Molecular cloning and characterization of two putative appetite regulators in winter flounder (Pleuronectes americanus): Preprothyrotropin-releasing hormone (TRH) and preproorexin (OX)

Peptides

Volumn 31, Issue 9, 2010, Pages 1737-1747

  Buckley, Colleen ^a   MacDonald, Erin E ^a   Tuziak, Sarah M ^a   Volkoff, Hélne ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

Cloning; Expression; Fasting; Feeding; Orexin; Season; TRH; Winter flounder

Indexed keywords

HORMONE PRECURSOR; MESSENGER RNA; OREXIN; PREPROOREXIN; PREPROPROTIRELIN; PROTIRELIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; DIET RESTRICTION; FLOUNDER; GASTROINTESTINAL TRACT; HORMONAL REGULATION; HYPOTHALAMUS; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE ANALYSIS; PREOPTIC AREA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEASONAL VARIATION; SEQUENCE HOMOLOGY; SPECIES COMPARISON; SPECIES DIFFERENCE; SUMMER; TELENCEPHALON; TESTIS; WINTER;

AMINO ACID SEQUENCE; ANIMALS; APPETITE REGULATION; CLONING, MOLECULAR; DNA, COMPLEMENTARY; FEMALE; FISH PROTEINS; FLOUNDER; FOOD DEPRIVATION; GENE EXPRESSION REGULATION; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; ORGAN SPECIFICITY; PHYLOGENY; PROTEIN PRECURSORS; RECOMBINANT PROTEINS; RNA, MESSENGER; SEASONS; SEQUENCE ALIGNMENT; TELENCEPHALON; THYROTROPIN-RELEASING HORMONE;

PSEUDOPLEURONECTES AMERICANUS;

EID: 77955656151     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2010.05.017     Document Type: Article

References (98)

