Using the Noninformative Families in Family-Based Association Tests: A Powerful New Testing Strategy

American Journal of Human Genetics

Volumn 73, Issue 4, 2003, Pages 801-811

  Lange, Christoph ^a   DeMeo, Dawn ^b   Silverman, Edwin K ^b   Weiss, Scott T ^b   Laird, Nan M ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ASTHMA; CALCULATION; FAMILY; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; HYPOTHESIS; METHODOLOGY; PHENOTYPE; POPULATION RESEARCH; PRIORITY JOURNAL; SIMULATION; STATISTICAL ANALYSIS; STRATIFICATION;

EID: 0142122910     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/378591     Document Type: Article

References (20)

1. Abecasis GR, Cardon LR, Cookson WOC (2000) A general test of association for quantitative traits in nuclear families. Am J Hum Genet 66:279-292
2. DeMeo DL, Lange C, Silverman EK, Senter JM, Drazen JM, Barth MJ, Laird NM, Weiss ST (2002) Univariate and multivariate family based analysis of the arg130gln polymorphism of the IL13 gene in the childhood asthma management program. Genet Epidemiol 23:335-348
3. Falconer DS, Mackay TFC (1997) Introduction to quantitative genetics. Longman, New York
4. Childhood Asthma Management Program Research Group (1999) The childhood asthma management program (CAMP): design, rationale, and methods. Control Clin Trials 20:91-120
5. Laird NM, Horvath S, Xu X (2000) Implementing a unified approach to family based tests of association. Genet Epidemiol Suppl 19:S36-S42
6. Lange C, DeMeo D, Laird NM (2002) Power and design considerations for a general class of family-based association tests: quantitative traits. Am J Hum Genet 71:1330-1341
7. Lange C, Laird NM (2002a) Analytical sample size and power calculations for a general class of family-based association tests: dichotomous traits. Am J Hum Genet 71:575-584
8. Lange C, Laird NM (2002b) On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power and optimality considerations. Genet Epidemiol 23:165-180
9. Lange C, Lyon H, DeMeo D, Raby B, Silverman EK, Weiss ST. A new powerful nonparametric two-stage testing strategy for family-based association tests for testing multiple phenotypes using all available data. Hum Hered, in press
10. Lange C, Silverman EK, Xu X, Weiss ST, Laird NM (2003) A multivariate transmission disequilibrium test. Biostatistics 71:195-206
11. Lange C, Whittaker JC (2001) A generalized estimating equation approach to mapping of quantitative trait loci (QTL). Genetics 159:1325-1337
12. Liang KY, Zeger SL (1986) Longitudinal data analysis using generalized linear models. Biometrika 73:13-22
13. Martínez O, Curnow RN (1992) Estimating the locations and the sizes of the effects of quantitative trait loci using flanking markers. Theor Appl Genet 85:480-488
14. Nelder JA, McCullagh P (1989) Generalized linear models, 2nd ed. Chapman and Hall, London
15. Prentice R, Zhao L (1991) Estimating equations for parameters in means and covariance of multivariate discrete and continuous response. Biometrics 47:825-839
16. Rabinowitz D, Laird NM (2000) A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered 50:211-223
17. Risch N, Merikangas (1996) The future of genetic studies of complex human diseases. Science 273:1516-1517
18. Spielman RS, McGinnis RE, Ewens WJ (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516
19. Thomson G (1995) Analysis of complex human genetic traits: an ordered-notation method and new tests for mode of inheritance. Am J Hum Genet 57:474-486
20. Zhao H (2000) Family-based association studies. Stat Methods Med Res 9:563-587