Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women

Cancer Causes and Control

Volumn 21, Issue 6, 2010, Pages 897-908

  Lin, Jennifer ^a   Zee, Robert Y L ^a   Liu, Kuang Yu ^a   Zhang, Shumin M ^a   Lee, I Min ^a,b   Manson, JoAnn E ^a,b   Giovannucci, Edward ^b   Buring, Julie E ^a,b   Cook, Nancy R ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Colorectal cancer; CYP19A1; Estrogen receptors; HSD17B2; Progesterone receptor; Sex hormone genes

Indexed keywords

AROMATASE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; PROGESTERONE RECEPTOR; TESTOSTERONE 17BETA DEHYDROGENASE; TESTOSTERONE 17BETA DEHYDROGENASE 2; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD SAMPLING; CANCER RISK; CAUCASIAN; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC REGULATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; COLORECTAL NEOPLASMS; ESTRADIOL DEHYDROGENASES; ETHNIC GROUPS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC VARIATION; GONADAL STEROID HORMONES; HAPLOTYPES; HUMANS; LOGISTIC MODELS; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; RECEPTORS, STEROID; RISK FACTORS;

EID: 77955652695     PISSN: 09575243     EISSN: 15737225     Source Type: Journal    
DOI: 10.1007/s10552-010-9518-5     Document Type: Article