1. C.E. Alvarez, and J.G. Sutcliffe Hypocretin is an early member of the incretin gene family Neurosci Lett 324 2002 169 172
2. N. Amiya, M. Amano, Y. Oka, M. Iigo, A. Takahashi, and K. Yamamori Immunohistochemical localization of orexin/hypocretin-like immunoreactive peptides and melanin-concentrating hormone in the brain and pituitary of medaka Neurosci Lett 427 2007 16 21
3. R. Anadon, M. Becerra, M.L. Diaz, and M.J. Manso Presence and development of thyrotropin-releasing hormone-immunoreactive amacrine cells in the retina of a teleost, the brown trout (Salmo trutta fario) Neurosci Lett 299 2001 225 228
4. H. Ando, J. Ando, and A. Urano Localization of mRNA encoding thyrotropin-releasing hormone precursor in the brain of sockeye salmon Zoolog Sci 15 1998 945 953 (Pubitemid 128366726)
5. Y. Aoki, T. Masuda, M. Iigo, and T. Yanagisawa Molecular cloning of prepro-thyrotropin-releasing hormone cDNA from medaka (Oryzias latipes) Gen Comp Endocrinol 150 2007 364 370
6. Y. Aoki, H. Ono, S. Yasuo, T. Masuda, T. Yoshimura, and S. Ebihara Molecular evolution of prepro-thyrotropin-releasing hormone in the chicken (Gallus gallus) and its expression in the brain Zoolog Sci 24 2007 686 692
7. Y. Aoki, M. Takahashi, T. Masuda, T. Tsukamoto, M. Iigo, and T. Yanagisawa Molecular cloning of prepro-thyrotropin-releasing hormone cDNAs from the common carp Cyprinus carpio and goldfish Carassius auratus Gen Comp Endocrinol 141 2005 84 92
8. L. Appelbaum, G.X. Wang, G.S. Maro, R. Mori, A. Tovin, and W. Marin Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish Proc Natl Acad Sci U S A 106 2009 21942 21947
9. Z.A. Archer, P.A. Findlay, S.M. Rhind, J.G. Mercer, and C.L. Adam Orexin gene expression and regulation by photoperiod in the sheep hypothalamus Regul Pept 104 2002 41 45
10. T.F. Batten, M.L. Cambre, L. Moons, and F. Vandesande Comparative distribution of neuropeptide-immunoreactive systems in the brain of the green molly, Poecilia latipinna J Comp Neurol 302 1990 893 919
11. T.F. Batten, L. Moons, M.L. Cambre, F. Vandesande, T. Seki, and M. Suzuki Thyrotropin-releasing hormone-immunoreactive system in the brain and pituitary gland of the sea bass (Dicentrarchus labrax, Teleostei) Gen Comp Endocrinol 79 1990 385 392
12. H.R. Berthoud, L.M. Patterson, G.M. Sutton, C. Morrison, and H. Zheng Orexin inputs to caudal raphe neurons involved in thermal, cardiovascular, and gastrointestinal regulation Histochem Cell Biol 123 2005 147 156
13. R. Bilek TRH-like peptides in prostate gland and other tissues Physiol Res 49 Suppl. 1 2000 S19 S26
14. A. Boelen, W.M. Wiersinga, and E. Fliers Fasting-induced changes in the hypothalamus-pituitary-thyroid axis Thyroid 18 2008 123 129
15. N.R. Bromage The effects of mammalian thyrotropin-releasing hormone on the pituitary-thyroid axis of teleost fish Gen Comp Endocrinol 25 1975 292 297
16. M. Bulant, K. Richter, K. Kuchler, and G. Kreil A cDNA from brain of Xenopus laevis coding for a new precursor of thyrotropin-releasing hormone FEBS Lett 296 1992 292 296
17. M.P. Burton, and D.R. Idler The reproductive cycle in winter flounder, Pseudopleuronectes americanus (Walbaum) Can J Zool 62 1984 2563 2567
18. J.M. CerdaReverter, and L.F. Canosa Neuroendocrine systems of the fish brain N.J. Bernier, G. Van Der Kraak, A.P. Farrell, C.J. Brauner, Fish physiology 2009 Academic Press 3 74 [chapter 1]
19. A. Chatterjee, Y.L. Hsieh, and J.Y.L. Yu Molecular cloning of cDNA encoding thyroid stimulating hormone beta subunit of bighead carp Aristichthys nobilis and regulation of its gene expression Mol Cell Endocrinol 174 2001 1 9
20. M.I. Chiamolera, and F.E. Wondisford Minireview: thyrotropin-releasing hormone and the thyroid hormone feedback mechanism Endocrinology 150 2009 1091 1096
