Notch1-induced mammary tumor development is cyclin D1-dependent and correlates with expansion of pre-malignant multipotent duct-limited progenitors

Oncogene

Volumn 29, Issue 32, 2010, Pages 4543-4554

  Ling, H ^a   Sylvestre, J R ^a   Jolicoeur, P ^a,b,c  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

mammary tumors; Notch1; stem cells

Indexed keywords

BETA1 INTEGRIN; CD24 ANTIGEN; CYCLIN D1; MYC PROTEIN; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASAL CELL; BASAL CELL CARCINOMA; BREAST CARCINOGENESIS; BREAST MALFORMATION; CANCER STEM CELL; CELL DIFFERENTIATION; CELL POPULATION; CELL PROLIFERATION; CELL RENEWAL; CELL SURVIVAL; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; INTRADUCTAL CARCINOMA; MALIGNANT TRANSFORMATION; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; MULTIPOTENT STEM CELL; NONHUMAN; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL EXPANSION;

ANIMALS; ANTIGENS, CD24; ANTIGENS, CD29; APOPTOSIS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN D1; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; MAMMARY TUMOR VIRUS, MOUSE; MICE; MICE, TRANSGENIC; MULTIPOTENT STEM CELLS; PTEN PHOSPHOHYDROLASE; RECEPTOR, NOTCH1; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MUS MUSCULUS;

EID: 77955657847     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.186     Document Type: Article

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