References (66)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T et al (2008) Cancer statistics, 2008. CA Cancer J Clin 58(2):71-96
2. Froggatt NJ, Green J, Brassett C, Evans DG, Bishop DT, Kolodner R et al (1999) A common MSH2 mutation in English and North American HNPCC families: origin, phenotypic expression, and sex specific differences in colorectal cancer. J Med Genet 36(2):97-102
3. Ochiai M, Watanabe M, Kushida H, Wakabayashi K, Sugimura T, Nagao M (1996) DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis. Carcinogenesis 17(1):95-98
4. Odagiri E, Jibiki K, Kato Y, Nakamura S, Oda S, Demura R et al (1985) Steroid receptors in dimethylhydrazine-induced colon carcinogenesis. Cancer 56(11):2627-2634
5. Gershbein LL (1993) Action of estrogen and adrenocorticoids on adenocarcinoma induction by 1,2-dimethylhydrazine in male rats. Res Commun Chem Pathol Pharmacol 81(1):117-120
6. Calle EE, Miracle-McMahill HL, Thun MJ, Heath CW Jr (1995) Estrogen replacement therapy and risk of fatal colon cancer in a prospective cohort of postmenopausal women. J Natl Cancer Inst 87(7):517-523
7. Potter JD, McMichael AJ (1983) Large bowel cancer in women in relation to reproductive and hormonal factors: a case-control study. J Natl Cancer Inst 71(4):703-709
8. Kune GA, Kune S, Watson LF (1989) Children, age at first birth, and colorectal cancer risk data from the Melbourne Colorectal Cancer Study. Am J Epidemiol 129(3):533-542
9. Singh S, Langman MJ (1995) Oestrogen and colonic epithelial cell growth. Gut 37(6):737-739
10. Narisawa T, Magadia NE, Weisburger JH, Wynder EL (1974) Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N0-nitro-N-nitrosoguanidine in rats. J Natl Cancer Inst 53(4):1093-1097
11. McMichael AJ, Potter JD (1985) Host factors in carcinogenesis: certain bile-acid metabolic profiles that selectively increase the risk of proximal colon cancer. J Natl Cancer Inst 75(2):185-191
12. McMichael AJ, Potter JD (1980) Reproduction, endogenous and exogenous sex hormones, and colon cancer: a review and hypothesis. J Natl Cancer Inst 65(6):1201-1207
13. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML et al (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. Jama 288(3):321-333
14. Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H et al (2004) Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. Jama 291(14):1701-1712
15. Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE et al (2008) Insulin, insulin-like growth factor-I, endogenous estradiol, and risk of colorectal cancer in postmenopausal women. Cancer Res 68(1):329-337 (Pubitemid 351380136)
16. Clendenen TV, Koenig KL, Shore RE, Levitz M, Arslan AA, Zeleniuch-Jacquotte A (2009) Postmenopausal levels of endogenous sex hormones and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 18(1):275-281
17. Giovannucci E (2002) Obesity, gender, and colon cancer. Gut 51(2):147
18. Enmark E, Gustafsson JA (1999) Oestrogen receptors-an overview. J Intern Med 246(2):133-138
19. Campbell-Thompson M, Lynch IJ, Bhardwaj B (2001) Expression of estrogen receptor (ER) subtypes and ERbeta isoforms in colon cancer. Cancer Res 61(2):632-640
20. Kono S,Honjo S,Todoroki I,Nishiwaki M,Hamada H, NishikawaH et al (1998) Glucose intolerance and adenomas of the sigmoid colon in Japanese men (Japan). Cancer Causes Control 9(4):441-446
21. Jassam N, Bell SM, Speirs V, Quirke P (2005) Loss of expression of oestrogen receptor beta in colon cancer and its association with Dukes' staging. Oncol Rep 14(1):17-21
22. Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB (1994) Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 7(4):536-540
23. Di Leo A, Linsalata M, Cavallini A, Messa C, Russo F (1992) Sex steroid hormone receptors, epidermal growth factor receptor, and polyamines in human colorectal cancer. Dis Colon Rectum 35(4):305-309
24. Singh S, Sheppard MC, Langman MJ (1993) Sex differences in the incidence of colorectal cancer: an exploration of oestrogen and progesterone receptors. Gut 34(5):611-615
25. Oshima CT, Wonraht DR, Catarino RM, Mattos D, Forones NM (1999) Estrogen and progesterone receptors in gastric and colorectal cancer. Hepatogastroenterology 46(30):3155-3158
26. Berta L, Fronticelli Baldelli C, Fazzari A, Radice E, Bargoni A, Frairia R et al (2003) Sex steroid receptors, secondary bile acids and colorectal cancer. A possible mechanism of interaction. Panminerva Med 45(4):261-266
27. Kaklamanos IG, Bathe OF, Franceschi D, Lazaris AC, Davaris P, Glinatsis M et al (1999) Expression of receptors for estrogen and progesterone in malignant colonic mucosa as a prognostic factor for patient survival. J Surg Oncol 72(4):225-229
28. Fiorelli G, Picariello L, Martineti V, Tonelli F, Brandi ML (1999) Estrogen synthesis in human colon cancer epithelial cells. J Steroid Biochem Mol Biol 71(5-6):223-230 (Pubitemid 30125685)
29. Means GD, Mahendroo MS, Corbin CJ, Mathis JM, Powell FE, Mendelson CR et al (1989) Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis. J Biol Chem 264(32): 19385-19391
30. Clemons M, Goss P (2001) Estrogen and the risk of breast cancer. N Engl J Med 344(4):276-285
31. Speer G, Cseh K, Winkler G, Takacs I, Barna I, Nagy Z et al (2001) Oestrogen and vitamin D receptor (VDR) genotypes and the expression of ErbB-2 and EGF receptor in human rectal cancers. Eur J Cancer 37(12):1463-1468
32. Slattery ML, Sweeney C, Murtaugh M, Ma KN, Wolff RK, Potter JD et al (2005) Associations between ERalpha, ERbeta, and AR genotypes and colon and rectal cancer. Cancer Epidemiol Biomarkers Prev 14(12):2936-2942 (Pubitemid 43068828)