21. S.H. Cho Compensatory growth of juvenile flounder Paralichthys olivaceus L. and changes in biochemical composition and body condition indices during starvation and after refeeding in winter season JWAS 36 2005 508 514
22. Y.H. Choi, D. Hartzell, M.J. Azain, and C.A. Baile TRH decreases food intake and increases water intake and body temperature in rats Physiol Behavior 77 2002 1 4
23. M.L. Diaz, M. Becerra, M.J. Manso, and R. Anadon Development of thyrotropin-releasing hormone immunoreactivity in the brain of the brown trout Salmo trutta fario J Comp Neurol 429 2001 299 320
24. M.L. Diaz, M. Becerra, M.J. Manso, and R. Anadon Distribution of thyrotropin-releasing hormone (TRH) immunoreactivity in the brain of the zebrafish (Danio rerio) J Comp Neurol 450 2002 45 60 (Pubitemid 34787696)
25. L. Dominguez, J.M. Lopez, and A. Gonzalez Distribution of thyrotropin-releasing hormone (TRH) immunoreactivity in the brain of urodele amphibians Brain Behav Evol 71 2008 231 246
26. L. Dominguez, R. Morona, A. Joven, A. Gonzalez, and J.M. Lopez Immunohistochemical localization of orexins (hypocretins) in the brain of reptiles and its relation to monoaminergic systems J Chem Neuroanat 39 2010 20 34
27. S. Dufour, and K. Rousseau Neuroendocrinology of fish metamorphosis and puberty: evolutionary and ecophysiological perspectives J Mar Sci Technol Taiwan 15 2007 55 68
28. J.G. Eales, and B.A. Himick The effect of TRH on plasma thyroid hormone levels of rainbow trout (Salmo gairdneri) and arctic charr (Salvelinus alpinus) Gen Comp Endocrinol 72 1988 333 339
29. H.M. Evans A comparative study of the brains in Pleuronectidae Proc R Soc Lond 122 1937 308 343
30. R.M. Facciolo, M. Crudo, G. Giusi, R. Alo, and M. Canonaco Light- and dark-dependent orexinergic neuronal signals promote neurodegenerative phenomena accounting for distinct behavioral responses in the teleost Thalassoma pavo J Neurosci Res 87 2009 748 757
31. J.H. Faraco, L. Appelbaum, W. Marin, S.E. Gaus, P. Mourrain, and E. Mignot Regulation of hypocretin (orexin) expression in embryonic zebrafish J Biol Chem 281 2006 29753 29761
32. E. Froiland, K. Murashita, E.H. Jorgensen, and T. Kurokawa Leptin and ghrelin in anadromous Arctic charr: cloning and change in expressions during a seasonal feeding cycle Gen Comp Endocrinol 165 2010 136 143
33. L. Galas, E. Raoult, M.C. Tonon, R. Okada, B.G. Jenks, and J.P. Castano TRH acts as a multifunctional hypophysiotropic factor in vertebrates Gen Comp Endocrinol 164 2009 40 50
34. J.A. Gonzalez, E. Horjales-Araujo, L. Fugger, C. Broberger, and D. Burdakov Stimulation of orexin/hypocretin neurones by thyrotropin-releasing hormone J Physiol 587 2009 1179 1186
35. A. Gorbman, and M. Hyder Failure of mammalian TRH to stimulate thyroid function in the lungfish Gen Comp Endocrinol 20 1973 588 589
36. K. Hamano, K. Inoue, and T. Yanagisawa Immunohistochemical localization of thyrotropin-releasing hormone in the brain of carp, Cyprinus carpio Gen Comp Endocrinol 80 1990 85 92
37. Y.S. Han, I.C. Liao, W.N. Tzeng, and J.Y.L. Yu Cloning of the cDNA for thyroid stimulating hormone alpha subunit and changes in activity of the pituitary-thyroid axis during silvering of the Japanese eel, Anguilla japonica J Mol Endocrinol 32 2004 179 194
38. J. Hara, D. Gerashchenko, J.P. Wisor, T. Sakurai, X. Xie, and T.S. Kilduff Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons J Neurosci 29 2009 3705 3714
39. S. Harder, O. Dammann, F. Buck, H. Zwiers, K. Lederis, and D. Richter Cloning of two thyrotropin-releasing hormone receptor subtypes from a lower vertebrate (Catostomus commersoni): functional expression, gene structure, and evolution Gen Comp Endocrinol 124 2001 236 245
40. S.A. Harmin, L.W. Crim, and M.D. Wiegand Plasma sex steroid profiles and the seasonal reproductive-cycle in male and female winter flounder, Pleuronectes americanus Mar Biol 121 1995 601 610
