:607-614.
7. Lange C., Laird N.M. On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations. Genet Epidemiol 2002, 23:165-180.
8. Lange C., DeMeo D., Silverman E.K., Weiss S.T., Laird N.M. Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet 2003, 73:801-811.
9. Lange C., DeMeo D., Silverman E.K., Weiss S.T., Laird N.M. PBAT: tools for family-based association studies. Am J Hum Genet 2004, 74:367-369.
10. Lange C., van Steen K., Andrew T., Lyon H., DeMeo D.L., Raby B., et al. A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol 2004, 3:1-27.
11. Lasky-Su J., Banaschewski T., Buitelaar J., Franke B., Brookes K., Sonuga-Barke E., et al. Partial replication of a DRD4 association in ADHD individuals using a statistically derived quantitative trait for ADHD in a family-based association test. Biol Psychiatry 2007, 62:985-990.
12. Lasky-Su J., Lyon H.N., Emilsson V., Heid I.M., Molony C., Raby B.A., et al. On the replication of genetic associations: timing can be everything!. Am J Hum Genet 2008, 82:849-858.
13. Lasky-Su J., Neale B.M., Franke B., Anney R.J., Zhou K., Maller J.B., et al. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Am J Med Genet B Neuropsychiatr Genet 2008, 147B:1345-1354.
14. Lasky-Su J., Lange C., Biederman J., Tsuang M., Doyle A.E., Smoller J.W., et al. Family-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individuals. Am J Med Genet B Neuropsychiatr Genet 2008, 147B:100-106.
15. Lasky-Su J, Murphy A, McQueen MB, Weiss ST, Lange C. An omnibus test for family-based association studies with multiple SNPs and multiple phenotype. Eur J Hum Genet 2010.
16. Rabinowitz D., Laird N. A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Heredity 2000, 50:211-223.
17. Rakovski C.S., Xu X., Lazarus R., Blacker D., Laird N.M. A new multimarker test for family-based association studies. Genet Epidemiol 2007, 31:9-17.
18. Spielman R.S., McGinnis R.E., Ewens W.J. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993, 52:506-516.
19. Van Steen K., McQueen M.B., Herbert A., Raby B., Lyon H., Demeo D.L., et al. Genomic screening and replication using the same data set in family-based association testing. Nat Genet 2005, 37:683-691.
20. Wasserman D., Geijer T., Sokolowski M., Rozanov V., Wasserman J. Nature and nurture in suicidal behavior, the role of genetics: some novel findings concerning personality traits and neural conduction. Physiol Behav 2007, 92:245-249.