33. Bethke L, Webb E, Sellick G, Rudd M, Penegar S, Withey L et al (2007) Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk. BMC Cancer 7:123
34. Tomlinson I, Webb E, Carvajal-Carmona L, Broderick P, Kemp Z, Spain S et al (2007) A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet 39(8):984-988
35. Zanke BW, Greenwood CM, Rangrej J, Kustra R, Tenesa A, Farrington SM et al (2007) Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet 39(8):989-994
36. Tomlinson IP, Webb E, Carvajal-Carmona L, Broderick P, Howarth K, Pittman AM et al (2008) A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genet 40(5):623-630 (Pubitemid 351601204)
37. Tenesa A, Farrington SM, Prendergast JG, Porteous ME, Walker M, Haq N et al (2008) Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet 40(5):631-637
38. Jaeger E, Webb E, Howarth K, Carvajal-Carmona L, Rowan A, Broderick P et al (2008) Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. Nat Genet 40(1):26-28
39. Broderick P, Carvajal-Carmona L, Pittman AM, Webb E, Howarth K, Rowan A et al (2007) A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nat Genet 39(11):1315-1317
40. Zhang SM, Buring JE, Lee IM, Cook NR, Ridker PM (2005) C-reactive protein levels are not associated with increased risk for colorectal cancer in women. Ann Intern Med 142(6):425-432
41. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21(2):263-265
42. Haiman CA, Stram DO, Pike MC, Kolonel LN, Burtt NP, Altshuler D et al (2003) A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort. Hum Mol Genet 12(20):2679-2692
43. Pearce CL, Hirschhorn JN, Wu AH, Burtt NP, Stram DO, Young S et al (2005) Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysis. J Natl Cancer Inst 97(1):51-59
44. Cox DG, Bretsky P, Kraft P, Pharoah P, Albanes D, Altshuler D et al (2008) Haplotypes of the estrogen receptor beta gene and breast cancer risk. Int J Cancer 122(2):387-392
45. Fallin D, Schork NJ (2000) Accuracy of haplotype frequency estimation for biallelic loci, via the expectation-maximization algorithm for unphased diploid genotype data. Am J Hum Genet 67(4):947-959
46. Zaykin DV, Westfall PH, Young SS, Karnoub MA, Wagner MJ, Ehm MG (2002) Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals. Hum Hered 53(2):79-91
47. Kraft P, Cox DG, Paynter RA, Hunter D, De Vivo I (2005) Accounting for haplotype uncertainty in matched association studies: a comparison of simple and flexible techniques. Genet Epidemiol 28(3):261-272
48. Ritchie MD, Hahn LW, Moore JH (2003) Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet Epidemiol 24(2):150-157
49. Hahn LW, Ritchie MD, Moore JH (2003) Multifactor dimensionality reduction software for detecting gene-gene and geneenvironment interactions. Bioinformatics 19(3):376-382
50. Moore JH (2004) Computational analysis of gene-gene interactions using multifactor dimensionality reduction. Expert Rev Mol Diagn 4(6):795-803
51. Benjamini Y, Yekutieli D (2005) Quantitative trait loci analysis using the false discovery rate. Genetics 171(2):783-790
52. Hankinson SE, Willett WC, Manson JE, Colditz GA, Hunter DJ, Spiegelman D et al (1998) Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women. J Natl Cancer Inst 90(17):1292-1299
53. Zeleniuch-Jacquotte A, Bruning PF, Bonfrer JM, Koenig KL, Shore RE, Kim MY et al (1997) Relation of serum levels of testosterone and dehydroepiandrosterone sulfate to risk of breast cancer in postmenopausal women. Am J Epidemiol 145(11): 1030-1038
54. Kaaks R, Rinaldi S, Key TJ, Berrino F, Peeters PH, Biessy C et al (2005) Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition. Endocr Relat Cancer 12(4):1071-1082
55. Haiman CA, Dossus L, Setiawan VW, Stram DO, Dunning AM, Thomas G et al (2007) Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women. Cancer Res 67(5):1893-1897
56. Dunning AM, Dowsett M, Healey CS, Tee L, Luben RN, Folkerd E et al (2004) Polymorphisms associated with circulating sex hormone levels in postmenopausal women. J Natl Cancer Inst 96(12):936-945
57. Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, Ballinger DG et al (2007) Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447 (7148):1087-1093
58. Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE et al (2007) A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet 39(7):870-874
59. Schumacher FR, Feigelson HS, Cox DG, Haiman CA, Albanes D, Buring J et al (2007) A common 8q24 variant in prostate and breast cancer from a large nested case-control study. Cancer Res 67(7):2951-2956
60. Stacey SN, Manolescu A, Sulem P, Rafnar T, Gudmundsson J, Gudjonsson SA et al (2007) Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet 39(7):865-869
61. Thomas G, Jacobs KB, Kraft P, Yeager M, Wacholder S, Cox DG et al (2009) A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet 41(5):579-584
62. Zheng W, Long J, Gao YT, Li C, Zheng Y, Xiang YB et al (2009) Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat Genet 41(3):324-328
63. Dunning AM, Healey CS, Baynes C, Maia AT, Scollen S, Vega A et al (2009) Association of ESR1 gene tagging SNPs with breast cancer risk. Hum Mol Genet 18(6):1131-1139
64. Chung CC, Magalhaes W, Gonzalez-Bosquet J, Chanock SJ (2009) Genome-wide association studies in cancer-current and future directions. Carcinogenesis
65. Watters JJ, Campbell JS, Cunningham MJ, Krebs EG, Dorsa DM (1997) Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signalling cascade and c-fos immediate early gene transcription. Endocrinology 138(9):4030-4033
66. Gilad LA, Bresler T, Gnainsky J, Smirnoff P, Schwartz B (2005) Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells. J Endocrinol 185(3):577-592