41. L.J. Hoskins, M. Xu, and H. Volkoff Interactions between gonadotropin-releasing hormone (GnRH) and orexin in the regulation of feeding and reproduction in goldfish (Carassius auratus) Horm Behav 54 2008 379 385
42. G. Huesa, A.N. van den Pol, and T.E. Finger Differential distribution of hypocretin (orexin) and melanin-concentrating hormone in the goldfish brain J Comp Neurol 488 2005 476 491
43. E. Iversen, J. Weeke, and P. Laurberg TRH immunoreactivity in the thyroid gland Scand J Clin Lab Invest 44 1984 703 709
44. I.M.D. Jackson, R. Saperstein, and S. Reichlin Thyrotropin releasing hormone (TRH) in pineal and hypothalamus of frog - effect of season and illumination Endocrinology 100 1977 97 100
45. O. Johren, S.J. Neidert, M. Kummer, A. Dendorfer, and P. Dominiak Prepro-orexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rats Endocrinology 142 2001 3324 3331
46. Y. Kagabu, T. Mishiba, T. Okino, and T. Yanagisawa Effects of thyrotropin-releasing hormone and its metabolites, cyclo(His-Pro) and TRH-OH, on growth hormone and prolactin synthesis in primary cultured pituitary cells of the common carp, Cyprinus carpio Gen Comp Endocrinol 111 1998 395 403
47. J. Kaslin, J.M. Nystedt, M. Ostergard, N. Peitsaro, and P. Panula The orexin/hypocretin system in zebrafish is connected to the aminergic and cholinergic systems J Neurosci 24 2004 2678 2689
48. A. Kehoe, and H. Volkoff The effects of temperature on feeding and on the expression of two appetite-related factors, Neuropeptide Y and cocaine and amphetamine regulated transcript in Atlantic cod (Gadus morhua) JWAS 39 2008 790 796
49. A.L. Kirchgessner Orexins in the brain-gut axis Endocr Rev 23 2002 1 15
50. K. Kojima, M. Kamijo, H. Kageyama, M. Uchiyama, S. Shioda, and K. Matsuda Neuronal relationship between orexin-A- and neuropeptide Y-induced orexigenic actions in goldfish Neuropeptides 43 2009 63 71
51. M.S. Kreider, A. Winokur, S. Manaker, A.I. Pack, and A.P. Fishman Characterization of thyrotropin-releasing hormone in the central nervous system of African lungfish Gen Comp Endocrinol 72 1988 115 122
52. X. Lin, H. Volkoff, Y. Narnaware, N.J. Bernier, P. Peyon, and R.E. Peter Brain regulation of feeding behavior and food intake in fish Comp Biochem Physiol A 126 2000 415 434
53. J.M. Lopez, L. Dominguez, and A. Gonzalez Immunohistochemical localization of thyrotropin-releasing hormone in the brain of reptiles J Chem Neuroanat 36 2008 251 263
54. J.M. Lopez, L. Dominguez, N. Moreno, and A. Gonzalez Comparative immunohistochemical analysis of the distribution of orexins (hypocretins) in the brain of amphibians Peptides 30 2009 873 887
55. J.M. Lopez, L. Dominguez, N. Moreno, R. Morona, A. Joven, and A. Gonzalez Distribution of orexin/hypocretin immunoreactivity in the brain of the lungfishes Protopterus dolloi and Neoceratodus forsteri Brain Behav Evol 74 2009 302 322
56. E. MacDonald, and H. Volkoff Cloning, distribution and effects of season and nutritional status on the expression of neuropeptide Y (NPY), cocaine and amphetamine regulated transcript (CART) and cholecystokinin (CCK) in winter flounder (Pseudopleuronectes americanus) Horm Behav 56 2009 58 65
57. E. Mclean, B. Ronsholdt, C. Sten, and Najamuddin Gastrointestinal delivery of peptide and protein drugs to aquacultured teleosts Aquaculture 177 1999 231 247
58. P. Melamed Hypothalamic and thyroidal regulation of growth hormone in tilapia Gen Comp Endocrinol 97 1995 13 30
59. P. Melamed, N. Eliahu, B. Levavi-Sivan, M. Ofir, O. Farchi-Pisanty, and F. Rentier-Delrue Hypothalamic and thyroidal regulation of growth hormone in tilapia Gen Comp Endocrinol 97 1995 13 30
60. S.M. Mendis-Handagama, and H.B. Siril Ariyaratne Leydig cells, thyroid hormones and steroidogenesis Indian J Exp Biol 43 2005 939 962
61. L. Mercier, C. Audet, J. de la Noue, B. Parent, C.C. Parrish, and N.W. Ross First feeding of winter flounder (Pseudopleuronectes americanus) larvae: use of Brachionus plicatilis acclimated at low temperature as live prey Aquaculture 229 2004 361 376
62. M. Nakabayashi, T. Suzuki, K. Takahashi, K. Totsune, Y. Muramatsu, and C. Kaneko Orexin-A expression in human peripheral tissues Mol Cell Endocrinol 205 2003 43 50
63. T. Nakamachi, K. Matsuda, K. Maruyama, T. Miura, M. Uchiyama, and H. Funahashi Regulation by orexin of feeding behaviour and locomotor activity in the goldfish J Neuroendocrinol 18 2006 290 297
64. Y.K. Narnaware, P.P. Peyon, X. Lin, and R.E. Peter Regulation of food intake by neuropeptide Y in goldfish Am J Physiol Regul Integr Comp Physiol 279 2000 R1025 R1034
65. J.P. Nixon, and L. Smale A comparative analysis of the distribution of immunoreactive orexin A and B in the brains of nocturnal and diurnal rodents Behav Brain Funct 3 2007 28
66. C.M. Novak, X. Jiang, C. Wang, J.A. Teske, C.M. Kotz, and J.A. Levine Caloric restriction and physical activity in zebrafish (Danio rerio) Neurosci Lett 383 2005 99 104
67. A. Ohide, H. Ando, T. Yanagisawa, and A. Urano Hydropathy profiles of predicted thyrotropin-releasing hormone precursors are highly conserved despite low similarity of primary structures J Neuroendocrinol 8 1996 695 701
68. T. Oscar, M. Mara Jess, and A. RamÛn Distribution of thyrotropin-releasing hormone immunoreactivity in the brain of the dogfish Scyliorhinus canicula J Comp Neurol 454 2002 65 81
69. R.E. Peter The brain and feeding behavior W.S. Hoar, D.J. Randall, J.R. Brett, Fish physiology vol. VIII 1979 Academic Press New York, NY 121 159
70. C. Peyron, D.K. Tighe, A.N. van den Pol, L. de Lecea, H.C. Heller, and J.G. Sutcliffe Neurons containing hypocretin (orexin) project to multiple neuronal systems J Neurosci 18 1998 9996 10015
71. S. Plante, C. Audet, Y. Lambert, and J. de la Noue Comparison of stress responses in wild and captive winter flounder (Pseudopleuronectes americanus Walbaum) broodstock Aquacult Res 34 2003 803 812
72. D.A. Prober, J. Rihel, A.A. Onah, R.J. Sung, and A.F. Schier Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish J Neurosci 26 2006 13400 13410
73. P.D.P. Rao, and E.F. Thomas Asymmetry of the olfactory system in the brain of the winter flounder, Pseudopleuronectes americanus J Comp Neurol 225 1984 492 510
74. J. Riehl, K. Honda, M. Kwan, J. Hong, E. Mignot, and S. Nishino Chronic oral administration of CG-3703, a thyrotropin releasing hormone analog, increases wake and decreases cataplexy in canine narcolepsy Neuropsychopharmacology 23 2000 34 45
75. T. Satoh, M. Yamada, T. Monden, M. Iizuka, and M. Mori Cloning of the mouse hypothalamic preprothyrotropin-releasing hormone (TRH) cDNA and tissue distribution of its mRNA Mol Brain Res 14 1992 131 135
76. S. Schuhler, A. Warner, N. Finney, G.W. Bennett, F.J. Ebling, and J.M. Brameld Thyrotrophin-releasing hormone decreases feeding and increases body temperature, activity and oxygen consumption in Siberian hamsters J Neuroendocrinol 19 2007 239 249
77. N. Shibusawa, K. Hashimoto, and M. Yamada Thyrotropin-releasing hormone (TRH) in the cerebellum Cerebellum 7 2008 84 95
78. K.G. Singletary, Y. Delville, W.J. Farrell, and W. Wilczynski Distribution of orexin/hypocretin immunoreactivity in the nervous system of the green Treefrog, Hyla cinerea Brain Res 1041 2005 231 236
79. K.G. Singletary, P. Deviche, C. Strand, and Y. Delville Distribution of orexin/hypocretin immunoreactivity in the brain of a male songbird, the house finch, Carpodacus mexicanus J Chem Neuroanat 32 2006 81 89
80. T.L. Stanton, A. Winokur, and A.L. Beckman Seasonal variation in thyrotropin-releasing hormone (TRH) content of different brain regions and the pineal in the mammalian hibernator, Citellus lateralis Regul Pept 3 1982 135 144
81. C.A. Steward, T.L. Horan, S. Schuhler, G.W. Bennett, and F.J.P. Ebling Central administration of thyrotropin releasing hormone (TRH) and related peptides inhibits feeding behavior in the Siberian hamster Neuroreport 14 2003 687 691
82. V. Strbak, J. Benicky, and M. Nikodemova Comparison of pancreatic and hypophysiotropic TRH systems Physiol Res 49 Suppl. 1 2000 S71 S78
83. H. Suzuki, A. Matsumoto, and T. Yamamoto Orexin-B-like immunoreactivity localized in both luteinizing hormone- and thyroid-stimulating hormone-containing cells in the Nile tilapia (Oreochromis niloticus) pituitary Tissue Cell 41 2009 75 78
84. H. Suzuki, Y. Miyoshi, and T. Yamamoto Orexin-A (hypocretin 1)-like immunoreactivity in growth hormone-containing cells of the Japanese seaperch (Lateolabrax japonicus) pituitary Gen Comp Endocrinol 150 2007 205 211
85. T. Suzuki, H. Kohno, T. Sakurada, T. Tadano, and K. Kisara Intra-cranical injection of thyrotropin releasing hormone (Trh) suppresses starvation-induced feeding and drinking in rats Pharmacol Biochem Behav 17 1982 249 253
86. J.A. Teske, C.J. Billington, and C.M. Kotz Hypocretin/orexin and energy expenditure Acta Physiol (Oxf) 198 2010 303 312
87. Y. Tonosaki, P.M.J.M. Cruijsen, K. Nishiyama, H. Yaginuma, and E.W. Roubos Low temperature stimulates alpha-melanophore-stimulating hormone secretion and inhibits background adaptation in Xenopus laevis J Neuroendocrinol 16 2004 894 905
88. V.L. Trudeau, G.M. Somoza, C.S. Nahorniak, and R.E. Peter Interactions of estradiol with gonadotropin-releasing hormone and thyrotropin-releasing hormone in the control of growth hormone secretion in the goldfish Neuroendocrinology 56 1992 483 490
89. S. Unniappan, J.M. Cerda-Reverter, and R.E. Peter In situ localization of preprogalanin mRNA in the goldfish brain and changes in its expression during feeding and starvation Gen Comp Endocrinol 136 2004 200 207
90. A.L. Van der Salm, M. Pavlidis, G. Flik, and S.E.W. Bonga Differential release of alpha-melanophore stimulating hormone isoforms by the pituitary gland of red porgy, Pagrus pagrus Gen Comp Endocrinol 135 2004 126 133
91. K. Vandenborne, S.A. Roelens, V.M. Darras, E.R. Kuhn, and S. Van der Geyten Cloning and hypothalamic distribution of the chicken thyrotropin- releasing hormone precursor cDNA J Endocrinol 186 2005 387 396
92. H. Volkoff, J.M. Bjorklund, and R.E. Peter Stimulation of feeding behavior and food consumption in the goldfish, Carassius auratus, by orexin-A and orexin-B Brain Res 846 1999 204 209
93. H. Volkoff, and R.E. Peter Characterization of two forms of cocaine- and amphetamine-regulated transcript (CART) peptide precursors in goldfish: molecular cloning and distribution, modulation of expression by nutritional status, and interactions with leptin Endocrinology 142 2001 5076 5088
94. H. Volkoff, S. Unniappan, and S.P. Kelly The endocrine regulation of food intake N. Bernier, G.V.D. Kraak, A. Farrell, C. Brauner, Fish physiology vol. 28 2009 Academic Press Burlington 421 465
95. Xu M. Endocrinal regulation of appetite and growth in Atlantic cod (Gadus morhua). Ph.D. thesis, Memorial University of Newfoundland, 1994 p.; 2009.
96. M. Xu, and H. Volkoff Molecular characterization of prepro-orexin in Atlantic cod (Gadus morhua): cloning, localization, developmental profile and role in food intake regulation Mol Cell Endocrinol 271 2007 28 37
97. M. Yamada, S. Radovick, F.E. Wondisford, Y. Nakayama, B.D. Weintraub, and J.F. Wilber Cloning and structure of human genomic DNA and hypothalamic cDNA encoding human prepro thyrotropin-releasing hormone Mol Endocrinol 4 1990 551 556
98. T. Yokogawa, W. Marin, J. Faraco, G. Pezeron, L. Appelbaum, and J. Zhang Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants PLoS Biol 5 2007 e277